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SGOL2 [cytosol]
Stable Identifier
R-HSA-376242
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
SGO2, Shugoshin-like 2, Shugoshin-2
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle Checkpoints (Homo sapiens)
Mitotic Spindle Checkpoint (Homo sapiens)
Amplification of signal from the kinetochores (Homo sapiens)
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal (Homo sapiens)
MAD2 associates with the Mad1 kinetochore complex (Homo sapiens)
Kinetochore:Mad1:MAD2 Complex [cytosol] (Homo sapiens)
Mad1:kinetochore complex [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
SGOL2 [cytosol] (Homo sapiens)
Mad1:kinetochore complex [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
SGOL2 [cytosol] (Homo sapiens)
MAD2 converted to an inhibitory state via interaction with Mad1 (Homo sapiens)
Kinetochore:Mad1:MAD2 Complex [cytosol] (Homo sapiens)
Mad1:kinetochore complex [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
SGOL2 [cytosol] (Homo sapiens)
Kinetochore:Mad1:MAD2* Complex [cytosol] (Homo sapiens)
Mad1:kinetochore complex [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
SGOL2 [cytosol] (Homo sapiens)
Mad1 binds kinetochore (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
SGOL2 [cytosol] (Homo sapiens)
Mad1:kinetochore complex [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
SGOL2 [cytosol] (Homo sapiens)
Release of activated MAD2 from kinetochores (Homo sapiens)
Kinetochore:Mad1:MAD2* Complex [cytosol] (Homo sapiens)
Mad1:kinetochore complex [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
SGOL2 [cytosol] (Homo sapiens)
Mad1:kinetochore complex [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
SGOL2 [cytosol] (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
M Phase (Homo sapiens)
Mitotic Metaphase and Anaphase (Homo sapiens)
Mitotic Anaphase (Homo sapiens)
Separation of Sister Chromatids (Homo sapiens)
ESPL1 (Separase) cleaves centromeric cohesin (Homo sapiens)
Cleaved Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
SGOL2 [cytosol] (Homo sapiens)
p-RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
SGOL2 [cytosol] (Homo sapiens)
Separation of sister chromatids (Homo sapiens)
Cleaved Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
SGOL2 [cytosol] (Homo sapiens)
Sister Centromere:Kinetochore:Microtubules [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
SGOL2 [cytosol] (Homo sapiens)
Mitotic Prometaphase (Homo sapiens)
EML4 and NUDC in mitotic spindle formation (Homo sapiens)
EML4 recruits NUDC to mitotic spindle (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
SGOL2 [cytosol] (Homo sapiens)
p-S274,S326-NUDC:EML4 homotrimer:Microtubule-bound kinetochore [spindle] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
SGOL2 [cytosol] (Homo sapiens)
Kinetochore capture of astral microtubules (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
SGOL2 [cytosol] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
SGOL2 [cytosol] (Homo sapiens)
Resolution of Sister Chromatid Cohesion (Homo sapiens)
CDK1 phosphorylates CDCA5 (Sororin) at centromeres (Homo sapiens)
Ac-Cohesin:PDS5:CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Ac-Cohesin:PDS5:WAPAL:Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
Sister Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
SGOL2 [cytosol] (Homo sapiens)
Sister Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
SGOL2 [cytosol] (Homo sapiens)
Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
SGOL2 [cytosol] (Homo sapiens)
Kinetochore assembly (Homo sapiens)
Ac-Cohesin:PDS5:CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Ac-Cohesin:PDS5:WAPAL:Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
Sister Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
SGOL2 [cytosol] (Homo sapiens)
Sister Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
SGOL2 [cytosol] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
SGOL2 [cytosol] (Homo sapiens)
PP2A-B56 dephosphorylates centromeric cohesin (Homo sapiens)
p-RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
SGOL2 [cytosol] (Homo sapiens)
p-STAG2,RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
SGOL2 [cytosol] (Homo sapiens)
Phosphorylation of cohesin by PLK1 at centromeres (Homo sapiens)
Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
SGOL2 [cytosol] (Homo sapiens)
p-STAG2,RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
SGOL2 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
Signaling by Rho GTPases (Homo sapiens)
RHO GTPase Effectors (Homo sapiens)
RHO GTPases Activate Formins (Homo sapiens)
AURKB phosphorylates DIAPH2-2 at kinetochores (Homo sapiens)
Kinetochore:CDC42:GTP:DIAPH2-2 [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
SGOL2 [cytosol] (Homo sapiens)
Kinetochore:CDC42:GTP:p-S196-DIAPH2-2 [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
SGOL2 [cytosol] (Homo sapiens)
CDC42:GTP recruits DIAPH2-2 to kinetochores (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
SGOL2 [cytosol] (Homo sapiens)
Kinetochore:CDC42:GTP:DIAPH2-2 [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
SGOL2 [cytosol] (Homo sapiens)
Kinetochore capture of astral microtubules is positively regulated by CDC42:GTP:p-S196-DIAPH2-2 (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
SGOL2 [cytosol] (Homo sapiens)
Kinetochore:CDC42:GTP:p-S196-DIAPH2-2 [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
SGOL2 [cytosol] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
SGOL2 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q562F6 SGO2
Gene Names
SGO2, SGOL2
Chain
chain:1-1265
Reference Genes
BioGPS Gene:151246 SGO2
COSMIC (genes):SGO2 SGO2
CTD Gene:151246 SGO2
dbSNP Gene:151246 SGO2
ENSEMBL:ENSG00000163535 SGO2
HGNC:30812 SGO2
KEGG:hsa:151246 SGO2
Monarch:151246 SGO2
NCBI Gene:151246 SGO2
OMIM:612425 SGO2
UCSC:Q562F6 SGO2
Reference Transcript
RefSeq:NM_001160046.1 SGO2
RefSeq:XM_005246345.5 SGO2
RefSeq:XM_047443503.1 SGO2
RefSeq:NM_152524.6 SGO2
RefSeq:XM_011510734.2 SGO2
Other Identifiers
11724054_a_at
11724055_x_at
11753254_a_at
151246
16889251
230165_PM_at
230165_at
235425_PM_at
235425_at
2522213
2522215
2522216
2522217
2522218
2522219
2522220
2522221
2522222
2522223
2522224
2522225
2522226
2522228
2522229
2522230
2522231
2522232
2522233
2522234
2522235
2522236
2522238
2522241
2522242
50770_at
53572_at
8047288
A_14_P114482
A_14_P124235
A_23_P411335
A_33_P3309607
GE87413
GO:0000775
GO:0000776
GO:0005515
GO:0005634
GO:0005654
GO:0005694
GO:0005829
GO:0007059
GO:0016604
GO:0022414
GO:0030892
GO:0043226
GO:0051177
GO:0051301
GO:0051321
HMNXSV003010853
HMNXSV003047762
HMNXSV003052091
Hs.111471.0.A1_3p_at
Hs.44269.0.A1_3p_at
ILMN_1746699
ILMN_2061641
PH_hs_0031197
TC02001161.hg
Participates
as a component of
Kinetochore [cytosol] (Homo sapiens)
Inferred To
Sgo2a [cytosol]
(Mus musculus)
sgo2 [cytosol]
(Danio rerio)
sgo2 [cytosol]
(Xenopus tropicalis)
SGO2 [cytosol]
(Bos taurus)
SGO2 [cytosol]
(Canis familiaris)
SGO2 [cytosol]
(Sus scrofa)
LOC424111 [cytosol]
(Gallus gallus)
Sgo2 [cytosol]
(Rattus norvegicus)
Cross References
RefSeq
NP_001153518.1
,
XP_011509036.1
,
NP_689737.4
,
XP_047299459.1
,
XP_005246402.1
ENSEMBL
ENSP00000386249
,
ENST00000409203
,
ENSG00000163535
,
ENSP00000350447
,
ENST00000357799
OpenTargets
ENSG00000163535
GeneCards
SGO2
HPA
ENSG00000163535-SGO2
PRO
Q562F6
Pharos - Targets
Q562F6
GlyGen
Q562F6
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q13257 MAD2L1
2
MAD2L1 [cytosol]
(R-HSA-141400)
Activated MAD2L1 [cytosol]
(R-HSA-141447)
0.731
11
UniProt:P67775 PPP2CA
4
PPP2CA [cytosol]
(R-HSA-165971)
PPP2CA [nucleoplasm]
(R-HSA-165978)
p-Y307-PPP2CA [cytosol]
(R-HSA-8857939)
MeL-PPP2CA [nucleoplasm]
(R-HSA-8857791)
0.564
2
UniProt:Q01105 SET
1
SET [nucleoplasm]
(R-HSA-451201)
0.527
2
UniProt:P62136 PPP1CA
2
PPP1CA [cytosol]
(R-HSA-163525)
PPP1CA [nucleoplasm]
(R-HSA-61995)
0.462
4
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