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INTS6 [nucleoplasm]
Stable Identifier
R-HSA-6807440
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Integrator complex subunit 6, INT6_HUMAN
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
RNA polymerase II transcribes snRNA genes (Homo sapiens)
CBCAP complex binds 7-methylguanosine cap of snRNA (Homo sapiens)
RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:CBCAP:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
Integrator [nucleoplasm] (Homo sapiens)
INTS6 [nucleoplasm] (Homo sapiens)
RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
Integrator [nucleoplasm] (Homo sapiens)
INTS6 [nucleoplasm] (Homo sapiens)
Dephosphorylation and dissociation of RNA polymerase II at 3' end of snRNA gene (Homo sapiens)
Integrator [nucleoplasm] (Homo sapiens)
INTS6 [nucleoplasm] (Homo sapiens)
RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
Integrator [nucleoplasm] (Homo sapiens)
INTS6 [nucleoplasm] (Homo sapiens)
Integrator complex processes the 3' end of snRNA (Homo sapiens)
Integrator [nucleoplasm] (Homo sapiens)
INTS6 [nucleoplasm] (Homo sapiens)
RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:CBCAP:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
Integrator [nucleoplasm] (Homo sapiens)
INTS6 [nucleoplasm] (Homo sapiens)
RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
Integrator [nucleoplasm] (Homo sapiens)
INTS6 [nucleoplasm] (Homo sapiens)
Pre-snRNA is elongated and capped with 7-methylguanosine (Homo sapiens)
RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
Integrator [nucleoplasm] (Homo sapiens)
INTS6 [nucleoplasm] (Homo sapiens)
RNA polymerase II (phosphoserine-5,7):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC:pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
RNA polymerase II (phospho-Ser5,7 CTD):RDRP1A,B:RDRP2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
Integrator [nucleoplasm] (Homo sapiens)
INTS6 [nucleoplasm] (Homo sapiens)
Pre-snRNA transcript initiation, Integrator binding, LEC binding (Homo sapiens)
Integrator [nucleoplasm] (Homo sapiens)
INTS6 [nucleoplasm] (Homo sapiens)
RNA polymerase II (phosphoserine-5,7):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC:pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
RNA polymerase II (phospho-Ser5,7 CTD):RDRP1A,B:RDRP2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
Integrator [nucleoplasm] (Homo sapiens)
INTS6 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9UL03 INTS6
Gene Names
INTS6, DBI1, DDX26, DDX26A
Chain
chain:1-887
Reference Genes
BioGPS Gene:26512 INTS6
COSMIC (genes):INTS6 INTS6
CTD Gene:26512 INTS6
dbSNP Gene:26512 INTS6
ENSEMBL:ENSG00000102786 INTS6
HGNC:14879 INTS6
KEGG:hsa:26512 INTS6
Monarch:26512 INTS6
NCBI Gene:26512 INTS6
OMIM:604331 INTS6
UCSC:Q9UL03 INTS6
Reference Transcript
RefSeq:NM_012141.2 INTS6
RefSeq:NM_001306091.1 INTS6
RefSeq:XM_011535040.2 INTS6
RefSeq:NM_001039937.1 INTS6
RefSeq:NM_001039938.1 INTS6
Other Identifiers
11727519_a_at
11727520_a_at
11727521_s_at
11734299_at
11734300_at
11746392_s_at
11746393_x_at
11751761_a_at
11751762_s_at
11752061_x_at
11754834_x_at
1568695_PM_s_at
1568695_s_at
16779232
17124008
218819_PM_at
218819_at
222239_PM_s_at
222239_s_at
235283_PM_at
235283_at
26512
2854576
2854578
2854580
2854581
2854583
3514487
3514489
3514491
3514492
3514493
3514494
3514495
3514496
3514497
3514498
3514501
3514503
3514509
3514510
3514512
3514513
3514514
3514515
3514516
3514517
3514518
3514520
3514521
3514522
3514523
3514524
3514525
3514526
3514529
3514532
3514533
3514534
3514540
3514541
3514542
3514543
3514544
3514545
3514546
3514547
3514548
3514549
3514550
3514551
3514552
3514553
3514554
3514555
3514556
3514557
3514558
3514559
3514560
3514561
3514562
3514563
3514564
3514565
3514566
3514567
46149_at
50525_at
52286_at
54126_at
61073_at
73184_at
7971692
82901_at
86784_at
A_23_P25653
A_24_P167614
A_24_P913760
A_33_P3316073
A_33_P3316078
GE56521
GE86320
GO:0004888
GO:0005515
GO:0005634
GO:0005654
GO:0005856
GO:0006355
GO:0015629
GO:0016073
GO:0016180
GO:0032039
GO:0034243
GO:0034472
GO:0043226
GO:0060089
HMNXSV003026790
HMNXSV003035851
Hs.146105.0.A1_3p_at
Hs.58570.1.S1_3p_a_at
Hs2.126155.1.S1_3p_s_at
ILMN_1655557
ILMN_2312304
PH_hs_0024564
TC13000678.hg
g11024693_3p_at
Participates
as a component of
Integrator [nucleoplasm] (Homo sapiens)
Inferred To
ints-6 [nucleoplasm]
(Caenorhabditis elegans)
IntS6 [nucleoplasm]
(Drosophila melanogaster)
Ints6 [nucleoplasm]
(Mus musculus)
Ints6 [nucleoplasm]
(Rattus norvegicus)
INTS6 [nucleoplasm]
(Bos taurus)
INTS6 [nucleoplasm]
(Canis familiaris)
INTS6 [nucleoplasm]
(Gallus gallus)
INTS6 [nucleoplasm]
(Sus scrofa)
ints6 [nucleoplasm]
(Dictyostelium discoideum)
ints6 [nucleoplasm]
(Xenopus tropicalis)
Ghost homologue of INTS6 [nucleoplasm]
(Danio rerio)
Cross References
ENSEMBL
ENSP00000381187
,
ENSP00000310260
,
ENSP00000411245
,
ENST00000311234
,
ENST00000442263
,
ENST00000398119
OpenTargets
ENSG00000102786
HPA
ENSG00000102786-INTS6
PRO
Q9UL03
Pharos - Targets
Q9UL03
PDB
8RBZ
,
7PKS
,
8RBX
,
7YCX
,
7CUN
,
7BV7
,
8RC4
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P67775 PPP2CA
4
PPP2CA [cytosol]
(R-HSA-165971)
PPP2CA [nucleoplasm]
(R-HSA-165978)
p-Y307-PPP2CA [cytosol]
(R-HSA-8857939)
MeL-PPP2CA [nucleoplasm]
(R-HSA-8857791)
0.643
3
UniProt:P33993 MCM7
1
MCM7 [nucleoplasm]
(R-HSA-68555)
0.625
10
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