Reactome | INTS7 [nucleoplasm]

INTS7 [nucleoplasm]

Stable Identifier

R-HSA-6807401

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Integrator complex subunit 7, INT7_HUMAN

Locations in the PathwayBrowser

Expand all

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - RNA polymerase II transcribes snRNA genes (Homo sapiens)
    - CBCAP complex binds 7-methylguanosine cap of snRNA (Homo sapiens)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:CBCAP:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
        
        Integrator [nucleoplasm] (Homo sapiens)
        
        INTS7 [nucleoplasm] (Homo sapiens)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
        
        Integrator [nucleoplasm] (Homo sapiens)
        
        INTS7 [nucleoplasm] (Homo sapiens)
    - Dephosphorylation and dissociation of RNA polymerase II at 3' end of snRNA gene (Homo sapiens)
      - Integrator [nucleoplasm] (Homo sapiens)
        
        INTS7 [nucleoplasm] (Homo sapiens)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
        
        Integrator [nucleoplasm] (Homo sapiens)
        
        INTS7 [nucleoplasm] (Homo sapiens)
    - Integrator complex processes the 3' end of snRNA (Homo sapiens)
      - Integrator [nucleoplasm] (Homo sapiens)
        
        INTS7 [nucleoplasm] (Homo sapiens)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:CBCAP:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
        
        Integrator [nucleoplasm] (Homo sapiens)
        
        INTS7 [nucleoplasm] (Homo sapiens)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
        
        Integrator [nucleoplasm] (Homo sapiens)
        
        INTS7 [nucleoplasm] (Homo sapiens)
    - Pre-snRNA is elongated and capped with 7-methylguanosine (Homo sapiens)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
        
        Integrator [nucleoplasm] (Homo sapiens)
        
        INTS7 [nucleoplasm] (Homo sapiens)
      - RNA polymerase II (phosphoserine-5,7):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC:pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
        
        RNA polymerase II (phospho-Ser5,7 CTD):RDRP1A,B:RDRP2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
        
        Integrator [nucleoplasm] (Homo sapiens)
        
        INTS7 [nucleoplasm] (Homo sapiens)
    - Pre-snRNA transcript initiation, Integrator binding, LEC binding (Homo sapiens)
      - Integrator [nucleoplasm] (Homo sapiens)
        
        INTS7 [nucleoplasm] (Homo sapiens)
      - RNA polymerase II (phosphoserine-5,7):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC:pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
        
        RNA polymerase II (phospho-Ser5,7 CTD):RDRP1A,B:RDRP2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
        
        Integrator [nucleoplasm] (Homo sapiens)
        
        INTS7 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9NVH2 INTS7

Gene Names

INTS7, C1orf73

Chain

chain:1-962

Reference Genes

BioGPS Gene:25896 INTS7

COSMIC (genes):INTS7 INTS7

CTD Gene:25896 INTS7

dbSNP Gene:25896 INTS7

ENSEMBL:ENSG00000143493 INTS7

HGNC:24484 INTS7

KEGG Gene (Homo sapiens):25896 INTS7

Monarch:25896 INTS7

NCBI Gene:25896 INTS7

OMIM:611350 INTS7

UCSC:Q9NVH2 INTS7

Reference Transcript

Other Identifiers

0002850411

11727540_a_at

11750331_x_at

11764234_s_at

16699021

218783_at

222250_3p_s_at

222250_s_at

2454533

2454534

2454535

2454536

2454537

2454540

2454541

2454542

2454545

2454546

2454548

2454552

2454553

2454554

2454557

2454558

2454560

2454561

2454562

2454564

2454566

2454568

2454569

2454571

2454574

2454576

2454578

2454581

2454582

2454583

2454584

25896

49075_at

62172_at

7924119

A_23_P52082

GE56586

GO:0000077

GO:0003674

GO:0005515

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0005694

GO:0005737

GO:0006950

GO:0006974

GO:0007049

GO:0008150

GO:0009058

GO:0016180

GO:0016604

GO:0032039

GO:0032991

GO:0034472

GO:0034641

GO:0042795

GO:0043226

GO:0071479

HMNXSV003049295

Hs.48604.1.S1_3p_x_at

ILMN_1718354

PH_hs_0035882

TC01003801.hg

TC01006094.hg

g6453464_3p_at

Participates

as a component of

Integrator [nucleoplasm] (Homo sapiens)

Inferred To

Ints7 [nucleoplasm] (Mus musculus)

Ints7 [nucleoplasm] (Rattus norvegicus)

INTS7 [nucleoplasm] (Canis familiaris)

INTS7 [nucleoplasm] (Gallus gallus)

INTS7 [nucleoplasm] (Sus scrofa)

ints-7 [nucleoplasm] (Caenorhabditis elegans)

ints7 [nucleoplasm] (Danio rerio)

ints7 [nucleoplasm] (Dictyostelium discoideum)

ints7 [nucleoplasm] (Xenopus tropicalis)

defl [nucleoplasm] (Drosophila melanogaster)

Cross References

RefSeq

NP_056249.1, NP_001186740.1, NP_001186741.1, NP_001186738.1

OpenTargets

ENSG00000143493

GeneCards

Q9NVH2

HPA

ENSG00000143493-INTS7

Ensembl

ENSP00000355959, ENSG00000143493, ENST00000440600, ENSP00000355960, ENSP00000355961, ENST00000366993, ENST00000366994, ENST00000366992, ENSP00000388908

PRO

Q9NVH2

Pharos - Targets

Q9NVH2

PDB

7CUN

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