Reactome | FGFR1OP [cytosol]

FGFR1OP [cytosol]

Stable Identifier

R-HSA-380309

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

FOP

Locations in the PathwayBrowser

Expand all

Organelle biogenesis and maintenance (Homo sapiens)

- Cilium Assembly (Homo sapiens)
  - Anchoring of the basal body to the plasma membrane (Homo sapiens)
    - C2CD3 and OFD1 recruit 5 distal appendage proteins to the centriole (Homo sapiens)
      - Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
        
        mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        FGFR1OP [cytosol] (Homo sapiens)
      - mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        FGFR1OP [cytosol] (Homo sapiens)
    - C2CD3 binds the mother centriole (Homo sapiens)
      - mother centriole [cytosol] (Homo sapiens)
        
        FGFR1OP [cytosol] (Homo sapiens)
      - mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        FGFR1OP [cytosol] (Homo sapiens)
    - CEP164 recruits RAB3IP-carrying Golgi-derived vesicles to the basal body (Homo sapiens)
      - basal body:transition zone proteins [cytosol] (Homo sapiens)
        
        basal body [cytosol] (Homo sapiens)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
        
        FGFR1OP [cytosol] (Homo sapiens)
      - basal body:transition zone proteins:RAB3IP:RAB11A:GTP:Golgi-derived vesicle [cytosol] (Homo sapiens)
        
        basal body:transition zone proteins [cytosol] (Homo sapiens)
        
        basal body [cytosol] (Homo sapiens)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
        
        FGFR1OP [cytosol] (Homo sapiens)
    - CP110 and CEP97 dissociate from the centriole (Homo sapiens)
      - basal body [cytosol] (Homo sapiens)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
        
        FGFR1OP [cytosol] (Homo sapiens)
      - centrosome:C2CD2:distal appendage proteins:TTBK2:MARK4 [cytosol] (Homo sapiens)
        
        Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Homo sapiens)
        
        Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
        
        mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        FGFR1OP [cytosol] (Homo sapiens)
    - MARK4 binds ODF2 in the centriole (Homo sapiens)
      - Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Homo sapiens)
        
        Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
        
        mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        FGFR1OP [cytosol] (Homo sapiens)
      - centrosome:C2CD2:distal appendage proteins:TTBK2:MARK4 [cytosol] (Homo sapiens)
        
        Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Homo sapiens)
        
        Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
        
        mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        FGFR1OP [cytosol] (Homo sapiens)
    - RAB3IP stimulates nucleotide exchange on RAB8A (Homo sapiens)
      - basal body:transition zone proteins:RAB3IP:RAB11A:GTP:Golgi-derived vesicle [cytosol] (Homo sapiens)
        
        basal body:transition zone proteins [cytosol] (Homo sapiens)
        
        basal body [cytosol] (Homo sapiens)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
        
        FGFR1OP [cytosol] (Homo sapiens)
    - Recruitment of transition zone proteins (Homo sapiens)
      - basal body [cytosol] (Homo sapiens)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
        
        FGFR1OP [cytosol] (Homo sapiens)
      - basal body:transition zone proteins [cytosol] (Homo sapiens)
        
        basal body [cytosol] (Homo sapiens)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
        
        FGFR1OP [cytosol] (Homo sapiens)
    - The distal appendage proteins recruit TTBK2 (Homo sapiens)
      - Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
        
        mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        FGFR1OP [cytosol] (Homo sapiens)
      - Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Homo sapiens)
        
        Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
        
        mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        FGFR1OP [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:O95684 CEP43

Gene Names

CEP43, FGFR1OP, FOP

Chain

chain:1-399

Reference Genes

BioGPS Gene:11116 CEP43

CTD Gene:11116 CEP43

dbSNP Gene:11116 CEP43

ENSEMBL:ENSG00000213066 FGFR1OP

ENSEMBL_homo_sapiens_GENE:ENSG00000213066.14 CEP43

HGNC:17012 CEP43

KEGG Gene (Homo sapiens):11116 CEP43

Monarch:11116 CEP43

NCBI Gene:11116 CEP43

OMIM:605392 CEP43

UCSC:O95684 CEP43

Reference Transcript

Other Identifiers

11116

11737794_a_at

11747831_a_at

11751328_a_at

11751329_s_at

1568678_PM_s_at

1568678_s_at

17014630

205588_3p_s_at

205588_PM_s_at

205588_s_at

214124_3p_x_at

214124_PM_x_at

214124_x_at

239434_PM_at

239434_at

2859120

2936565

2936566

2936567

2936568

2936570

2936571

2936573

2936575

2936576

2936577

2936578

2936581

2936582

2936583

2936584

2936586

2936588

2936589

2936590

2936591

2936592

2936593

2936594

2936621

2936628

2936629

2936630

2936640

2936642

2936643

2936645

2936647

2936649

2936651

38571_at

46530_at

46531_g_at

8123342

8123362

82659_at

A_14_P127581

A_14_P130041

A_19_P00812394

A_23_P145134

A_24_P217804

GE81714

GO:0005515

GO:0005634

GO:0005737

GO:0005813

GO:0005814

GO:0005815

GO:0005829

GO:0005856

GO:0006469

GO:0007010

GO:0008284

GO:0015630

GO:0019901

GO:0030030

GO:0030292

GO:0030307

GO:0030335

GO:0034453

GO:0036211

GO:0042803

GO:0042995

GO:0043226

GO:0048471

GO:0048870

GO:0098772

HMNXSV003016311

Hs.108548.1.A1_3p_x_at

Hs.144830.0.A1_3p_at

ILMN_2411116

PH_hs_0008578

PH_hs_0029341

PH_hs_0038673

TC06004105.hg

g5901953_3p_at

g5901953_3p_s_at

Participates

as a component of

Other forms of this molecule

FGFR1OP(2-163)-FGFR1(429-822) fusion [cytosol]

FGFR1OP(2-163)-p-FGFR1(429-822) fusion [cytosol]

Inferred To

CEP43 [cytosol] (Bos taurus)

CEP43 [cytosol] (Canis familiaris)

CEP43 [cytosol] (Sus scrofa)

FGFR1OP [cytosol] (Gallus gallus)

Cep43 [cytosol] (Mus musculus)

Cep43 [cytosol] (Rattus norvegicus)

cep43 [cytosol] (Xenopus tropicalis)

Cross References

RefSeq

NP_919410.1, NP_008976.1

OpenTargets

ENSG00000213066

HPA

ENSG00000213066-CEP43

GeneCards

O95684

Ensembl

ENSP00000230248, ENST00000366847, ENSP00000516073, ENST00000705170, ENSG00000213066, ENST00000349556, ENSP00000355812

PRO

O95684

Pharos - Targets

O95684

PDB

2D68

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P50552 VASP	1	VASP [cytosol] (R-HSA-446323)	0.666	5
UniProt:Q92878 RAD50	1	RAD50 [nucleoplasm] (R-HSA-75160)	0.615	3
UniProt:P07948 LYN	7	MyrG2-PalmC3-LYN [lysosomal membrane] (R-HSA-9707903) MyrG2-PalmC3-LYN [endocytic vesicle membrane] (R-HSA-9705728) LYN [plasma membrane] (R-HSA-197943) p-Y397-LYN [cytosol] (R-HSA-8942608) p-Y397-LYN [plasma membrane] (R-HSA-2454229) MyrG2-PalmC3-LYN [plasma membrane] (R-HSA-9606875) LYN [cytosol] (R-HSA-354251)	0.527	2
UniProt:Q96NL6 SCLT1	1	SCLT1 [cytosol] (R-HSA-5620935)	0.483	2

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