Reactome | INTS10 [nucleoplasm]

INTS10 [nucleoplasm]

Stable Identifier

R-HSA-6807420

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Integrator complex subunit 10, INT10_HUMAN

Locations in the PathwayBrowser

Expand all

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - RNA polymerase II transcribes snRNA genes (Homo sapiens)
    - CBCAP complex binds 7-methylguanosine cap of snRNA (Homo sapiens)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:CBCAP:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
        
        Integrator [nucleoplasm] (Homo sapiens)
        
        INTS10 [nucleoplasm] (Homo sapiens)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
        
        Integrator [nucleoplasm] (Homo sapiens)
        
        INTS10 [nucleoplasm] (Homo sapiens)
    - Dephosphorylation and dissociation of RNA polymerase II at 3' end of snRNA gene (Homo sapiens)
      - Integrator [nucleoplasm] (Homo sapiens)
        
        INTS10 [nucleoplasm] (Homo sapiens)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
        
        Integrator [nucleoplasm] (Homo sapiens)
        
        INTS10 [nucleoplasm] (Homo sapiens)
    - Integrator complex processes the 3' end of snRNA (Homo sapiens)
      - Integrator [nucleoplasm] (Homo sapiens)
        
        INTS10 [nucleoplasm] (Homo sapiens)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:CBCAP:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
        
        Integrator [nucleoplasm] (Homo sapiens)
        
        INTS10 [nucleoplasm] (Homo sapiens)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
        
        Integrator [nucleoplasm] (Homo sapiens)
        
        INTS10 [nucleoplasm] (Homo sapiens)
    - Pre-snRNA is elongated and capped with 7-methylguanosine (Homo sapiens)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
        
        Integrator [nucleoplasm] (Homo sapiens)
        
        INTS10 [nucleoplasm] (Homo sapiens)
      - RNA polymerase II (phosphoserine-5,7):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC:pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
        
        RNA polymerase II (phospho-Ser5,7 CTD):RDRP1A,B:RDRP2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
        
        Integrator [nucleoplasm] (Homo sapiens)
        
        INTS10 [nucleoplasm] (Homo sapiens)
    - Pre-snRNA transcript initiation, Integrator binding, LEC binding (Homo sapiens)
      - Integrator [nucleoplasm] (Homo sapiens)
        
        INTS10 [nucleoplasm] (Homo sapiens)
      - RNA polymerase II (phosphoserine-5,7):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC:pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
        
        RNA polymerase II (phospho-Ser5,7 CTD):RDRP1A,B:RDRP2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
        
        Integrator [nucleoplasm] (Homo sapiens)
        
        INTS10 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9NVR2 INTS10

Gene Names

INTS10, C8orf35

Chain

chain:1-710

Reference Genes

BioGPS Gene:55174 INTS10

COSMIC (genes):INTS10 INTS10

CTD Gene:55174 INTS10

dbSNP Gene:55174 INTS10

ENSEMBL:ENSG00000104613 INTS10

HGNC:25548 INTS10

KEGG:hsa:55174 INTS10

Monarch:55174 INTS10

NCBI Gene:55174 INTS10

OMIM:611353 INTS10

UCSC:Q9NVR2 INTS10

Reference Transcript

RefSeq:NM_018142.2 INTS10

Other Identifiers

11720813_at

11720814_s_at

1560172_PM_at

1560172_at

17066246

229632_PM_s_at

229632_s_at

237504_PM_at

237504_at

3088416

3088417

3088418

3088419

3088420

3088422

3088423

3088424

3088425

3088426

3088427

3088428

3088429

3088430

3088432

3088433

3088434

3088435

3088436

3088437

3088438

3088439

3088440

3088441

3088442

3088443

3088444

3088445

3088446

3088447

3088448

3088449

3088451

3088454

3088455

3088456

3088457

3088458

3088459

3088460

3088464

3088465

3088466

3088470

3088471

3088473

38226_at

45800_at

55174

57174_at

8144894

86786_at

A_14_P135483

A_23_P157607

GE82308

GE869488

GO:0005515

GO:0005634

GO:0005654

GO:0006355

GO:0016073

GO:0016180

GO:0032039

GO:0034243

GO:0043226

HMNXSV003025499

Hs.227074.0.A1_3p_at

Hs.5105.1.S1_3p_s_at

Hs2.418335.1.S1_3p_at

ILMN_1679483

PH_hs_0026782

TC08000148.hg

Participates

as a component of

Integrator [nucleoplasm] (Homo sapiens)

Inferred To

INTS10 [nucleoplasm] (Bos taurus)

INTS10 [nucleoplasm] (Canis familiaris)

INTS10 [nucleoplasm] (Gallus gallus)

INTS10 [nucleoplasm] (Sus scrofa)

ints10 [nucleoplasm] (Danio rerio)

ints10 [nucleoplasm] (Xenopus tropicalis)

IntS10 [nucleoplasm] (Drosophila melanogaster)

Ghost homologue of INTS10 [nucleoplasm] (Caenorhabditis elegans)

Ghost homologue of INTS10 [nucleoplasm] (Dictyostelium discoideum)

Ints10 [nucleoplasm] (Mus musculus)

Ints10 [nucleoplasm] (Rattus norvegicus)

Cross References

ENSEMBL

ENSP00000381064, ENST00000397977, ENSG00000104613

OpenTargets

ENSG00000104613

GeneCards

INTS10

HPA

ENSG00000104613-INTS10

PRO

Q9NVR2

Pharos - Targets

Q9NVR2

GlyGen

Q9NVR2

PDB

8RBZ, 9EOC, 9FA7, 9EOF, 9FA4, 8RC4, 9EP1, 8RBX

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P67775 PPP2CA	4	PPP2CA [cytosol] (R-HSA-165971) PPP2CA [nucleoplasm] (R-HSA-165978) p-Y307-PPP2CA [cytosol] (R-HSA-8857939) MeL-PPP2CA [nucleoplasm] (R-HSA-8857791)	0.527	2