Reactome | PPME1 [nucleoplasm]

PPME1 [nucleoplasm]

Stable Identifier

R-HSA-8857790

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Protein phosphatase methylesterase 1, PPME1_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q9Y570 PPME1

Gene Names

PPME1, PME1, PP2593, PRO0750

Chain

initiator methionine:1, chain:2-386

Reference Genes

BioGPS Gene:51400 PPME1

COSMIC (genes):PPME1 PPME1

CTD Gene:51400 PPME1

dbSNP Gene:51400 PPME1

ENSEMBL:ENSG00000214517.10 PPME1

HGNC:30178 PPME1

KEGG Gene (Homo sapiens):51400 PPME1

Monarch:51400 PPME1

NCBI Gene:51400 PPME1

OMIM:611117 PPME1

UCSC:Q9Y570 PPME1

Reference Transcript

Other Identifiers

0001340022

11744165_a_at

16728949

217841_PM_s_at

217841_s_at

3340163

3340169

3340172

3340183

3340184

3340187

3340189

3340190

3340192

3340194

3340195

3340196

3340198

3340201

3340203

3340204

3340205

49077_PM_at

49077_at

51400

7942503

A_14_P134209

A_24_P4701

A_24_P4705

GE58689

GE79816

GO:0000086

GO:0000278

GO:0003723

GO:0004864

GO:0005515

GO:0005622

GO:0005634

GO:0005654

GO:0006468

GO:0006482

GO:0016787

GO:0019888

GO:0019901

GO:0019903

GO:0036211

GO:0043086

GO:0043226

GO:0045296

GO:0050790

GO:0051721

GO:0051722

GO:0051723

GO:0052689

GO:0098772

GO:0106222

GO:0140096

HMNXSV003041087

ILMN_1732772

PH_hs_0003975

TC11000784.hg

g7706644_3p_a_at

g7706644_3p_s_at

Inferred To

Dmel\CG5068 [nucleoplasm] (Drosophila melanogaster)

Ppme1 [nucleoplasm] (Mus musculus)

Ppme1 [nucleoplasm] (Rattus norvegicus)

ppe1 [nucleoplasm] (Schizosaccharomyces pombe)

PPE1 [nucleoplasm] (Saccharomyces cerevisiae)

PPME1 [nucleoplasm] (Bos taurus)

PPME1 [nucleoplasm] (Caenorhabditis elegans)

PPME1 [nucleoplasm] (Canis familiaris)

PPME1 [nucleoplasm] (Sus scrofa)

ppme1 [nucleoplasm] (Dictyostelium discoideum)

ppme1 [nucleoplasm] (Xenopus tropicalis)

wu:fk72d03 [nucleoplasm] (Danio rerio)

Cross References

RefSeq

NP_001258522.1, NP_057231.1

Guide to Pharmacology - Targets

2875

OpenTargets

ENSG00000214517

ZINC - Substances

PPME1_HUMAN

ZINC target

Q9Y570

PRO

Q9Y570

PDB

3C5V, 3C5W

GeneCards

Q9Y570

HPA

ENSG00000214517-PPME1

Ensembl

ENSG00000214517, ENST00000328257, ENSP00000329867, ENSP00000381461, ENST00000398427

Pharos - Targets

Q9Y570

ZINC - Predictions - Purchasable

PPME1_HUMAN

HMDB Protein

HMDBP11895

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P30153 PPP2R1A	2	PPP2R1A [cytosol] (R-HSA-165982) PPP2R1A [nucleoplasm] (R-HSA-165968)	0.939	13
UniProt:P67775 PPP2CA	4	MeL-PPP2CA [nucleoplasm] (R-HSA-8857791) p-Y307-PPP2CA [cytosol] (R-HSA-8857939) PPP2CA [cytosol] (R-HSA-165971) PPP2CA [nucleoplasm] (R-HSA-165978)	0.788	6
UniProt:P62714 PPP2CB	4	MeL-PPP2CB [nucleoplasm] (R-HSA-8857799) p-Y307-PPP2CB [cytosol] (R-HSA-8857935) PPP2CB [nucleoplasm] (R-HSA-165991) PPP2CB [cytosol] (R-HSA-165987)	0.643	3
UniProt:Q9NY27 PPP4R2	1	PPP4R2 [nucleoplasm] (R-HSA-5687747)	0.569	3
UniProt:Q66LE6 PPP2R2D	1	PPP2R2D [nucleoplasm] (R-HSA-2160962)	0.569	3
UniProt:P67775-1 PPP2CA			0.499	2

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