Reactome | PPME1 [nucleoplasm]

PPME1 [nucleoplasm]

Stable Identifier

R-HSA-8857790

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Protein phosphatase methylesterase 1, PPME1_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q9Y570 PPME1

Gene Names

PPME1, PME1, PP2593, PRO0750

Chain

initiator methionine:, chain:2-386

Reference Genes

BioGPS Gene:51400 PPME1

COSMIC (genes):PPME1 PPME1

CTD Gene:51400 PPME1

dbSNP Gene:51400 PPME1

ENSEMBL:ENSG00000214517 PPME1

HGNC:30178 PPME1

KEGG:hsa:51400 PPME1

Monarch:51400 PPME1

NCBI Gene:51400 PPME1

OMIM:611117 PPME1

UCSC:Q9Y570 PPME1

Reference Transcript

Other Identifiers

11744165_a_at

16728949

217841_PM_s_at

217841_s_at

3340162

3340163

3340169

3340172

3340175

3340183

3340184

3340187

3340188

3340189

3340190

3340191

3340192

3340194

3340195

3340196

3340197

3340198

3340199

3340200

3340201

3340203

3340204

3340205

49077_PM_at

49077_at

51400

7942503

A_14_P112549

A_14_P134209

A_24_P4701

A_24_P4705

GE58689

GE79816

GO:0000086

GO:0003723

GO:0003824

GO:0004864

GO:0005515

GO:0005654

GO:0006482

GO:0016787

GO:0019888

GO:0019901

GO:0019903

GO:0045296

GO:0051721

GO:0051722

GO:0051723

GO:0052689

GO:0098772

GO:0106222

GO:0140096

HMNXSV003041087

ILMN_1732772

PH_hs_0003975

TC11000784.hg

g7706644_3p_a_at

g7706644_3p_s_at

Inferred To

Dmel\CG5068 [nucleoplasm] (Drosophila melanogaster)

Ppme1 [nucleoplasm] (Mus musculus)

Ppme1 [nucleoplasm] (Rattus norvegicus)

ppe1 [nucleoplasm] (Schizosaccharomyces pombe)

PPE1 [nucleoplasm] (Saccharomyces cerevisiae)

PPME1 [nucleoplasm] (Bos taurus)

PPME1 [nucleoplasm] (Caenorhabditis elegans)

PPME1 [nucleoplasm] (Canis familiaris)

PPME1 [nucleoplasm] (Sus scrofa)

ppme1 [nucleoplasm] (Danio rerio)

ppme1 [nucleoplasm] (Dictyostelium discoideum)

ppme1 [nucleoplasm] (Xenopus tropicalis)

Cross References

RefSeq

NP_057231.1, NP_001258522.1

Guide to Pharmacology - Targets

2875

OpenTargets

ENSG00000214517

ENSEMBL

ENSP00000329867, ENST00000398427, ENST00000328257, ENSG00000214517, ENSP00000381461

ZINC - Substances

PPME1_HUMAN

ZINC target

Q9Y570

PRO

Q9Y570

GlyGen

Q9Y570

PDB

7SOY, 3C5W, 3C5V

HPA

ENSG00000214517-PPME1

GeneCards

PPME1

Pharos - Targets

Q9Y570

ZINC - Predictions - Purchasable

PPME1_HUMAN

HMDB Protein

HMDBP11895

Interactors (13)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P30153 PPP2R1A	2	PPP2R1A [cytosol] (R-HSA-165982) PPP2R1A [nucleoplasm] (R-HSA-165968)	0.948	16
UniProt:P67775 PPP2CA	4	PPP2CA [cytosol] (R-HSA-165971) PPP2CA [nucleoplasm] (R-HSA-165978) p-Y307-PPP2CA [cytosol] (R-HSA-8857939) MeL-PPP2CA [nucleoplasm] (R-HSA-8857791)	0.877	9
UniProt:P62714 PPP2CB	4	MeL-PPP2CB [nucleoplasm] (R-HSA-8857799) p-Y307-PPP2CB [cytosol] (R-HSA-8857935) PPP2CB [nucleoplasm] (R-HSA-165991) PPP2CB [cytosol] (R-HSA-165987)	0.837	7
UniProt:Q66LE6 PPP2R2D	1	PPP2R2D [nucleoplasm] (R-HSA-2160962)	0.745	7
UniProt:Q9NY27 PPP4R2	1	PPP4R2 [nucleoplasm] (R-HSA-5687747)	0.745	6
UniProt:Q03154 ACY1	6	ACY1 [cytosol] (R-HSA-5433075) ACY1 R353C [cytosol] (R-HSA-5579111) ACY1 P369Hfs*47 [cytosol] (R-HSA-5579105) ACY1 R197W [cytosol] (R-HSA-5579041) ACY1 E233D [cytosol] (R-HSA-5579040) ACY1 R393H [cytosol] (R-HSA-5579106)	0.643	3
UniProt:Q08188 TGM3			0.589	2
UniProt:P63151 PPP2R2A	2	PPP2R2A [nucleoplasm] (R-HSA-1564978) PPP2R2A [cytosol] (R-HSA-377253)	0.527	2
UniProt:P29084 GTF2E2	1	GTF2E2 [nucleoplasm] (R-HSA-65563)	0.527	2
UniProt:Q00005 2ABB			0.527	2
UniProt:P60510 PPP4C	1	PPP4C [nucleoplasm] (R-HSA-5687750)	0.527	2
UniProt:Q6IN85 P4R3A			0.527	3
UniProt:P67775-1 PPP2CA			0.499	2

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