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PPME1 [nucleoplasm]
Stable Identifier
R-HSA-8857790
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Protein phosphatase methylesterase 1, PPME1_HUMAN
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
Mitotic G2-G2/M phases (Homo sapiens)
G2/M Transition (Homo sapiens)
Cyclin A/B1/B2 associated events during G2/M transition (Homo sapiens)
PP2A demethylation by PPME1 (Homo sapiens)
PPME1 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9Y570 PPME1
Gene Names
PPME1, PME1, PP2593, PRO0750
Chain
initiator methionine:, chain:2-386
Reference Genes
BioGPS Gene:51400 PPME1
COSMIC (genes):PPME1 PPME1
CTD Gene:51400 PPME1
dbSNP Gene:51400 PPME1
ENSEMBL:ENSG00000214517 PPME1
HGNC:30178 PPME1
KEGG:hsa:51400 PPME1
Monarch:51400 PPME1
NCBI Gene:51400 PPME1
OMIM:611117 PPME1
UCSC:Q9Y570 PPME1
Reference Transcript
RefSeq:NM_001271593.2 PPME1
RefSeq:NM_016147.3 PPME1
Other Identifiers
11744165_a_at
16728949
217841_PM_s_at
217841_s_at
3340162
3340163
3340169
3340172
3340175
3340183
3340184
3340187
3340188
3340189
3340190
3340191
3340192
3340194
3340195
3340196
3340197
3340198
3340199
3340200
3340201
3340203
3340204
3340205
49077_PM_at
49077_at
51400
7942503
A_14_P112549
A_14_P134209
A_24_P4701
A_24_P4705
GE58689
GE79816
GO:0000086
GO:0003723
GO:0003824
GO:0004864
GO:0005515
GO:0005654
GO:0006482
GO:0016787
GO:0019888
GO:0019901
GO:0019903
GO:0045296
GO:0051721
GO:0051722
GO:0051723
GO:0052689
GO:0098772
GO:0106222
GO:0140096
HMNXSV003041087
ILMN_1732772
PH_hs_0003975
TC11000784.hg
g7706644_3p_a_at
g7706644_3p_s_at
Inferred To
Dmel\CG5068 [nucleoplasm]
(Drosophila melanogaster)
Ppme1 [nucleoplasm]
(Mus musculus)
Ppme1 [nucleoplasm]
(Rattus norvegicus)
ppe1 [nucleoplasm]
(Schizosaccharomyces pombe)
PPE1 [nucleoplasm]
(Saccharomyces cerevisiae)
PPME1 [nucleoplasm]
(Bos taurus)
PPME1 [nucleoplasm]
(Caenorhabditis elegans)
PPME1 [nucleoplasm]
(Canis familiaris)
PPME1 [nucleoplasm]
(Sus scrofa)
ppme1 [nucleoplasm]
(Danio rerio)
ppme1 [nucleoplasm]
(Dictyostelium discoideum)
ppme1 [nucleoplasm]
(Xenopus tropicalis)
Cross References
RefSeq
NP_057231.1
,
NP_001258522.1
Guide to Pharmacology - Targets
2875
OpenTargets
ENSG00000214517
ENSEMBL
ENSP00000329867
,
ENST00000398427
,
ENST00000328257
,
ENSG00000214517
,
ENSP00000381461
ZINC - Substances
PPME1_HUMAN
ZINC target
Q9Y570
PRO
Q9Y570
GlyGen
Q9Y570
PDB
7SOY
,
3C5W
,
3C5V
HPA
ENSG00000214517-PPME1
GeneCards
PPME1
Pharos - Targets
Q9Y570
ZINC - Predictions - Purchasable
PPME1_HUMAN
HMDB Protein
HMDBP11895
Interactors (13)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P30153 PPP2R1A
2
PPP2R1A [cytosol]
(R-HSA-165982)
PPP2R1A [nucleoplasm]
(R-HSA-165968)
0.948
16
UniProt:P67775 PPP2CA
4
PPP2CA [cytosol]
(R-HSA-165971)
PPP2CA [nucleoplasm]
(R-HSA-165978)
p-Y307-PPP2CA [cytosol]
(R-HSA-8857939)
MeL-PPP2CA [nucleoplasm]
(R-HSA-8857791)
0.877
9
UniProt:P62714 PPP2CB
4
MeL-PPP2CB [nucleoplasm]
(R-HSA-8857799)
p-Y307-PPP2CB [cytosol]
(R-HSA-8857935)
PPP2CB [nucleoplasm]
(R-HSA-165991)
PPP2CB [cytosol]
(R-HSA-165987)
0.837
7
UniProt:Q66LE6 PPP2R2D
1
PPP2R2D [nucleoplasm]
(R-HSA-2160962)
0.745
7
UniProt:Q9NY27 PPP4R2
1
PPP4R2 [nucleoplasm]
(R-HSA-5687747)
0.745
6
UniProt:Q03154 ACY1
6
ACY1 [cytosol]
(R-HSA-5433075)
ACY1 R353C [cytosol]
(R-HSA-5579111)
ACY1 P369Hfs*47 [cytosol]
(R-HSA-5579105)
ACY1 R197W [cytosol]
(R-HSA-5579041)
ACY1 E233D [cytosol]
(R-HSA-5579040)
ACY1 R393H [cytosol]
(R-HSA-5579106)
0.643
3
UniProt:Q08188 TGM3
0.589
2
UniProt:P63151 PPP2R2A
2
PPP2R2A [nucleoplasm]
(R-HSA-1564978)
PPP2R2A [cytosol]
(R-HSA-377253)
0.527
2
UniProt:P29084 GTF2E2
1
GTF2E2 [nucleoplasm]
(R-HSA-65563)
0.527
2
UniProt:Q00005 2ABB
0.527
2
UniProt:P60510 PPP4C
1
PPP4C [nucleoplasm]
(R-HSA-5687750)
0.527
2
UniProt:Q6IN85 P4R3A
0.527
3
UniProt:P67775-1 PPP2CA
0.499
2
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