Reactome | FECH [mitochondrial inner membrane]

FECH [mitochondrial inner membrane]

Stable Identifier

R-HSA-189441

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial inner membrane

Synonyms

Ferrochelatase, HEMZ_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P22830 FECH

Gene Names

FECH

Chain

transit peptide:1-54, chain:55-423

Reference Genes

BioGPS Gene:2235 FECH

COSMIC (genes):FECH FECH

CTD Gene:2235 FECH

dbSNP Gene:2235 FECH

ENSEMBL:ENSG00000066926 FECH

HGNC:3647 FECH

KEGG:hsa:2235 FECH

Monarch:2235 FECH

NCBI Gene:2235 FECH

OMIM:612386 FECH

UCSC:P22830 FECH

Reference Transcript

Other Identifiers

11727807_at

11727808_s_at

11727809_at

11746263_a_at

16855477

203115_PM_at

203115_at

203116_PM_s_at

203116_s_at

2235

229696_PM_at

229696_at

33914_r_at

3644723

3809629

3809630

3809631

3809632

3809633

3809634

3809635

3809636

3809637

3809638

3809639

3809640

3809641

3809642

3809643

3809644

3809645

3809647

3809648

3809649

3809651

3809652

3809653

3809654

3809655

3809659

3809660

47417_at

49398_at

8023466

A_23_P89798

A_32_P151933

A_33_P3214635

D00726_at

GE57038

GO:0003723

GO:0003824

GO:0004325

GO:0005506

GO:0005515

GO:0005739

GO:0005743

GO:0005759

GO:0006091

GO:0006629

GO:0006779

GO:0006783

GO:0006784

GO:0006785

GO:0008198

GO:0008203

GO:0009410

GO:0009416

GO:0009589

GO:0010038

GO:0010288

GO:0010999

GO:0016829

GO:0017085

GO:0020037

GO:0030154

GO:0030218

GO:0030350

GO:0034379

GO:0042802

GO:0042803

GO:0043226

GO:0045471

GO:0046501

GO:0046685

GO:0046872

GO:0046906

GO:0046984

GO:0048034

GO:0051537

GO:0051597

GO:0060586

GO:0065003

GO:0070541

GO:0071549

HMNXSV003056104

Hs.112222.0.A1_3p_at

Hs.26.0.S2_3p_at

ILMN_1774091

ILMN_2364305

PH_hs_0025907

TC18000536.hg

g4557592_3p_a_at

Participates

as a member of

as a component of

2x(FECH:2Fe-2S cluster) [mitochondrial inner membrane] (Homo sapiens)

Inferred To

FECH [mitochondrial inner membrane] (Bos taurus)

FECH [mitochondrial inner membrane] (Canis familiaris)

FECH [mitochondrial inner membrane] (Dictyostelium discoideum)

FECH [mitochondrial inner membrane] (Drosophila melanogaster)

FECH [mitochondrial inner membrane] (Gallus gallus)

FECH [mitochondrial inner membrane] (Mus musculus)

FECH [mitochondrial inner membrane] (Plasmodium falciparum)

FECH [mitochondrial inner membrane] (Schizosaccharomyces pombe)

FECH [mitochondrial inner membrane] (Sus scrofa)

fech [mitochondrial inner membrane] (Danio rerio)

fecl-1 [mitochondrial inner membrane] (Caenorhabditis elegans)

HEM15 [mitochondrial inner membrane] (Saccharomyces cerevisiae)

Fech [mitochondrial inner membrane] (Rattus norvegicus)

Cross References

OpenTargets

ENSG00000066926

ENSEMBL

ENSP00000262093, ENST00000262093, ENST00000652755, ENSP00000498358, ENSG00000066926

HPA

ENSG00000066926-FECH

GeneCards

FECH

PRO

P22830

Pharos - Targets

P22830

Orphanet

FECH

GlyGen

P22830

HMDB Protein

HMDBP01058

PDB

4KLR, 2PNJ, 7CTC, 4KLC, 2HRE, 3AQI, 7CT7, 2QD1, 2QD4, 2QD2, 2QD3, 3HCR, 1HRK, 3HCO, 2PO5, 3HCN, 4MK4, 3HCP, 4F4D, 2PO7, 2HRC, 4KLA, 2QD5, 3W1W, 4KMM

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P67775 PPP2CA	4	PPP2CA [cytosol] (R-HSA-165971) PPP2CA [nucleoplasm] (R-HSA-165978) p-Y307-PPP2CA [cytosol] (R-HSA-8857939) MeL-PPP2CA [nucleoplasm] (R-HSA-8857791)	0.671	4
UniProt:P16035 TIMP2	4	TIMP2 [specific granule lumen] (R-HSA-6799625) TIMP2 [tertiary granule lumen] (R-HSA-6800881) TIMP2 [ficolin-1-rich granule lumen] (R-HSA-6800944) TIMP2 [extracellular region] (R-HSA-1454879)	0.499	2
UniProt:P10809 HSPD1	6	HSPD1(1-26) [mitochondrial matrix] (R-HSA-8986171) HSPD1(1-573) [mitochondrial inner membrane] (R-HSA-1299442) HSPD1 [mitochondrial inner membrane] (R-HSA-1299455) HSPD1(1-573) [mitochondrial intermembrane space] (R-HSA-1267963) HSPD1(1-573) [cytosol] (R-HSA-1267989) HSPD1 [mitochondrial matrix] (R-HSA-1299448)	0.483	4