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FECH [mitochondrial matrix]
Stable Identifier
R-HSA-189441
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
mitochondrial matrix
Synonyms
Ferrochelatase, HEMZ_HUMAN
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Metabolism of porphyrins (Homo sapiens)
Heme biosynthesis (Homo sapiens)
FECH binds Fe2+ to PRIN9 to form heme (Homo sapiens)
2x(FECH:2Fe-2S cluster) [mitochondrial matrix] (Homo sapiens)
FECH [mitochondrial matrix] (Homo sapiens)
External Reference Information
External Reference
UniProt:P22830 FECH
Gene Names
FECH
Chain
transit peptide:1-54, chain:55-423
Reference Genes
BioGPS Gene:2235 FECH
COSMIC (genes):FECH FECH
CTD Gene:2235 FECH
dbSNP Gene:2235 FECH
ENSEMBL:ENSG00000066926.13 FECH
HGNC:3647 FECH
KEGG Gene (Homo sapiens):2235 FECH
Monarch:2235 FECH
NCBI Gene:2235 FECH
OMIM:612386 FECH
UCSC:P22830 FECH
Reference Transcript
RefSeq:NM_000140.3 FECH
RefSeq:NM_001012515.2 FECH
Other Identifiers
0002320725
11727807_at
11727808_s_at
11727809_at
11746263_a_at
16855477
203115_PM_at
203115_at
203116_PM_s_at
203116_s_at
2235
229696_PM_at
229696_at
33914_r_at
3644723
3809629
3809630
3809631
3809632
3809633
3809634
3809635
3809636
3809639
3809643
3809644
3809645
3809647
3809648
3809649
3809651
3809653
3809654
3809655
3809659
3809660
47417_at
49398_at
8023466
A_23_P89798
A_32_P151933
A_33_P3214635
D00726_at
GE57038
GO:0002376
GO:0003723
GO:0004325
GO:0005506
GO:0005515
GO:0005622
GO:0005737
GO:0005739
GO:0005743
GO:0005759
GO:0006091
GO:0006629
GO:0006779
GO:0006783
GO:0008198
GO:0008203
GO:0009416
GO:0009589
GO:0010468
GO:0010999
GO:0016020
GO:0016829
GO:0020037
GO:0030154
GO:0030218
GO:0030350
GO:0034379
GO:0036211
GO:0042803
GO:0043226
GO:0046501
GO:0046872
GO:0046906
GO:0046984
GO:0048856
GO:0051536
GO:0051537
GO:0055065
GO:0055072
GO:0065003
HMNXSV003056104
Hs.112222.0.A1_3p_at
Hs.26.0.S2_3p_at
ILMN_1774091
ILMN_2364305
PH_hs_0025907
TC18000536.hg
g4557592_3p_a_at
Participates
as a component of
2x(FECH:2Fe-2S cluster) [mitochondrial matrix] (Homo sapiens)
Inferred To
FECH [mitochondrial matrix]
(Bos taurus)
FECH [mitochondrial matrix]
(Canis familiaris)
FECH [mitochondrial matrix]
(Danio rerio)
FECH [mitochondrial matrix]
(Dictyostelium discoideum)
FECH [mitochondrial matrix]
(Drosophila melanogaster)
FECH [mitochondrial matrix]
(Gallus gallus)
FECH [mitochondrial matrix]
(Mus musculus)
FECH [mitochondrial matrix]
(Plasmodium falciparum)
FECH [mitochondrial matrix]
(Schizosaccharomyces pombe)
FECH [mitochondrial matrix]
(Sus scrofa)
HEM15 [mitochondrial matrix]
(Saccharomyces cerevisiae)
fecl-1 [mitochondrial matrix]
(Caenorhabditis elegans)
Fech [mitochondrial matrix]
(Rattus norvegicus)
fech [mitochondrial matrix]
(Xenopus tropicalis)
Cross References
RefSeq
NP_000131.2
,
NP_001012533.1
OpenTargets
ENSG00000066926
GeneCards
P22830
HPA
ENSG00000066926-FECH
Ensembl
ENSG00000066926
,
ENSP00000498358
,
ENST00000652755
,
ENSP00000262093
,
ENST00000262093
PRO
P22830
Pharos - Targets
P22830
Orphanet
16039
HMDB Protein
HMDBP01058
PDB
4KLA
,
3HCN
,
4KLC
,
3W1W
,
2HRE
,
2HRC
,
2QD5
,
4KLR
,
7CT7
,
2PO7
,
2QD4
,
3AQI
,
2QD3
,
2PO5
,
4MK4
,
4F4D
,
7CTC
,
2QD2
,
3HCR
,
3HCP
,
2QD1
,
1HRK
,
4KMM
,
2PNJ
,
3HCO
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