Reactome | EIF4E [cytosol]

EIF4E [cytosol]

Stable Identifier

R-HSA-72578

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

eIF4E, eIF-4F 25 kDa subunit, eukaryotic translation initiation factor 4E, mRNA cap-binding protein, Eukaryotic translation initiation factor 4E, eIF-4E

Locations in the PathwayBrowser

Expand all

Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Viral Infection Pathways (Homo sapiens)
    - Dengue Virus Infection (Homo sapiens)
      - Dengue Virus Genome Translation and Replication (Homo sapiens)
        
        Cap-dependent translation of DENV genomic RNA (Homo sapiens)
        
        EIF4F [cytosol] (Homo sapiens)
        
        EIF4E1/EIF4E3 [cytosol] (Homo sapiens)
        
        EIF4E [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P06730 EIF4E

Gene Names

EIF4E, EIF4EL1, EIF4F

Chain

initiator methionine:1, chain:2-217

Reference Genes

BioGPS Gene:1977 EIF4E

COSMIC - genes:EIF4E EIF4E

CTD Gene:1977 EIF4E

dbSNP Gene:1977 EIF4E

ENSEMBL:ENSG00000151247 EIF4E

HGNC:3287 EIF4E

KEGG:hsa:1977 EIF4E

Monarch:1977 EIF4E

NCBI Gene:1977 EIF4E

OMIM:133440 EIF4E

UCSC:P06730 EIF4E

Reference Transcript

Participates

as a component of

as an output of

as an input of

as a member of

EIF4E1/EIF4E3 [cytosol] (Homo sapiens)

Inferred To

Eif4e [cytosol] (Mus musculus)

Homologues of EIF4E [cytosol] (Canis familiaris)

LOC119866572 [cytosol] (Canis familiaris)

eif4e [cytosol] (Xenopus tropicalis)

EIF4E [cytosol] (Bos taurus)

EIF4E [cytosol] (Canis familiaris)

EIF4E [cytosol] (Danio rerio)

EIF4E [cytosol] (Dictyostelium discoideum)

EIF4E [cytosol] (Drosophila melanogaster)

EIF4E [cytosol] (Gallus gallus)

EIF4E [cytosol] (Plasmodium falciparum)

EIF4E [cytosol] (Rattus norvegicus)

EIF4E [cytosol] (Sus scrofa)

tif452 [cytosol] (Schizosaccharomyces pombe)

CDC33 [cytosol] (Saccharomyces cerevisiae)

ife-1 [cytosol] (Caenorhabditis elegans)

Cross References

RefSeq

NP_001124151.1, NP_001317946.1, NP_001959.1, NP_001124150.1

ZINC - World Drugs

IF4E_HUMAN

OpenTargets

ENSG00000151247

ENSEMBL

ENST00000280892, ENSP00000425561, ENST00000505992, ENSP00000389624, ENSG00000151247, ENSP00000280892, ENST00000450253

ZINC - FDA approved

IF4E_HUMAN

ZINC - Substances

IF4E_HUMAN

ZINC target

P06730

PRO

P06730

GlyGen

P06730

PDB

2GPQ, 5EI3, 4AZA, 3AM7, 5EHC, 2V8Y, 5EKV, 5ZK7, 9DON, 7D6Y, 5ZK9, 2V8X, 2V8W, 3U7X, 5ZJZ, 5ZJY, 7EZW, 7MEU, 4TQC, 4UED, 5ZML, 4DUM, 8QM9, 8QM8, 7F07, 4TPW, 7D8B, 7XTP, 8SX4, 5EIR, 5ZK5, 1IPB, 8QM4, 1IPC, 1WKW, 3TF2, 8QM6, 8QM7, 2W97, 8QM5, 4DT6, 5GW6, 5T46, 4BEA, 4TQB

GeneCards

EIF4E

HPA

ENSG00000151247-EIF4E

Pharos - Targets

P06730

Orphanet

EIF4E

ZINC - Predictions - Purchasable

IF4E_HUMAN

Interactors (40)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q13541 EIF4EBP1	2	EIF4EBP1 [cytosol] (R-HSA-72580) p-T37,T46-EIF4EBP1 [cytosol] (R-HSA-165685)	0.983	37
UniProt:Q13542 4EBP2			0.965	19
UniProt:Q9NRA8 4ET			0.944	15
UniProt:Q04637 EIF4G1	2	EIF4G1 [cytosol] (R-HSA-72584) p-S1108,S1148,S1192-EIF4G1 [cytosol] (R-HSA-165762)	0.937	15
UniProt:O60516 4EBP3			0.926	12
ChEBI:50210 7-METHYL-GTP			0.878	9
UniProt:P60842 EIF4A1	1	EIF4A1 [cytosol] (R-HSA-72573)	0.848	6
UniProt:O00571 DDX3X	4	DDX3X [ficolin-1-rich granule lumen] (R-HSA-6801273) DDX3X [extracellular region] (R-HSA-6806507) DDX3X [secretory granule lumen] (R-HSA-6801275) DDX3X [nucleoplasm] (R-HSA-9921623)	0.825	8
UniProt:O43432 EIF4G3	1	EIF4G3 [cytosol] (R-HSA-1678827)	0.813	7
UniProt:Q63ZY3 KANK2			0.781	7
UniProt:P14373 TRIM27	2	TRIM27 [cytosol] (R-HSA-8851002) TRIM27 [nucleoplasm] (R-HSA-2997690)	0.742	5
UniProt:Q9UNK9 ANGE1			0.725	6
UniProt:Q60953	4	polySUMO3-K65,K160,K490-PML [nucleoplasm] (R-MMU-3000386) polySUMO2-K65,K160,K490-PML [nucleoplasm] (R-MMU-3000423) monoSUMO1-K65,160,490-PML [nucleoplasm] (R-MMU-3000440) PML [nucleoplasm] (R-MMU-1031706)	0.697	4
ChEBI:191209 7-METHYL-GUANOSINE-5'-TRIPHOSPHATE-5'-GUANOSINE			0.683	4
UniProt:P18247 POLG			0.672	6
UniProt:P48775 TDO2	1	TDO2 [cytosol] (R-HSA-71184)	0.666	4
UniProt:P55884 EIF3B	1	EIF3B [cytosol] (R-HSA-72542)	0.643	8
UniProt:O43148 RNMT	1	RNMT [nucleoplasm] (R-HSA-77060)	0.626	8
ChEBI:63729 7-METHYLGUANOSINE 5'-DIPHOSPHATE			0.623	2
UniProt:O43432-1 EIF4G3			0.623	2
UniProt:P29590 PML	5	PML [cytosol] (R-HSA-5624327) PML [nucleoplasm] (R-HSA-1031706) monoSUMO1-K65,160,490-PML [nucleoplasm] (R-HSA-3000440) polySUMO2-K65,K160,K490-PML [nucleoplasm] (R-HSA-3000423) polySUMO3-K65,K160,K490-PML [nucleoplasm] (R-HSA-3000386)	0.622	5
UniProt:P18541 Z			0.618	4
UniProt:Q04743 EMX2	1	EMX2 [nucleoplasm] (R-HSA-1641477)	0.591	4
UniProt:Q8TEQ6 GEMIN5	2	GEMIN5 [cytosol] (R-HSA-191833) GEMIN5 [nucleoplasm] (R-HSA-191765)	0.582	3
UniProt:P42704 LRPPRC	1	LRPPRC [mitochondrial matrix] (R-HSA-5336174)	0.576	6
UniProt:Q14240 EIF4A2	1	EIF4A2 [cytosol] (R-HSA-72575)	0.564	2
UniProt:P11940 PABPC1	1	PABPC1 [cytosol] (R-HSA-156803)	0.558	5
UniProt:O73557 Z			0.558	3
UniProt:Q5T124 UBXN11	1	UBXN11 [cytosol] (R-HSA-9696514)	0.556	3
UniProt:P03427 PB2			0.547	2
UniProt:P10636-8 MAPT	3	MAPT-8 [cytosol] (R-HSA-9619519) p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521)	0.527	4
UniProt:O75821 EIF3G	1	EIF3G [cytosol] (R-HSA-72538)	0.527	2
UniProt:P62753 RPS6	4	RPS6 [cytosol] (R-HSA-72381) p-5S-RPS6 [cytosol] (R-HSA-165727) 3OHR147-RPS6 [cytosol] (R-HSA-9629876) RPS6 [nucleoplasm] (R-HSA-6790606)	0.527	2
UniProt:P42345 MTOR	2	MTOR [cytosol] (R-HSA-165662) MTOR [nucleoplasm] (R-HSA-5083674)	0.527	4
UniProt:O15372 EIF3H	1	EIF3H [cytosol] (R-HSA-72544)	0.527	2
UniProt:P67775 PPP2CA	4	PPP2CA [cytosol] (R-HSA-165971) PPP2CA [nucleoplasm] (R-HSA-165978) p-Y307-PPP2CA [cytosol] (R-HSA-8857939) MeL-PPP2CA [nucleoplasm] (R-HSA-8857791)	0.524	2
UniProt:Q60809 Cnot7	1	Cnot7 [cytosol] (R-MMU-9817672)	0.499	2
UniProt:P26196 DDX6	1	DDX6 [cytosol] (R-HSA-430032)	0.483	2
UniProt:Q03014 HHEX	1	HHEX [nucleoplasm] (R-HSA-452702)	0.463	3
UniProt:Q92900 UPF1	2	UPF1 [cytosol] (R-HSA-927734) p-4S-UPF1 [cytosol] (R-HSA-927856)	0.462	3

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