Reactome | EIF4E [cytosol]

EIF4E [cytosol]

Stable Identifier

R-HSA-72578

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

eIF4E, eIF-4F 25 kDa subunit, eukaryotic translation initiation factor 4E, mRNA cap-binding protein, Eukaryotic translation initiation factor 4E, eIF-4E

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External Reference Information

External Reference

UniProt:P06730 EIF4E

Gene Names

EIF4E, EIF4EL1, EIF4F

Chain

initiator methionine:1, chain:2-217

Reference Genes

BioGPS Gene:1977 EIF4E

COSMIC (genes):EIF4E EIF4E

CTD Gene:1977 EIF4E

dbSNP Gene:1977 EIF4E

ENSEMBL:ENSG00000151247 EIF4E

ENSEMBL:ENSG00000151247.13 EIF4E

HGNC:3287 EIF4E

KEGG Gene (Homo sapiens):1977 EIF4E

Monarch:1977 EIF4E

NCBI Gene:1977 EIF4E

OMIM:133440 EIF4E

UCSC:P06730 EIF4E

Reference Transcript

Other Identifiers

11732130_x_at

11736166_s_at

11741416_s_at

11741417_x_at

11758512_s_at

1977

201435_PM_s_at

201435_s_at

201436_3p_at

201436_PM_at

201436_at

201437_PM_s_at

201437_s_at

2779004

2779005

2779006

2779007

2779008

2779009

2779010

2779011

2779012

2779014

2779015

2779017

2779027

2779039

3087021

3761830

3761831

3761832

37752_at

56158_r_at

73201_at

A_23_P118643

A_23_P118649

A_32_P203300

GE57839

GO:0000082

GO:0000278

GO:0000339

GO:0000340

GO:0000932

GO:0001662

GO:0003723

GO:0003743

GO:0005515

GO:0005576

GO:0005615

GO:0005634

GO:0005737

GO:0005829

GO:0005845

GO:0006412

GO:0006413

GO:0006417

GO:0010494

GO:0016281

GO:0016442

GO:0017148

GO:0019827

GO:0019899

GO:0023052

GO:0030154

GO:0030182

GO:0031370

GO:0033391

GO:0036464

GO:0043226

GO:0045182

GO:0045665

GO:0045931

GO:0048471

GO:0048856

GO:0070062

GO:0071549

GO:0098794

GO:0098978

GO:0099578

GO:0140297

HMNXSV003040115

HMNXSV003042746

Hs.79306.0.A1_3p_a_at

Hs.79306.0.A3_3p_at

Hs.79306.0.A3_3p_x_at

ILMN_1658955

ILMN_2050761

M15353_at

PH_hs_0004585

RNA147602|p0706_imsncRNA477

g4503534_3p_a_at

g4503534_3p_x_at

Participates

as a component of

as an input of

as an output of

as a member of

EIF4E1/EIF4E3 [cytosol] (Homo sapiens)

Inferred To

Eif4e [cytosol] (Mus musculus)

eif4e1b [cytosol] (Xenopus tropicalis)

Homologues of EIF4E [cytosol] (Caenorhabditis elegans)

Homologues of EIF4E [cytosol] (Dictyostelium discoideum)

Homologues of EIF4E [cytosol] (Drosophila melanogaster)

Homologues of EIF4E [cytosol] (Schizosaccharomyces pombe)

ife-3 [cytosol] (Caenorhabditis elegans)

eIF4E3 [cytosol] (Drosophila melanogaster)

ife-5 [cytosol] (Caenorhabditis elegans)

tif452 [cytosol] (Schizosaccharomyces pombe)

eIF4E7 [cytosol] (Drosophila melanogaster)

tif451 [cytosol] (Schizosaccharomyces pombe)

EIF4E [cytosol] (Bos taurus)

EIF4E [cytosol] (Canis familiaris)

EIF4E [cytosol] (Danio rerio)

EIF4E [cytosol] (Dictyostelium discoideum)

EIF4E [cytosol] (Drosophila melanogaster)

EIF4E [cytosol] (Gallus gallus)

EIF4E [cytosol] (Plasmodium falciparum)

EIF4E [cytosol] (Rattus norvegicus)

EIF4E [cytosol] (Sus scrofa)

eIF4E6 [cytosol] (Drosophila melanogaster)

eIF4E4 [cytosol] (Drosophila melanogaster)

ife-2 [cytosol] (Caenorhabditis elegans)

CDC33 [cytosol] (Saccharomyces cerevisiae)

eIF4E5 [cytosol] (Drosophila melanogaster)

ife-1 [cytosol] (Caenorhabditis elegans)

Cross References

RefSeq

NP_001124150.1, NP_001124151.1, NP_001959.1, NP_001317946.1

ZINC - World Drugs

IF4E_HUMAN

OpenTargets

ENSG00000151247

ZINC - FDA approved

IF4E_HUMAN

ZINC - Substances

IF4E_HUMAN

ZINC target

P06730

PRO

P06730

PDB

7F07, 5ZK9, 4TQB, 7D6Y, 1IPC, 7EZW, 4AZA, 5ZJZ, 1WKW, 4TPW, 3U7X, 4DT6, 7D8B, 4DUM, 7MEU, 5GW6, 5ZK7, 2GPQ, 2W97, 1IPB, 3AM7, 2V8Y, 5EI3, 5ZK5, 4UED, 5ZJY, 4BEA, 5EHC, 5T46, 2V8W, 4TQC, 5EIR, 5ZML, 5EKV, 7XTP, 3TF2, 2V8X

HPA

ENSG00000151247-EIF4E

GeneCards

P06730

Ensembl

ENSP00000425561, ENST00000450253, ENST00000280892, ENSP00000280892, ENSG00000151247, ENST00000505992, ENSP00000389624

Pharos - Targets

P06730

ZINC - Predictions - Purchasable

IF4E_HUMAN

Orphanet

18985

Interactors (28)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q13541 EIF4EBP1	2	EIF4EBP1 [cytosol] (R-HSA-72580) p-T37,T46-EIF4EBP1 [cytosol] (R-HSA-165685)	0.98	31
UniProt:Q13542 4EBP2			0.956	14
UniProt:Q04637 EIF4G1	2	p-S1108,S1148,S1192-EIF4G1 [cytosol] (R-HSA-165762) EIF4G1 [cytosol] (R-HSA-72584)	0.915	10
UniProt:Q9NRA8 4ET			0.912	11
UniProt:O60516 4EBP3			0.896	11
UniProt:Q63ZY3 KANK2			0.781	7
UniProt:O00571 DDX3X	3	DDX3X [secretory granule lumen] (R-HSA-6801275) DDX3X [extracellular region] (R-HSA-6806507) DDX3X [ficolin-1-rich granule lumen] (R-HSA-6801273)	0.775	7
ChEBI:50210 7-METHYL-GTP			0.773	7
UniProt:P14373 TRIM27	2	TRIM27 [nucleoplasm] (R-HSA-2997690) TRIM27 [cytosol] (R-HSA-8851002)	0.742	5
UniProt:P60842 EIF4A1	1	EIF4A1 [cytosol] (R-HSA-72573)	0.669	3
UniProt:P48775 TDO2	1	TDO2 [cytosol] (R-HSA-71184)	0.666	4
UniProt:O43432-1 EIF4G3			0.623	2
UniProt:Q04743 EMX2			0.591	4
UniProt:Q8TEQ6 GEMIN5	2	GEMIN5 [nucleoplasm] (R-HSA-191765) GEMIN5 [cytosol] (R-HSA-191833)	0.582	3
UniProt:P42704 LRPPRC	1	LRPPRC [mitochondrial matrix] (R-HSA-5336174)	0.576	6
UniProt:O15372 EIF3H	1	EIF3H [cytosol] (R-HSA-72544)	0.564	2
UniProt:Q14240 EIF4A2	1	EIF4A2 [cytosol] (R-HSA-72575)	0.564	2
UniProt:O73557 Z			0.558	3
UniProt:P11940 PABPC1	1	PABPC1 [cytosol] (R-HSA-156803)	0.558	5
UniProt:Q5T124 UBXN11	1	UBXN11 [cytosol] (R-HSA-9696514)	0.556	3
UniProt:P03427 PB2			0.547	2
UniProt:O43432 EIF4G3	1	EIF4G3 [cytosol] (R-HSA-1678827)	0.527	2
UniProt:P55884 EIF3B	1	EIF3B [cytosol] (R-HSA-72542)	0.527	7
UniProt:Q9UNK9 ANGE1			0.527	2
UniProt:P62753 RPS6	4	RPS6 [nucleoplasm] (R-HSA-6790606) 3OHR147-RPS6 [cytosol] (R-HSA-9629876) p-5S-RPS6 [cytosol] (R-HSA-165727) RPS6 [cytosol] (R-HSA-72381)	0.527	2
UniProt:P67775 PPP2CA	4	MeL-PPP2CA [nucleoplasm] (R-HSA-8857791) p-Y307-PPP2CA [cytosol] (R-HSA-8857939) PPP2CA [nucleoplasm] (R-HSA-165978) PPP2CA [cytosol] (R-HSA-165971)	0.524	2
UniProt:Q60809 Cnot7	1	Cnot7 [cytosol] (R-MMU-9817672)	0.499	2
UniProt:Q92900 UPF1	2	UPF1 [cytosol] (R-HSA-927734) p-4S-UPF1 [cytosol] (R-HSA-927856)	0.462	3