EIF4E [cytosol]

Stable Identifier
R-HSA-72578
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
eIF4E, eIF-4F 25 kDa subunit, eukaryotic translation initiation factor 4E, mRNA cap-binding protein, Eukaryotic translation initiation factor 4E, eIF-4E
Icon
EIF4E [cytosol] icon
EIF4E [cytosol] icon
Locations in the PathwayBrowser
Expand all
External Reference Information
External Reference
UniProt:P06730 EIF4E
Gene Names
EIF4E, EIF4EL1, EIF4F
Chain
initiator methionine:, chain:2-217
Reference Genes
BioGPS Gene:1977 EIF4E
COSMIC (genes):EIF4E EIF4E
CTD Gene:1977 EIF4E
dbSNP Gene:1977 EIF4E
ENSEMBL:ENSG00000151247 EIF4E
ENSEMBL_homo_sapiens_GENE:ENSG00000151247.13 EIF4E
HGNC:3287 EIF4E
KEGG Gene (Homo sapiens):1977 EIF4E
Monarch:1977 EIF4E
NCBI Gene:1977 EIF4E
OMIM:133440 EIF4E
UCSC:P06730 EIF4E
Reference Transcript
Other Identifiers
11732130_x_at
11736166_s_at
11741416_s_at
11741417_x_at
11758512_s_at
1977
201435_PM_s_at
201435_s_at
201436_3p_at
201436_PM_at
201436_at
201437_PM_s_at
201437_s_at
2779004
2779005
2779006
2779007
2779008
2779009
2779010
2779011
2779012
2779014
2779015
2779017
2779027
2779039
3087021
3761830
3761831
3761832
37752_at
56158_r_at
73201_at
A_23_P118643
A_23_P118649
A_32_P203300
GE57839
GO:0000082
GO:0000278
GO:0000339
GO:0000340
GO:0000932
GO:0001662
GO:0003723
GO:0003743
GO:0005515
GO:0005576
GO:0005615
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0006406
GO:0006412
GO:0006413
GO:0006417
GO:0006913
GO:0010494
GO:0016281
GO:0016442
GO:0016604
GO:0016607
GO:0017148
GO:0019827
GO:0019899
GO:0023052
GO:0030154
GO:0030182
GO:0031370
GO:0033391
GO:0036464
GO:0043226
GO:0045182
GO:0045665
GO:0045931
GO:0048471
GO:0048856
GO:0051028
GO:0051168
GO:0070062
GO:0071549
GO:0098794
GO:0098808
GO:0098978
GO:0099578
GO:0140297
HMNXSV003040115
HMNXSV003042746
Hs.79306.0.A1_3p_a_at
Hs.79306.0.A3_3p_at
Hs.79306.0.A3_3p_x_at
ILMN_1658955
ILMN_2050761
M15353_at
PH_hs_0004585
RNA147602|p0706_imsncRNA477
g4503534_3p_a_at
g4503534_3p_x_at
Participates
as a component of
as an input of
as an output of
as a member of
Inferred To
Eif4e [cytosol] (Mus musculus)
Homologues of EIF4E [cytosol] (Caenorhabditis elegans)
Homologues of EIF4E [cytosol] (Canis familiaris)
Homologues of EIF4E [cytosol] (Dictyostelium discoideum)
Homologues of EIF4E [cytosol] (Drosophila melanogaster)
Homologues of EIF4E [cytosol] (Schizosaccharomyces pombe)
ife-3 [cytosol] (Caenorhabditis elegans)
eIF4E3 [cytosol] (Drosophila melanogaster)
ife-5 [cytosol] (Caenorhabditis elegans)
tif452 [cytosol] (Schizosaccharomyces pombe)
Ghost homologue of EIF4E [cytosol] (Plasmodium falciparum)
eIF4E7 [cytosol] (Drosophila melanogaster)
LOC119866572 [cytosol] (Canis familiaris)
tif451 [cytosol] (Schizosaccharomyces pombe)
eif4e [cytosol] (Xenopus tropicalis)
EIF4E [cytosol] (Bos taurus)
EIF4E [cytosol] (Canis familiaris)
EIF4E [cytosol] (Danio rerio)
EIF4E [cytosol] (Dictyostelium discoideum)
EIF4E [cytosol] (Drosophila melanogaster)
EIF4E [cytosol] (Gallus gallus)
EIF4E [cytosol] (Rattus norvegicus)
EIF4E [cytosol] (Sus scrofa)
eIF4E6 [cytosol] (Drosophila melanogaster)
eIF4E4 [cytosol] (Drosophila melanogaster)
ife-2 [cytosol] (Caenorhabditis elegans)
CDC33 [cytosol] (Saccharomyces cerevisiae)
eIF4E5 [cytosol] (Drosophila melanogaster)
ife-1 [cytosol] (Caenorhabditis elegans)
Cross References
RefSeq
ZINC - World Drugs
OpenTargets
ZINC - FDA approved
ZINC - Substances
ZINC target
PRO
PDB
GeneCards
HPA
Ensembl
Pharos - Targets
Orphanet
ZINC - Predictions - Purchasable
Interactors (31)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:Q13541 EIF4EBP1  2 0.981 34
 UniProt:Q13542 4EBP2      0.959 17
 UniProt:Q9NRA8 4ET      0.939 14
 UniProt:O60516 4EBP3      0.926 12
 UniProt:Q04637 EIF4G1  2 0.924 13
 UniProt:P60842 EIF4A1  1 0.802 5
 UniProt:Q63ZY3 KANK2      0.781 7
 UniProt:O00571 DDX3X  3 0.775 7
 ChEBI:50210 7-METHYL-GTP      0.773 7
 UniProt:P14373 TRIM27  2 0.742 5
 UniProt:P48775 TDO2  1 0.666 4
 UniProt:O43432 EIF4G3  1 0.643 5
 UniProt:P55884 EIF3B  1 0.643 8
 UniProt:Q9UNK9 ANGE1      0.643 5
 UniProt:O43432-1 EIF4G3      0.623 2
 UniProt:Q04743 EMX2  1 0.591 4
 UniProt:Q8TEQ6 GEMIN5  2 0.582 3
 UniProt:P42704 LRPPRC  1 0.576 6
 UniProt:Q14240 EIF4A2  1 0.564 2
 UniProt:O73557 Z      0.558 3
 UniProt:P11940 PABPC1  1 0.558 5
 UniProt:Q5T124 UBXN11  1 0.556 3
 UniProt:P03427 PB2      0.547 2
 UniProt:O15372 EIF3H  1 0.527 2
 UniProt:O75821 EIF3G  1 0.527 2
 UniProt:P10636-8 MAPT  3 0.527 4
 UniProt:P62753 RPS6  4 0.527 2
 UniProt:P67775 PPP2CA  4 0.524 2
 UniProt:Q60809 Cnot7  1 0.499 2
 UniProt:P26196 DDX6  1 0.483 2
 UniProt:Q92900 UPF1  2 0.462 3
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