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INTS3 [nucleoplasm]
Stable Identifier
R-HSA-6807435
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Integrator complex subunit 3, INT3_HUMAN
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
RNA polymerase II transcribes snRNA genes (Homo sapiens)
CBCAP complex binds 7-methylguanosine cap of snRNA (Homo sapiens)
RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:CBCAP:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
Integrator [nucleoplasm] (Homo sapiens)
INTS3 [nucleoplasm] (Homo sapiens)
RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
Integrator [nucleoplasm] (Homo sapiens)
INTS3 [nucleoplasm] (Homo sapiens)
Dephosphorylation and dissociation of RNA polymerase II at 3' end of snRNA gene (Homo sapiens)
Integrator [nucleoplasm] (Homo sapiens)
INTS3 [nucleoplasm] (Homo sapiens)
RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
Integrator [nucleoplasm] (Homo sapiens)
INTS3 [nucleoplasm] (Homo sapiens)
Integrator complex processes the 3' end of snRNA (Homo sapiens)
Integrator [nucleoplasm] (Homo sapiens)
INTS3 [nucleoplasm] (Homo sapiens)
RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:CBCAP:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
Integrator [nucleoplasm] (Homo sapiens)
INTS3 [nucleoplasm] (Homo sapiens)
RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
Integrator [nucleoplasm] (Homo sapiens)
INTS3 [nucleoplasm] (Homo sapiens)
Pre-snRNA is elongated and capped with 7-methylguanosine (Homo sapiens)
RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
Integrator [nucleoplasm] (Homo sapiens)
INTS3 [nucleoplasm] (Homo sapiens)
RNA polymerase II (phosphoserine-5,7):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC:pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
RNA polymerase II (phospho-Ser5,7 CTD):RDRP1A,B:RDRP2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
Integrator [nucleoplasm] (Homo sapiens)
INTS3 [nucleoplasm] (Homo sapiens)
Pre-snRNA transcript initiation, Integrator binding, LEC binding (Homo sapiens)
Integrator [nucleoplasm] (Homo sapiens)
INTS3 [nucleoplasm] (Homo sapiens)
RNA polymerase II (phosphoserine-5,7):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC:pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
RNA polymerase II (phospho-Ser5,7 CTD):RDRP1A,B:RDRP2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
Integrator [nucleoplasm] (Homo sapiens)
INTS3 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q68E01 INTS3
Gene Names
INTS3, C1orf193, C1orf60
Chain
chain:1-1043
Reference Genes
BioGPS Gene:65123 INTS3
COSMIC (genes):INTS3 INTS3
CTD Gene:65123 INTS3
dbSNP Gene:65123 INTS3
ENSEMBL:ENSG00000143624 INTS3
ENSEMBL_homo_sapiens_GENE:ENSG00000143624.14 INTS3
ENSEMBL_homo_sapiens_GENE:ENSG00000262826.5 INTS3
HGNC:26153 INTS3
KEGG Gene (Homo sapiens):65123 INTS3
Monarch:65123 INTS3
NCBI Gene:65123 INTS3
OMIM:611347 INTS3
UCSC:Q68E01 INTS3
Reference Transcript
RefSeq:NM_001324475.1 INTS3
RefSeq:NM_023015.4 INTS3
RefSeq:XM_005245461.2 INTS3
Other Identifiers
11720354_a_at
11720355_a_at
11746983_a_at
11746984_x_at
11750108_x_at
11758827_at
16671217
202809_PM_s_at
202809_s_at
2359818
2359819
2359820
2359821
2359822
2359823
2359824
2359830
2359831
2359832
2359833
2359835
2359837
2359839
2359841
2359843
2359846
2359848
2359850
2359852
2359856
2359857
2359858
2359859
2359860
2359861
2359862
2359863
2359866
2359867
2359868
2359869
2359870
2359871
2359872
2359873
2359874
2359875
2359876
2359877
2359878
2359879
2359880
2359882
2359884
2359886
2359887
2359888
2359889
2359890
2359891
2359892
2359893
41406_at
65123
73597_at
7905631
A_14_P129616
A_23_P126757
A_33_P3281537
GE56355
GO:0000278
GO:0000724
GO:0005515
GO:0005634
GO:0005654
GO:0005694
GO:0005737
GO:0006281
GO:0006310
GO:0006351
GO:0006355
GO:0006974
GO:0010212
GO:0016073
GO:0016180
GO:0023052
GO:0032039
GO:0034243
GO:0035861
GO:0043226
GO:0044818
GO:0070876
HMNXSV003004222
HMNXSV003032803
ILMN_1756086
PH_hs_0005894
TC01001263.hg
g12711679_3p_at
Participates
as a component of
Integrator [nucleoplasm] (Homo sapiens)
Inferred To
Ints3 [nucleoplasm]
(Mus musculus)
Ints3 [nucleoplasm]
(Rattus norvegicus)
Ghost homologue of INTS3 [nucleoplasm]
(Xenopus tropicalis)
IntS3 [nucleoplasm]
(Drosophila melanogaster)
ints-3 [nucleoplasm]
(Caenorhabditis elegans)
INTS3 [nucleoplasm]
(Bos taurus)
INTS3 [nucleoplasm]
(Canis familiaris)
INTS3 [nucleoplasm]
(Gallus gallus)
INTS3 [nucleoplasm]
(Sus scrofa)
ints3 [nucleoplasm]
(Danio rerio)
ints3 [nucleoplasm]
(Dictyostelium discoideum)
Cross References
RefSeq
NP_001311404.1
,
NP_075391.3
,
XP_005245518.1
OpenTargets
ENSG00000143624
HPA
ENSG00000143624-INTS3
GeneCards
Q68E01
Ensembl
ENST00000571768
,
ENST00000435409
,
ENSP00000404290
,
ENSP00000460221
,
ENST00000512605
,
ENSP00000318641
,
ENST00000576422
,
ENSP00000425437
,
ENST00000576030
,
ENSG00000143624
,
ENSP00000459907
,
ENST00000318967
,
ENSP00000458631
,
ENSG00000262826
PRO
Q68E01
Pharos - Targets
Q68E01
PDB
4OWW
,
6WLG
,
4OWX
,
4OWT
,
7BV7
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