Reactome | IER3 [cytosol]

IER3 [cytosol]

Stable Identifier

R-HSA-6811515

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

IEX1, Radiation-inducible immediate-early gene IEX-1

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P46695 IER3

Gene Names

IER3, DIF2, IEX1, PRG1

Chain

chain:1-156

Reference Genes

BioGPS Gene:8870 IER3

COSMIC (genes):IER3 IER3

CTD Gene:8870 IER3

dbSNP Gene:8870 IER3

ENSEMBL:ENSG00000137331 IER3

ENSEMBL:ENSG00000206478 IER3

ENSEMBL:ENSG00000227231 IER3

ENSEMBL:ENSG00000230128 IER3

ENSEMBL:ENSG00000235030 IER3

ENSEMBL:ENSG00000237155 IER3

HGNC:5392 IER3

KEGG Gene (Homo sapiens):8870 IER3

Monarch:8870 IER3

NCBI Gene:8870 IER3

OMIM:602996 IER3

UCSC:P46695 IER3

Reference Transcript

RefSeq:NM_003897.3 IER3

Other Identifiers

0000450519

11720062_s_at

1237_at

17017018

17028909

17031687

17034143

17039184

17041752

201631_s_at

2948628

2948629

2948631

2948632

2948633

2948634

2948635

2948637

8124848

8178435

8179704

8870

ADDON002807.hg

A_23_P42257

A_33_P3423551

GE54675

GO:0003674

GO:0005515

GO:0005575

GO:0005622

GO:0005634

GO:0005737

GO:0005829

GO:0006915

GO:0006950

GO:0007165

GO:0008150

GO:0008219

GO:0009653

GO:0014066

GO:0016020

GO:0016021

GO:0043066

GO:0043226

GO:0048856

GO:2001020

ILMN_1682717

PH_hs_0004390

S81914_at

TC6_cox_hap2000143.hg

TC6_dbb_hap3000132.hg

TC6_mann_hap4000121.hg

TC6_qbl_hap6000133.hg

TC6_ssto_hap7000123.hg

g4503328_3p_a_at

Participant Of

output

MAPKs phosphorylate PP2A

hasComponent

PP2A-B56-beta,gamma:IER3:p-T,Y-MAPK dimers [cytosol]

input

IER3 recruits MAPKs to PP2A-B56-beta,gamma

Inferred To

Ier3 [cytosol] (Mus musculus)

Ier3 [cytosol] (Rattus norvegicus)

IER3 [cytosol] (Bos taurus)

IER3 [cytosol] (Canis familiaris)

IER3 [cytosol] (Danio rerio)

IER3 [cytosol] (Sus scrofa)

Ghost homologue of IER3 [cytosol] (Caenorhabditis elegans)

Ghost homologue of IER3 [cytosol] (Dictyostelium discoideum)

Ghost homologue of IER3 [cytosol] (Drosophila melanogaster)

Ghost homologue of IER3 [cytosol] (Schizosaccharomyces pombe)

Ghost homologue of IER3 [cytosol] (Xenopus tropicalis)

Cross References

RefSeq

NP_003888.2

OpenTargets

ENSG00000137331

GeneCards

P46695

HPA

ENSG00000137331-IER3

Ensembl

ENST00000439190, ENST00000450236, ENST00000383560, ENSP00000259874, ENSP00000397956, ENST00000259874, ENSP00000406245, ENSG00000230128, ENSG00000137331, ENST00000416884, ENSP00000398139, ENSG00000206478, ENST00000435856, ENSP00000412283, ENSP00000373054, ENSG00000237155, ENSG00000227231, ENSG00000235030

PRO

P46695

Interactors (11)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q04206 RELA	6	MeK310-RELA [nucleoplasm] (R-HSA-8865233) SUMO3-K37,K122,K123-RELA [nucleoplasm] (R-HSA-4755466) p-S276,5xAcK-RELA [nucleoplasm] (R-HSA-5660642) p-S276-RELA [nucleoplasm] (R-HSA-5624468) RELA [nucleoplasm] (R-HSA-177676) RELA [cytosol] (R-HSA-168172)	0.591	6
UniProt:O43765 SGTA	1	SGTA [cytosol] (R-HSA-5423595)	0.556	6
UniProt:P55061 BI1			0.556	3
UniProt:P11912 CD79A	2	CD79A [plasma membrane] (R-HSA-197154) p-Y188,Y199-CD79A [plasma membrane] (R-HSA-983539)	0.556	3
UniProt:Q9UKG4 SLC13A4	1	SLC13A4 [plasma membrane] (R-HSA-433098)	0.556	3
UniProt:Q9Y320 TMX2			0.556	3
UniProt:Q8N5K1 CISD2			0.556	3
UniProt:Q9Y680 FKBP7			0.556	3
UniProt:P67775 PPP2CA	4	PPP2CA [cytosol] (R-HSA-165971) p-Y307-PPP2CA [cytosol] (R-HSA-8857939) PPP2CA [nucleoplasm] (R-HSA-165978) MeL-PPP2CA [nucleoplasm] (R-HSA-8857791)	0.524	2
UniProt:Q15173 PPP2R5B	2	PPP2R5B [cytosol] (R-HSA-535469) p-S368-PPP2R5B [cytosol] (R-HSA-6811453)	0.524	4
UniProt:P49069 CAMLG	1	CAMLG [endoplasmic reticulum membrane] (R-HSA-9609522)	0.508	2

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