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IER3 [cytosol]
Stable Identifier
R-HSA-6811515
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
IEX1, Radiation-inducible immediate-early gene IEX-1
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Intracellular signaling by second messengers (Homo sapiens)
PIP3 activates AKT signaling (Homo sapiens)
Negative regulation of the PI3K/AKT network (Homo sapiens)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Homo sapiens)
IER3 recruits MAPKs to PP2A-B56-beta,gamma (Homo sapiens)
IER3 [cytosol] (Homo sapiens)
PP2A-B56-beta,gamma:IER3:p-T,Y-MAPK dimers [cytosol] (Homo sapiens)
IER3 [cytosol] (Homo sapiens)
MAPKs phosphorylate PP2A (Homo sapiens)
IER3 [cytosol] (Homo sapiens)
PP2A-B56-beta,gamma:IER3:p-T,Y-MAPK dimers [cytosol] (Homo sapiens)
IER3 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P46695 IER3
Gene Names
IER3, DIF2, IEX1, PRG1
Chain
chain:1-156
Reference Genes
BioGPS Gene:8870 IER3
COSMIC (genes):IER3 IER3
CTD Gene:8870 IER3
dbSNP Gene:8870 IER3
ENSEMBL:ENSG00000137331 IER3
ENSEMBL:ENSG00000206478 IER3
ENSEMBL:ENSG00000227231 IER3
ENSEMBL:ENSG00000230128 IER3
ENSEMBL:ENSG00000235030 IER3
ENSEMBL:ENSG00000237155 IER3
HGNC:5392 IER3
KEGG Gene (Homo sapiens):8870 IER3
Monarch:8870 IER3
NCBI Gene:8870 IER3
OMIM:602996 IER3
UCSC:P46695 IER3
Reference Transcript
RefSeq:NM_003897.3 IER3
Other Identifiers
0000450519
11720062_s_at
1237_at
17017018
17028909
17031687
17034143
17039184
17041752
201631_s_at
2948628
2948629
2948631
2948632
2948633
2948634
2948635
2948637
8124848
8178435
8179704
8870
ADDON002807.hg
A_23_P42257
A_33_P3423551
GE54675
GO:0003674
GO:0005515
GO:0005575
GO:0005622
GO:0005634
GO:0005737
GO:0005829
GO:0006915
GO:0006950
GO:0007165
GO:0008150
GO:0008219
GO:0009653
GO:0014066
GO:0016020
GO:0016021
GO:0043066
GO:0043226
GO:0048856
GO:2001020
ILMN_1682717
PH_hs_0004390
S81914_at
TC6_cox_hap2000143.hg
TC6_dbb_hap3000132.hg
TC6_mann_hap4000121.hg
TC6_qbl_hap6000133.hg
TC6_ssto_hap7000123.hg
g4503328_3p_a_at
Participant Of
output
MAPKs phosphorylate PP2A
hasComponent
PP2A-B56-beta,gamma:IER3:p-T,Y-MAPK dimers [cytosol]
input
IER3 recruits MAPKs to PP2A-B56-beta,gamma
Inferred To
Ier3 [cytosol] (Mus musculus)
Ier3 [cytosol] (Rattus norvegicus)
IER3 [cytosol] (Bos taurus)
IER3 [cytosol] (Canis familiaris)
IER3 [cytosol] (Danio rerio)
IER3 [cytosol] (Sus scrofa)
Ghost homologue of IER3 [cytosol] (Caenorhabditis elegans)
Ghost homologue of IER3 [cytosol] (Dictyostelium discoideum)
Ghost homologue of IER3 [cytosol] (Drosophila melanogaster)
Ghost homologue of IER3 [cytosol] (Schizosaccharomyces pombe)
Ghost homologue of IER3 [cytosol] (Xenopus tropicalis)
Cross References
RefSeq
NP_003888.2
OpenTargets
ENSG00000137331
GeneCards
P46695
HPA
ENSG00000137331-IER3
Ensembl
ENST00000439190
,
ENST00000450236
,
ENST00000383560
,
ENSP00000259874
,
ENSP00000397956
,
ENST00000259874
,
ENSP00000406245
,
ENSG00000230128
,
ENSG00000137331
,
ENST00000416884
,
ENSP00000398139
,
ENSG00000206478
,
ENST00000435856
,
ENSP00000412283
,
ENSP00000373054
,
ENSG00000237155
,
ENSG00000227231
,
ENSG00000235030
PRO
P46695
Interactors (11)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q04206 RELA
6
MeK310-RELA [nucleoplasm]
(R-HSA-8865233)
SUMO3-K37,K122,K123-RELA [nucleoplasm]
(R-HSA-4755466)
p-S276,5xAcK-RELA [nucleoplasm]
(R-HSA-5660642)
p-S276-RELA [nucleoplasm]
(R-HSA-5624468)
RELA [nucleoplasm]
(R-HSA-177676)
RELA [cytosol]
(R-HSA-168172)
0.591
6
UniProt:O43765 SGTA
1
SGTA [cytosol]
(R-HSA-5423595)
0.556
6
UniProt:P55061 BI1
0.556
3
UniProt:P11912 CD79A
2
CD79A [plasma membrane]
(R-HSA-197154)
p-Y188,Y199-CD79A [plasma membrane]
(R-HSA-983539)
0.556
3
UniProt:Q9UKG4 SLC13A4
1
SLC13A4 [plasma membrane]
(R-HSA-433098)
0.556
3
UniProt:Q9Y320 TMX2
0.556
3
UniProt:Q8N5K1 CISD2
0.556
3
UniProt:Q9Y680 FKBP7
0.556
3
UniProt:P67775 PPP2CA
4
PPP2CA [cytosol]
(R-HSA-165971)
p-Y307-PPP2CA [cytosol]
(R-HSA-8857939)
PPP2CA [nucleoplasm]
(R-HSA-165978)
MeL-PPP2CA [nucleoplasm]
(R-HSA-8857791)
0.524
2
UniProt:Q15173 PPP2R5B
2
PPP2R5B [cytosol]
(R-HSA-535469)
p-S368-PPP2R5B [cytosol]
(R-HSA-6811453)
0.524
4
UniProt:P49069 CAMLG
1
CAMLG [endoplasmic reticulum membrane]
(R-HSA-9609522)
0.508
2
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