Reactome | IER3 [cytosol]

IER3 [cytosol]

Stable Identifier

R-HSA-6811515

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

IEX1, Radiation-inducible immediate-early gene IEX-1

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P46695 IER3

Gene Names

IER3, DIF2, IEX1, PRG1

Chain

chain:1-156

Reference Genes

BioGPS Gene:8870 IER3

COSMIC (genes):IER3 IER3

CTD Gene:8870 IER3

dbSNP Gene:8870 IER3

ENSEMBL:ENSG00000137331 IER3

ENSEMBL_homo_sapiens_GENE:ENSG00000137331 IER3

ENSEMBL_homo_sapiens_GENE:ENSG00000206478 IER3

ENSEMBL_homo_sapiens_GENE:ENSG00000227231 IER3

ENSEMBL_homo_sapiens_GENE:ENSG00000230128 IER3

ENSEMBL_homo_sapiens_GENE:ENSG00000235030 IER3

ENSEMBL_homo_sapiens_GENE:ENSG00000237155 IER3

HGNC:5392 IER3

KEGG Gene (Homo sapiens):8870 IER3

Monarch:8870 IER3

NCBI Gene:8870 IER3

OMIM:602996 IER3

UCSC:P46695 IER3

Reference Transcript

RefSeq:NM_003897.3 IER3

Other Identifiers

0000450519

11720062_s_at

1237_at

17017018

17028909

17031687

17034143

17039184

17041752

201631_s_at

2948631

2948632

2948633

2948634

2948635

2948637

43847

8124848

8178435

8179704

8870

A0A1U9X7X2

A_23_P42257

A_33_P3423551

AAB36278

AAC33793

AAH00844

AAH05080

AAP35349

AB088101

AB202099

ADDON002807.hg

AF083421

AK314162

AL662797

AQY76892

AQY76893

BA000025

BAB63319

BAC54933

BAE78619

BAG36846

BC000844

BC005080

BT006703

CAA65304

CAA74886

CCDS4689

CH471081

EAX03329

EAX03331

ENSG00000137331

ENSG00000206478

ENSG00000227231

ENSG00000230128

ENSG00000235030

ENSG00000237155

ENSP00000259874

ENSP00000373054

ENSP00000397956

ENSP00000398139

ENSP00000406245

ENSP00000412283

ENST00000259874

ENST00000383560

ENST00000416884

ENST00000435856

ENST00000439190

ENST00000450236

EntrezGene:8870

g4503328_3p_a_at

GE54675

GO:0003674

GO:0005515

GO:0005575

GO:0005622

GO:0005623

GO:0005634

GO:0005737

GO:0005829

GO:0006915

GO:0006950

GO:0007165

GO:0008150

GO:0008219

GO:0009653

GO:0014066

GO:0016020

GO:0016021

GO:0043066

GO:0043226

GO:0048856

GO:2001020

HGNC:5392

HPA043847

IER3

IER3-201

IER3-203

IER3-205

IER3-208

IER3-209

IER3-212

ILMN_1682717

IPR024829

KY500405

KY500406

MIM:602996

NM_003897

NP_003888

PH_hs_0004390

PR02100

Q5ST77

Q5ST79

S81914

S81914_at

TC6_cox_hap2000143.hg

TC6_dbb_hap3000132.hg

TC6_mann_hap4000121.hg

TC6_qbl_hap6000133.hg

TC6_ssto_hap7000123.hg

uc003nrn.4

UPI0000000DB0

UPI00001AFA8D

X96438

Y14551

Participant Of

input

IER3 recruits MAPKs to PP2A-B56-beta,gamma

output

MAPKs phosphorylate PP2A

hasComponent

PP2A-B56-beta,gamma:IER3:p-T,Y-MAPK dimers [cytosol]

Inferred To

IER3 [cytosol] (Bos taurus)

IER3 [cytosol] (Canis familiaris)

IER3 [cytosol] (Mus musculus)

IER3 [cytosol] (Rattus norvegicus)

IER3 [cytosol] (Sus scrofa)

Ghost homologue of IER3 [cytosol] (Caenorhabditis elegans)

Ghost homologue of IER3 [cytosol] (Danio rerio)

Ghost homologue of IER3 [cytosol] (Dictyostelium discoideum)

Ghost homologue of IER3 [cytosol] (Drosophila melanogaster)

Ghost homologue of IER3 [cytosol] (Gallus gallus)

Ghost homologue of IER3 [cytosol] (Saccharomyces cerevisiae)

Ghost homologue of IER3 [cytosol] (Schizosaccharomyces pombe)

Ghost homologue of IER3 [cytosol] (Taeniopygia guttata)

Ghost homologue of IER3 [cytosol] (Xenopus tropicalis)

Homologues of IER3 [cytosol] (Rattus norvegicus)

Homologues of IER3 [cytosol] (Sus scrofa)

Cross References

RefSeq

NP_003888.2

OpenTargets

ENSG00000137331

GeneCards

P46695

PRO

P46695

Interactors (11)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q04206 RELA	6	MeK310-RELA [nucleoplasm] (R-HSA-8865233) SUMO3-K37,K122,K123-RELA [nucleoplasm] (R-HSA-4755466) p-S276,5xAcK-RELA [nucleoplasm] (R-HSA-5660642) p-S276-RELA [nucleoplasm] (R-HSA-5624468) RELA [cytosol] (R-HSA-168172) RELA [nucleoplasm] (R-HSA-177676)	0.591	6
UniProt:P67775 PPP2CA	4	MeL-PPP2CA [nucleoplasm] (R-HSA-8857791) p-Y307-PPP2CA [cytosol] (R-HSA-8857939) PPP2CA [nucleoplasm] (R-HSA-165978) PPP2CA [cytosol] (R-HSA-165971)	0.524	2
UniProt:Q15173 PPP2R5B	2	PPP2R5B [cytosol] (R-HSA-535469) p-S368-PPP2R5B [cytosol] (R-HSA-6811453)	0.524	4
UniProt:P49069 CAMLG			0.508	2
UniProt:O43765 SGTA			0.488	4
UniProt:P55061 BI1			0.488	2
UniProt:Q9UKG4 SLC13A4	1	SLC13A4 [plasma membrane] (R-HSA-433098)	0.488	2
UniProt:P11912 CD79A	2	CD79A [plasma membrane] (R-HSA-197154) p-Y188,Y199-CD79A [plasma membrane] (R-HSA-983539)	0.488	2
UniProt:Q9Y680 FKBP7			0.488	2
UniProt:Q8N5K1 CISD2			0.488	2
UniProt:Q9Y320 TMX2			0.488	2