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STRN [cytosol]
Stable Identifier
R-HSA-9037081
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Striatin
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
PI3K/AKT Signaling in Cancer (Homo sapiens)
Constitutive Signaling by Aberrant PI3K in Cancer (Homo sapiens)
PI3K inhibitors block PI3K catalytic activity (Homo sapiens)
PI3K Inhibitors:PI3K [cytosol] (Homo sapiens)
PI3K mutants,Activator:PI3K [plasma membrane] (Homo sapiens)
Activator:PI3K [plasma membrane] (Homo sapiens)
ESRs:STRN:ESTG:MyrG-pY419 SRC:PI3K alpha [plasma membrane] (Homo sapiens)
ESRs:STRN:ESTG:MyrG-pY419-SRC [plasma membrane] (Homo sapiens)
ESRs:STRN:ESTG [cytosol] (Homo sapiens)
STRN [cytosol] (Homo sapiens)
PI3K mutants,Activator:PI3K [plasma membrane] (Homo sapiens)
Activator:PI3K [plasma membrane] (Homo sapiens)
ESRs:STRN:ESTG:MyrG-pY419 SRC:PI3K alpha [plasma membrane] (Homo sapiens)
ESRs:STRN:ESTG:MyrG-pY419-SRC [plasma membrane] (Homo sapiens)
ESRs:STRN:ESTG [cytosol] (Homo sapiens)
STRN [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Intracellular signaling by second messengers (Homo sapiens)
PIP3 activates AKT signaling (Homo sapiens)
Negative regulation of the PI3K/AKT network (Homo sapiens)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Homo sapiens)
PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
Activator:PI3K [plasma membrane] (Homo sapiens)
ESRs:STRN:ESTG:MyrG-pY419 SRC:PI3K alpha [plasma membrane] (Homo sapiens)
ESRs:STRN:ESTG:MyrG-pY419-SRC [plasma membrane] (Homo sapiens)
ESRs:STRN:ESTG [cytosol] (Homo sapiens)
STRN [cytosol] (Homo sapiens)
PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
Activator:PI3K [plasma membrane] (Homo sapiens)
ESRs:STRN:ESTG:MyrG-pY419 SRC:PI3K alpha [plasma membrane] (Homo sapiens)
ESRs:STRN:ESTG:MyrG-pY419-SRC [plasma membrane] (Homo sapiens)
ESRs:STRN:ESTG [cytosol] (Homo sapiens)
STRN [cytosol] (Homo sapiens)
Signaling by Nuclear Receptors (Homo sapiens)
ESR-mediated signaling (Homo sapiens)
Extra-nuclear estrogen signaling (Homo sapiens)
ESR binds STRN (Homo sapiens)
PalmS-ESRs:STRN:ESTG [plasma membrane] (Homo sapiens)
STRN [cytosol] (Homo sapiens)
STRN [cytosol] (Homo sapiens)
ESR-associated SRC autophosphorylates (Homo sapiens)
ESRs:STRN:ESTG:MyrG-SRC [plasma membrane] (Homo sapiens)
ESRs:STRN:ESTG [cytosol] (Homo sapiens)
STRN [cytosol] (Homo sapiens)
ESRs:STRN:ESTG:MyrG-pY419-SRC [plasma membrane] (Homo sapiens)
ESRs:STRN:ESTG [cytosol] (Homo sapiens)
STRN [cytosol] (Homo sapiens)
ESTG binding induces ESR depalmitoylation (Homo sapiens)
ESRs:STRN:ESTG [cytosol] (Homo sapiens)
STRN [cytosol] (Homo sapiens)
PalmS-ESRs:STRN:ESTG [plasma membrane] (Homo sapiens)
STRN [cytosol] (Homo sapiens)
G-proteins dissociate from plasma-membrane estrogen receptors (Homo sapiens)
ESRs:STRN:ESTG [cytosol] (Homo sapiens)
STRN [cytosol] (Homo sapiens)
ESTG:ESRs:STRN:heterotrimeric G(i) protein [plasma membrane] (Homo sapiens)
ESRs:STRN:ESTG [cytosol] (Homo sapiens)
STRN [cytosol] (Homo sapiens)
Heterotrimeric G protein (i) binds membrane-associated ESRs:ESTG (Homo sapiens)
ESRs:STRN:ESTG [cytosol] (Homo sapiens)
STRN [cytosol] (Homo sapiens)
ESTG:ESRs:STRN:heterotrimeric G(i) protein [plasma membrane] (Homo sapiens)
ESRs:STRN:ESTG [cytosol] (Homo sapiens)
STRN [cytosol] (Homo sapiens)
Membrane estrogen receptors bind SRC (Homo sapiens)
ESRs:STRN:ESTG [cytosol] (Homo sapiens)
STRN [cytosol] (Homo sapiens)
ESRs:STRN:ESTG:MyrG-SRC [plasma membrane] (Homo sapiens)
ESRs:STRN:ESTG [cytosol] (Homo sapiens)
STRN [cytosol] (Homo sapiens)
PI3K binds membrane-associated estrogen receptors (Homo sapiens)
ESRs:STRN:ESTG:MyrG-pY419 SRC:PI3K alpha [plasma membrane] (Homo sapiens)
ESRs:STRN:ESTG:MyrG-pY419-SRC [plasma membrane] (Homo sapiens)
ESRs:STRN:ESTG [cytosol] (Homo sapiens)
STRN [cytosol] (Homo sapiens)
ESRs:STRN:ESTG:MyrG-pY419-SRC [plasma membrane] (Homo sapiens)
ESRs:STRN:ESTG [cytosol] (Homo sapiens)
STRN [cytosol] (Homo sapiens)
PTK2 is recruited to methylated ESR1 (Homo sapiens)
Me260-ESR1:STRN:ESTG: MyrG-pY419 SRC:PI3Kalpha:pY-PTK2 [plasma membrane] (Homo sapiens)
Me260-ESR1:STRN:ESTG:MyrG-pY419 SRC:PI3K alpha [plasma membrane] (Homo sapiens)
STRN [cytosol] (Homo sapiens)
Me260-ESR1:STRN:ESTG:MyrG-pY419 SRC:PI3K alpha [plasma membrane] (Homo sapiens)
STRN [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:O43815 STRN
Gene Names
STRN
Chain
chain:1-780
Reference Genes
BioGPS Gene:6801 STRN
COSMIC (genes):STRN STRN
CTD Gene:6801 STRN
dbSNP Gene:6801 STRN
ENSEMBL:ENSG00000115808 STRN
ENSEMBL_homo_sapiens_GENE:ENSG00000115808.13 STRN
HGNC:11424 STRN
KEGG Gene (Homo sapiens):6801 STRN
Monarch:6801 STRN
NCBI Gene:6801 STRN
OMIM:614765 STRN
UCSC:O43815 STRN
Reference Transcript
RefSeq:NM_003162.3 STRN
Other Identifiers
11730500_at
11755875_a_at
16896374
205520_PM_at
205520_at
215287_PM_at
215287_at
227422_PM_at
227422_at
230734_PM_x_at
230734_x_at
236388_PM_at
236388_at
236980_PM_at
236980_at
242989_PM_at
242989_at
244354_PM_at
244354_at
2548253
2548254
2548256
2548257
2548258
2548260
2548262
2548263
2548265
2548266
2548268
2548270
2548271
2548273
2548275
2548276
2548277
2548279
2548281
2548282
2548283
2548285
2548286
2548289
2548291
2548292
2548296
2548299
2548301
2548302
2548303
2548304
2548305
2548317
2548318
2548319
2804784
31736_at
33298_at
4032637
53132_at
60565_at
62989_f_at
62990_r_at
62991_f_at
6801
70775_at
78779_at
8051443
81992_at
82977_at
A_19_P00316199
A_19_P00316200
A_19_P00322614
A_19_P00808033
A_23_P165521
A_32_P174398
A_32_P78904
A_32_P92536
GE81242
GE872109
GO:0005515
GO:0005516
GO:0005737
GO:0005829
GO:0005886
GO:0005923
GO:0007626
GO:0008285
GO:0014069
GO:0016020
GO:0016055
GO:0016358
GO:0023052
GO:0030154
GO:0030331
GO:0030425
GO:0032991
GO:0034330
GO:0042995
GO:0043025
GO:0043197
GO:0043226
GO:0044877
GO:0045202
GO:0045211
GO:0048856
GO:0051721
GO:0070016
GO:0070830
GO:0090443
HMNXSV003019811
Hs.127486.0.A1_3p_at
Hs.128434.0.S1_3p_at
Hs.135162.0.A1_3p_at
Hs.211253.0.A1_3p_at
Hs.46667.0.A1_3p_at
Hs.5635.0.A1_3p_at
Hs.90787.0.A1_3p_at
ILMN_1749882
ILMN_2129273
PH_hs_0007315
PH_hs_0033959
TC02001736.hg
TC02004160.hg
g4507282_3p_at
Participates
as a component of
Me260-ESR1:STRN:ESTG:MyrG-pY419 SRC:PI3K alpha [plasma membrane] (Homo sapiens)
PalmS-ESRs:STRN:ESTG [plasma membrane] (Homo sapiens)
ESRs:STRN:ESTG [cytosol] (Homo sapiens)
as an input of
ESR binds STRN (Homo sapiens)
Other forms of this molecule
STRN(1-265)-PDGFRA(580-1089) fusion [cytosol]
p-11Y-STRN(1-265)-PDGFRA(580-1089) fusion [cytosol]
STRN(1-137)-ALK(1058-1620) fusion [cytosol]
STRN(1-137)-p-7Y-ALK(1058-1620) fusion [cytosol]
Inferred To
Strn [cytosol]
(Mus musculus)
Strn [cytosol]
(Rattus norvegicus)
cash-1 [cytosol]
(Caenorhabditis elegans)
strn [cytosol]
(Danio rerio)
strn [cytosol]
(Dictyostelium discoideum)
strn [cytosol]
(Xenopus tropicalis)
Cka [cytosol]
(Drosophila melanogaster)
FAR8 [cytosol]
(Saccharomyces cerevisiae)
STRN [cytosol]
(Bos taurus)
STRN [cytosol]
(Canis familiaris)
STRN [cytosol]
(Gallus gallus)
STRN [cytosol]
(Schizosaccharomyces pombe)
STRN [cytosol]
(Sus scrofa)
Cross References
RefSeq
NP_003153.2
OpenTargets
ENSG00000115808
HPA
ENSG00000115808-STRN
GeneCards
O43815
Ensembl
ENST00000263918
,
ENSG00000115808
,
ENSP00000263918
PRO
O43815
Pharos - Targets
O43815
Interactors (43)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q13033 STRN3
0.88
12
UniProt:Q9Y6E0 STK24
4
STK24(1-313) [nucleoplasm]
(R-HSA-351944)
STK24(314-443) [cytosol]
(R-HSA-351898)
STK24(1-313) [cytosol]
(R-HSA-351892)
STK24 [cytosol]
(R-HSA-351829)
0.871
7
UniProt:Q9P289 STK26
3
MST4(306-416) [cytosol]
(R-HSA-351903)
MST4(1-305) [cytosol]
(R-HSA-351855)
MST4 [cytosol]
(R-HSA-351918)
0.864
7
UniProt:O00506 STK25
0.864
7
UniProt:P30153 PPP2R1A
2
PPP2R1A [nucleoplasm]
(R-HSA-165968)
PPP2R1A [cytosol]
(R-HSA-165982)
0.848
10
UniProt:P67775 PPP2CA
4
MeL-PPP2CA [nucleoplasm]
(R-HSA-8857791)
p-Y307-PPP2CA [cytosol]
(R-HSA-8857939)
PPP2CA [nucleoplasm]
(R-HSA-165978)
PPP2CA [cytosol]
(R-HSA-165971)
0.84
7
UniProt:Q9BUL8 PDC10
0.823
7
UniProt:Q9P2B4 CT2NL
0.816
8
UniProt:Q9Y3A3 PHOCN
0.794
7
UniProt:P62714 PPP2CB
4
MeL-PPP2CB [nucleoplasm]
(R-HSA-8857799)
p-Y307-PPP2CB [cytosol]
(R-HSA-8857935)
PPP2CB [nucleoplasm]
(R-HSA-165991)
PPP2CB [cytosol]
(R-HSA-165987)
0.788
6
UniProt:Q5VSL9 STRP1
0.773
6
UniProt:Q9BRV8 SIKE1
1
SIKE1 [cytosol]
(R-HSA-916828)
0.725
6
UniProt:Q9NRL3 STRN4
0.725
5
UniProt:P30154 PPP2R1B
2
PPP2R1B [cytosol]
(R-HSA-165980)
PPP2R1B [nucleoplasm]
(R-HSA-166000)
0.725
5
UniProt:Q14BN4 SLMAP
0.706
6
UniProt:Q8WZ74 CTTB2
0.643
4
UniProt:Q9NVK5 FGFR1OP2
2
FGFR1OP(1-132)-FGFR1(429-822) fusion [cytosol]
(R-HSA-1606443)
FGFR1OP(1-132)-p-FGFR1(429-822) fusion [cytosol]
(R-HSA-1838998)
0.643
5
UniProt:P63167 DYNLL1
6
DYNLL1 [ciliary tip]
(R-HSA-5625335)
DYNLL1 [cilium]
(R-HSA-5624863)
DYNLL1 [ficolin-1-rich granule membrane]
(R-HSA-6801518)
DYNLL1 [tertiary granule membrane]
(R-HSA-6801482)
DYNLL1 [plasma membrane]
(R-HSA-54017)
DYNLL1 [cytosol]
(R-HSA-387105)
0.643
3
UniProt:Q9ULQ0 STRP2
0.643
4
UniProt:Q9Y228 T3JAM
0.623
4
UniProt:Q13043 STK4
4
STK4(1-487) [cytosol]
(R-HSA-201627)
p-T183-STK4(1-326) [cytosol]
(R-HSA-2028682)
p-T183-STK4(1-487) [cytosol]
(R-HSA-2028258)
STK4(327-487) [cytosol]
(R-HSA-2028668)
0.615
4
UniProt:Q6NUQ1 RINT1
1
RINT1 [cytosol]
(R-HSA-6810991)
0.556
3
UniProt:Q9UBB9 TFIP11
1
TFIP11 [nucleoplasm]
(R-HSA-8869310)
0.556
3
UniProt:Q7Z398 ZNF550
1
ZNF550 [nucleoplasm]
(R-HSA-1973896)
0.527
2
UniProt:P78371 CCT2
3
CCT2 [extracellular region]
(R-HSA-6806220)
CCT2 [azurophil granule lumen]
(R-HSA-6799356)
CCT2 [cytosol]
(R-HSA-390464)
0.527
2
UniProt:Q99832 CCT7
1
CCT7 [cytosol]
(R-HSA-390451)
0.527
2
UniProt:Q8N4C8 MINK1
1
MINK1 [cytosol]
(R-HSA-2532788)
0.527
3
UniProt:Q96FJ2 DYNLL2
4
DYNLL2 [cytosol]
(R-HSA-2029024)
DYNLL2 [plasma membrane]
(R-HSA-140527)
DYNLL2 [cilium]
(R-HSA-5624865)
DYNLL2 [ciliary tip]
(R-HSA-5625337)
0.527
2
UniProt:P49368 CCT3
1
CCT3 [cytosol]
(R-HSA-390463)
0.527
2
UniProt:P50990 CCT8
5
CCT8 [secretory granule lumen]
(R-HSA-6801035)
CCT8 [ficolin-1-rich granule lumen]
(R-HSA-6800894)
CCT8 [extracellular region]
(R-HSA-6806238)
CCT8 [azurophil granule lumen]
(R-HSA-6799369)
CCT8 [cytosol]
(R-HSA-390449)
0.527
2
UniProt:P50991 CCT4
1
CCT4 [cytosol]
(R-HSA-390458)
0.527
2
UniProt:Q13554 CAMK2B
5
p-T287-CAMK2B [plasma membrane]
(R-HSA-432791)
p-T287-CAMK2B [nucleoplasm]
(R-HSA-444787)
p-T287-CAMK2B [endocytic vesicle membrane]
(R-HSA-417009)
CAMK2B [cytosol]
(R-HSA-9611360)
p-T287-CAMK2B [cytosol]
(R-HSA-445371)
0.527
2
UniProt:P40227 CCT6A
1
CCT6A [cytosol]
(R-HSA-390454)
0.527
2
UniProt:O95274 LYPD3
2
cleaved GPI-LYPD3 [extracellular region]
(R-HSA-8941013)
GPI-LYPD3 [plasma membrane]
(R-HSA-8940752)
0.527
2
UniProt:P20155 ISK2
0.527
2
UniProt:P48643 CCT5
1
CCT5 [cytosol]
(R-HSA-390447)
0.527
2
UniProt:O95819 MAP4K4
1
MAP4K4 [cytosol]
(R-HSA-3214893)
0.527
2
UniProt:Q9UMS4 PRPF19
1
PRPF19 [nucleoplasm]
(R-HSA-5420907)
0.527
2
UniProt:P17987 TCP1
1
TCP1 [cytosol]
(R-HSA-390448)
0.527
2
UniProt:Q9GZV8 PRDM14
1
PRDM14 [nucleoplasm]
(R-HSA-1112608)
0.527
2
UniProt:P62195 PSMC5
2
PSMC5 [nucleoplasm]
(R-HSA-174312)
PSMC5 [cytosol]
(R-HSA-68780)
0.527
2
UniProt:Q9H2K2 TNKS2
1
TNKS2 [cytosol]
(R-HSA-3640824)
0.525
2
UniProt:Q13188 STK3
4
p-T180-STK3(1-322) [cytosol]
(R-HSA-2028696)
STK3(323-491) [cytosol]
(R-HSA-2028684)
STK3(1-491) [cytosol]
(R-HSA-2028280)
p-T180-STK3(1-491) [cytosol]
(R-HSA-2028274)
0.483
3
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