Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
INTS8 [nucleoplasm]
Stable Identifier
R-HSA-6807409
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Integrator complex subunit 8, INT8_HUMAN
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
RNA polymerase II transcribes snRNA genes (Homo sapiens)
CBCAP complex binds 7-methylguanosine cap of snRNA (Homo sapiens)
RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:CBCAP:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
Integrator [nucleoplasm] (Homo sapiens)
INTS8 [nucleoplasm] (Homo sapiens)
RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
Integrator [nucleoplasm] (Homo sapiens)
INTS8 [nucleoplasm] (Homo sapiens)
Dephosphorylation and dissociation of RNA polymerase II at 3' end of snRNA gene (Homo sapiens)
Integrator [nucleoplasm] (Homo sapiens)
INTS8 [nucleoplasm] (Homo sapiens)
RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
Integrator [nucleoplasm] (Homo sapiens)
INTS8 [nucleoplasm] (Homo sapiens)
Integrator complex processes the 3' end of snRNA (Homo sapiens)
Integrator [nucleoplasm] (Homo sapiens)
INTS8 [nucleoplasm] (Homo sapiens)
RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:CBCAP:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
Integrator [nucleoplasm] (Homo sapiens)
INTS8 [nucleoplasm] (Homo sapiens)
RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
Integrator [nucleoplasm] (Homo sapiens)
INTS8 [nucleoplasm] (Homo sapiens)
Pre-snRNA is elongated and capped with 7-methylguanosine (Homo sapiens)
RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
Integrator [nucleoplasm] (Homo sapiens)
INTS8 [nucleoplasm] (Homo sapiens)
RNA polymerase II (phosphoserine-5,7):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC:pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
RNA polymerase II (phospho-Ser5,7 CTD):RDRP1A,B:RDRP2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
Integrator [nucleoplasm] (Homo sapiens)
INTS8 [nucleoplasm] (Homo sapiens)
Pre-snRNA transcript initiation, Integrator binding, LEC binding (Homo sapiens)
Integrator [nucleoplasm] (Homo sapiens)
INTS8 [nucleoplasm] (Homo sapiens)
RNA polymerase II (phosphoserine-5,7):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC:pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
RNA polymerase II (phospho-Ser5,7 CTD):RDRP1A,B:RDRP2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
Integrator [nucleoplasm] (Homo sapiens)
INTS8 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q75QN2 INTS8
Gene Names
INTS8, C8orf52
Chain
chain:1-995
Reference Genes
BioGPS Gene:55656 INTS8
COSMIC (genes):INTS8 INTS8
CTD Gene:55656 INTS8
dbSNP Gene:55656 INTS8
ENSEMBL:ENSG00000164941 INTS8
HGNC:26048 INTS8
KEGG:hsa:55656 INTS8
Monarch:55656 INTS8
NCBI Gene:55656 INTS8
OMIM:611351 INTS8
UCSC:Q75QN2 INTS8
Reference Transcript
RefSeq:XM_017013619.1 INTS8
RefSeq:NM_017864.3 INTS8
Other Identifiers
11756772_a_at
17070998
218905_PM_at
218905_at
3107660
3107662
3107663
3107664
3107665
3107666
3107667
3107668
3107669
3107670
3107671
3107672
3107673
3107675
3107676
3107677
3107679
3107682
3107684
3107685
3107687
3107688
3107689
3107690
3107692
3107693
3107694
3107695
3107696
3107697
3107698
3107699
3107700
3107701
3107702
3107703
3107704
3107705
3107706
3107707
3107708
3107710
3107711
3107712
3107713
3107714
3107715
52546_at
55656
58931_i_at
58932_r_at
61296_at
8147396
A_14_P113166
A_14_P138997
A_23_P43079
GO:0005515
GO:0005634
GO:0005654
GO:0006355
GO:0016073
GO:0016180
GO:0032039
GO:0034243
GO:0034472
GO:0043226
HMNXSV003042643
ILMN_1759084
PH_hs_0024162
TC08000578.hg
g8923495_3p_at
Participates
as a component of
Integrator [nucleoplasm] (Homo sapiens)
Inferred To
INTS8 [nucleoplasm]
(Bos taurus)
INTS8 [nucleoplasm]
(Canis familiaris)
INTS8 [nucleoplasm]
(Dictyostelium discoideum)
INTS8 [nucleoplasm]
(Gallus gallus)
INTS8 [nucleoplasm]
(Sus scrofa)
ints8 [nucleoplasm]
(Danio rerio)
ints8 [nucleoplasm]
(Xenopus tropicalis)
IntS8 [nucleoplasm]
(Drosophila melanogaster)
ints-8 [nucleoplasm]
(Caenorhabditis elegans)
Ints8 [nucleoplasm]
(Mus musculus)
Ints8 [nucleoplasm]
(Rattus norvegicus)
Cross References
ENSEMBL
ENSP00000430338
,
ENST00000523731
OpenTargets
ENSG00000164941
HPA
ENSG00000164941-INTS8
PRO
Q75QN2
Pharos - Targets
Q75QN2
PDB
9EP4
,
8RBX
,
8RBZ
,
7PKS
,
9EOF
,
8RC4
,
7CUN
,
7YCX
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P67775 PPP2CA
4
PPP2CA [cytosol]
(R-HSA-165971)
PPP2CA [nucleoplasm]
(R-HSA-165978)
p-Y307-PPP2CA [cytosol]
(R-HSA-8857939)
MeL-PPP2CA [nucleoplasm]
(R-HSA-8857791)
0.527
2
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text