Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Statistics
Our Logo
License Agreement
Disclaimer
Content
Table of Contents
DOIs
Data Schema
ORCID Integration Project
Docs
User Guide
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
Data Model
Computational inferred events
Linking to Us
Citing us
Tools
Pathway Browser
Analyze Data
Species Comparison
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Author/Reviewer Search
Site map
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Statistics
Our Logo
License Agreement
Disclaimer
Content
Table of Contents
DOIs
Data Schema
ORCID Integration Project
Docs
User Guide
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
Data Model
Computational inferred events
Linking to Us
Citing us
Tools
Pathway Browser
Analyze Data
Species Comparison
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Author/Reviewer Search
Site map
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Download
Search ...
Go!
INTS8
Stable Identifier
R-HSA-6807409
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Integrator complex subunit 8, INT8_HUMAN
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
RNA polymerase II transcribes snRNA genes (Homo sapiens)
CBCAP complex binds 7-methylguanosine cap of snRNA (Homo sapiens)
RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:CBCAP:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
Integrator [nucleoplasm] (Homo sapiens)
INTS8 [nucleoplasm] (Homo sapiens)
RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
Integrator [nucleoplasm] (Homo sapiens)
INTS8 [nucleoplasm] (Homo sapiens)
Dephosphorylation and dissociation of RNA polymerase II at 3' end of snRNA gene (Homo sapiens)
Integrator [nucleoplasm] (Homo sapiens)
INTS8 [nucleoplasm] (Homo sapiens)
RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
Integrator [nucleoplasm] (Homo sapiens)
INTS8 [nucleoplasm] (Homo sapiens)
Integrator complex processes the 3' end of snRNA (Homo sapiens)
Integrator [nucleoplasm] (Homo sapiens)
INTS8 [nucleoplasm] (Homo sapiens)
RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:CBCAP:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
Integrator [nucleoplasm] (Homo sapiens)
INTS8 [nucleoplasm] (Homo sapiens)
RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
Integrator [nucleoplasm] (Homo sapiens)
INTS8 [nucleoplasm] (Homo sapiens)
Pre-snRNA is elongated and capped with 7-methylguanosine (Homo sapiens)
RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
Integrator [nucleoplasm] (Homo sapiens)
INTS8 [nucleoplasm] (Homo sapiens)
RNA polymerase II (phosphoserine-5,7):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC:pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
RNA polymerase II (phospho-Ser5,7 CTD):RDRP1A,B:RDRP2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
Integrator [nucleoplasm] (Homo sapiens)
INTS8 [nucleoplasm] (Homo sapiens)
Pre-snRNA transcript initiation, Integrator binding, LEC binding (Homo sapiens)
Integrator [nucleoplasm] (Homo sapiens)
INTS8 [nucleoplasm] (Homo sapiens)
RNA polymerase II (phosphoserine-5,7):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC:pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
RNA polymerase II (phospho-Ser5,7 CTD):RDRP1A,B:RDRP2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
Integrator [nucleoplasm] (Homo sapiens)
INTS8 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q75QN2 INTS8
Gene Names
INTS8, C8orf52
Chain
chain:1-995
Reference Genes
BioGPS Gene:55656 INTS8
COSMIC (genes):INTS8 INTS8
CTD Gene:55656 INTS8
dbSNP Gene:55656 INTS8
ENSEMBL:ENSG00000164941 INTS8
HGNC:26048 INTS8
KEGG Gene (Homo sapiens):hsa:55656 INTS8
Monarch:55656 INTS8
NCBI Gene:55656 INTS8
OMIM:611351 INTS8
UCSC:Q75QN2 INTS8
Reference Transcript
RefSeq:XM_017013619.1 INTS8
RefSeq:NM_017864.3 INTS8
Other Identifiers
0000840551
11756772_a_at
17070998
218905_at
55656
57299
58931_i_at
61296_at
8147396
A_14_P113166
A_14_P138997
AAH50536
AAH64915
AAI36755
AB161944
AK000537
AK001403
BAA91238
BAA91671
BAD10863
BC050536
BC064915
BC136754
BK005731
BX538203
CAD98067
CCDS34925
CH471060
DAA05731
EAW91726
ENSG00000164941
ENSP00000430338
ENST00000523731
EntrezGene:55656
g8923495_3p_at
GO:0003674
GO:0005515
GO:0005575
GO:0005622
GO:0005623
GO:0005634
GO:0005654
GO:0008150
GO:0009058
GO:0016180
GO:0032039
GO:0034641
GO:0042795
GO:0043226
GO:0043234
HGNC:26048
HPA057299
Hs.727669
ILMN_1759084
INTS8
INTS8-217
IPR011990
MIM:611351
NM_017864
NP_060334
PH_hs_0024162
TC08000578.hg
uc003yhb.5
UPI000023B7D0
XM_017013616
XM_017013617
XM_017013618
XP_016869105
XP_016869106
XP_016869107
Participant Of
hasComponent
Integrator [nucleoplasm]
Inferred To
INTS8 [nucleoplasm] (Bos taurus)
INTS8 [nucleoplasm] (Canis familiaris)
INTS8 [nucleoplasm] (Danio rerio)
INTS8 [nucleoplasm] (Drosophila melanogaster)
INTS8 [nucleoplasm] (Gallus gallus)
INTS8 [nucleoplasm] (Mus musculus)
INTS8 [nucleoplasm] (Rattus norvegicus)
INTS8 [nucleoplasm] (Sus scrofa)
INTS8 [nucleoplasm] (Taeniopygia guttata)
INTS8 [nucleoplasm] (Xenopus tropicalis)
Homologues of INTS8 [nucleoplasm] (Danio rerio)
Homologues of INTS8 [nucleoplasm] (Rattus norvegicus)
Homologues of INTS8 [nucleoplasm] (Taeniopygia guttata)
Homologues of INTS8 [nucleoplasm] (Xenopus tropicalis)
Cross References
RefSeq
NP_060334.2
,
XP_016869108.1
GeneCards
Q75QN2
PRO
Q75QN2
© 2018
Reactome
