Reactome | INTS8 [nucleoplasm]

INTS8 [nucleoplasm]

Stable Identifier

R-HSA-6807409

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Integrator complex subunit 8, INT8_HUMAN

Locations in the PathwayBrowser

Expand all

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - RNA polymerase II transcribes snRNA genes (Homo sapiens)
    - CBCAP complex binds 7-methylguanosine cap of snRNA (Homo sapiens)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:CBCAP:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
        
        Integrator [nucleoplasm] (Homo sapiens)
        
        INTS8 [nucleoplasm] (Homo sapiens)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
        
        Integrator [nucleoplasm] (Homo sapiens)
        
        INTS8 [nucleoplasm] (Homo sapiens)
    - Dephosphorylation and dissociation of RNA polymerase II at 3' end of snRNA gene (Homo sapiens)
      - Integrator [nucleoplasm] (Homo sapiens)
        
        INTS8 [nucleoplasm] (Homo sapiens)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
        
        Integrator [nucleoplasm] (Homo sapiens)
        
        INTS8 [nucleoplasm] (Homo sapiens)
    - Integrator complex processes the 3' end of snRNA (Homo sapiens)
      - Integrator [nucleoplasm] (Homo sapiens)
        
        INTS8 [nucleoplasm] (Homo sapiens)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:CBCAP:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
        
        Integrator [nucleoplasm] (Homo sapiens)
        
        INTS8 [nucleoplasm] (Homo sapiens)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
        
        Integrator [nucleoplasm] (Homo sapiens)
        
        INTS8 [nucleoplasm] (Homo sapiens)
    - Pre-snRNA is elongated and capped with 7-methylguanosine (Homo sapiens)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
        
        Integrator [nucleoplasm] (Homo sapiens)
        
        INTS8 [nucleoplasm] (Homo sapiens)
      - RNA polymerase II (phosphoserine-5,7):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC:pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
        
        RNA polymerase II (phospho-Ser5,7 CTD):RDRP1A,B:RDRP2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
        
        Integrator [nucleoplasm] (Homo sapiens)
        
        INTS8 [nucleoplasm] (Homo sapiens)
    - Pre-snRNA transcript initiation, Integrator binding, LEC binding (Homo sapiens)
      - Integrator [nucleoplasm] (Homo sapiens)
        
        INTS8 [nucleoplasm] (Homo sapiens)
      - RNA polymerase II (phosphoserine-5,7):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC:pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
        
        RNA polymerase II (phospho-Ser5,7 CTD):RDRP1A,B:RDRP2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
        
        Integrator [nucleoplasm] (Homo sapiens)
        
        INTS8 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q75QN2 INTS8

Gene Names

INTS8, C8orf52

Chain

chain:1-995

Reference Genes

BioGPS Gene:55656 INTS8

COSMIC (genes):INTS8 INTS8

CTD Gene:55656 INTS8

dbSNP Gene:55656 INTS8

ENSEMBL:ENSG00000164941 INTS8

HGNC:26048 INTS8

KEGG Gene (Homo sapiens):55656 INTS8

Monarch:55656 INTS8

NCBI Gene:55656 INTS8

OMIM:611351 INTS8

UCSC:Q75QN2 INTS8

Reference Transcript

Other Identifiers

0000840551

11756772_a_at

17070998

218905_at

3107662

3107663

3107664

3107665

3107666

3107667

3107668

3107669

3107670

3107671

3107672

3107673

3107675

3107676

3107677

3107679

3107682

3107685

3107687

3107688

3107690

3107692

3107696

3107697

3107700

3107702

3107704

3107705

3107706

3107708

3107710

3107711

3107712

3107713

3107714

3107715

55656

57299

58931_i_at

61296_at

8147396

A_14_P113166

A_14_P138997

AAH50536

AAH64915

AAI36755

AB161944

AK000537

AK001403

BAA91238

BAA91671

BAD10863

BC050536

BC064915

BC136754

BK005731

BX538203

CAD98067

CCDS34925

CH471060

DAA05731

E5RG48

E5RH10

E5RIN8

E5RJF0

E5RJL5

EAW91726

ENSG00000164941

ENSP00000430338

ENST00000523731

ENST00000523731.5

EntrezGene:55656

EntrezGene:INTS8

g8923495_3p_at

GO:0003674

GO:0005515

GO:0005575

GO:0005622

GO:0005623

GO:0005634

GO:0005654

GO:0008150

GO:0009058

GO:0016180

GO:0032039

GO:0032991

GO:0034472

GO:0034641

GO:0042795

GO:0043226

H0YC12

HGNC:26048

HPA057299

ILMN_1759084

INTS8

INTS8-217

IPR011990

IPR038751

J3KNV5

MIM:611351

NM_017864

NP_060334

PH_hs_0024162

TC08000578.hg

UPI000023B7D0

XM_017013616

XM_017013617

XM_017013618

XP_016869105

XP_016869106

XP_016869107

Participant Of

hasComponent

Integrator [nucleoplasm]

Inferred To

Ghost homologue of INTS8 [nucleoplasm] (Dictyostelium discoideum)

INTS8 [nucleoplasm] (Bos taurus)

INTS8 [nucleoplasm] (Canis familiaris)

INTS8 [nucleoplasm] (Gallus gallus)

INTS8 [nucleoplasm] (Sus scrofa)

INTS8 [nucleoplasm] (Xenopus tropicalis)

ints8 [nucleoplasm] (Danio rerio)

IntS8 [nucleoplasm] (Drosophila melanogaster)

ints-8 [nucleoplasm] (Caenorhabditis elegans)

Ints8 [nucleoplasm] (Mus musculus)

Ints8 [nucleoplasm] (Rattus norvegicus)

Cross References

RefSeq

XP_016869108.1, NP_060334.2

OpenTargets

ENSG00000164941

GeneCards

Q75QN2

HPA

ENSG00000164941-INTS8

Ensembl

ENST00000523731, ENSP00000430338, ENSG00000164941

PRO

Q75QN2

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