Reactome | SFTPD [extracellular region]

SFTPD [extracellular region]

Stable Identifier

R-HSA-391099

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

Pulmonary surfactant-associated protein D (SP-D), SFTPD_HUMAN

Locations in the PathwayBrowser

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Cell-Cell communication (Homo sapiens)

- Signal regulatory protein family interactions (Homo sapiens)
  - SIRPA binds SFTPA oligomer, SFTPD oligomer (Homo sapiens)
    - SFTPA oligomer, SFTPD oligomer [extracellular region] (Homo sapiens)
      - SFTPD oligomer [extracellular region] (Homo sapiens)
        
        SFTPD trimer [extracellular region] (Homo sapiens)
        
        SFTPD [extracellular region] (Homo sapiens)
    - SIRPA:SFTPA oligomer, SFTPD oligomer [plasma membrane] (Homo sapiens)
      - SFTPA oligomer, SFTPD oligomer [extracellular region] (Homo sapiens)
        
        SFTPD oligomer [extracellular region] (Homo sapiens)
        
        SFTPD trimer [extracellular region] (Homo sapiens)
        
        SFTPD [extracellular region] (Homo sapiens)

Immune System (Homo sapiens)

- Adaptive Immune System (Homo sapiens)
  - Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell (Homo sapiens)
    - OSCAR binds collagen and SP-D (Homo sapiens)
      - Collagen types I,II,III/SP-D [extracellular region] (Homo sapiens)
        
        SFTPD oligomer [extracellular region] (Homo sapiens)
        
        SFTPD trimer [extracellular region] (Homo sapiens)
        
        SFTPD [extracellular region] (Homo sapiens)
      - OSCAR:Collagen I,II,III/SP-D [extracellular region] (Homo sapiens)
        
        Collagen types I,II,III/SP-D [extracellular region] (Homo sapiens)
        
        SFTPD oligomer [extracellular region] (Homo sapiens)
        
        SFTPD trimer [extracellular region] (Homo sapiens)
        
        SFTPD [extracellular region] (Homo sapiens)
- Innate Immune System (Homo sapiens)
  - Toll-like Receptor Cascades (Homo sapiens)
    - Regulation of TLR by endogenous ligand (Homo sapiens)
      - SFTPA/SFTPD binds TLR2:TLR1 (Homo sapiens)
        
        SFTPA oligomer, SFTPD oligomer [extracellular region] (Homo sapiens)
        
        SFTPD oligomer [extracellular region] (Homo sapiens)
        
        SFTPD trimer [extracellular region] (Homo sapiens)
        
        SFTPD [extracellular region] (Homo sapiens)
        
        SFTPA/SFTPD:TLR2:TLR1 [plasma membrane] (Homo sapiens)
        
        SFTPA oligomer, SFTPD oligomer [extracellular region] (Homo sapiens)
        
        SFTPD oligomer [extracellular region] (Homo sapiens)
        
        SFTPD trimer [extracellular region] (Homo sapiens)
        
        SFTPD [extracellular region] (Homo sapiens)
      - SFTPA/SFTPD binds TLR4:LY96 (Homo sapiens)
        
        SFTPA oligomer, SFTPD oligomer [extracellular region] (Homo sapiens)
        
        SFTPD oligomer [extracellular region] (Homo sapiens)
        
        SFTPD trimer [extracellular region] (Homo sapiens)
        
        SFTPD [extracellular region] (Homo sapiens)
        
        SP-A/SP-D:TLR4:MD2 [plasma membrane] (Homo sapiens)
        
        SFTPA oligomer, SFTPD oligomer [extracellular region] (Homo sapiens)
        
        SFTPD oligomer [extracellular region] (Homo sapiens)
        
        SFTPD trimer [extracellular region] (Homo sapiens)
        
        SFTPD [extracellular region] (Homo sapiens)
    - Toll Like Receptor 2 (TLR2) Cascade (Homo sapiens)
      - Toll Like Receptor TLR1:TLR2 Cascade (Homo sapiens)
        
        TLR1:TLR2 is recruited to ligand:CD14 (Homo sapiens)
        
        SFTPA oligomer, SFTPD oligomer [extracellular region] (Homo sapiens)
        
        SFTPD oligomer [extracellular region] (Homo sapiens)
        
        SFTPD trimer [extracellular region] (Homo sapiens)
        
        SFTPD [extracellular region] (Homo sapiens)
    - Toll Like Receptor 4 (TLR4) Cascade (Homo sapiens)
      - Transfer of LPS onto TLR4 (Homo sapiens)
        
        SFTPA oligomer, SFTPD oligomer [extracellular region] (Homo sapiens)
        
        SFTPD oligomer [extracellular region] (Homo sapiens)
        
        SFTPD trimer [extracellular region] (Homo sapiens)
        
        SFTPD [extracellular region] (Homo sapiens)

External Reference Information

External Reference

UniProt:P35247 SFTPD

Gene Names

SFTPD, COLEC7, PSPD, SFTP4

Chain

signal peptide:1-20, chain:21-375

Reference Genes

COSMIC (genes):SFTPD SFTPD

dbSNP Gene:6441 SFTPD

ENSEMBL:ENSG00000133661 SFTPD

Participates

as a component of

Other forms of this molecule

SFTPD [endoplasmic reticulum membrane]

SFTPD [clathrin-coated endocytic vesicle]

Inferred To

Ghost homologue of SFTPD [extracellular region] (Gallus gallus)

Sftpd [extracellular region] (Mus musculus)

Sftpd [extracellular region] (Rattus norvegicus)

mbl2 [extracellular region] (Danio rerio)

Homologues of SFTPD [extracellular region] (Danio rerio)

Homologues of SFTPD [extracellular region] (Sus scrofa)

SFTPD [extracellular region] (Bos taurus)

SFTPD [extracellular region] (Canis familiaris)

SFTPD [extracellular region] (Plasmodium falciparum)

SFTPD [extracellular region] (Sus scrofa)

hbl4 [extracellular region] (Danio rerio)

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P0DTC2 S	20	S(686-815) [plasma membrane] (R-COV-9770188) Spike S2' Fragment [plasma membrane] (R-COV-9770189) S1 [plasma membrane] (R-COV-9769950) fully glycosylated Spike [plasma membrane] (R-COV-9733472) nascent Spike [endoplasmic reticulum lumen] (R-COV-9694796) 14-sugar N-glycan unfolded Spike [endoplasmic reticulum lumen] (R-COV-9694459) Man(9) N-glycan unfolded Spike [endoplasmic reticulum lumen] (R-COV-9696892) high-mannose N-glycan unfolded Spike [endoplasmic reticulum lumen] (R-COV-9696875) high-mannose N-glycan folded Spike [endoplasmic reticulum lumen] (R-COV-9696880) high-mannose N-glycan folded Spike [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9766369) high-mannose N-glycan-PALM-Spike [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9696943) di-antennary N-glycan-PALM-Spike [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9696920) complex N-glycan-PALM-Spike S1 Fragment [virion membrane] (R-COV-9694638) complex N-glycan-PALM-Spike S2 Fragment [virion membrane] (R-COV-9694791) complex N-glycan-PALM-Spike S2 Fragment [endocytic vesicle membrane] (R-COV-9694343) complex N-glycan-PALM-Spike S1 Fragment [endocytic vesicle membrane] (R-COV-9694745) fully glycosylated Spike [virion membrane] (R-COV-9698327) fully glycosylated Spike [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9698330) complex N-glycan-PALM-Spike S2 Fragment [plasma membrane] (R-COV-9769952) fully glycosylated Spike [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9696997)	0.544	3