Reactome | SFTPD [extracellular region]

SFTPD [extracellular region]

Stable Identifier

R-HSA-391099

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

Pulmonary surfactant-associated protein D (SP-D), SFTPD_HUMAN

Locations in the PathwayBrowser

Expand all

Cell-Cell communication (Homo sapiens)

- Signal regulatory protein family interactions (Homo sapiens)
  - SIRPA binds SFTPA oligomer, SFTPD oligomer (Homo sapiens)
    - SFTPA oligomer, SFTPD oligomer [extracellular region] (Homo sapiens)
      - SFTPD oligomer [extracellular region] (Homo sapiens)
        
        SFTPD trimer [extracellular region] (Homo sapiens)
        
        SFTPD [extracellular region] (Homo sapiens)
    - SIRPA:SFTPA oligomer, SFTPD oligomer [plasma membrane] (Homo sapiens)
      - SFTPA oligomer, SFTPD oligomer [extracellular region] (Homo sapiens)
        
        SFTPD oligomer [extracellular region] (Homo sapiens)
        
        SFTPD trimer [extracellular region] (Homo sapiens)
        
        SFTPD [extracellular region] (Homo sapiens)

Immune System (Homo sapiens)

- Adaptive Immune System (Homo sapiens)
  - Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell (Homo sapiens)
    - OSCAR binds collagen and SP-D (Homo sapiens)
      - Collagen types I,II,III/SP-D [extracellular region] (Homo sapiens)
        
        SFTPD oligomer [extracellular region] (Homo sapiens)
        
        SFTPD trimer [extracellular region] (Homo sapiens)
        
        SFTPD [extracellular region] (Homo sapiens)
      - OSCAR:Collagen I,II,III/SP-D [extracellular region] (Homo sapiens)
        
        Collagen types I,II,III/SP-D [extracellular region] (Homo sapiens)
        
        SFTPD oligomer [extracellular region] (Homo sapiens)
        
        SFTPD trimer [extracellular region] (Homo sapiens)
        
        SFTPD [extracellular region] (Homo sapiens)
- Innate Immune System (Homo sapiens)
  - Toll-like Receptor Cascades (Homo sapiens)
    - Regulation of TLR by endogenous ligand (Homo sapiens)
      - SFTPA/SFTPD binds TLR2:TLR1 (Homo sapiens)
        
        SFTPA oligomer, SFTPD oligomer [extracellular region] (Homo sapiens)
        
        SFTPD oligomer [extracellular region] (Homo sapiens)
        
        SFTPD trimer [extracellular region] (Homo sapiens)
        
        SFTPD [extracellular region] (Homo sapiens)
        
        SFTPA/SFTPD:TLR2:TLR1 [plasma membrane] (Homo sapiens)
        
        SFTPA oligomer, SFTPD oligomer [extracellular region] (Homo sapiens)
        
        SFTPD oligomer [extracellular region] (Homo sapiens)
        
        SFTPD trimer [extracellular region] (Homo sapiens)
        
        SFTPD [extracellular region] (Homo sapiens)
      - SFTPA/SFTPD binds TLR4:LY96 (Homo sapiens)
        
        SFTPA oligomer, SFTPD oligomer [extracellular region] (Homo sapiens)
        
        SFTPD oligomer [extracellular region] (Homo sapiens)
        
        SFTPD trimer [extracellular region] (Homo sapiens)
        
        SFTPD [extracellular region] (Homo sapiens)
        
        SP-A/SP-D:TLR4:MD2 [plasma membrane] (Homo sapiens)
        
        SFTPA oligomer, SFTPD oligomer [extracellular region] (Homo sapiens)
        
        SFTPD oligomer [extracellular region] (Homo sapiens)
        
        SFTPD trimer [extracellular region] (Homo sapiens)
        
        SFTPD [extracellular region] (Homo sapiens)
    - Toll Like Receptor 2 (TLR2) Cascade (Homo sapiens)
      - Toll Like Receptor TLR1:TLR2 Cascade (Homo sapiens)
        
        TLR1:TLR2 is recruited to ligand:CD14 (Homo sapiens)
        
        SFTPA oligomer, SFTPD oligomer [extracellular region] (Homo sapiens)
        
        SFTPD oligomer [extracellular region] (Homo sapiens)
        
        SFTPD trimer [extracellular region] (Homo sapiens)
        
        SFTPD [extracellular region] (Homo sapiens)
    - Toll Like Receptor 4 (TLR4) Cascade (Homo sapiens)
      - Transfer of LPS onto TLR4 (Homo sapiens)
        
        SFTPA oligomer, SFTPD oligomer [extracellular region] (Homo sapiens)
        
        SFTPD oligomer [extracellular region] (Homo sapiens)
        
        SFTPD trimer [extracellular region] (Homo sapiens)
        
        SFTPD [extracellular region] (Homo sapiens)

External Reference Information

External Reference

UniProt:P35247 SFTPD

Gene Names

SFTPD, COLEC7, PSPD, SFTP4

Chain

signal peptide:1-20, chain:21-375

Reference Genes

BioGPS Gene:6441 SFTPD

COSMIC (genes):SFTPD SFTPD

CTD Gene:6441 SFTPD

dbSNP Gene:6441 SFTPD

ENSEMBL:ENSG00000133661 SFTPD

ENSEMBL:ENSG00000133661.17 SFTPD

HGNC:10803 SFTPD

KEGG Gene (Homo sapiens):6441 SFTPD

Monarch:6441 SFTPD

NCBI Gene:6441 SFTPD

OMIM:178635 SFTPD

UCSC:P35247 SFTPD

Reference Transcript

Other Identifiers

11724148_at

16716008

214199_PM_at

214199_at

31775_at

3297323

3297324

3297330

3297331

3297332

3297333

3297334

3297337

3297338

3297341

3297342

6441

7934719

A_32_P107617

GE81224

GO:0001817

GO:0002376

GO:0002682

GO:0005515

GO:0005576

GO:0005581

GO:0005615

GO:0005737

GO:0005764

GO:0005768

GO:0005771

GO:0005773

GO:0005783

GO:0005789

GO:0005791

GO:0006898

GO:0007155

GO:0007585

GO:0016192

GO:0030139

GO:0030246

GO:0031410

GO:0032703

GO:0042130

GO:0042742

GO:0042802

GO:0043129

GO:0043152

GO:0043226

GO:0045087

GO:0045334

GO:0048246

GO:0048286

GO:0048856

GO:0048870

GO:0050766

GO:0052403

GO:0072593

GO:0098542

GO:1905226

HMNXSV003039661

Hs.253495.0.S1_3p_at

ILMN_1768575

PH_hs_0013362

TC10001458.hg

Participates

as a component of

Other forms of this molecule

SFTPD [endoplasmic reticulum membrane]

SFTPD [clathrin-coated endocytic vesicle]

Inferred To

Sftpd [extracellular region] (Mus musculus)

Sftpd [extracellular region] (Rattus norvegicus)

mbl2 [extracellular region] (Xenopus tropicalis)

Homologues of SFTPD [extracellular region] (Danio rerio)

Homologues of SFTPD [extracellular region] (Sus scrofa)

SFTPD [extracellular region] (Bos taurus)

SFTPD [extracellular region] (Canis familiaris)

SFTPD [extracellular region] (Danio rerio)

SFTPD [extracellular region] (Plasmodium falciparum)

SFTPD [extracellular region] (Sus scrofa)

colec10 [extracellular region] (Danio rerio)

MBL [extracellular region] (Gallus gallus)

Cross References

RefSeq

NP_003010.4, XP_011538389.1

OpenTargets

ENSG00000133661

GeneCards

P35247

HPA

ENSG00000133661-SFTPD

Ensembl

ENST00000372292, ENSG00000133661, ENSP00000361366

PRO

P35247

Pharos - Targets

P35247

Orphanet

25947

HMDB Protein

HMDBP14631

PDB

3G84, 3IKP, 3G83, 3IKR, 5OXR, 3DBZ, 2GGX, 4M18, 3IKQ, 1B08, 5OXS, 1M7L, 2RIA, 2ORK, 2RIB, 2ORJ, 2RIC, 4E52, 3G81, 2RID, 1PW9, 4M17, 2OS9, 1PWB, 2GGU, 2RIE, 3IKN

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P0DTC2 S	20	S(686-815) [plasma membrane] (R-COV-9770188) Spike S2' Fragment [plasma membrane] (R-COV-9770189) S1 [plasma membrane] (R-COV-9769950) fully glycosylated Spike [plasma membrane] (R-COV-9733472) nascent Spike [endoplasmic reticulum lumen] (R-COV-9694796) 14-sugar N-glycan unfolded Spike [endoplasmic reticulum lumen] (R-COV-9694459) Man(9) N-glycan unfolded Spike [endoplasmic reticulum lumen] (R-COV-9696892) high-mannose N-glycan unfolded Spike [endoplasmic reticulum lumen] (R-COV-9696875) high-mannose N-glycan folded Spike [endoplasmic reticulum lumen] (R-COV-9696880) high-mannose N-glycan folded Spike [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9766369) high-mannose N-glycan-PALM-Spike [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9696943) di-antennary N-glycan-PALM-Spike [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9696920) tri-antennary N-glycan-PALM-Spike [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9697006) fully glycosylated Spike [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9696997) complex N-glycan-PALM-Spike S2 Fragment [plasma membrane] (R-COV-9769952) fully glycosylated Spike [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9698330) fully glycosylated Spike [virion membrane] (R-COV-9698327) complex N-glycan-PALM-Spike S1 Fragment [endocytic vesicle membrane] (R-COV-9694745) complex N-glycan-PALM-Spike S2 Fragment [endocytic vesicle membrane] (R-COV-9694343) complex N-glycan-PALM-Spike S2 Fragment [virion membrane] (R-COV-9694791)	0.544	3