Reactome | SFTPD [extracellular region]

SFTPD [extracellular region]

Stable Identifier

R-HSA-391099

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

Pulmonary surfactant-associated protein D (SP-D), SFTPD_HUMAN

Locations in the PathwayBrowser

Expand all

Cell-Cell communication (Homo sapiens)

- Signal regulatory protein family interactions (Homo sapiens)
  - SIRPA binds SFTPA oligomer, SFTPD oligomer (Homo sapiens)
    - SFTPA oligomer, SFTPD oligomer [extracellular region] (Homo sapiens)
      - SFTPD oligomer [extracellular region] (Homo sapiens)
        
        SFTPD trimer [extracellular region] (Homo sapiens)
        
        SFTPD [extracellular region] (Homo sapiens)
    - SIRPA:SFTPA oligomer, SFTPD oligomer [plasma membrane] (Homo sapiens)
      - SFTPA oligomer, SFTPD oligomer [extracellular region] (Homo sapiens)
        
        SFTPD oligomer [extracellular region] (Homo sapiens)
        
        SFTPD trimer [extracellular region] (Homo sapiens)
        
        SFTPD [extracellular region] (Homo sapiens)

Immune System (Homo sapiens)

- Adaptive Immune System (Homo sapiens)
  - Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell (Homo sapiens)
    - OSCAR binds collagen and SP-D (Homo sapiens)
      - Collagen types I,II,III/SP-D [extracellular region] (Homo sapiens)
        
        SFTPD oligomer [extracellular region] (Homo sapiens)
        
        SFTPD trimer [extracellular region] (Homo sapiens)
        
        SFTPD [extracellular region] (Homo sapiens)
      - OSCAR:Collagen I,II,III/SP-D [extracellular region] (Homo sapiens)
        
        Collagen types I,II,III/SP-D [extracellular region] (Homo sapiens)
        
        SFTPD oligomer [extracellular region] (Homo sapiens)
        
        SFTPD trimer [extracellular region] (Homo sapiens)
        
        SFTPD [extracellular region] (Homo sapiens)
- Innate Immune System (Homo sapiens)
  - Toll-like Receptor Cascades (Homo sapiens)
    - Regulation of TLR by endogenous ligand (Homo sapiens)
      - SFTPA/SFTPD binds TLR2:TLR1 (Homo sapiens)
        
        SFTPA oligomer, SFTPD oligomer [extracellular region] (Homo sapiens)
        
        SFTPD oligomer [extracellular region] (Homo sapiens)
        
        SFTPD trimer [extracellular region] (Homo sapiens)
        
        SFTPD [extracellular region] (Homo sapiens)
        
        SFTPA/SFTPD:TLR2:TLR1 [plasma membrane] (Homo sapiens)
        
        SFTPA oligomer, SFTPD oligomer [extracellular region] (Homo sapiens)
        
        SFTPD oligomer [extracellular region] (Homo sapiens)
        
        SFTPD trimer [extracellular region] (Homo sapiens)
        
        SFTPD [extracellular region] (Homo sapiens)
      - SFTPA/SFTPD binds TLR4:LY96 (Homo sapiens)
        
        SFTPA oligomer, SFTPD oligomer [extracellular region] (Homo sapiens)
        
        SFTPD oligomer [extracellular region] (Homo sapiens)
        
        SFTPD trimer [extracellular region] (Homo sapiens)
        
        SFTPD [extracellular region] (Homo sapiens)
        
        SP-A/SP-D:TLR4:MD2 [plasma membrane] (Homo sapiens)
        
        SFTPA oligomer, SFTPD oligomer [extracellular region] (Homo sapiens)
        
        SFTPD oligomer [extracellular region] (Homo sapiens)
        
        SFTPD trimer [extracellular region] (Homo sapiens)
        
        SFTPD [extracellular region] (Homo sapiens)
    - Toll Like Receptor 2 (TLR2) Cascade (Homo sapiens)
      - Toll Like Receptor TLR1:TLR2 Cascade (Homo sapiens)
        
        TLR1:TLR2 is recruited to ligand:CD14 (Homo sapiens)
        
        SFTPA oligomer, SFTPD oligomer [extracellular region] (Homo sapiens)
        
        SFTPD oligomer [extracellular region] (Homo sapiens)
        
        SFTPD trimer [extracellular region] (Homo sapiens)
        
        SFTPD [extracellular region] (Homo sapiens)
    - Toll Like Receptor 4 (TLR4) Cascade (Homo sapiens)
      - Transfer of LPS onto TLR4 (Homo sapiens)
        
        SFTPA oligomer, SFTPD oligomer [extracellular region] (Homo sapiens)
        
        SFTPD oligomer [extracellular region] (Homo sapiens)
        
        SFTPD trimer [extracellular region] (Homo sapiens)
        
        SFTPD [extracellular region] (Homo sapiens)

External Reference Information

External Reference

UniProt:P35247 SFTPD

Gene Names

SFTPD, COLEC7, PSPD, SFTP4

Chain

signal peptide:1-20, chain:21-375

Reference Genes

BioGPS Gene:6441 SFTPD

COSMIC (genes):SFTPD SFTPD

CTD Gene:6441 SFTPD

dbSNP Gene:6441 SFTPD

ENSEMBL:ENSG00000133661 SFTPD

HGNC:10803 SFTPD

KEGG:hsa:6441 SFTPD

Monarch:6441 SFTPD

NCBI Gene:6441 SFTPD

OMIM:178635 SFTPD

UCSC:P35247 SFTPD

Reference Transcript

Participates

as a component of

Other forms of this molecule

SFTPD [clathrin-coated endocytic vesicle]

SFTPD [endoplasmic reticulum membrane]

Inferred To

Sftpd [extracellular region] (Mus musculus)

Sftpd [extracellular region] (Rattus norvegicus)

SFTPD [extracellular region] (Bos taurus)

SFTPD [extracellular region] (Canis familiaris)

SFTPD [extracellular region] (Plasmodium falciparum)

SFTPD [extracellular region] (Sus scrofa)

frm [extracellular region] (Drosophila melanogaster)

hbl2 [extracellular region] (Danio rerio)

Cross References

RefSeq

NP_003010.4, XP_011538389.1

OpenTargets

ENSG00000133661

ENSEMBL

ENSG00000133661, ENST00000372292, ENSP00000361366

HPA

ENSG00000133661-SFTPD

GeneCards

SFTPD

PRO

P35247

Pharos - Targets

P35247

GlyGen

P35247

HMDB Protein

HMDBP14631

PDB

2OS9, 1M7L, 3G84, 3IKR, 3IKN, 3IKQ, 3IKP, 1PWB, 2ORJ, 2ORK, 2RIE, 2GGU, 4M17, 2RID, 1PW9, 4M18, 1B08, 2RIC, 2GGX, 2RIB, 2RIA, 3DBZ, 3G81, 3G83, 5OXR, 5OXS, 4E52

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P0DTC2 S	20	S(686-815) [plasma membrane] (R-COV-9770188) Spike S2' Fragment [plasma membrane] (R-COV-9770189) S1 [plasma membrane] (R-COV-9769950) fully glycosylated Spike [plasma membrane] (R-COV-9733472) nascent Spike [endoplasmic reticulum lumen] (R-COV-9694796) 14-sugar N-glycan unfolded Spike [endoplasmic reticulum lumen] (R-COV-9694459) Man(9) N-glycan unfolded Spike [endoplasmic reticulum lumen] (R-COV-9696892) high-mannose N-glycan unfolded Spike [endoplasmic reticulum lumen] (R-COV-9696875) high-mannose N-glycan folded Spike [endoplasmic reticulum lumen] (R-COV-9696880) high-mannose N-glycan folded Spike [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9766369) high-mannose N-glycan-PALM-Spike [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9696943) di-antennary N-glycan-PALM-Spike [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9696920) fully glycosylated Spike [virion membrane] (R-COV-9698327) complex N-glycan-PALM-Spike S1 Fragment [virion membrane] (R-COV-9694638) complex N-glycan-PALM-Spike S2 Fragment [virion membrane] (R-COV-9694791) complex N-glycan-PALM-Spike S2 Fragment [endocytic vesicle membrane] (R-COV-9694343) complex N-glycan-PALM-Spike S1 Fragment [endocytic vesicle membrane] (R-COV-9694745) fully glycosylated Spike [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9698330) complex N-glycan-PALM-Spike S2 Fragment [plasma membrane] (R-COV-9769952) fully glycosylated Spike [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9696997)	0.544	3