Reactome | CHOL [mitochondrial matrix]

CHOL [mitochondrial matrix]

Stable Identifier

R-ALL-193840

Type

Chemical Compound [SimpleEntity]

Compartment

mitochondrial matrix

Synonyms

cholesterol

Icon

Locations in the PathwayBrowser

for Species:

Expand all

Metabolism (Bos taurus)

- Biological oxidations (Bos taurus)
  - Phase I - Functionalization of compounds (Bos taurus)
    - Cytochrome P450 - arranged by substrate type (Bos taurus)
      - Endogenous sterols (Bos taurus)
        
        CYP27A1 27-hydroxylates CHOL (Bos taurus)
        
        CHOL [mitochondrial matrix]
- Metabolism of lipids (Bos taurus)
  - Metabolism of steroids (Bos taurus)
    - Bile acid and bile salt metabolism (Bos taurus)
      - Synthesis of bile acids and bile salts (Bos taurus)
        
        Synthesis of bile acids and bile salts via 27-hydroxycholesterol (Bos taurus)
        
        CYP27A1 27-hydroxylates CHOL (Bos taurus)
        
        CHOL [mitochondrial matrix]

Metabolism (Canis familiaris)

- Biological oxidations (Canis familiaris)
  - Phase I - Functionalization of compounds (Canis familiaris)
    - Cytochrome P450 - arranged by substrate type (Canis familiaris)
      - Endogenous sterols (Canis familiaris)
        
        CYP27A1 27-hydroxylates CHOL (Canis familiaris)
        
        CHOL [mitochondrial matrix]
- Metabolism of lipids (Canis familiaris)
  - Metabolism of steroids (Canis familiaris)
    - Bile acid and bile salt metabolism (Canis familiaris)
      - Synthesis of bile acids and bile salts (Canis familiaris)
        
        Synthesis of bile acids and bile salts via 27-hydroxycholesterol (Canis familiaris)
        
        CYP27A1 27-hydroxylates CHOL (Canis familiaris)
        
        CHOL [mitochondrial matrix]

Metabolism (Homo sapiens)

- Biological oxidations (Homo sapiens)
  - Phase I - Functionalization of compounds (Homo sapiens)
    - Cytochrome P450 - arranged by substrate type (Homo sapiens)
      - Endogenous sterols (Homo sapiens)
        
        CYP27A1 27-hydroxylates CHOL (Homo sapiens)
        
        CHOL [mitochondrial matrix]
- Metabolism of lipids (Homo sapiens)
  - Metabolism of steroids (Homo sapiens)
    - Bile acid and bile salt metabolism (Homo sapiens)
      - Synthesis of bile acids and bile salts (Homo sapiens)
        
        Synthesis of bile acids and bile salts via 27-hydroxycholesterol (Homo sapiens)
        
        CYP27A1 27-hydroxylates CHOL (Homo sapiens)
        
        CHOL [mitochondrial matrix]

Metabolism (Mus musculus)

- Biological oxidations (Mus musculus)
  - Phase I - Functionalization of compounds (Mus musculus)
    - Cytochrome P450 - arranged by substrate type (Mus musculus)
      - Endogenous sterols (Mus musculus)
        
        CYP27A1 27-hydroxylates CHOL (Mus musculus)
        
        CHOL [mitochondrial matrix]
- Metabolism of lipids (Mus musculus)
  - Metabolism of steroids (Mus musculus)
    - Bile acid and bile salt metabolism (Mus musculus)
      - Synthesis of bile acids and bile salts (Mus musculus)
        
        Synthesis of bile acids and bile salts via 27-hydroxycholesterol (Mus musculus)
        
        CYP27A1 27-hydroxylates CHOL (Mus musculus)
        
        CHOL [mitochondrial matrix]

Metabolism (Rattus norvegicus)

- Biological oxidations (Rattus norvegicus)
  - Phase I - Functionalization of compounds (Rattus norvegicus)
    - Cytochrome P450 - arranged by substrate type (Rattus norvegicus)
      - Endogenous sterols (Rattus norvegicus)
        
        CYP27A1 27-hydroxylates CHOL (Rattus norvegicus)
        
        CHOL [mitochondrial matrix]
- Metabolism of lipids (Rattus norvegicus)
  - Metabolism of steroids (Rattus norvegicus)
    - Bile acid and bile salt metabolism (Rattus norvegicus)
      - Synthesis of bile acids and bile salts (Rattus norvegicus)
        
        Synthesis of bile acids and bile salts via 27-hydroxycholesterol (Rattus norvegicus)
        
        CYP27A1 27-hydroxylates CHOL (Rattus norvegicus)
        
        CHOL [mitochondrial matrix]

Metabolism (Sus scrofa)

- Biological oxidations (Sus scrofa)
  - Phase I - Functionalization of compounds (Sus scrofa)
    - Cytochrome P450 - arranged by substrate type (Sus scrofa)
      - Endogenous sterols (Sus scrofa)
        
        CYP27A1 27-hydroxylates CHOL (Sus scrofa)
        
        CHOL [mitochondrial matrix]
- Metabolism of lipids (Sus scrofa)
  - Metabolism of steroids (Sus scrofa)
    - Bile acid and bile salt metabolism (Sus scrofa)
      - Synthesis of bile acids and bile salts (Sus scrofa)
        
        Synthesis of bile acids and bile salts via 27-hydroxycholesterol (Sus scrofa)
        
        CYP27A1 27-hydroxylates CHOL (Sus scrofa)
        
        CHOL [mitochondrial matrix]

External Reference Information

External Reference

cholesterol [ChEBI:16113]

Participates

as an input of

Other forms of this molecule

CHOL [lipid droplet]

CHOL [early endosome]

CHOL [cornified envelope]

cholesterol [mitochondrial intermembrane space]

CHOL [mitochondrial outer membrane]

CHOL [mitochondrial inner membrane]

CHOL [lysosomal membrane]

cholesterol [endosome lumen]

cholesterol [endosome membrane]

cholesterol [clathrin-coated endocytic vesicle membrane]

CHOL [endoplasmic reticulum lumen]

CHOL [smooth endoplasmic reticulum]

CHOL [transport vesicle membrane]

CHOL [lysosomal lumen]

CHOL [cytosol]

cholesterol [endocytic vesicle lumen]

CHOL [plasma membrane]

CHOL [endoplasmic reticulum membrane]

CHOL [extracellular region]

Cross References

Guide to Pharmacology - Ligands

2718

COMPOUND

C00187

PubChem Substance

8145005

HMDB Metabolite

HMDB0000067

ZINC

000003875383