Reactome | CTSL1(114-288) [lysosomal lumen]

CTSL1(114-288) [lysosomal lumen]

Stable Identifier

R-HSA-1181225

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

lysosomal lumen

Synonyms

Cathepsin L1, CTSL1, CATL1_HUMAN

Locations in the PathwayBrowser

Expand all

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional regulation by RUNX1 (Homo sapiens)
      - RUNX1 regulates transcription of genes involved in differentiation of keratinocytes (Homo sapiens)
        
        SERPINB13 binds cathepsin L (Homo sapiens)
        
        Cathepsin L [lysosomal lumen] (Homo sapiens)
        
        CTSL1(114-288) [lysosomal lumen] (Homo sapiens)
        
        SERPINB13:cathepsin L [lysosomal lumen] (Homo sapiens)
        
        Cathepsin L [lysosomal lumen] (Homo sapiens)
        
        CTSL1(114-288) [lysosomal lumen] (Homo sapiens)

External Reference Information

External Reference

UniProt:P07711 CTSL

Gene Names

CTSL, CTSL1

Chain

signal peptide:1-17, propeptide:18-113, chain:114-288, propeptide:289-291, chain:292-333

Reference Genes

BioGPS Gene:1514 CTSL

CTD Gene:1514 CTSL

dbSNP Gene:1514 CTSL

ENSEMBL:ENSG00000135047 CTSL

ENSEMBL_homo_sapiens_GENE:ENSG00000135047 CTSL

HGNC:2537 CTSL

KEGG Gene (Homo sapiens):1514 CTSL

Monarch:1514 CTSL

NCBI Gene:1514 CTSL

OMIM:116880 CTSL

UCSC:P07711 CTSL

Reference Transcript

Other Identifiers

0003170047

0003990021

11725332_a_at

1514

17086540

1CJL

1CS8

1ICF

1MHW

202087_s_at

2NQD

2VHS

2XU1

2XU3

2XU4

2XU5

2YJ2

2YJ8

2YJ9

2YJB

2YJC

3178148

3178149

3178150

3178151

3178152

3178162

3178163

3178164

3178165

3178168

3178170

3178171

3178174

3178177

3178179

3178180

3178184

3287329

3287613

3288117

3288119

3289420

3297461

3299180

37391_at

3BC3

3H89

3H8B

3H8C

3HHA

3HWN

3IV2

3K24

3KSE

3OF8

3OF9

459

4AXL

4AXM

5F02

5I4H

5MAE

5MAJ

5MQY

6EZP

6EZX

6F06

8156228

A0A024R276

A_23_P94533

AAA66974

AAH12612

AL160279

BC012612

BX537395

CAA28877

CAA30981

CAB000459

CAD97637

CAG33334

CCDS6675

CH471089

CR457053

CTSL

CTSL-201

CTSL-203

EAW62731

EAW62732

EAW62733

EAW62734

EAW62736

ENSG00000135047

ENSP00000345344

ENSP00000365061

ENST00000340342

ENST00000343150

EntrezGene:1514

g4503154_3p_a_at

GE63282

GO:0001968

GO:0002250

GO:0002376

GO:0003674

GO:0004197

GO:0004252

GO:0005515

GO:0005518

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005623

GO:0005634

GO:0005737

GO:0005764

GO:0005768

GO:0005773

GO:0006508

GO:0008150

GO:0008219

GO:0008233

GO:0008234

GO:0009056

GO:0016787

GO:0019882

GO:0019886

GO:0022617

GO:0030154

GO:0030198

GO:0030574

GO:0031410

GO:0036021

GO:0042393

GO:0043202

GO:0043226

GO:0043394

GO:0045616

GO:0048856

GO:0051603

GO:0070062

GO:0071888

GO:0097067

GO:0097655

HGNC:2537

ILMN_1694757

ILMN_1812995

ILMN_2374036

IPR000169

IPR000668

IPR013128

IPR013201

IPR025660

IPR025661

IPR038765

IPR039417

M20496

MIM:116880

NM_001257971

NM_001257972

NM_001257973

NM_001912

NM_145918

NP_001244900

NP_001244901

NP_001244902

NP_001903

NP_666023

PF00112

PF08246

PH_hs_0030125

PR00705

Q5T8F0

SM00645

SM00848

TC09000400.hg

TC09002062.hg

uc004aph.4

uc004api.4

UPI000004CAA2

X05256

X12451

X12451_at

XM_005251716

XM_011518263

XM_017014293

XP_005251773

XP_011516565

XP_016869782

Participant Of

hasCandidate

Cathepsin [lysosomal lumen]

hasMember

Other forms of this molecule

CTSL1(114-288) [early endosome lumen]

CTSL(114-288) [extracellular region]

CTSL(292-333) [extracellular region]

CTSL(292-333) [endolysosome lumen]

CTSL(114-288) [endolysosome lumen]

Inferred To

Homologues of CTSL1(114-288) [lysosomal lumen] (Caenorhabditis elegans)

Homologues of CTSL1(114-288) [lysosomal lumen] (Danio rerio)

Homologues of CTSL1(114-288) [lysosomal lumen] (Dictyostelium discoideum)

Homologues of CTSL1(114-288) [lysosomal lumen] (Drosophila melanogaster)

Homologues of CTSL1(114-288) [lysosomal lumen] (Gallus gallus)

Homologues of CTSL1(114-288) [lysosomal lumen] (Mus musculus)

Homologues of CTSL1(114-288) [lysosomal lumen] (Rattus norvegicus)

CTSL1(114-288) [lysosomal lumen] (Bos taurus)

CTSL1(114-288) [lysosomal lumen] (Caenorhabditis elegans)

CTSL1(114-288) [lysosomal lumen] (Canis familiaris)

CTSL1(114-288) [lysosomal lumen] (Danio rerio)

CTSL1(114-288) [lysosomal lumen] (Dictyostelium discoideum)

CTSL1(114-288) [lysosomal lumen] (Drosophila melanogaster)

CTSL1(114-288) [lysosomal lumen] (Gallus gallus)

CTSL1(114-288) [lysosomal lumen] (Mus musculus)

CTSL1(114-288) [lysosomal lumen] (Rattus norvegicus)

CTSL1(114-288) [lysosomal lumen] (Sus scrofa)

CTSL1(114-288) [lysosomal lumen] (Taeniopygia guttata)

CTSL1(114-288) [lysosomal lumen] (Xenopus tropicalis)

Cross References

RefSeq

NP_001244901.1, NP_001244900.1, NP_666023.1, NP_001903.1, XP_005251773.1

ZINC - World Drugs

CATL1_HUMAN

OpenTargets

ENSG00000135047

ZINC - FDA approved

CATL1_HUMAN

ZINC - Substances

CATL1_HUMAN

ZINC target

P07711

ZINC - Biogenic

CATL1_HUMAN

PRO

P07711

PDB

2NQD, 5MQY, 3HWN, 2YJC, 2XU5, 5I4H, 2VHS, 5F02, 3HHA, 2XU1, 1CJL, 4AXM, 3H8C, 3IV2, 2YJ8, 3H8B, 6EZX, 3K24, 1ICF, 4AXL, 1MHW, 2XU3, 3KSE, 2YJ9, 3OF8, 5MAE, 1CS8, 2XU4, 2YJB, 3H89, 6F06, 2YJ2, 5MAJ, 6EZP, 3OF9, 3BC3

ZINC - Metabolites

CATL1_HUMAN

GeneCards

P07711

DOCK Blaster

2YJ9, 2YJ2, 3HWN, 2YJ8, 3KSE, 2NQD, 1MHW, 5MAJ, 3H8C, 3IV2, 1CS8, 3HHA, 2YJB, 2YJC, 5F02, 1CJL, 2VHS, 2XU5, 3BC3, 1ICF, 3H8B, 4AXL, 5I4H, 2XU1, 5MAE, 3OF9, 5MQY, 2XU4, 3OF8, 3H89, 3K24, 4AXM, 2XU3

BRENDA (Homo sapiens)

3.4.22.15

ZINC - Predictions - Purchasable

CATL1_HUMAN