Reactome | CTSL1(114-288) [lysosomal lumen]

CTSL1(114-288) [lysosomal lumen]

Stable Identifier

R-HSA-1181225

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

lysosomal lumen

Synonyms

Cathepsin L1, CTSL1, CATL1_HUMAN

Locations in the PathwayBrowser

Expand all

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional regulation by RUNX1 (Homo sapiens)
      - RUNX1 regulates transcription of genes involved in differentiation of keratinocytes (Homo sapiens)
        
        SERPINB13 binds cathepsin L (Homo sapiens)
        
        Cathepsin L [lysosomal lumen] (Homo sapiens)
        
        CTSL1(114-288) [lysosomal lumen] (Homo sapiens)
        
        SERPINB13:cathepsin L [lysosomal lumen] (Homo sapiens)
        
        Cathepsin L [lysosomal lumen] (Homo sapiens)
        
        CTSL1(114-288) [lysosomal lumen] (Homo sapiens)

External Reference Information

External Reference

UniProt:P07711 CTSL

Gene Names

CTSL, CTSL1

Chain

signal peptide:1-17, propeptide:18-113, chain:114-333, chain:114-288, propeptide:289-291, chain:292-333

Reference Genes

BioGPS Gene:1514 CTSL

COSMIC (genes):CTSL CTSL

CTD Gene:1514 CTSL

dbSNP Gene:1514 CTSL

ENSEMBL:ENSG00000135047.16 CTSL

HGNC:2537 CTSL

KEGG Gene (Homo sapiens):1514 CTSL

Monarch:1514 CTSL

NCBI Gene:1514 CTSL

OMIM:116880 CTSL

UCSC:P07711 CTSL

Reference Transcript

Other Identifiers

0003170047

0003990021

11725332_a_at

1514

17086540

202087_PM_s_at

202087_s_at

3178148

3178149

3178150

3178151

3178152

3178153

3178154

3178155

3178156

3178157

3178158

3178159

3178160

3178161

3178162

3178163

3178164

3178165

3178168

3178170

3178171

3178174

3178177

3178179

3178180

3178181

3178182

3178183

3178184

3178192

3287329

3287613

3288117

3288119

3289420

3297461

3299180

37391_at

8156228

A_14_P100589

A_23_P94533

GE63282

GO:0001968

GO:0002250

GO:0002376

GO:0003674

GO:0004197

GO:0005515

GO:0005518

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005634

GO:0005737

GO:0005764

GO:0005768

GO:0005771

GO:0005773

GO:0005794

GO:0005886

GO:0006508

GO:0006955

GO:0008150

GO:0008233

GO:0008234

GO:0012501

GO:0016020

GO:0016192

GO:0016324

GO:0016540

GO:0016787

GO:0019064

GO:0019065

GO:0019882

GO:0019886

GO:0030154

GO:0030163

GO:0030312

GO:0030574

GO:0031012

GO:0031410

GO:0031638

GO:0034230

GO:0036021

GO:0039654

GO:0042393

GO:0042583

GO:0043202

GO:0043226

GO:0043231

GO:0043373

GO:0043394

GO:0046718

GO:0048002

GO:0048856

GO:0051603

GO:0051604

GO:0060309

GO:0061024

GO:0062023

GO:0070062

GO:0071682

GO:0071888

GO:0097067

GO:0097655

GO:1901135

HMNXSV003047746

ILMN_1694757

ILMN_1812995

ILMN_1828672

ILMN_2374036

PH_hs_0030125

TC09000400.hg

TC09002062.hg

X12451_at

g4503154_3p_a_at

Participates

as a candidate of

Cathepsin [lysosomal lumen] (Homo sapiens)

as a member of

Other forms of this molecule

CTSL(114-288) [extracellular region]

CTSL(292-333) [extracellular region]

CTSL1(114-288) [early endosome lumen]

CTSL(292-333) [endolysosome lumen]

CTSL(114-288) [endolysosome lumen]

CTSL(114-288) [endocytic vesicle lumen]

CTSL(292-333) [endocytic vesicle lumen]

Inferred To

cprF [lysosomal lumen] (Dictyostelium discoideum)

im:6910535 [lysosomal lumen] (Danio rerio)

SERA5 [lysosomal lumen] (Plasmodium falciparum)

Homologues of CTSL1(114-288) [lysosomal lumen] (Danio rerio)

Homologues of CTSL1(114-288) [lysosomal lumen] (Dictyostelium discoideum)

Homologues of CTSL1(114-288) [lysosomal lumen] (Plasmodium falciparum)

cprC [lysosomal lumen] (Dictyostelium discoideum)

Ctsl [lysosomal lumen] (Mus musculus)

Ctsl [lysosomal lumen] (Rattus norvegicus)

cprD [lysosomal lumen] (Dictyostelium discoideum)

cfaD [lysosomal lumen] (Dictyostelium discoideum)

cprE [lysosomal lumen] (Dictyostelium discoideum)

ctsl1a [lysosomal lumen] (Danio rerio)

cprG [lysosomal lumen] (Dictyostelium discoideum)

cprB [lysosomal lumen] (Dictyostelium discoideum)

ctsl1b [lysosomal lumen] (Danio rerio)

ctsv [lysosomal lumen] (Xenopus tropicalis)

CTSL1(114-288) [lysosomal lumen] (Canis familiaris)

CTSL1(114-288) [lysosomal lumen] (Danio rerio)

CTSL1(114-288) [lysosomal lumen] (Dictyostelium discoideum)

CTSL1(114-288) [lysosomal lumen] (Plasmodium falciparum)

CTSV [lysosomal lumen] (Gallus gallus)

Cross References

RefSeq

NP_001903.1, NP_001244901.1, NP_001244900.1, XP_005251773.1, NP_666023.1

ZINC - World Drugs

CATL1_HUMAN

Guide to Pharmacology - Targets

2351

OpenTargets

ENSG00000135047

ZINC - FDA approved

CATL1_HUMAN

ZINC - Substances

CATL1_HUMAN

ZINC target

P07711

ZINC - Biogenic

CATL1_HUMAN

PRO

P07711

PDB

5MAE, 6JD0, 3HWN, 2YJC, 3OF9, 6F06, 2YJB, 1CJL, 2XU3, 2XU1, 5F02, 3K24, 2VHS, 2NQD, 4AXM, 3OF8, 1CS8, 2XU5, 2YJ9, 2YJ8, 5MQY, 2XU4, 6EZX, 1MHW, 4AXL, 3H8B, 1ICF, 2YJ2, 3H8C, 3IV2, 6JD8, 6EZP, 5MAJ, 3H89, 3KSE, 5I4H, 3HHA, 3BC3

ZINC - Investigational

CATL1_HUMAN

ZINC - Metabolites

CATL1_HUMAN

IntEnz

3.4.22.15

HPA

ENSG00000135047-CTSL

GeneCards

P07711

Ensembl

ENSP00000502968, ENSP00000503470, ENST00000676946, ENSP00000502901, ENSP00000503439, ENST00000676480, ENSP00000503938, ENST00000677761, ENSP00000504473, ENST00000340342, ENST00000677262, ENSG00000135047, ENST00000343150, ENST00000677864, ENST00000676531, ENST00000679149, ENSP00000504313, ENSP00000503881, ENSP00000503298, ENSP00000365061, ENST00000679157, ENSP00000504279, ENST00000677821, ENST00000676881, ENST00000678442, ENSP00000503851, ENSP00000345344, ENST00000677019, ENSP00000504405, ENSP00000503897, ENST00000676769

Pharos - Targets

P07711

ZINC - Predictions - Purchasable

CATL1_HUMAN

HMDB Protein

HMDBP13478

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P59594 S	12	nascent Spike [endoplasmic reticulum lumen] (R-COV-9682868) N-glycan Spike [endoplasmic reticulum lumen] (R-COV-9683594) trimmed unfolded N-glycan Spike [endoplasmic reticulum lumen] (R-COV-9683716) trimmed N-glycan Spike [endoplasmic reticulum lumen] (R-COV-9683608) trimmed N-glycan-PALM-Spike [endoplasmic reticulum lumen] (R-COV-9683638) trimmed N-glycan-PALM-Spike [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9683657) complex N-glycan-PALM-Spike [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9683617) complex N-glycan-PALM-Spike [virion membrane] (R-COV-9685469) complex N-glycan-PALM-Spike S2 Fragment [endocytic vesicle membrane] (R-COV-9686730) complex N-glycan-PALM-Spike S1 Fragment [endocytic vesicle membrane] (R-COV-9686693) complex N-glycan-PALM-Spike S1 Fragment [virion membrane] (R-COV-9686706) complex N-glycan-PALM-Spike S2 Fragment [virion membrane] (R-COV-9686724)	0.623	2
UniProt:P0DTC2 S	20	S(686-815) [plasma membrane] (R-COV-9770188) Spike S2' Fragment [plasma membrane] (R-COV-9770189) S1 [plasma membrane] (R-COV-9769950) fully glycosylated Spike [plasma membrane] (R-COV-9733472) nascent Spike [endoplasmic reticulum lumen] (R-COV-9694796) 14-sugar N-glycan unfolded Spike [endoplasmic reticulum lumen] (R-COV-9694459) Man(9) N-glycan unfolded Spike [endoplasmic reticulum lumen] (R-COV-9696892) high-mannose N-glycan unfolded Spike [endoplasmic reticulum lumen] (R-COV-9696875) high-mannose N-glycan folded Spike [endoplasmic reticulum lumen] (R-COV-9696880) high-mannose N-glycan folded Spike [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9766369) high-mannose N-glycan-PALM-Spike [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9696943) di-antennary N-glycan-PALM-Spike [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9696920) tri-antennary N-glycan-PALM-Spike [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9697006) fully glycosylated Spike [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9696997) complex N-glycan-PALM-Spike S2 Fragment [plasma membrane] (R-COV-9769952) fully glycosylated Spike [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9698330) fully glycosylated Spike [virion membrane] (R-COV-9698327) complex N-glycan-PALM-Spike S1 Fragment [endocytic vesicle membrane] (R-COV-9694745) complex N-glycan-PALM-Spike S2 Fragment [endocytic vesicle membrane] (R-COV-9694343) complex N-glycan-PALM-Spike S2 Fragment [virion membrane] (R-COV-9694791)	0.623	3

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