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Heparan(2)-SDC4 [Golgi lumen]
Stable Identifier
R-HSA-2076446
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
Golgi lumen
Synonyms
SDC4, Syndecan-4, SDC4_HUMAN
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of glycosylation (Homo sapiens)
Diseases associated with glycosaminoglycan metabolism (Homo sapiens)
Defective EXT1 causes exostoses 1, TRPS2 and CHDS (Homo sapiens)
Defective EXT1 (in EXT1:EXT2) does not transfer GlcA to heparan (Homo sapiens)
Heparan(2)-PGs [Golgi lumen] (Homo sapiens)
Heparan(2)-SDC4 [Golgi lumen] (Homo sapiens)
Defective EXT2 causes exostoses 2 (Homo sapiens)
Defective EXT2 (in EXT1:EXT2) does not transfer GlcA to heparan (Homo sapiens)
Heparan(2)-PGs [Golgi lumen] (Homo sapiens)
Heparan(2)-SDC4 [Golgi lumen] (Homo sapiens)
Metabolism (Homo sapiens)
Metabolism of carbohydrates (Homo sapiens)
Glycosaminoglycan metabolism (Homo sapiens)
Heparan sulfate/heparin (HS-GAG) metabolism (Homo sapiens)
HS-GAG biosynthesis (Homo sapiens)
EXT1:EXT2 transfer GlcNAc to the heparan chain (Homo sapiens)
Heparan(2)-PGs [Golgi lumen] (Homo sapiens)
Heparan(2)-SDC4 [Golgi lumen] (Homo sapiens)
EXT1:EXT2 transfers GlcA to heparan (Homo sapiens)
Heparan(2)-PGs [Golgi lumen] (Homo sapiens)
Heparan(2)-SDC4 [Golgi lumen] (Homo sapiens)
External Reference Information
External Reference
UniProt:P31431 SDC4
Gene Names
SDC4
Chain
signal peptide:1-18, chain:19-198
Reference Genes
BioGPS Gene:6385 SDC4
COSMIC (genes):SDC4 SDC4
CTD Gene:6385 SDC4
dbSNP Gene:6385 SDC4
ENSEMBL:ENSG00000124145 SDC4
ENSEMBL_homo_sapiens_GENE:ENSG00000124145 SDC4
HGNC:10661 SDC4
KEGG Gene (Homo sapiens):6385 SDC4
Monarch:6385 SDC4
NCBI Gene:6385 SDC4
OMIM:600017 SDC4
UCSC:P31431 SDC4
Reference Transcript
RefSeq:NM_002999.3 SDC4
Other Identifiers
0004590577
11717638_at
11717639_x_at
11749921_a_at
13240
16919567
1EJP
1EJQ
1OBY
1YBO
202071_at
35844_at
3907235
3907236
3907239
3907240
3907242
3907247
3907248
5716
6385
8066513
A_23_P109034
A_24_P373976
AA151028
AA258502
AAH30805
AK222695
AK223243
AK312507
AL021578
BAA02550
BAA19613
BAD96415
BAD96963
BAG35408
BC030805
CAA47406
CAB013240
CAG46842
CAG46871
CCDS13350
CH471077
CR542045
CR542074
D13292
D79206
D79206_s_at
EAW75861
EAW75862
ENSG00000124145
ENSP00000361818
ENST00000372733
EntrezGene:6385
g4506860_3p_s_at
GE79134
GO:0001523
GO:0001657
GO:0001843
GO:0001968
GO:0002376
GO:0003674
GO:0005080
GO:0005515
GO:0005575
GO:0005576
GO:0005615
GO:0005622
GO:0005623
GO:0005737
GO:0005764
GO:0005773
GO:0005794
GO:0005796
GO:0005886
GO:0005887
GO:0005925
GO:0006024
GO:0006027
GO:0006464
GO:0006629
GO:0006810
GO:0006950
GO:0007010
GO:0007155
GO:0008150
GO:0008283
GO:0009056
GO:0009058
GO:0009790
GO:0009986
GO:0010762
GO:0016020
GO:0016021
GO:0016192
GO:0019899
GO:0022607
GO:0030154
GO:0034330
GO:0040011
GO:0042060
GO:0042130
GO:0042802
GO:0043034
GO:0043202
GO:0043226
GO:0045121
GO:0045860
GO:0048646
GO:0048856
GO:0048870
GO:0050900
GO:0051496
GO:0051894
GO:0060122
GO:0070053
GO:0070062
GO:1903543
GO:1903553
HGNC:10661
HPA005716
ILMN_1663042
ILMN_1666181
IPR001050
IPR003585
IPR027789
IPR030479
MIM:600017
NM_002999
NP_002990
PF01034
PH_hs_0029525
SDC4
SDC4-201
SM00294
TC20000878.hg
uc002xnu.4
UPI000003B45C
X67016
XM_011528977
XP_011527279
Participant Of
hasMember
Heparan(2)-PGs [Golgi lumen]
Other forms of this molecule
SDC4 [plasma membrane]
Heparan-SDC4 [Golgi lumen]
Heparan(1)-SDC4 [Golgi lumen]
Heparan(3)-SDC4 [Golgi lumen]
Heparan(4)-SDC4 [Golgi lumen]
HS(5)-SDC4 [plasma membrane]
HS(3)-SDC4 [plasma membrane]
HS(1)-SDC4 [plasma membrane]
HS(2)-SDC4 [plasma membrane]
HS(4)-SDC4 [plasma membrane]
HS(1)-SDC4 [Golgi lumen]
Gal-Gal-Xyl-SDC4 [Golgi lumen]
GlcA-Gal-Gal-Xyl-SDC4 [Golgi lumen]
Gal-Xyl-SDC4 [Golgi lumen]
XylS-SDC4 [Golgi lumen]
SDC4 [Golgi lumen]
HS(6)-SDC4 [lysosomal lumen]
SDC4 [lysosomal lumen]
HS(6)-SDC4 [plasma membrane]
HS(5)-SDC4 [Golgi lumen]
HS(4)-SDC4 [Golgi lumen]
HS(2)-SDC4 [Golgi lumen]
HS(3)-SDC4 [Golgi lumen]
HS(6)-SDC4 [Golgi lumen]
Inferred To
Homologues of Heparan(2)-SDC4 [Golgi lumen] (Bos taurus)
Heparan(2)-SDC4 [Golgi lumen] (Bos taurus)
Heparan(2)-SDC4 [Golgi lumen] (Caenorhabditis elegans)
Heparan(2)-SDC4 [Golgi lumen] (Canis familiaris)
Heparan(2)-SDC4 [Golgi lumen] (Danio rerio)
Heparan(2)-SDC4 [Golgi lumen] (Drosophila melanogaster)
Heparan(2)-SDC4 [Golgi lumen] (Gallus gallus)
Heparan(2)-SDC4 [Golgi lumen] (Mus musculus)
Heparan(2)-SDC4 [Golgi lumen] (Rattus norvegicus)
Heparan(2)-SDC4 [Golgi lumen] (Sus scrofa)
Heparan(2)-SDC4 [Golgi lumen] (Taeniopygia guttata)
Modified Residues
Name
O-xylosyl-L-serine (ChEBI:63648) at unknown position
Modification
alpha-D-GlcNAc-(1->4)-beta-D-GlcA-(1->4)-alpha-D-GlcNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl-yl group
PsiMod Name
O-xylosyl-L-serine
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O3-xylosylserine.
Cross References
RefSeq
NP_002990.2
OpenTargets
ENSG00000124145
GeneCards
P31431
DOCK Blaster
1YBO
,
1OBY
PRO
P31431
PDB
1YBO
,
1OBY
,
1EJQ
,
1EJP
HMDB Protein
HMDBP02435
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P16871 IL7R
3
IL7R [plasma membrane]
(R-HSA-449945)
IL7R [clathrin-coated vesicle membrane]
(R-HSA-9028500)
p-Y449-IL7R [plasma membrane]
(R-HSA-1295531)
0.488
2
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