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CHOL [lysosomal lumen]
Stable Identifier
R-ALL-8848047
Type
Chemical Compound [SimpleEntity]
Compartment
lysosomal lumen
Synonyms
cholesterol
Icon
Locations in the PathwayBrowser
for Species:
Homo sapiens
Bos taurus
Caenorhabditis elegans
Canis familiaris
Danio rerio
Dictyostelium discoideum
Drosophila melanogaster
Gallus gallus
Mus musculus
Plasmodium falciparum
Rattus norvegicus
Saccharomyces cerevisiae
Schizosaccharomyces pombe
Sus scrofa
Xenopus tropicalis
Expand all
Transport of small molecules (Bos taurus)
ABC-family proteins mediated transport (Bos taurus)
ABC transporters in lipid homeostasis (Bos taurus)
ABCA5 transports CHOL from lysosomal lumen to cytosol (Bos taurus)
CHOL [lysosomal lumen]
Plasma lipoprotein assembly, remodeling, and clearance (Bos taurus)
Plasma lipoprotein clearance (Bos taurus)
LDL clearance (Bos taurus)
LDL translocates from endosome lumen to lysosome lumen (Bos taurus)
LDL [lysosomal lumen] (Bos taurus)
CHOL [lysosomal lumen]
LIPA hydrolyses sterol esters to sterols and fatty acids (Bos taurus)
CHOL [lysosomal lumen]
LDL [lysosomal lumen] (Bos taurus)
CHOL [lysosomal lumen]
LIPA-degraded LDL [lysosomal lumen] (Bos taurus)
CHOL [lysosomal lumen]
NPC2 binds CHOL (Bos taurus)
CHOL [lysosomal lumen]
NPC2:CHOL [lysosomal lumen] (Bos taurus)
CHOL [lysosomal lumen]
NPC2 transfers CHOL to NPC1 (Bos taurus)
NPC2:CHOL [lysosomal lumen] (Bos taurus)
CHOL [lysosomal lumen]
Transport of small molecules (Caenorhabditis elegans)
Plasma lipoprotein assembly, remodeling, and clearance (Caenorhabditis elegans)
Plasma lipoprotein clearance (Caenorhabditis elegans)
LDL clearance (Caenorhabditis elegans)
NPC2 binds CHOL (Caenorhabditis elegans)
CHOL [lysosomal lumen]
NPC2:CHOL [lysosomal lumen] (Caenorhabditis elegans)
CHOL [lysosomal lumen]
NPC2 transfers CHOL to NPC1 (Caenorhabditis elegans)
NPC2:CHOL [lysosomal lumen] (Caenorhabditis elegans)
CHOL [lysosomal lumen]
Transport of small molecules (Canis familiaris)
ABC-family proteins mediated transport (Canis familiaris)
ABC transporters in lipid homeostasis (Canis familiaris)
ABCA5 transports CHOL from lysosomal lumen to cytosol (Canis familiaris)
CHOL [lysosomal lumen]
Plasma lipoprotein assembly, remodeling, and clearance (Canis familiaris)
Plasma lipoprotein clearance (Canis familiaris)
LDL clearance (Canis familiaris)
LDL translocates from endosome lumen to lysosome lumen (Canis familiaris)
LDL [lysosomal lumen] (Canis familiaris)
CHOL [lysosomal lumen]
LIPA hydrolyses sterol esters to sterols and fatty acids (Canis familiaris)
CHOL [lysosomal lumen]
LDL [lysosomal lumen] (Canis familiaris)
CHOL [lysosomal lumen]
LIPA-degraded LDL [lysosomal lumen] (Canis familiaris)
CHOL [lysosomal lumen]
NPC2 binds CHOL (Canis familiaris)
CHOL [lysosomal lumen]
NPC2:CHOL [lysosomal lumen] (Canis familiaris)
CHOL [lysosomal lumen]
NPC2 transfers CHOL to NPC1 (Canis familiaris)
NPC2:CHOL [lysosomal lumen] (Canis familiaris)
CHOL [lysosomal lumen]
Transport of small molecules (Danio rerio)
Plasma lipoprotein assembly, remodeling, and clearance (Danio rerio)
Plasma lipoprotein clearance (Danio rerio)
LDL clearance (Danio rerio)
NPC2 binds CHOL (Danio rerio)
CHOL [lysosomal lumen]
NPC2:CHOL [lysosomal lumen] (Danio rerio)
CHOL [lysosomal lumen]
Transport of small molecules (Dictyostelium discoideum)
ABC-family proteins mediated transport (Dictyostelium discoideum)
ABC transporters in lipid homeostasis (Dictyostelium discoideum)
ABCA5 transports CHOL from lysosomal lumen to cytosol (Dictyostelium discoideum)
CHOL [lysosomal lumen]
Plasma lipoprotein assembly, remodeling, and clearance (Dictyostelium discoideum)
Plasma lipoprotein clearance (Dictyostelium discoideum)
LDL clearance (Dictyostelium discoideum)
NPC2 binds CHOL (Dictyostelium discoideum)
CHOL [lysosomal lumen]
NPC2:CHOL [lysosomal lumen] (Dictyostelium discoideum)
CHOL [lysosomal lumen]
NPC2 transfers CHOL to NPC1 (Dictyostelium discoideum)
NPC2:CHOL [lysosomal lumen] (Dictyostelium discoideum)
CHOL [lysosomal lumen]
Transport of small molecules (Drosophila melanogaster)
Plasma lipoprotein assembly, remodeling, and clearance (Drosophila melanogaster)
Plasma lipoprotein clearance (Drosophila melanogaster)
LDL clearance (Drosophila melanogaster)
NPC2 binds CHOL (Drosophila melanogaster)
CHOL [lysosomal lumen]
NPC2:CHOL [lysosomal lumen] (Drosophila melanogaster)
CHOL [lysosomal lumen]
NPC2 transfers CHOL to NPC1 (Drosophila melanogaster)
NPC2:CHOL [lysosomal lumen] (Drosophila melanogaster)
CHOL [lysosomal lumen]
Transport of small molecules (Gallus gallus)
ABC-family proteins mediated transport (Gallus gallus)
ABC transporters in lipid homeostasis (Gallus gallus)
ABCA5 transports CHOL from lysosomal lumen to cytosol (Gallus gallus)
CHOL [lysosomal lumen]
Plasma lipoprotein assembly, remodeling, and clearance (Gallus gallus)
Plasma lipoprotein clearance (Gallus gallus)
LDL clearance (Gallus gallus)
LDL translocates from endosome lumen to lysosome lumen (Gallus gallus)
LDL [lysosomal lumen] (Gallus gallus)
CHOL [lysosomal lumen]
LIPA hydrolyses sterol esters to sterols and fatty acids (Gallus gallus)
CHOL [lysosomal lumen]
LDL [lysosomal lumen] (Gallus gallus)
CHOL [lysosomal lumen]
LIPA-degraded LDL [lysosomal lumen] (Gallus gallus)
CHOL [lysosomal lumen]
NPC2 binds CHOL (Gallus gallus)
CHOL [lysosomal lumen]
NPC2:CHOL [lysosomal lumen] (Gallus gallus)
CHOL [lysosomal lumen]
NPC2 transfers CHOL to NPC1 (Gallus gallus)
NPC2:CHOL [lysosomal lumen] (Gallus gallus)
CHOL [lysosomal lumen]
Transport of small molecules (Homo sapiens)
ABC-family proteins mediated transport (Homo sapiens)
ABC transporters in lipid homeostasis (Homo sapiens)
ABCA5 transports CHOL from lysosomal lumen to cytosol (Homo sapiens)
CHOL [lysosomal lumen]
Plasma lipoprotein assembly, remodeling, and clearance (Homo sapiens)
Plasma lipoprotein clearance (Homo sapiens)
LDL clearance (Homo sapiens)
LDL translocates from endosome lumen to lysosome lumen (Homo sapiens)
LDL [lysosomal lumen] (Homo sapiens)
CHOL [lysosomal lumen]
LIPA hydrolyses sterol esters to sterols and fatty acids (Homo sapiens)
CHOL [lysosomal lumen]
LDL [lysosomal lumen] (Homo sapiens)
CHOL [lysosomal lumen]
LIPA-degraded LDL [lysosomal lumen] (Homo sapiens)
CHOL [lysosomal lumen]
NPC2 binds CHOL (Homo sapiens)
CHOL [lysosomal lumen]
NPC2:CHOL [lysosomal lumen] (Homo sapiens)
CHOL [lysosomal lumen]
NPC2 transfers CHOL to NPC1 (Homo sapiens)
NPC2:CHOL [lysosomal lumen] (Homo sapiens)
CHOL [lysosomal lumen]
Transport of small molecules (Mus musculus)
ABC-family proteins mediated transport (Mus musculus)
ABC transporters in lipid homeostasis (Mus musculus)
ABCA5 transports CHOL from lysosomal lumen to cytosol (Mus musculus)
CHOL [lysosomal lumen]
Plasma lipoprotein assembly, remodeling, and clearance (Mus musculus)
Plasma lipoprotein clearance (Mus musculus)
LDL clearance (Mus musculus)
LDL translocates from endosome lumen to lysosome lumen (Mus musculus)
LDL [lysosomal lumen] (Mus musculus)
CHOL [lysosomal lumen]
LIPA hydrolyses sterol esters to sterols and fatty acids (Mus musculus)
CHOL [lysosomal lumen]
LDL [lysosomal lumen] (Mus musculus)
CHOL [lysosomal lumen]
LIPA-degraded LDL [lysosomal lumen] (Mus musculus)
CHOL [lysosomal lumen]
NPC2 binds CHOL (Mus musculus)
CHOL [lysosomal lumen]
NPC2:CHOL [lysosomal lumen] (Mus musculus)
CHOL [lysosomal lumen]
NPC2 transfers CHOL to NPC1 (Mus musculus)
NPC2:CHOL [lysosomal lumen] (Mus musculus)
CHOL [lysosomal lumen]
Transport of small molecules (Plasmodium falciparum)
ABC-family proteins mediated transport (Plasmodium falciparum)
ABC transporters in lipid homeostasis (Plasmodium falciparum)
ABCA5 transports CHOL from lysosomal lumen to cytosol (Plasmodium falciparum)
CHOL [lysosomal lumen]
Transport of small molecules (Rattus norvegicus)
ABC-family proteins mediated transport (Rattus norvegicus)
ABC transporters in lipid homeostasis (Rattus norvegicus)
ABCA5 transports CHOL from lysosomal lumen to cytosol (Rattus norvegicus)
CHOL [lysosomal lumen]
Plasma lipoprotein assembly, remodeling, and clearance (Rattus norvegicus)
Plasma lipoprotein clearance (Rattus norvegicus)
LDL clearance (Rattus norvegicus)
LDL translocates from endosome lumen to lysosome lumen (Rattus norvegicus)
LDL [lysosomal lumen] (Rattus norvegicus)
CHOL [lysosomal lumen]
LIPA hydrolyses sterol esters to sterols and fatty acids (Rattus norvegicus)
CHOL [lysosomal lumen]
LDL [lysosomal lumen] (Rattus norvegicus)
CHOL [lysosomal lumen]
LIPA-degraded LDL [lysosomal lumen] (Rattus norvegicus)
CHOL [lysosomal lumen]
NPC2 binds CHOL (Rattus norvegicus)
CHOL [lysosomal lumen]
NPC2:CHOL [lysosomal lumen] (Rattus norvegicus)
CHOL [lysosomal lumen]
NPC2 transfers CHOL to NPC1 (Rattus norvegicus)
NPC2:CHOL [lysosomal lumen] (Rattus norvegicus)
CHOL [lysosomal lumen]
Transport of small molecules (Saccharomyces cerevisiae)
Plasma lipoprotein assembly, remodeling, and clearance (Saccharomyces cerevisiae)
Plasma lipoprotein clearance (Saccharomyces cerevisiae)
LDL clearance (Saccharomyces cerevisiae)
NPC2 binds CHOL (Saccharomyces cerevisiae)
CHOL [lysosomal lumen]
NPC2:CHOL [lysosomal lumen] (Saccharomyces cerevisiae)
CHOL [lysosomal lumen]
NPC2 transfers CHOL to NPC1 (Saccharomyces cerevisiae)
NPC2:CHOL [lysosomal lumen] (Saccharomyces cerevisiae)
CHOL [lysosomal lumen]
Transport of small molecules (Schizosaccharomyces pombe)
Plasma lipoprotein assembly, remodeling, and clearance (Schizosaccharomyces pombe)
Plasma lipoprotein clearance (Schizosaccharomyces pombe)
LDL clearance (Schizosaccharomyces pombe)
NPC2 binds CHOL (Schizosaccharomyces pombe)
CHOL [lysosomal lumen]
NPC2:CHOL [lysosomal lumen] (Schizosaccharomyces pombe)
CHOL [lysosomal lumen]
Transport of small molecules (Sus scrofa)
ABC-family proteins mediated transport (Sus scrofa)
ABC transporters in lipid homeostasis (Sus scrofa)
ABCA5 transports CHOL from lysosomal lumen to cytosol (Sus scrofa)
CHOL [lysosomal lumen]
Plasma lipoprotein assembly, remodeling, and clearance (Sus scrofa)
Plasma lipoprotein clearance (Sus scrofa)
LDL clearance (Sus scrofa)
LDL translocates from endosome lumen to lysosome lumen (Sus scrofa)
LDL [lysosomal lumen] (Sus scrofa)
CHOL [lysosomal lumen]
LIPA hydrolyses sterol esters to sterols and fatty acids (Sus scrofa)
CHOL [lysosomal lumen]
LDL [lysosomal lumen] (Sus scrofa)
CHOL [lysosomal lumen]
LIPA-degraded LDL [lysosomal lumen] (Sus scrofa)
CHOL [lysosomal lumen]
NPC2 binds CHOL (Sus scrofa)
CHOL [lysosomal lumen]
NPC2:CHOL [lysosomal lumen] (Sus scrofa)
CHOL [lysosomal lumen]
NPC2 transfers CHOL to NPC1 (Sus scrofa)
NPC2:CHOL [lysosomal lumen] (Sus scrofa)
CHOL [lysosomal lumen]
Transport of small molecules (Xenopus tropicalis)
ABC-family proteins mediated transport (Xenopus tropicalis)
ABC transporters in lipid homeostasis (Xenopus tropicalis)
ABCA5 transports CHOL from lysosomal lumen to cytosol (Xenopus tropicalis)
CHOL [lysosomal lumen]
Plasma lipoprotein assembly, remodeling, and clearance (Xenopus tropicalis)
Plasma lipoprotein clearance (Xenopus tropicalis)
LDL clearance (Xenopus tropicalis)
NPC2 binds CHOL (Xenopus tropicalis)
CHOL [lysosomal lumen]
NPC2:CHOL [lysosomal lumen] (Xenopus tropicalis)
CHOL [lysosomal lumen]
NPC2 transfers CHOL to NPC1 (Xenopus tropicalis)
NPC2:CHOL [lysosomal lumen] (Xenopus tropicalis)
CHOL [lysosomal lumen]
External Reference Information
External Reference
cholesterol [ChEBI:16113]
Participates
as a component of
NPC2:CHOL [lysosomal lumen] (Homo sapiens)
NPC2:CHOL [lysosomal lumen] (Gallus gallus)
NPC2:CHOL [lysosomal lumen] (Drosophila melanogaster)
NPC2:CHOL [lysosomal lumen] (Rattus norvegicus)
NPC2:CHOL [lysosomal lumen] (Canis familiaris)
NPC2:CHOL [lysosomal lumen] (Sus scrofa)
NPC2:CHOL [lysosomal lumen] (Caenorhabditis elegans)
NPC2:CHOL [lysosomal lumen] (Dictyostelium discoideum)
NPC2:CHOL [lysosomal lumen] (Xenopus tropicalis)
NPC2:CHOL [lysosomal lumen] (Mus musculus)
NPC2:CHOL [lysosomal lumen] (Saccharomyces cerevisiae)
NPC2:CHOL [lysosomal lumen] (Danio rerio)
NPC2:CHOL [lysosomal lumen] (Schizosaccharomyces pombe)
NPC2:CHOL [lysosomal lumen] (Bos taurus)
LDL [lysosomal lumen] (Homo sapiens)
LDL [lysosomal lumen] (Rattus norvegicus)
LDL [lysosomal lumen] (Canis familiaris)
LDL [lysosomal lumen] (Mus musculus)
LDL [lysosomal lumen] (Bos taurus)
LDL [lysosomal lumen] (Sus scrofa)
LDL [lysosomal lumen] (Gallus gallus)
LIPA-degraded LDL [lysosomal lumen] (Homo sapiens)
LIPA-degraded LDL [lysosomal lumen] (Rattus norvegicus)
LIPA-degraded LDL [lysosomal lumen] (Canis familiaris)
LIPA-degraded LDL [lysosomal lumen] (Bos taurus)
LIPA-degraded LDL [lysosomal lumen] (Mus musculus)
LIPA-degraded LDL [lysosomal lumen] (Sus scrofa)
LIPA-degraded LDL [lysosomal lumen] (Gallus gallus)
as an input of
NPC2 binds CHOL (Saccharomyces cerevisiae)
NPC2 binds CHOL (Schizosaccharomyces pombe)
NPC2 binds CHOL (Dictyostelium discoideum)
NPC2 binds CHOL (Caenorhabditis elegans)
NPC2 binds CHOL (Drosophila melanogaster)
NPC2 binds CHOL (Gallus gallus)
NPC2 binds CHOL (Xenopus tropicalis)
NPC2 binds CHOL (Danio rerio)
NPC2 binds CHOL (Sus scrofa)
NPC2 binds CHOL (Bos taurus)
NPC2 binds CHOL (Canis familiaris)
NPC2 binds CHOL (Rattus norvegicus)
NPC2 binds CHOL (Mus musculus)
ABCA5 transports CHOL from lysosomal lumen to cytosol (Homo sapiens)
ABCA5 transports CHOL from lysosomal lumen to cytosol (Mus musculus)
ABCA5 transports CHOL from lysosomal lumen to cytosol (Rattus norvegicus)
ABCA5 transports CHOL from lysosomal lumen to cytosol (Canis familiaris)
ABCA5 transports CHOL from lysosomal lumen to cytosol (Bos taurus)
ABCA5 transports CHOL from lysosomal lumen to cytosol (Sus scrofa)
ABCA5 transports CHOL from lysosomal lumen to cytosol (Xenopus tropicalis)
ABCA5 transports CHOL from lysosomal lumen to cytosol (Gallus gallus)
ABCA5 transports CHOL from lysosomal lumen to cytosol (Dictyostelium discoideum)
ABCA5 transports CHOL from lysosomal lumen to cytosol (Plasmodium falciparum)
NPC2 binds CHOL (Homo sapiens)
as an output of
LIPA hydrolyses sterol esters to sterols and fatty acids (Gallus gallus)
LIPA hydrolyses sterol esters to sterols and fatty acids (Homo sapiens)
LIPA hydrolyses sterol esters to sterols and fatty acids (Mus musculus)
LIPA hydrolyses sterol esters to sterols and fatty acids (Rattus norvegicus)
LIPA hydrolyses sterol esters to sterols and fatty acids (Canis familiaris)
LIPA hydrolyses sterol esters to sterols and fatty acids (Bos taurus)
LIPA hydrolyses sterol esters to sterols and fatty acids (Sus scrofa)
Other forms of this molecule
CHOL [lipid droplet]
CHOL [early endosome]
CHOL [mitochondrial matrix]
CHOL [cornified envelope]
cholesterol [mitochondrial intermembrane space]
CHOL [mitochondrial outer membrane]
CHOL [mitochondrial inner membrane]
CHOL [lysosomal membrane]
cholesterol [endosome lumen]
cholesterol [endosome membrane]
cholesterol [clathrin-coated endocytic vesicle membrane]
CHOL [endoplasmic reticulum lumen]
CHOL [smooth endoplasmic reticulum]
CHOL [transport vesicle membrane]
CHOL [cytosol]
cholesterol [endocytic vesicle lumen]
CHOL [plasma membrane]
CHOL [endoplasmic reticulum membrane]
CHOL [extracellular region]
Cross References
Guide to Pharmacology - Ligands
2718
COMPOUND
C00187
PubChem Substance
8145005
HMDB Metabolite
HMDB0000067
ZINC
000003875383
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