Reactome | HAVCR1 [plasma membrane]

HAVCR1 [plasma membrane]

Stable Identifier

R-HSA-5660386

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Hepatitis A virus cellular receptor 1, HAVR1_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q96D42 HAVCR1

Gene Names

HAVCR1, KIM1, TIM1, TIMD1

Chain

signal peptide:1-20, chain:21-364

Reference Genes

BioGPS Gene:26762 HAVCR1

COSMIC (genes):HAVCR1 HAVCR1

CTD Gene:26762 HAVCR1

dbSNP Gene:26762 HAVCR1

ENSEMBL:ENSG00000113249 HAVCR1

ENSEMBL_homo_sapiens_GENE:ENSG00000113249.14 HAVCR1

HGNC:17866 HAVCR1

KEGG Gene (Homo sapiens):26762 HAVCR1

Monarch:26762 HAVCR1

NCBI Gene:26762 HAVCR1

OMIM:606518 HAVCR1

UCSC:Q96D42 HAVCR1

Reference Transcript

Other Identifiers

11749216_a_at

17002128

207052_PM_at

207052_at

244567_PM_at

244567_at

26762

2883314

2883316

2883318

2883319

2883320

2883321

2883322

2883323

2883326

2883330

2883333

2883334

2883336

2883337

2883338

2883339

2883340

2883341

2883342

33000_at

76776_at

8115455

GO:0001618

GO:0001786

GO:0002376

GO:0005515

GO:0005886

GO:0005929

GO:0006911

GO:0008289

GO:0009986

GO:0016020

GO:0016192

GO:0031514

GO:0033005

GO:0043226

GO:0046718

GO:0061024

HMNXSV003041986

Hs.125395.0.A1_3p_at

ILMN_1852151

TC05001977.hg

g6912407_3p_at

This entity regulates

Positively

Cross References

RefSeq

NP_001295085.1, NP_036338.2, NP_001166864.1

OpenTargets

ENSG00000113249

GeneCards

Q96D42

HPA

ENSG00000113249-HAVCR1

Ensembl

ENSP00000344844, ENST00000339252, ENST00000523175, ENSP00000427898, ENSG00000113249

PRO

Q96D42

Pharos - Targets

Q96D42

PDB

5DZO, 5F70

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P0DTC2 S	20	S(686-815) [plasma membrane] (R-COV-9770188) Spike S2' Fragment [plasma membrane] (R-COV-9770189) S1 [plasma membrane] (R-COV-9769950) fully glycosylated Spike [plasma membrane] (R-COV-9733472) nascent Spike [endoplasmic reticulum lumen] (R-COV-9694796) 14-sugar N-glycan unfolded Spike [endoplasmic reticulum lumen] (R-COV-9694459) Man(9) N-glycan unfolded Spike [endoplasmic reticulum lumen] (R-COV-9696892) high-mannose N-glycan unfolded Spike [endoplasmic reticulum lumen] (R-COV-9696875) high-mannose N-glycan folded Spike [endoplasmic reticulum lumen] (R-COV-9696880) high-mannose N-glycan folded Spike [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9766369) high-mannose N-glycan-PALM-Spike [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9696943) di-antennary N-glycan-PALM-Spike [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9696920) tri-antennary N-glycan-PALM-Spike [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9697006) fully glycosylated Spike [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9696997) complex N-glycan-PALM-Spike S2 Fragment [plasma membrane] (R-COV-9769952) fully glycosylated Spike [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9698330) fully glycosylated Spike [virion membrane] (R-COV-9698327) complex N-glycan-PALM-Spike S1 Fragment [endocytic vesicle membrane] (R-COV-9694745) complex N-glycan-PALM-Spike S2 Fragment [endocytic vesicle membrane] (R-COV-9694343) complex N-glycan-PALM-Spike S2 Fragment [virion membrane] (R-COV-9694791)	0.667	7
IntAct:EBI-25890541 CCSB			0.556	3
UniProt:P0DOX8 IGL1			0.532	3
UniProt:P01876 IGHA1	1	IGHA1 [extracellular region] (R-HSA-1478809)	0.532	3

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