Reactome | TRPV2 [plasma membrane]

TRPV2 [plasma membrane]

Stable Identifier

R-HSA-2671909

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Transient receptor potential cation channel subfamily V member 2, TRPV2_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q9Y5S1 TRPV2

Gene Names

TRPV2, VRL

Chain

chain:1-764

Reference Genes

BioGPS Gene:51393 TRPV2

COSMIC (genes):TRPV2 TRPV2

CTD Gene:51393 TRPV2

dbSNP Gene:51393 TRPV2

ENSEMBL:ENSG00000187688 TRPV2

ENSEMBL_homo_sapiens_GENE:ENSG00000187688.15 TRPV2

HGNC:18082 TRPV2

KEGG Gene (Homo sapiens):51393 TRPV2

Monarch:51393 TRPV2

NCBI Gene:51393 TRPV2

OMIM:606676 TRPV2

UCSC:Q9Y5S1 TRPV2

Reference Transcript

RefSeq:NM_016113.4 TRPV2

Other Identifiers

11727389_a_at

11755902_a_at

16831442

219282_PM_s_at

219282_s_at

222855_PM_s_at

222855_s_at

3712063

3712064

3712066

3712067

3712068

3712070

3712071

3712072

3712073

3712076

3712078

3712079

3712080

3712082

3712083

3712084

3712085

3712090

3712092

3712096

3712097

44668_at

51393

8005171

90304_g_at

90306_at

A_23_P207911

GE58685

GO:0005215

GO:0005216

GO:0005261

GO:0005262

GO:0005515

GO:0005737

GO:0005886

GO:0006811

GO:0006816

GO:0007600

GO:0009266

GO:0009986

GO:0015075

GO:0016020

GO:0030154

GO:0030424

GO:0031410

GO:0032584

GO:0034220

GO:0042470

GO:0043226

GO:0044295

GO:0044297

GO:0045773

GO:0048856

GO:0050877

GO:0055085

GO:0070588

GO:0090280

GO:0120162

HMNXSV003012439

HMNXSV003051932

Hs.279746.0.S1_3p_s_at

ILMN_2049536

PH_hs_0014393

TC17000188.hg

g7706764_3p_s_at

Participates

as a member of

TRPs [plasma membrane] (Homo sapiens)

Inferred To

Homologues of TRPV2 [plasma membrane] (Caenorhabditis elegans)

nan [plasma membrane] (Drosophila melanogaster)

ocr-3 [plasma membrane] (Caenorhabditis elegans)

ocr-2 [plasma membrane] (Caenorhabditis elegans)

YVC1 [plasma membrane] (Saccharomyces cerevisiae)

trpv2 [plasma membrane] (Xenopus tropicalis)

TRPV1 [plasma membrane] (Danio rerio)

Trpv2 [plasma membrane] (Mus musculus)

Trpv2 [plasma membrane] (Rattus norvegicus)

TRPV2 [plasma membrane] (Bos taurus)

TRPV2 [plasma membrane] (Canis familiaris)

TRPV2 [plasma membrane] (Gallus gallus)

TRPV2 [plasma membrane] (Sus scrofa)

ocr-1 [plasma membrane] (Caenorhabditis elegans)

ocr-4 [plasma membrane] (Caenorhabditis elegans)

Cross References

RefSeq

NP_057197.2

Guide to Pharmacology - Targets

508

OpenTargets

ENSG00000187688

GeneCards

Q9Y5S1

HPA

ENSG00000187688-TRPV2

Ensembl

ENSG00000187688, ENSP00000342222, ENST00000338560

ZINC target

Q9Y5S1

PRO

Q9Y5S1

Pharos - Targets

Q9Y5S1

ZINC - Predictions - Purchasable

TRPV2_HUMAN

PDB

2F37

HMDB Protein

HMDBP08083

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P0DTC2 S	20	S(686-815) [plasma membrane] (R-COV-9770188) Spike S2' Fragment [plasma membrane] (R-COV-9770189) S1 [plasma membrane] (R-COV-9769950) fully glycosylated Spike [plasma membrane] (R-COV-9733472) nascent Spike [endoplasmic reticulum lumen] (R-COV-9694796) 14-sugar N-glycan unfolded Spike [endoplasmic reticulum lumen] (R-COV-9694459) Man(9) N-glycan unfolded Spike [endoplasmic reticulum lumen] (R-COV-9696892) high-mannose N-glycan unfolded Spike [endoplasmic reticulum lumen] (R-COV-9696875) high-mannose N-glycan folded Spike [endoplasmic reticulum lumen] (R-COV-9696880) high-mannose N-glycan folded Spike [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9766369) high-mannose N-glycan-PALM-Spike [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9696943) di-antennary N-glycan-PALM-Spike [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9696920) tri-antennary N-glycan-PALM-Spike [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9697006) fully glycosylated Spike [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9696997) complex N-glycan-PALM-Spike S2 Fragment [plasma membrane] (R-COV-9769952) fully glycosylated Spike [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9698330) fully glycosylated Spike [virion membrane] (R-COV-9698327) complex N-glycan-PALM-Spike S1 Fragment [endocytic vesicle membrane] (R-COV-9694745) complex N-glycan-PALM-Spike S2 Fragment [endocytic vesicle membrane] (R-COV-9694343) complex N-glycan-PALM-Spike S2 Fragment [virion membrane] (R-COV-9694791)	0.499	2

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