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XylS-SDC4 [Golgi lumen]
Stable Identifier
R-HSA-2064195
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
Golgi lumen
Synonyms
xylosyl-SDC4, Syndecan-4, SDC4_HUMAN, SDC4
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of metabolism (Homo sapiens)
Diseases of glycosylation (Homo sapiens)
Diseases associated with glycosaminoglycan metabolism (Homo sapiens)
Defective B4GALT7 causes EDS, progeroid type (Homo sapiens)
Defective B4GALT7 does not transfer Gal to xylosyl-unit of the tetrasaccharide linker (Homo sapiens)
xylosyl-core proteins [Golgi lumen] (Homo sapiens)
XylS-SDC4 [Golgi lumen] (Homo sapiens)
Metabolism (Homo sapiens)
Metabolism of carbohydrates (Homo sapiens)
Glycosaminoglycan metabolism (Homo sapiens)
Chondroitin sulfate/dermatan sulfate metabolism (Homo sapiens)
A tetrasaccharide linker sequence is required for GAG synthesis (Homo sapiens)
B4GALT7 transfers Gal group to xylosyl-unit of the tetrasaccharide linker (Homo sapiens)
xylosyl-core proteins [Golgi lumen] (Homo sapiens)
XylS-SDC4 [Golgi lumen] (Homo sapiens)
XYLTs transfer Xyl to core protein (Homo sapiens)
xylosyl-core proteins [Golgi lumen] (Homo sapiens)
XylS-SDC4 [Golgi lumen] (Homo sapiens)
Heparan sulfate/heparin (HS-GAG) metabolism (Homo sapiens)
A tetrasaccharide linker sequence is required for GAG synthesis (Homo sapiens)
B4GALT7 transfers Gal group to xylosyl-unit of the tetrasaccharide linker (Homo sapiens)
xylosyl-core proteins [Golgi lumen] (Homo sapiens)
XylS-SDC4 [Golgi lumen] (Homo sapiens)
XYLTs transfer Xyl to core protein (Homo sapiens)
xylosyl-core proteins [Golgi lumen] (Homo sapiens)
XylS-SDC4 [Golgi lumen] (Homo sapiens)
External Reference Information
External Reference
UniProt:P31431 SDC4
Gene Names
SDC4
Chain
signal peptide:1-18, chain:19-198
Reference Genes
BioGPS Gene:6385 SDC4
COSMIC (genes):SDC4 SDC4
CTD Gene:6385 SDC4
dbSNP Gene:6385 SDC4
ENSEMBL:ENSG00000124145 SDC4
ENSEMBL_homo_sapiens_GENE:ENSG00000124145.6 SDC4
HGNC:10661 SDC4
KEGG Gene (Homo sapiens):6385 SDC4
Monarch:6385 SDC4
NCBI Gene:6385 SDC4
OMIM:600017 SDC4
UCSC:P31431 SDC4
Reference Transcript
RefSeq:NM_002999.3 SDC4
Other Identifiers
11717638_at
11717639_x_at
11749921_a_at
16919567
202071_PM_at
202071_at
35844_at
3907235
3907236
3907239
3907240
3907242
3907247
3907248
6385
8066513
A_23_P109034
A_24_P373976
D79206_s_at
GE79134
GO:0001657
GO:0001843
GO:0001968
GO:0002376
GO:0005080
GO:0005515
GO:0005576
GO:0005615
GO:0005764
GO:0005773
GO:0005794
GO:0005796
GO:0005886
GO:0005925
GO:0007010
GO:0007155
GO:0009986
GO:0010762
GO:0016020
GO:0016192
GO:0016477
GO:0030154
GO:0034330
GO:0042060
GO:0042130
GO:0042802
GO:0043034
GO:0043202
GO:0043226
GO:0048856
GO:0048870
GO:0051496
GO:0051894
GO:0060089
GO:0060122
GO:0070053
GO:0070062
GO:1903543
GO:1903553
HMNXSV003007882
ILMN_1663042
PH_hs_0029525
TC20000878.hg
g4506860_3p_s_at
Participates
as a member of
xylosyl-core proteins [Golgi lumen] (Homo sapiens)
Other forms of this molecule
SDC4 [lysosomal lumen]
HS(6)-SDC4 [lysosomal lumen]
HS(1)-SDC4 [Golgi lumen]
HS(2)-SDC4 [Golgi lumen]
HS(3)-SDC4 [Golgi lumen]
HS(4)-SDC4 [Golgi lumen]
HS(6)-SDC4 [Golgi lumen]
HS(5)-SDC4 [Golgi lumen]
Heparan-SDC4 [Golgi lumen]
Heparan(1)-SDC4 [Golgi lumen]
Heparan(2)-SDC4 [Golgi lumen]
Heparan(4)-SDC4 [Golgi lumen]
Heparan(3)-SDC4 [Golgi lumen]
SDC4 [Golgi lumen]
HS(4)-SDC4 [plasma membrane]
HS(6)-SDC4 [plasma membrane]
HS(2)-SDC4 [plasma membrane]
HS(1)-SDC4 [plasma membrane]
HS(3)-SDC4 [plasma membrane]
HS(5)-SDC4 [plasma membrane]
Gal-Gal-Xyl-SDC4 [Golgi lumen]
GlcA-Gal-Gal-Xyl-SDC4 [Golgi lumen]
Gal-Xyl-SDC4 [Golgi lumen]
Inferred To
Sdc4 [Golgi lumen]
(Mus musculus)
Sdc4 [Golgi lumen]
(Rattus norvegicus)
sdc4 [Golgi lumen]
(Danio rerio)
SDC4 [Golgi lumen]
(Bos taurus)
SDC4 [Golgi lumen]
(Canis familiaris)
SDC4 [Golgi lumen]
(Gallus gallus)
SDC4 [Golgi lumen]
(Sus scrofa)
Sdc [Golgi lumen]
(Drosophila melanogaster)
sdn-1 [Golgi lumen]
(Caenorhabditis elegans)
Modified Residues
Name
O-xylosyl-L-serine at unknown position
PsiMod Name
O-xylosyl-L-serine
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O3-xylosylserine.
Cross References
RefSeq
NP_002990.2
OpenTargets
ENSG00000124145
HPA
ENSG00000124145-SDC4
GeneCards
P31431
Ensembl
ENSP00000361818
,
ENSG00000124145
,
ENST00000372733
PRO
P31431
Pharos - Targets
P31431
HMDB Protein
HMDBP02435
PDB
1OBY
,
1YBO
,
8BLV
,
1EJP
,
1EJQ
Interactors (6)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P0DTC2 S
20
S(686-815) [plasma membrane]
(R-COV-9770188)
Spike S2' Fragment [plasma membrane]
(R-COV-9770189)
S1 [plasma membrane]
(R-COV-9769950)
fully glycosylated Spike [plasma membrane]
(R-COV-9733472)
nascent Spike [endoplasmic reticulum lumen]
(R-COV-9694796)
14-sugar N-glycan unfolded Spike [endoplasmic reticulum lumen]
(R-COV-9694459)
Man(9) N-glycan unfolded Spike [endoplasmic reticulum lumen]
(R-COV-9696892)
high-mannose N-glycan unfolded Spike [endoplasmic reticulum lumen]
(R-COV-9696875)
high-mannose N-glycan folded Spike [endoplasmic reticulum lumen]
(R-COV-9696880)
high-mannose N-glycan folded Spike [endoplasmic reticulum-Golgi intermediate compartment]
(R-COV-9766369)
high-mannose N-glycan-PALM-Spike [endoplasmic reticulum-Golgi intermediate compartment]
(R-COV-9696943)
di-antennary N-glycan-PALM-Spike [endoplasmic reticulum-Golgi intermediate compartment]
(R-COV-9696920)
tri-antennary N-glycan-PALM-Spike [endoplasmic reticulum-Golgi intermediate compartment]
(R-COV-9697006)
fully glycosylated Spike [endoplasmic reticulum-Golgi intermediate compartment]
(R-COV-9696997)
complex N-glycan-PALM-Spike S2 Fragment [plasma membrane]
(R-COV-9769952)
fully glycosylated Spike [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-COV-9698330)
fully glycosylated Spike [virion membrane]
(R-COV-9698327)
complex N-glycan-PALM-Spike S1 Fragment [endocytic vesicle membrane]
(R-COV-9694745)
complex N-glycan-PALM-Spike S2 Fragment [endocytic vesicle membrane]
(R-COV-9694343)
complex N-glycan-PALM-Spike S2 Fragment [virion membrane]
(R-COV-9694791)
0.599
17
UniProt:P34741 SDC2
20
SDC2 [plasma membrane]
(R-HSA-2090052)
p-Y179,Y191-SDC2 [plasma membrane]
(R-HSA-4093306)
SDC2 [lysosomal lumen]
(R-HSA-2090083)
HS(6)-SDC2 [lysosomal lumen]
(R-HSA-2090064)
HS(1)-SDC2 [Golgi lumen]
(R-HSA-2076607)
HS(2)-SDC2 [Golgi lumen]
(R-HSA-2076603)
HS(3)-SDC2 [Golgi lumen]
(R-HSA-2076443)
HS(4)-SDC2 [Golgi lumen]
(R-HSA-2076356)
HS(6)-SDC2 [Golgi lumen]
(R-HSA-2076588)
HS(5)-SDC2 [Golgi lumen]
(R-HSA-2076320)
Heparan-SDC2 [Golgi lumen]
(R-HSA-2076608)
Heparan(1)-SDC2 [Golgi lumen]
(R-HSA-2076536)
Heparan(2)-SDC2 [Golgi lumen]
(R-HSA-2076397)
Heparan(4)-SDC2 [Golgi lumen]
(R-HSA-2076576)
Heparan(3)-SDC2 [Golgi lumen]
(R-HSA-2076361)
SDC2 [Golgi lumen]
(R-HSA-2054101)
HS(4)-SDC2 [plasma membrane]
(R-HSA-2076683)
HS(6)-SDC2 [plasma membrane]
(R-HSA-2076661)
HS(2)-SDC2 [plasma membrane]
(R-HSA-2076644)
HS(1)-SDC2 [plasma membrane]
(R-HSA-2076643)
0.59
4
UniProt:Q01453 PMP22
1
PMP22 [plasma membrane]
(R-HSA-9615623)
0.556
3
UniProt:P16871 IL7R
3
p-Y449-IL7R [plasma membrane]
(R-HSA-1295531)
IL7R [plasma membrane]
(R-HSA-449945)
IL7R [clathrin-coated endocytic vesicle membrane]
(R-HSA-9028500)
0.556
3
UniProt:O15530 PDPK1
3
p-S241-PDPK1 [cytosol]
(R-HSA-9860799)
PDPK1 [cytosol]
(R-HSA-202210)
PDPK1 [plasma membrane]
(R-HSA-61459)
0.527
3
UniProt:P32249 GPR183
1
GPR183 [plasma membrane]
(R-HSA-8851676)
0.527
2
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