Reactome | HS(2)-SDC4 [plasma membrane]

HS(2)-SDC4 [plasma membrane]

Stable Identifier

R-HSA-2076694

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

SDC4, Syndecan-4, SDC4_HUMAN

Locations in the PathwayBrowser

Expand all

Hemostasis (Homo sapiens)

- Cell surface interactions at the vascular wall (Homo sapiens)
  - PSGs bind proteoglycans and TGF-beta1 (Homo sapiens)
    - PSGs:Proteoglycan,TGFB1 [plasma membrane] (Homo sapiens)
      - Proteoglycans,TGFB1 [plasma membrane] (Homo sapiens)
        
        Syndecans1-4 [plasma membrane] (Homo sapiens)
        
        Syndecan-4 [plasma membrane] (Homo sapiens)
        
        HS(2)-SDC4 [plasma membrane] (Homo sapiens)
    - Proteoglycans,TGFB1 [plasma membrane] (Homo sapiens)
      - Syndecans1-4 [plasma membrane] (Homo sapiens)
        
        Syndecan-4 [plasma membrane] (Homo sapiens)
        
        HS(2)-SDC4 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P31431 SDC4

Gene Names

SDC4

Chain

signal peptide:1-18, chain:19-198

Reference Genes

BioGPS Gene:6385 SDC4

COSMIC (genes):SDC4 SDC4

CTD Gene:6385 SDC4

dbSNP Gene:6385 SDC4

ENSEMBL:ENSG00000124145 SDC4

HGNC:10661 SDC4

KEGG:hsa:6385 SDC4

Monarch:6385 SDC4

NCBI Gene:6385 SDC4

OMIM:600017 SDC4

UCSC:P31431 SDC4

Reference Transcript

RefSeq:NM_002999.3 SDC4

Other Identifiers

11717638_at

11717639_x_at

11749921_a_at

16919567

202071_PM_at

202071_at

35844_at

3907235

3907236

3907239

3907240

3907242

3907247

3907248

6385

8066513

A_23_P109034

A_24_P373976

D79206_s_at

GE79134

GO:0001657

GO:0001843

GO:0001968

GO:0005080

GO:0005515

GO:0005576

GO:0005796

GO:0005886

GO:0005925

GO:0009986

GO:0010762

GO:0016020

GO:0016477

GO:0042060

GO:0042130

GO:0042802

GO:0043034

GO:0043202

GO:0043226

GO:0048856

GO:0048870

GO:0051496

GO:0051894

GO:0060089

GO:0060122

GO:0070053

GO:0070062

GO:1903543

GO:1903553

HMNXSV003007882

ILMN_1663042

PH_hs_0029525

TC20000878.hg

g4506860_3p_s_at

Participates

as a member of

Other forms of this molecule

HS(4)-SDC4 [plasma membrane]

HS(6)-SDC4 [plasma membrane]

HS(1)-SDC4 [plasma membrane]

HS(3)-SDC4 [plasma membrane]

HS(5)-SDC4 [plasma membrane]

XylS-SDC4 [Golgi lumen]

Gal-Xyl-SDC4 [Golgi lumen]

SDC4 [Golgi lumen]

Gal-Gal-Xyl-SDC4 [Golgi lumen]

GlcA-Gal-Gal-Xyl-SDC4 [Golgi lumen]

HS(3)-SDC4 [Golgi lumen]

HS(4)-SDC4 [Golgi lumen]

HS(2)-SDC4 [Golgi lumen]

HS(1)-SDC4 [Golgi lumen]

Heparan(4)-SDC4 [Golgi lumen]

Heparan(3)-SDC4 [Golgi lumen]

Heparan(2)-SDC4 [Golgi lumen]

Heparan(1)-SDC4 [Golgi lumen]

Heparan-SDC4 [Golgi lumen]

HS(5)-SDC4 [Golgi lumen]

HS(6)-SDC4 [Golgi lumen]

HS(6)-SDC4 [lysosomal lumen]

SDC4 [lysosomal lumen]

Inferred To

sdn-1 [plasma membrane] (Caenorhabditis elegans)

Sdc4 [plasma membrane] (Mus musculus)

Sdc4 [plasma membrane] (Rattus norvegicus)

sdc4 [plasma membrane] (Danio rerio)

SDC4 [plasma membrane] (Bos taurus)

SDC4 [plasma membrane] (Canis familiaris)

SDC4 [plasma membrane] (Gallus gallus)

SDC4 [plasma membrane] (Sus scrofa)

Sdc [plasma membrane] (Drosophila melanogaster)

Modified Residues

Name

O-xylosyl-L-serine (ChEBI:63653) at unknown position

Modification

beta-D-GlcA-(1->4)-alpha-D-GlcNS-(1->4)-beta-D-IdoA-(1->4)-alpha-D-GlcNS-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl-yl group

PsiMod Name

O-xylosyl-L-serine

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O3-xylosylserine.

Cross References

RefSeq

NP_002990.2

OpenTargets

ENSG00000124145

ENSEMBL

ENSP00000361818

HPA

ENSG00000124145-SDC4

PRO

P31431

Pharos - Targets

P31431

GlyGen

P31431

HMDB Protein

HMDBP02435

PDB

1YBO, 8BLV, 1EJQ, 1EJP, 1OBY

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P0DTC2 S	20	S(686-815) [plasma membrane] (R-COV-9770188) Spike S2' Fragment [plasma membrane] (R-COV-9770189) S1 [plasma membrane] (R-COV-9769950) fully glycosylated Spike [plasma membrane] (R-COV-9733472) nascent Spike [endoplasmic reticulum lumen] (R-COV-9694796) 14-sugar N-glycan unfolded Spike [endoplasmic reticulum lumen] (R-COV-9694459) Man(9) N-glycan unfolded Spike [endoplasmic reticulum lumen] (R-COV-9696892) high-mannose N-glycan unfolded Spike [endoplasmic reticulum lumen] (R-COV-9696875) high-mannose N-glycan folded Spike [endoplasmic reticulum lumen] (R-COV-9696880) high-mannose N-glycan folded Spike [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9766369) high-mannose N-glycan-PALM-Spike [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9696943) di-antennary N-glycan-PALM-Spike [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9696920) complex N-glycan-PALM-Spike S1 Fragment [virion membrane] (R-COV-9694638) complex N-glycan-PALM-Spike S2 Fragment [virion membrane] (R-COV-9694791) complex N-glycan-PALM-Spike S2 Fragment [endocytic vesicle membrane] (R-COV-9694343) complex N-glycan-PALM-Spike S1 Fragment [endocytic vesicle membrane] (R-COV-9694745) fully glycosylated Spike [virion membrane] (R-COV-9698327) fully glycosylated Spike [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9698330) complex N-glycan-PALM-Spike S2 Fragment [plasma membrane] (R-COV-9769952) fully glycosylated Spike [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9696997)	0.599	17
UniProt:P34741 SDC2	20	HS(4)-SDC2 [plasma membrane] (R-HSA-2076683) HS(6)-SDC2 [plasma membrane] (R-HSA-2076661) HS(2)-SDC2 [plasma membrane] (R-HSA-2076644) HS(1)-SDC2 [plasma membrane] (R-HSA-2076643) HS(3)-SDC2 [plasma membrane] (R-HSA-2076631) HS(5)-SDC2 [plasma membrane] (R-HSA-2076665) SDC2 [endoplasmic reticulum lumen] (R-HSA-8956741) p-SDC2 [endoplasmic reticulum lumen] (R-HSA-8956945) XylS-SDC2 [Golgi lumen] (R-HSA-2064109) Gal-Xyl-SDC2 [Golgi lumen] (R-HSA-2064132) SDC2 [Golgi lumen] (R-HSA-2054101) Gal-Gal-Xyl-SDC2 [Golgi lumen] (R-HSA-2063988) GlcA-Gal-Gal-Xyl-SDC2 [Golgi lumen] (R-HSA-2063997) HS(3)-SDC2 [Golgi lumen] (R-HSA-2076443) HS(4)-SDC2 [Golgi lumen] (R-HSA-2076356) HS(2)-SDC2 [Golgi lumen] (R-HSA-2076603) HS(1)-SDC2 [Golgi lumen] (R-HSA-2076607) Heparan(4)-SDC2 [Golgi lumen] (R-HSA-2076576) Heparan(3)-SDC2 [Golgi lumen] (R-HSA-2076361) Heparan(2)-SDC2 [Golgi lumen] (R-HSA-2076397)	0.59	4
UniProt:Q01453 PMP22	1	PMP22 [plasma membrane] (R-HSA-9615623)	0.556	3
UniProt:P16871 IL7R	3	IL7R [clathrin-coated endocytic vesicle membrane] (R-HSA-9028500) IL7R [plasma membrane] (R-HSA-449945) p-Y449-IL7R [plasma membrane] (R-HSA-1295531)	0.556	3
UniProt:O15530 PDPK1	3	p-S241-PDPK1 [cytosol] (R-HSA-9860799) PDPK1 [cytosol] (R-HSA-202210) PDPK1 [plasma membrane] (R-HSA-61459)	0.527	3
UniProt:P32249 GPR183	1	GPR183 [plasma membrane] (R-HSA-8851676)	0.527	2