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HS(6)-SDC4 [plasma membrane]
Stable Identifier
R-HSA-2076633
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
SDC4, Syndecan-4, SDC4_HUMAN
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Viral Infection Pathways (Homo sapiens)
SARS-CoV Infections (Homo sapiens)
SARS-CoV-2 Infection (Homo sapiens)
Early SARS-CoV-2 Infection Events (Homo sapiens)
Attachment and Entry (Homo sapiens)
Direct Host Cell Membrane Membrane Fusion and Release of SARS-CoV-2 Nucleocapsid (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS/HPIN-PGs [plasma membrane] (Homo sapiens)
HS(6)-SDC4 [plasma membrane] (Homo sapiens)
S3:M:E:encapsidated SARS-CoV-2 genomic RNA: 7a:O-glycosyl 3a tetramer:glycosylated-ACE2:HSPGs [extracellular region] (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS/HPIN-PGs [plasma membrane] (Homo sapiens)
HS(6)-SDC4 [plasma membrane] (Homo sapiens)
Endocytosis of SARS-CoV-2 Virion (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS/HPIN-PGs [plasma membrane] (Homo sapiens)
HS(6)-SDC4 [plasma membrane] (Homo sapiens)
S3:M:E:encapsidated SARS-CoV-2 genomic RNA: 7a:O-glycosyl 3a tetramer:glycosylated-ACE2:HSPGs [extracellular region] (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS/HPIN-PGs [plasma membrane] (Homo sapiens)
HS(6)-SDC4 [plasma membrane] (Homo sapiens)
FURIN Mediated SARS-CoV-2 Spike Protein Cleavage and Endocytosis (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS/HPIN-PGs [plasma membrane] (Homo sapiens)
HS(6)-SDC4 [plasma membrane] (Homo sapiens)
S3:M:E:encapsidated SARS-CoV-2 genomic RNA: 7a:O-glycosyl 3a tetramer:glycosylated-ACE2:HSPGs [extracellular region] (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS/HPIN-PGs [plasma membrane] (Homo sapiens)
HS(6)-SDC4 [plasma membrane] (Homo sapiens)
Spike glycoprotein of SARS-CoV-2 binds ACE2 on host cell (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS/HPIN-PGs [plasma membrane] (Homo sapiens)
HS(6)-SDC4 [plasma membrane] (Homo sapiens)
S3:M:E:encapsidated SARS-CoV-2 genomic RNA: 7a:O-glycosyl 3a tetramer:glycosylated-ACE2:HSPGs [extracellular region] (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS/HPIN-PGs [plasma membrane] (Homo sapiens)
HS(6)-SDC4 [plasma membrane] (Homo sapiens)
TMPRSS2 Mediated SARS-CoV-2 Spike Protein Cleavage and Endocytosis (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS/HPIN-PGs [plasma membrane] (Homo sapiens)
HS(6)-SDC4 [plasma membrane] (Homo sapiens)
S3:M:E:encapsidated SARS-CoV-2 genomic RNA: 7a:O-glycosyl 3a tetramer:glycosylated-ACE2:HSPGs [extracellular region] (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS/HPIN-PGs [plasma membrane] (Homo sapiens)
HS(6)-SDC4 [plasma membrane] (Homo sapiens)
Extracellular matrix organization (Homo sapiens)
Non-integrin membrane-ECM interactions (Homo sapiens)
Syndecan interactions (Homo sapiens)
Syndecan-4 binds ACTN1 (Homo sapiens)
Syndecan-4 [plasma membrane] (Homo sapiens)
HS(6)-SDC4 [plasma membrane] (Homo sapiens)
Syndecan-4:ACTN1 [plasma membrane] (Homo sapiens)
Syndecan-4 [plasma membrane] (Homo sapiens)
HS(6)-SDC4 [plasma membrane] (Homo sapiens)
Syndecan-4 binds PI(4,5)P2 (Homo sapiens)
Syndecan-4 [plasma membrane] (Homo sapiens)
HS(6)-SDC4 [plasma membrane] (Homo sapiens)
Syndecan-4:PI(4,5)P2 [plasma membrane] (Homo sapiens)
Syndecan-4 [plasma membrane] (Homo sapiens)
HS(6)-SDC4 [plasma membrane] (Homo sapiens)
Syndecan-4:PI(4,5)P2 binds PKC alpha:DAG (Homo sapiens)
Syndecan-4:PI(4,5)P2 [plasma membrane] (Homo sapiens)
Syndecan-4 [plasma membrane] (Homo sapiens)
HS(6)-SDC4 [plasma membrane] (Homo sapiens)
Syndecan-4:PI(4,5)P2:Protein kinase C, alpha type:DAG [plasma membrane] (Homo sapiens)
Syndecan-4:PI(4,5)P2 [plasma membrane] (Homo sapiens)
Syndecan-4 [plasma membrane] (Homo sapiens)
HS(6)-SDC4 [plasma membrane] (Homo sapiens)
Syndecans 1, 2 & 4 bind VTN (Homo sapiens)
Syndecan-1, 2 & 4:VTN [plasma membrane] (Homo sapiens)
Syndecans 1, 2 & 4 [plasma membrane] (Homo sapiens)
Syndecan-4 [plasma membrane] (Homo sapiens)
HS(6)-SDC4 [plasma membrane] (Homo sapiens)
Syndecans 1, 2 & 4 [plasma membrane] (Homo sapiens)
Syndecan-4 [plasma membrane] (Homo sapiens)
HS(6)-SDC4 [plasma membrane] (Homo sapiens)
Syndecans 1, 2, 4, (3) bind FGF2 (Homo sapiens)
SDC1, 2, 4, (3) [plasma membrane] (Homo sapiens)
Syndecan-4 [plasma membrane] (Homo sapiens)
HS(6)-SDC4 [plasma membrane] (Homo sapiens)
SDC1,2,4,(3):FGF2 [plasma membrane] (Homo sapiens)
SDC1, 2, 4, (3) [plasma membrane] (Homo sapiens)
Syndecan-4 [plasma membrane] (Homo sapiens)
HS(6)-SDC4 [plasma membrane] (Homo sapiens)
Syndecans 2, (4) bind TGFB1 (Homo sapiens)
Syndecans 2, (4) [plasma membrane] (Homo sapiens)
Syndecan-4 [plasma membrane] (Homo sapiens)
HS(6)-SDC4 [plasma membrane] (Homo sapiens)
Syndecans 2, (4):TGFB1 [plasma membrane] (Homo sapiens)
Syndecans 2, (4) [plasma membrane] (Homo sapiens)
Syndecan-4 [plasma membrane] (Homo sapiens)
HS(6)-SDC4 [plasma membrane] (Homo sapiens)
Hemostasis (Homo sapiens)
Cell surface interactions at the vascular wall (Homo sapiens)
PSGs bind proteoglycans and TGF-beta1 (Homo sapiens)
PSGs:Proteoglycan,TGFB1 [plasma membrane] (Homo sapiens)
Proteoglycans,TGFB1 [plasma membrane] (Homo sapiens)
Syndecans1-4 [plasma membrane] (Homo sapiens)
Syndecan-4 [plasma membrane] (Homo sapiens)
HS(6)-SDC4 [plasma membrane] (Homo sapiens)
Proteoglycans,TGFB1 [plasma membrane] (Homo sapiens)
Syndecans1-4 [plasma membrane] (Homo sapiens)
Syndecan-4 [plasma membrane] (Homo sapiens)
HS(6)-SDC4 [plasma membrane] (Homo sapiens)
Metabolism (Homo sapiens)
Metabolism of carbohydrates (Homo sapiens)
Glycosaminoglycan metabolism (Homo sapiens)
Heparan sulfate/heparin (HS-GAG) metabolism (Homo sapiens)
HS-GAG biosynthesis (Homo sapiens)
Some HSPGs are secreted to the plasma membrane (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS/HPIN-PGs [plasma membrane] (Homo sapiens)
HS(6)-SDC4 [plasma membrane] (Homo sapiens)
HS-GAG degradation (Homo sapiens)
HS-GAGs translocate to the lysosome for degradation (Homo sapiens)
HS/HPIN-PGs [plasma membrane] (Homo sapiens)
HS(6)-SDC4 [plasma membrane] (Homo sapiens)
Heparanase 2 (HPSE2) binds heparan sulfate proteoglycans (Homo sapiens)
HPSE2:HS/HPIN-PGs [plasma membrane] (Homo sapiens)
HS/HPIN-PGs [plasma membrane] (Homo sapiens)
HS(6)-SDC4 [plasma membrane] (Homo sapiens)
HS/HPIN-PGs [plasma membrane] (Homo sapiens)
HS(6)-SDC4 [plasma membrane] (Homo sapiens)
Metabolism of vitamins and cofactors (Homo sapiens)
Metabolism of fat-soluble vitamins (Homo sapiens)
Retinoid metabolism and transport (Homo sapiens)
CR:atREs binds apoE and HSPG (Homo sapiens)
CR:atREs:HSPG:apoE [plasma membrane] (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS/HPIN-PGs [plasma membrane] (Homo sapiens)
HS(6)-SDC4 [plasma membrane] (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS/HPIN-PGs [plasma membrane] (Homo sapiens)
HS(6)-SDC4 [plasma membrane] (Homo sapiens)
LRPs transport extracellular CR:atREs:HSPG:apoE to cytosol (Homo sapiens)
CR:atREs:HSPG:apoE [early endosome] (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS/HPIN-PGs [plasma membrane] (Homo sapiens)
HS(6)-SDC4 [plasma membrane] (Homo sapiens)
CR:atREs:HSPG:apoE [plasma membrane] (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS/HPIN-PGs [plasma membrane] (Homo sapiens)
HS(6)-SDC4 [plasma membrane] (Homo sapiens)
NREH hydrolyses atREs (HSPG:apoE) to atROL and FAs (Homo sapiens)
CR:atREs:HSPG:apoE [early endosome] (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS/HPIN-PGs [plasma membrane] (Homo sapiens)
HS(6)-SDC4 [plasma membrane] (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS/HPIN-PGs [plasma membrane] (Homo sapiens)
HS(6)-SDC4 [plasma membrane] (Homo sapiens)
Sensory Perception (Homo sapiens)
Visual phototransduction (Homo sapiens)
Retinoid metabolism and transport (Homo sapiens)
CR:atREs binds apoE and HSPG (Homo sapiens)
CR:atREs:HSPG:apoE [plasma membrane] (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS/HPIN-PGs [plasma membrane] (Homo sapiens)
HS(6)-SDC4 [plasma membrane] (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS/HPIN-PGs [plasma membrane] (Homo sapiens)
HS(6)-SDC4 [plasma membrane] (Homo sapiens)
LRPs transport extracellular CR:atREs:HSPG:apoE to cytosol (Homo sapiens)
CR:atREs:HSPG:apoE [early endosome] (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS/HPIN-PGs [plasma membrane] (Homo sapiens)
HS(6)-SDC4 [plasma membrane] (Homo sapiens)
CR:atREs:HSPG:apoE [plasma membrane] (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS/HPIN-PGs [plasma membrane] (Homo sapiens)
HS(6)-SDC4 [plasma membrane] (Homo sapiens)
NREH hydrolyses atREs (HSPG:apoE) to atROL and FAs (Homo sapiens)
CR:atREs:HSPG:apoE [early endosome] (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS/HPIN-PGs [plasma membrane] (Homo sapiens)
HS(6)-SDC4 [plasma membrane] (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS/HPIN-PGs [plasma membrane] (Homo sapiens)
HS(6)-SDC4 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P31431 SDC4
Gene Names
SDC4
Chain
signal peptide:1-18, chain:19-198
Reference Genes
BioGPS Gene:6385 SDC4
COSMIC (genes):SDC4 SDC4
CTD Gene:6385 SDC4
dbSNP Gene:6385 SDC4
ENSEMBL:ENSG00000124145.6 SDC4
HGNC:10661 SDC4
KEGG Gene (Homo sapiens):6385 SDC4
Monarch:6385 SDC4
NCBI Gene:6385 SDC4
OMIM:600017 SDC4
UCSC:P31431 SDC4
Reference Transcript
RefSeq:NM_002999.3 SDC4
Other Identifiers
11717638_at
11717639_x_at
11749921_a_at
16919567
202071_PM_at
202071_at
35844_at
3907235
3907236
3907239
3907240
3907242
3907247
3907248
6385
8066513
A_23_P109034
A_24_P373976
D79206_s_at
GE79134
GO:0001657
GO:0001843
GO:0001968
GO:0002376
GO:0005080
GO:0005515
GO:0005576
GO:0005615
GO:0005764
GO:0005773
GO:0005794
GO:0005796
GO:0005886
GO:0005925
GO:0007010
GO:0007155
GO:0009986
GO:0010762
GO:0016020
GO:0016192
GO:0016477
GO:0030154
GO:0034330
GO:0036211
GO:0042060
GO:0042130
GO:0042802
GO:0043034
GO:0043202
GO:0043226
GO:0045121
GO:0045860
GO:0048856
GO:0048870
GO:0051496
GO:0051894
GO:0060089
GO:0060122
GO:0070053
GO:0070062
GO:1903543
GO:1903553
HMNXSV003007882
ILMN_1663042
PH_hs_0029525
TC20000878.hg
g4506860_3p_s_at
Participates
as a member of
Syndecan-4 [plasma membrane] (Homo sapiens)
HS/HPIN-PGs [plasma membrane] (Homo sapiens)
Other forms of this molecule
SDC4 [lysosomal lumen]
HS(6)-SDC4 [lysosomal lumen]
HS(6)-SDC4 [Golgi lumen]
HS(5)-SDC4 [Golgi lumen]
Heparan-SDC4 [Golgi lumen]
Heparan(1)-SDC4 [Golgi lumen]
Heparan(2)-SDC4 [Golgi lumen]
Heparan(3)-SDC4 [Golgi lumen]
Heparan(4)-SDC4 [Golgi lumen]
HS(1)-SDC4 [Golgi lumen]
HS(2)-SDC4 [Golgi lumen]
HS(4)-SDC4 [Golgi lumen]
HS(3)-SDC4 [Golgi lumen]
HS(4)-SDC4 [plasma membrane]
HS(2)-SDC4 [plasma membrane]
HS(1)-SDC4 [plasma membrane]
HS(3)-SDC4 [plasma membrane]
HS(5)-SDC4 [plasma membrane]
XylS-SDC4 [Golgi lumen]
Gal-Xyl-SDC4 [Golgi lumen]
SDC4 [Golgi lumen]
Gal-Gal-Xyl-SDC4 [Golgi lumen]
GlcA-Gal-Gal-Xyl-SDC4 [Golgi lumen]
Inferred To
HS(6)-SDC4 [plasma membrane]
(Danio rerio)
sdn-1 [plasma membrane]
(Caenorhabditis elegans)
Sdc4 [plasma membrane]
(Mus musculus)
Sdc4 [plasma membrane]
(Rattus norvegicus)
SDC4 [plasma membrane]
(Bos taurus)
SDC4 [plasma membrane]
(Gallus gallus)
SDC4 [plasma membrane]
(Sus scrofa)
Sdc [plasma membrane]
(Drosophila melanogaster)
Modified Residues
Name
O-xylosyl-L-serine (ChEBI:63666) at unknown position
Modification
beta-D-IdoA-(1->4)-alpha-D-GlcNS6S-(1->4)-beta-D-IdoA2S-(1->4)-alpha-D-GlcNS3S-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl-yl group
PsiMod Name
O-xylosyl-L-serine
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O3-xylosylserine.
Cross References
RefSeq
NP_002990.2
OpenTargets
ENSG00000124145
HPA
ENSG00000124145-SDC4
GeneCards
P31431
Ensembl
ENST00000372733
,
ENSP00000361818
,
ENSG00000124145
PRO
P31431
Pharos - Targets
P31431
HMDB Protein
HMDBP02435
PDB
1YBO
,
1OBY
,
1EJQ
,
1EJP
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P0DTC2 S
20
S(686-815) [plasma membrane]
(R-COV-9770188)
Spike S2' Fragment [plasma membrane]
(R-COV-9770189)
S1 [plasma membrane]
(R-COV-9769950)
fully glycosylated Spike [plasma membrane]
(R-COV-9733472)
nascent Spike [endoplasmic reticulum lumen]
(R-COV-9694796)
14-sugar N-glycan unfolded Spike [endoplasmic reticulum lumen]
(R-COV-9694459)
Man(9) N-glycan unfolded Spike [endoplasmic reticulum lumen]
(R-COV-9696892)
high-mannose N-glycan unfolded Spike [endoplasmic reticulum lumen]
(R-COV-9696875)
high-mannose N-glycan folded Spike [endoplasmic reticulum lumen]
(R-COV-9696880)
high-mannose N-glycan folded Spike [endoplasmic reticulum-Golgi intermediate compartment]
(R-COV-9766369)
high-mannose N-glycan-PALM-Spike [endoplasmic reticulum-Golgi intermediate compartment]
(R-COV-9696943)
di-antennary N-glycan-PALM-Spike [endoplasmic reticulum-Golgi intermediate compartment]
(R-COV-9696920)
tri-antennary N-glycan-PALM-Spike [endoplasmic reticulum-Golgi intermediate compartment]
(R-COV-9697006)
fully glycosylated Spike [endoplasmic reticulum-Golgi intermediate compartment]
(R-COV-9696997)
complex N-glycan-PALM-Spike S2 Fragment [plasma membrane]
(R-COV-9769952)
fully glycosylated Spike [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-COV-9698330)
fully glycosylated Spike [virion membrane]
(R-COV-9698327)
complex N-glycan-PALM-Spike S1 Fragment [endocytic vesicle membrane]
(R-COV-9694745)
complex N-glycan-PALM-Spike S2 Fragment [endocytic vesicle membrane]
(R-COV-9694343)
complex N-glycan-PALM-Spike S2 Fragment [virion membrane]
(R-COV-9694791)
0.599
17
UniProt:Q01453 PMP22
1
PMP22 [plasma membrane]
(R-HSA-9615623)
0.556
3
UniProt:P16871 IL7R
3
p-Y449-IL7R [plasma membrane]
(R-HSA-1295531)
IL7R [plasma membrane]
(R-HSA-449945)
IL7R [clathrin-coated endocytic vesicle membrane]
(R-HSA-9028500)
0.556
3
UniProt:O15530 PDPK1
2
PDPK1 [cytosol]
(R-HSA-202210)
PDPK1 [plasma membrane]
(R-HSA-61459)
0.527
3
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