Reactome | SFTPD [clathrin-coated endocytic vesicle]

SFTPD [clathrin-coated endocytic vesicle]

Stable Identifier

R-HSA-5686343

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

clathrin-coated endocytic vesicle

Synonyms

Pulmonary surfactant-associated protein D (SP-D), SFTPD_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P35247 SFTPD

Gene Names

SFTPD, COLEC7, PSPD, SFTP4

Chain

signal peptide:1-20, chain:21-375

Reference Genes

BioGPS Gene:6441 SFTPD

COSMIC (genes):SFTPD SFTPD

CTD Gene:6441 SFTPD

dbSNP Gene:6441 SFTPD

ENSEMBL:ENSG00000133661 SFTPD

HGNC:10803 SFTPD

KEGG:hsa:6441 SFTPD

Monarch:6441 SFTPD

NCBI Gene:6441 SFTPD

OMIM:178635 SFTPD

UCSC:P35247 SFTPD

Reference Transcript

Participates

as a component of

SFTPD trimer [clathrin-coated endocytic vesicle] (Homo sapiens)

Other forms of this molecule

SFTPD [extracellular region]

SFTPD [endoplasmic reticulum membrane]

Inferred To

SFTPD [clathrin-coated endocytic vesicle] (Bos taurus)

SFTPD [clathrin-coated endocytic vesicle] (Canis familiaris)

Sftpd [clathrin-coated endocytic vesicle] (Mus musculus)

Sftpd [clathrin-coated endocytic vesicle] (Rattus norvegicus)

Cross References

RefSeq

NP_003010.4, XP_011538389.1

OpenTargets

ENSG00000133661

ENSEMBL

ENSG00000133661, ENST00000372292, ENSP00000361366

HPA

ENSG00000133661-SFTPD

GeneCards

SFTPD

PRO

P35247

Pharos - Targets

P35247

GlyGen

P35247

HMDB Protein

HMDBP14631

PDB

2OS9, 1M7L, 3G84, 3IKR, 3IKN, 3IKQ, 3IKP, 1PWB, 2ORJ, 2ORK, 2RIE, 2GGU, 4M17, 2RID, 1PW9, 4M18, 1B08, 2RIC, 2GGX, 2RIB, 2RIA, 3DBZ, 3G81, 3G83, 5OXR, 5OXS, 4E52

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P0DTC2 S	20	S(686-815) [plasma membrane] (R-COV-9770188) Spike S2' Fragment [plasma membrane] (R-COV-9770189) S1 [plasma membrane] (R-COV-9769950) fully glycosylated Spike [plasma membrane] (R-COV-9733472) nascent Spike [endoplasmic reticulum lumen] (R-COV-9694796) 14-sugar N-glycan unfolded Spike [endoplasmic reticulum lumen] (R-COV-9694459) Man(9) N-glycan unfolded Spike [endoplasmic reticulum lumen] (R-COV-9696892) high-mannose N-glycan unfolded Spike [endoplasmic reticulum lumen] (R-COV-9696875) high-mannose N-glycan folded Spike [endoplasmic reticulum lumen] (R-COV-9696880) high-mannose N-glycan folded Spike [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9766369) high-mannose N-glycan-PALM-Spike [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9696943) di-antennary N-glycan-PALM-Spike [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9696920) fully glycosylated Spike [virion membrane] (R-COV-9698327) complex N-glycan-PALM-Spike S1 Fragment [virion membrane] (R-COV-9694638) complex N-glycan-PALM-Spike S2 Fragment [virion membrane] (R-COV-9694791) complex N-glycan-PALM-Spike S2 Fragment [endocytic vesicle membrane] (R-COV-9694343) complex N-glycan-PALM-Spike S1 Fragment [endocytic vesicle membrane] (R-COV-9694745) fully glycosylated Spike [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9698330) complex N-glycan-PALM-Spike S2 Fragment [plasma membrane] (R-COV-9769952) fully glycosylated Spike [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9696997)	0.544	3

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