Reactome | LDLR [endolysosome membrane]

LDLR [endolysosome membrane]

Stable Identifier

R-HSA-6784818

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endolysosome membrane

Synonyms

LDL receptor, low-density lipoprotein receptor

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P01130 LDLR

Gene Names

LDLR

Chain

signal peptide:1-21, chain:22-860

Reference Genes

BioGPS Gene:3949 LDLR

COSMIC (genes):LDLR LDLR

CTD Gene:3949 LDLR

dbSNP Gene:3949 LDLR

ENSEMBL:ENSG00000130164 LDLR

HGNC:6547 LDLR

KEGG Gene (Homo sapiens):3949 LDLR

Monarch:3949 LDLR

NCBI Gene:3949 LDLR

OMIM:606945 LDLR

UCSC:P01130 LDLR

Reference Transcript

Other Identifiers

11720028_x_at

11746974_a_at

11748045_x_at

13159

16858386

1AJJ

1D2J

1F5Y

1F8Z

1HJ7

1HZ8

1I0U

1IJQ

1LDL

1LDR

1LRX

1N7D

1XFE

202067_s_at

217173_s_at

2FCW

2KRI

2LGP

2M7P

2MG9

2W2M

2W2N

2W2O

2W2P

2W2Q

3821016

3821017

3821021

3821022

3821023

3821026

3821029

3821031

3821034

3821035

3821036

3821037

3821041

3821042

3821044

3821045

3821046

3821048

3821052

3821054

3821055

3949

3BPS

3GCW

3GCX

3M0C

3P5B

3P5C

3SO6

4NE9

5OY9

5OYL

8025828

9647

A0A024R7D5

A_23_P208595

AAA56833

AAH14514

AAM56036

AAP36025

AAP72971

AB209409

AC011485

ACN81317

AK295612

AK296312

AK299038

AK300313

AY114155

AY324609

BAD92646

BAG58495

BAG59010

BAG61112

BAG62065

BC014514

BT007361

CCDS12254

CCDS56083

CCDS56084

CCDS56085

CCDS58651

CH471106

EAW84169

EAW84171

ENSG00000130164

ENSP00000397829

ENSP00000437639

ENSP00000440520

ENSP00000453346

ENSP00000454071

ENST00000455727

ENST00000455727.6

ENST00000535915

ENST00000535915.5

ENST00000545707

ENST00000545707.5

ENST00000558013

ENST00000558013.5

ENST00000558518

ENST00000558518.5

EntrezGene:3949

EntrezGene:LDLR

FJ525879

GO:0001540

GO:0001618

GO:0002020

GO:0002376

GO:0003674

GO:0005041

GO:0005509

GO:0005515

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005623

GO:0005737

GO:0005764

GO:0005768

GO:0005769

GO:0005770

GO:0005773

GO:0005794

GO:0005886

GO:0005887

GO:0005905

GO:0006629

GO:0006810

GO:0006869

GO:0006897

GO:0006898

GO:0006909

GO:0006950

GO:0007616

GO:0008150

GO:0008202

GO:0008203

GO:0009056

GO:0009058

GO:0009897

GO:0009986

GO:0010008

GO:0010628

GO:0010629

GO:0010867

GO:0010899

GO:0015914

GO:0016020

GO:0016021

GO:0016032

GO:0016192

GO:0016323

GO:0019899

GO:0030154

GO:0030169

GO:0030229

GO:0030299

GO:0030301

GO:0030669

GO:0031410

GO:0032050

GO:0032991

GO:0034362

GO:0034381

GO:0034382

GO:0034383

GO:0034384

GO:0036020

GO:0036477

GO:0042157

GO:0042159

GO:0042592

GO:0042632

GO:0042802

GO:0043167

GO:0043226

GO:0043235

GO:0044281

GO:0044403

GO:0045177

GO:0046718

GO:0048844

GO:0048856

GO:0050729

GO:0050877

GO:0051246

GO:0051248

GO:0061024

GO:0061771

GO:0061889

GO:0070508

GO:0071398

GO:0071404

GO:0090118

GO:0090181

GO:0097242

GO:0097443

GO:0150094

GO:1903979

GO:1905167

GO:1905907

GO:1990666

H0YMD1

HGNC:6547

HPA009647

HPA013159

Hs.213289.0.S1_3p_a_at

Hs.213289.1.S1_3p_a_at

IPR000033

IPR000152

IPR000742

IPR001881

IPR002172

IPR009030

IPR011042

IPR013032

IPR018097

IPR023415

IPR036055

L00336

L00337

L00338

L00339

L00340

L00341

L00343

L00344

L00345

L00346

L00347

L00348

L00349

L00350

L00351

L00352

L29401

LDLR

LDLR-202

LDLR-203

LDLR-204

LDLR-207

LDLR-208

LRG_274

LRG_274t1

MIM:143890

MIM:606945

NM_000527

NM_001195798

NM_001195799

NM_001195800

NM_001195803

NP_000518

NP_001182727

NP_001182728

NP_001182729

NP_001182732

PF00057

PF00058

PF07645

PF14670

PR00261

SM00135

SM00179

SM00181

SM00192

TC19000191.hg

UPI00000015DF

UPI0001639662

UPI00017A7120

UPI00017A7C70

UPI00017A7DDE

XM_011528010

XP_011526312

XR_001753685

XR_001753686

Participant Of

hasComponent

PCSK9:LDLR [endolysosome membrane]

Other forms of this molecule

LDLR [endosome membrane]

LDLR [clathrin-coated endocytic vesicle membrane]

LDLR [plasma membrane]

Inferred To

Ghost homologue of LDLR [endolysosome membrane] (Dictyostelium discoideum)

Ghost homologue of LDLR [endolysosome membrane] (Gallus gallus)

Ghost homologue of LDLR [endolysosome membrane] (Saccharomyces cerevisiae)

Ghost homologue of LDLR [endolysosome membrane] (Schizosaccharomyces pombe)

Ghost homologue of LDLR [endolysosome membrane] (Sus scrofa)

Homologues of LDLR [endolysosome membrane] (Drosophila melanogaster)

LDLR [endolysosome membrane] (Caenorhabditis elegans)

LDLR [endolysosome membrane] (Canis familiaris)

LDLR [endolysosome membrane] (Danio rerio)

LDLR [endolysosome membrane] (Drosophila melanogaster)

LDLR [endolysosome membrane] (Mus musculus)

LDLR [endolysosome membrane] (Rattus norvegicus)

LDLR [endolysosome membrane] (Xenopus tropicalis)

Cross References

RefSeq

NP_001182729.1, NP_001182727.1, NP_001182732.1, NP_000518.1, NP_001182728.1

OpenTargets

ENSG00000130164

ZINC - Substances

LDLR_HUMAN

GeneCards

P01130

ZINC target

P01130

PRO

P01130

Orphanet

16347

ZINC - Predictions - Purchasable

LDLR_HUMAN

HMDB Protein

HMDBP02065

PDB

2LGP, 1F8Z, 1IJQ, 5OYL, 3P5C, 1AJJ, 2KRI, 3P5B, 3SO6, 5OY9, 2W2P, 1XFE, 2W2Q, 2FCW, 2MG9, 3GCX, 3M0C, 2W2N, 1I0U, 1LDR, 2M7P, 1F5Y, 1LRX, 2W2O, 1D2J, 3BPS, 3GCW, 1N7D, 1HZ8, 2W2M, 1LDL, 4NE9, 1HJ7

Interactors (10)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q8NBP7-1 PCSK9			0.719	4
UniProt:P02649 APOE	9	APOE [endosome lumen] (R-HSA-174804) APOE [endocytic vesicle lumen] (R-HSA-3221641) APOE [endosome membrane] (R-HSA-174766) APOE [clathrin-coated endocytic vesicle membrane] (R-HSA-174651) APOE [plasma membrane] (R-HSA-174615) APOE [early endosome] (R-HSA-2429687) p-APOE [endoplasmic reticulum lumen] (R-HSA-8956980) APOE [extracellular region] (R-HSA-174646) APOE [endoplasmic reticulum lumen] (R-HSA-6784908)	0.71	4
UniProt:Q8NBP7 PCSK9	5	PCSK9 [lysosomal membrane] (R-HSA-8855128) PCSK9 [endolysosome membrane] (R-HSA-6784823) PCSK9 [extracellular region] (R-HSA-6784727) p-PCSK9 [endoplasmic reticulum lumen] (R-HSA-8956943) PCSK9 [endoplasmic reticulum lumen] (R-HSA-8956745)	0.676	10
UniProt:P30533 AMRP			0.667	3
UniProt:P02749 APOH	2	APOH [platelet dense granule lumen] (R-HSA-8848901) APOH [extracellular region] (R-HSA-8848905)	0.618	3
UniProt:D3ZAR1	2	LDLRAP1 [plasma membrane] (R-RNO-171143) LDLRAP1 [clathrin-coated endocytic vesicle membrane] (R-RNO-8869097)	0.558	3
UniProt:P04114 APOB	23	10xdHF-10xglutamyl semialdehyde (Pro)-6xL-tyrosine residue-3xOxoH-2xmodified L-lysine residue-N'-formyl-L-kynurenine-APOB(28-4563) [endocytic vesicle lumen] (R-HSA-2239461) APOB(28-4563) [endocytic vesicle lumen] (R-HSA-2512789) AcK-APOB(28-4563) [endocytic vesicle lumen] (R-HSA-2239446) AcK-APOB(28-4563) [extracellular region] (R-HSA-2173751) APOB(28-4563) [lysosomal lumen] (R-HSA-8876369) APOB(28-2179) [endosome lumen] (R-HSA-174716) APOB(28-2179) [endosome membrane] (R-HSA-174762) APOB(28-4563) [plasma membrane] (R-HSA-171089) APOB(28-4563) [clathrin-coated endocytic vesicle membrane] (R-HSA-171155) APOB(28-4563) [endosome lumen] (R-HSA-171119) APOB(28-4563) [endosome membrane] (R-HSA-171121) APOB(28-2179) [clathrin-coated endocytic vesicle membrane] (R-HSA-174788) APOB(28-2179) [plasma membrane] (R-HSA-174625) APOB(28-2179) [endoplasmic reticulum lumen] (R-HSA-174620) APOB(28-2179) [endoplasmic reticulum membrane] (R-HSA-174637) APOB(28-4563) [smooth endoplasmic reticulum] (R-HSA-8866317) APOB(28-2179) [cytosol] (R-HSA-2395786) APOB(28-2179) [extracellular region] (R-HSA-174770) APOB(28-2179) [early endosome] (R-HSA-2429651) 10xdHF-10xglutamyl semialdehyde (Pro)-6xL-tyrosine residue-3xOxoH-2xmodified L-lysine residue-N'-formyl-L-kynurenine-APOB(28-4563) [extracellular region] (R-HSA-2173702) APOB(28-4563) [extracellular region] (R-HSA-171065) APOB(28-4563) [endoplasmic reticulum lumen] (R-HSA-6784882) p-APOB(28-4563) [endoplasmic reticulum lumen] (R-HSA-8957068)	0.558	4
UniProt:Q08117-2 TLE5			0.488	2
UniProt:P17948 FLT1	1	VEGFR1 [plasma membrane] (R-HSA-3004464)	0.463	2
UniProt:P04578 env	7	Transmembrane protein gp41 (P04578) [cytosol] (R-HIV-189359) Surface protein gp120 (P04578) [cytosol] (R-HIV-189269) Glycosylated Envelope glycoprotein gp160 [Golgi membrane] (R-HIV-3149443) Envelope glycoprotein gp160 [endoplasmic reticulum membrane] (R-HIV-189343) Transmembrane protein gp41 [viral envelope] (R-HIV-171195) Surface protein gp120 [viral envelope] (R-HIV-171211) ENV [viral envelope] (R-HIV-173439)	0.462	2