Reactome | LDLR [endolysosome membrane]

LDLR [endolysosome membrane]

Stable Identifier

R-HSA-6784818

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endolysosome membrane

Synonyms

LDL receptor, low-density lipoprotein receptor

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P01130 LDLR

Gene Names

LDLR

Chain

signal peptide:1-21, chain:22-860

Reference Genes

BioGPS Gene:3949 LDLR

COSMIC (genes):LDLR LDLR

CTD Gene:3949 LDLR

dbSNP Gene:3949 LDLR

ENSEMBL:ENSG00000130164.14 LDLR

HGNC:6547 LDLR

KEGG Gene (Homo sapiens):3949 LDLR

Monarch:3949 LDLR

NCBI Gene:3949 LDLR

OMIM:606945 LDLR

UCSC:P01130 LDLR

Reference Transcript

Other Identifiers

0005340372

11720028_x_at

11720029_a_at

11746974_a_at

11748045_x_at

16858386

202067_PM_s_at

202067_s_at

202068_PM_s_at

202068_s_at

217173_PM_s_at

217173_s_at

32855_at

3821016

3821017

3821021

3821022

3821023

3821026

3821029

3821031

3821034

3821035

3821036

3821037

3821041

3821042

3821044

3821045

3821046

3821048

3821052

3821054

3821055

3949

8025828

A_14_P117693

A_23_P208595

A_24_P117029

GE61153

GO:0001540

GO:0001618

GO:0001920

GO:0002020

GO:0002376

GO:0005041

GO:0005509

GO:0005515

GO:0005576

GO:0005615

GO:0005622

GO:0005737

GO:0005764

GO:0005768

GO:0005769

GO:0005770

GO:0005773

GO:0005794

GO:0005886

GO:0005887

GO:0005905

GO:0006629

GO:0006869

GO:0006897

GO:0006898

GO:0006909

GO:0006954

GO:0007616

GO:0008202

GO:0008203

GO:0009897

GO:0009986

GO:0010008

GO:0010628

GO:0010629

GO:0010867

GO:0010899

GO:0010989

GO:0015914

GO:0016020

GO:0016021

GO:0016192

GO:0016323

GO:0022600

GO:0023052

GO:0030154

GO:0030163

GO:0030169

GO:0030229

GO:0030299

GO:0030301

GO:0030669

GO:0031410

GO:0032050

GO:0032991

GO:0034362

GO:0034381

GO:0034383

GO:0034384

GO:0036020

GO:0036477

GO:0038024

GO:0042157

GO:0042159

GO:0042632

GO:0042802

GO:0043226

GO:0043235

GO:0045177

GO:0046718

GO:0048844

GO:0048856

GO:0050729

GO:0050877

GO:0051246

GO:0051248

GO:0051649

GO:0060090

GO:0061771

GO:0061889

GO:0070508

GO:0071398

GO:0071404

GO:0071813

GO:0090118

GO:0090181

GO:0097242

GO:0097443

GO:0150094

GO:1903979

GO:1905167

GO:1905907

GO:1990666

HMNXSV003057635

Hs.213289.0.S1_3p_a_at

Hs.213289.1.S1_3p_a_at

ILMN_1651611

ILMN_2053415

L00352_at

PH_hs_0012331

TC19000191.hg

g8051613_3p_a_at

Participates

as a component of

PCSK9:LDLR [endolysosome membrane] (Homo sapiens)

Other forms of this molecule

LDLR [endosome membrane]

LDLR [clathrin-coated endocytic vesicle membrane]

LDLR [plasma membrane]

Inferred To

Ghost homologue of LDLR [endolysosome membrane] (Dictyostelium discoideum)

Ghost homologue of LDLR [endolysosome membrane] (Gallus gallus)

Ghost homologue of LDLR [endolysosome membrane] (Saccharomyces cerevisiae)

Ghost homologue of LDLR [endolysosome membrane] (Schizosaccharomyces pombe)

Ghost homologue of LDLR [endolysosome membrane] (Xenopus tropicalis)

Ldlr [endolysosome membrane] (Mus musculus)

Ldlr [endolysosome membrane] (Rattus norvegicus)

ldlr [endolysosome membrane] (Danio rerio)

LDLR [endolysosome membrane] (Bos taurus)

LDLR [endolysosome membrane] (Canis familiaris)

LDLR [endolysosome membrane] (Sus scrofa)

egg-1 [endolysosome membrane] (Caenorhabditis elegans)

LpR2 [endolysosome membrane] (Drosophila melanogaster)

Cross References

RefSeq

NP_001182728.1, NP_001182729.1, NP_001182727.1, NP_001182732.1, NP_000518.1

OpenTargets

ENSG00000130164

ZINC - Substances

LDLR_HUMAN

ZINC target

P01130

PRO

P01130

PDB

2W2O, 1F5Y, 1I0U, 2M7P, 3SO6, 2W2N, 5OY9, 1HJ7, 1HZ8, 1LDL, 2W2M, 2KRI, 1IJQ, 1N7D, 3P5B, 1AJJ, 1F8Z, 2LGP, 2MG9, 5OYL, 3P5C, 2FCW, 3GCX, 1XFE, 1D2J, 2W2Q, 2W2P, 4NE9, 3BPS, 1LDR, 3M0C, 3GCW

HPA

ENSG00000130164-LDLR

GeneCards

P01130

Ensembl

ENST00000455727, ENSP00000437639, ENST00000535915, ENSP00000453346, ENSG00000130164, ENSP00000454071, ENST00000545707, ENSP00000440520, ENST00000558518, ENST00000558013, ENSP00000397829

Pharos - Targets

P01130

ZINC - Predictions - Purchasable

LDLR_HUMAN

Orphanet

16347

HMDB Protein

HMDBP02065

Interactors (12)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q8NBP7-1 PCSK9			0.719	4
UniProt:P02649 APOE	10	APOE-4 [extracellular region] (R-HSA-9711070) APOE [early endosome] (R-HSA-2429687) APOE [endosome lumen] (R-HSA-174804) APOE [endosome membrane] (R-HSA-174766) APOE [clathrin-coated endocytic vesicle membrane] (R-HSA-174651) APOE [plasma membrane] (R-HSA-174615) APOE [endocytic vesicle lumen] (R-HSA-3221641) p-APOE [endoplasmic reticulum lumen] (R-HSA-8956980) APOE [endoplasmic reticulum lumen] (R-HSA-6784908) APOE [extracellular region] (R-HSA-174646)	0.71	4
UniProt:Q8NBP7 PCSK9	5	PCSK9 [endolysosome membrane] (R-HSA-6784823) PCSK9 [lysosomal membrane] (R-HSA-8855128) PCSK9 [extracellular region] (R-HSA-6784727) p-PCSK9 [endoplasmic reticulum lumen] (R-HSA-8956943) PCSK9 [endoplasmic reticulum lumen] (R-HSA-8956745)	0.676	10
UniProt:P30533 AMRP			0.667	3
UniProt:P02749 APOH	2	APOH [extracellular region] (R-HSA-8848905) APOH [platelet dense granule lumen] (R-HSA-8848901)	0.618	3
UniProt:P04114 APOB	20	APOB(28-2179) [cytosol] (R-HSA-2395786) APOB(28-2179) [early endosome] (R-HSA-2429651) APOB(28-4563) [lysosomal lumen] (R-HSA-8876369) APOB(28-2179) [endosome lumen] (R-HSA-174716) APOB(28-2179) [endosome membrane] (R-HSA-174762) APOB(28-4563) [plasma membrane] (R-HSA-171089) APOB(28-4563) [clathrin-coated endocytic vesicle membrane] (R-HSA-171155) APOB(28-4563) [endosome lumen] (R-HSA-171119) APOB(28-4563) [endosome membrane] (R-HSA-171121) APOB(28-2179) [clathrin-coated endocytic vesicle membrane] (R-HSA-174788) APOB(28-2179) [plasma membrane] (R-HSA-174625) APOB(28-2179) [endoplasmic reticulum lumen] (R-HSA-174620) APOB(28-2179) [extracellular region] (R-HSA-174770) APOB(28-2179) [endoplasmic reticulum membrane] (R-HSA-174637) APOB(28-4563) [smooth endoplasmic reticulum] (R-HSA-8866317) APOB(28-4563) [endocytic vesicle lumen] (R-HSA-2512789) 10xdHF-10xglutamyl semialdehyde (Pro)-6xL-tyrosine residue-3xOxoH-2xmodified L-lysine residue-N'-formyl-L-kynurenine-APOB(28-4563) [endocytic vesicle lumen] (R-HSA-2239461) AcK-APOB(28-4563) [endocytic vesicle lumen] (R-HSA-2239446) AcK-APOB(28-4563) [extracellular region] (R-HSA-2173751) p-APOB(28-4563) [endoplasmic reticulum lumen] (R-HSA-8957068)	0.558	4
UniProt:D3ZAR1	2	Ldlrap1 [clathrin-coated endocytic vesicle membrane] (R-RNO-8869097) Ldlrap1 [plasma membrane] (R-RNO-171143)	0.558	3
UniProt:Q08117-2 TLE5			0.556	3
UniProt:Q9H2K0 MTIF3	1	MTIF3 [mitochondrial matrix] (R-HSA-5368284)	0.556	3
UniProt:P0DTC2 S	20	S(686-815) [plasma membrane] (R-COV-9770188) Spike S2' Fragment [plasma membrane] (R-COV-9770189) S1 [plasma membrane] (R-COV-9769950) fully glycosylated Spike [plasma membrane] (R-COV-9733472) nascent Spike [endoplasmic reticulum lumen] (R-COV-9694796) 14-sugar N-glycan unfolded Spike [endoplasmic reticulum lumen] (R-COV-9694459) Man(9) N-glycan unfolded Spike [endoplasmic reticulum lumen] (R-COV-9696892) high-mannose N-glycan unfolded Spike [endoplasmic reticulum lumen] (R-COV-9696875) high-mannose N-glycan folded Spike [endoplasmic reticulum lumen] (R-COV-9696880) high-mannose N-glycan folded Spike [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9766369) high-mannose N-glycan-PALM-Spike [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9696943) di-antennary N-glycan-PALM-Spike [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9696920) tri-antennary N-glycan-PALM-Spike [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9697006) fully glycosylated Spike [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9696997) complex N-glycan-PALM-Spike S2 Fragment [plasma membrane] (R-COV-9769952) fully glycosylated Spike [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9698330) fully glycosylated Spike [virion membrane] (R-COV-9698327) complex N-glycan-PALM-Spike S1 Fragment [endocytic vesicle membrane] (R-COV-9694745) complex N-glycan-PALM-Spike S2 Fragment [endocytic vesicle membrane] (R-COV-9694343) complex N-glycan-PALM-Spike S2 Fragment [virion membrane] (R-COV-9694791)	0.537	4
UniProt:P17948 FLT1	1	VEGFR1 [plasma membrane] (R-HSA-3004464)	0.463	2
UniProt:P04578 env	7	Surface protein gp120 (P04578) [cytosol] (R-HIV-189269) Transmembrane protein gp41 (P04578) [cytosol] (R-HIV-189359) Glycosylated Envelope glycoprotein gp160 [Golgi membrane] (R-HIV-3149443) Envelope glycoprotein gp160 [endoplasmic reticulum membrane] (R-HIV-189343) Transmembrane protein gp41 [viral envelope] (R-HIV-171195) Surface protein gp120 [viral envelope] (R-HIV-171211) ENV [viral envelope] (R-HIV-173439)	0.462	2

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