Reactome | CTSL1(114-288) [early endosome lumen]

CTSL1(114-288) [early endosome lumen]

Stable Identifier

R-HSA-4127474

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

early endosome lumen

Synonyms

CTSL1, Cathepsin L1 heavy chain, CATL1_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P07711 CTSL

Gene Names

CTSL, CTSL1

Chain

signal peptide:1-17, propeptide:18-113, chain:114-333, chain:114-288, propeptide:289-291, chain:292-333

Reference Genes

BioGPS Gene:1514 CTSL

COSMIC (genes):CTSL CTSL

CTD Gene:1514 CTSL

dbSNP Gene:1514 CTSL

ENSEMBL:ENSG00000135047 CTSL

HGNC:2537 CTSL

KEGG:hsa:1514 CTSL

Monarch:1514 CTSL

NCBI Gene:1514 CTSL

OMIM:116880 CTSL

UCSC:P07711 CTSL

Reference Transcript

Other Identifiers

11725332_a_at

1514

17086540

202087_PM_s_at

202087_s_at

3178148

3178149

3178150

3178151

3178152

3178153

3178154

3178155

3178156

3178157

3178158

3178159

3178160

3178161

3178162

3178163

3178164

3178165

3178166

3178167

3178168

3178169

3178170

3178171

3178172

3178173

3178174

3178175

3178176

3178177

3178178

3178179

3178180

3178181

3178182

3178183

3178184

3178192

3178206

3287329

3287613

3288117

3288119

3289420

3297461

3299180

37391_at

8156228

A_14_P100589

A_23_P94533

A_33_P3399101

GE63282

GO:0001968

GO:0002250

GO:0002376

GO:0003824

GO:0004197

GO:0005515

GO:0005518

GO:0005576

GO:0005615

GO:0005634

GO:0005764

GO:0005768

GO:0005771

GO:0005773

GO:0005794

GO:0005886

GO:0006508

GO:0006955

GO:0008234

GO:0008656

GO:0012501

GO:0016192

GO:0016324

GO:0016540

GO:0016787

GO:0019064

GO:0019065

GO:0019882

GO:0019886

GO:0030163

GO:0030312

GO:0030574

GO:0031012

GO:0031410

GO:0031638

GO:0034230

GO:0036021

GO:0039654

GO:0042393

GO:0042583

GO:0043202

GO:0043226

GO:0043231

GO:0043373

GO:0043394

GO:0046718

GO:0048002

GO:0051603

GO:0051604

GO:0060309

GO:0061024

GO:0062023

GO:0070062

GO:0071682

GO:0071888

GO:0097067

GO:0097655

GO:0098772

GO:0140096

GO:1901135

GO:2001235

HMNXSV003021699

HMNXSV003047746

ILMN_1694757

ILMN_1812995

ILMN_2374036

PH_hs_0030125

TC09000400.hg

TC09002062.hg

X12451_at

g4503154_3p_a_at

Participates

as a candidate of

CTSS-like proteins [early endosome lumen] (Homo sapiens)

Other forms of this molecule

CTSL(292-333) [endocytic vesicle lumen]

CTSL(114-288) [endocytic vesicle lumen]

CTSL(114-288) [endolysosome lumen]

CTSL(292-333) [endolysosome lumen]

CTSL1(114-288) [lysosomal lumen]

CTSL(292-333) [extracellular region]

CTSL(114-288) [extracellular region]

Cross References

RefSeq

NP_001244900.1, XP_005251773.1, NP_001244901.1, NP_666023.1, NP_001903.1

ZINC - World Drugs

CATL1_HUMAN

Guide to Pharmacology - Targets

2351

ENSEMBL

ENSP00000345344, ENST00000677019, ENSP00000504313, ENSP00000504279, ENST00000676769, ENST00000676946, ENSP00000502968, ENST00000677761, ENST00000340342, ENSP00000503938, ENST00000676531, ENST00000679149, ENST00000677864, ENST00000677262, ENSP00000504473, ENST00000677821, ENSP00000503881, ENSP00000503851, ENSP00000503470, ENSP00000503897, ENSP00000365061, ENSP00000504405, ENST00000343150, ENSP00000502901, ENSP00000503439, ENST00000679157, ENST00000678442, ENST00000676881, ENST00000676480, ENSP00000503298

OpenTargets

ENSG00000135047

ZINC - FDA approved

CATL1_HUMAN

ZINC - Substances

CATL1_HUMAN

ZINC - Biogenic

CATL1_HUMAN

ZINC target

P07711

PRO

P07711

GlyGen

P07711

PDB

3HHA, 8QKB, 7ZXA, 8C77, 6EZX, 8AHV, 3BC3, 6F06, 7Z3T, 1MHW, 5MAE, 6JD8, 6JD0, 8OZA, 7QKB, 2XU5, 7Z58, 7QKC, 8B4F, 7ZVF, 1CJL, 2XU1, 8HFV, 2XU3, 8A4V, 3IV2, 5MAJ, 3HWN, 8HET, 3OF8, 3OF9, 3H89, 3K24, 8GX2, 2YJB, 6EZP, 2YJ8, 8PRX, 2YJ2, 8UAC, 2YJ9, 2NQD, 2XU4, 5I4H, 2VHS, 4AXL, 3KSE, 7QKD, 4AXM, 8A5B, 8A4W, 8A4X, 1CS8, 8A4U, 7W33, 5F02, 3H8C, 1ICF, 7W34, 5MQY, 2YJC, 8OFA, 7ZS7, 3H8B

ZINC - Investigational

CATL1_HUMAN

ZINC - Metabolites

CATL1_HUMAN

HPA

ENSG00000135047-CTSL

Pharos - Targets

P07711

ZINC - Predictions - Purchasable

CATL1_HUMAN

HMDB Protein

HMDBP13478

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P0DTC2 S	20	S(686-815) [plasma membrane] (R-COV-9770188) Spike S2' Fragment [plasma membrane] (R-COV-9770189) S1 [plasma membrane] (R-COV-9769950) fully glycosylated Spike [plasma membrane] (R-COV-9733472) nascent Spike [endoplasmic reticulum lumen] (R-COV-9694796) 14-sugar N-glycan unfolded Spike [endoplasmic reticulum lumen] (R-COV-9694459) Man(9) N-glycan unfolded Spike [endoplasmic reticulum lumen] (R-COV-9696892) high-mannose N-glycan unfolded Spike [endoplasmic reticulum lumen] (R-COV-9696875) high-mannose N-glycan folded Spike [endoplasmic reticulum lumen] (R-COV-9696880) high-mannose N-glycan folded Spike [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9766369) high-mannose N-glycan-PALM-Spike [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9696943) di-antennary N-glycan-PALM-Spike [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9696920) complex N-glycan-PALM-Spike S1 Fragment [virion membrane] (R-COV-9694638) complex N-glycan-PALM-Spike S2 Fragment [virion membrane] (R-COV-9694791) complex N-glycan-PALM-Spike S2 Fragment [endocytic vesicle membrane] (R-COV-9694343) complex N-glycan-PALM-Spike S1 Fragment [endocytic vesicle membrane] (R-COV-9694745) fully glycosylated Spike [virion membrane] (R-COV-9698327) fully glycosylated Spike [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9698330) complex N-glycan-PALM-Spike S2 Fragment [plasma membrane] (R-COV-9769952) fully glycosylated Spike [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9696997)	0.623	3
UniProt:P59594 S	12	nascent Spike [endoplasmic reticulum lumen] (R-COV-9682868) N-glycan Spike [endoplasmic reticulum lumen] (R-COV-9683594) trimmed unfolded N-glycan Spike [endoplasmic reticulum lumen] (R-COV-9683716) trimmed N-glycan Spike [endoplasmic reticulum lumen] (R-COV-9683608) trimmed N-glycan-PALM-Spike [endoplasmic reticulum lumen] (R-COV-9683638) trimmed N-glycan-PALM-Spike [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9683657) complex N-glycan-PALM-Spike [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9683617) complex N-glycan-PALM-Spike [virion membrane] (R-COV-9685469) complex N-glycan-PALM-Spike S2 Fragment [endocytic vesicle membrane] (R-COV-9686730) complex N-glycan-PALM-Spike S1 Fragment [endocytic vesicle membrane] (R-COV-9686693) complex N-glycan-PALM-Spike S1 Fragment [virion membrane] (R-COV-9686706) complex N-glycan-PALM-Spike S2 Fragment [virion membrane] (R-COV-9686724)	0.623	2
UniProt:P43235 CTSK	3	CTSK [endolysosome lumen] (R-HSA-1678985) CTSK [extracellular region] (R-HSA-2470897) CTSK [lysosomal lumen] (R-HSA-1181226)	0.527	3

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