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Ub-C85-UBE2D3 [cytosol]
Stable Identifier
R-HSA-8864191
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
UbcH5c, Ubiquitin-conjugating enzyme E2 D3, UB2D3_HUMAN
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by CSF3 (G-CSF) (Homo sapiens)
Inactivation of CSF3 (G-CSF) signaling (Homo sapiens)
SOCS1,3 ubiquitinates CSF3R in SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7 (Homo sapiens)
Ub:UBE2D1,2,3 [cytosol] (Homo sapiens)
Ub-C85-UBE2D1,2,3 [cytosol] (Homo sapiens)
Ub-C85-UBE2D3 [cytosol] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Protein ubiquitination (Homo sapiens)
E3 ubiquitin ligases ubiquitinate target proteins (Homo sapiens)
PEX2:PEX10:PEX12 binds PEX5S,L (in PEX5S:PEX13:PEX14) and Ub:UBE2D1,2,3 (Homo sapiens)
PEX2:PEX10:PEX12:PEX5S,L:Ub:UBE2D1,2,3:PEX13:PEX14 [peroxisomal membrane] (Homo sapiens)
Ub:UBE2D1,2,3 [cytosol] (Homo sapiens)
Ub-C85-UBE2D1,2,3 [cytosol] (Homo sapiens)
Ub-C85-UBE2D3 [cytosol] (Homo sapiens)
Ub:UBE2D1,2,3 [cytosol] (Homo sapiens)
Ub-C85-UBE2D1,2,3 [cytosol] (Homo sapiens)
Ub-C85-UBE2D3 [cytosol] (Homo sapiens)
PEX2:PEX10:PEX12 monoubiquitinates PEX5S,L at cysteine-11 (Homo sapiens)
PEX2:PEX10:PEX12:PEX5S,L:Ub:UBE2D1,2,3:PEX13:PEX14 [peroxisomal membrane] (Homo sapiens)
Ub:UBE2D1,2,3 [cytosol] (Homo sapiens)
Ub-C85-UBE2D1,2,3 [cytosol] (Homo sapiens)
Ub-C85-UBE2D3 [cytosol] (Homo sapiens)
RNF181 binds BCL10 and Ubiquitin:E2 (Homo sapiens)
RNF181:BCL10:Ub:E2 [cytoplasm] (Homo sapiens)
Ub:UBE2D1,UBE2D2,UBE2D3, UBE2E1,UBE2N [cytosol] (Homo sapiens)
Ub-UBE2D1,2,3,UBE2E1,UBE2N [cytosol] (Homo sapiens)
Ub-C85-UBE2D3 [cytosol] (Homo sapiens)
Ub:UBE2D1,UBE2D2,UBE2D3, UBE2E1,UBE2N [cytosol] (Homo sapiens)
Ub-UBE2D1,2,3,UBE2E1,UBE2N [cytosol] (Homo sapiens)
Ub-C85-UBE2D3 [cytosol] (Homo sapiens)
RNF181 polyubiquinates BCL10 (Homo sapiens)
RNF181:BCL10:Ub:E2 [cytoplasm] (Homo sapiens)
Ub:UBE2D1,UBE2D2,UBE2D3, UBE2E1,UBE2N [cytosol] (Homo sapiens)
Ub-UBE2D1,2,3,UBE2E1,UBE2N [cytosol] (Homo sapiens)
Ub-C85-UBE2D3 [cytosol] (Homo sapiens)
Ub:UBE2D1,UBE2D2,UBE2D3, UBE2E1,UBE2N [cytosol] (Homo sapiens)
Ub-UBE2D1,2,3,UBE2E1,UBE2N [cytosol] (Homo sapiens)
Ub-C85-UBE2D3 [cytosol] (Homo sapiens)
Programmed Cell Death (Homo sapiens)
Regulated Necrosis (Homo sapiens)
RIPK1-mediated regulated necrosis (Homo sapiens)
Regulation of necroptotic cell death (Homo sapiens)
STUB1 ubiquitinates RIPK3 at K55, K363 (Homo sapiens)
Ub:UBE2D3 [cytosol] (Homo sapiens)
Ub-C85-UBE2D3 [cytosol] (Homo sapiens)
Protein localization (Homo sapiens)
Peroxisomal protein import (Homo sapiens)
PEX2:PEX10:PEX12 binds PEX5L (in PEX5L:PEX7:PEX13:PEX14:PEX2:PEX10:PEX12) and Ub:UBE2D1,2,3 (Homo sapiens)
PEX2:PEX10:PEX12:PEX5L:Ub:UBE2D1,2,3:PEX7:PEX13:PEX14 [peroxisomal membrane] (Homo sapiens)
Ub:UBE2D1,2,3 [cytosol] (Homo sapiens)
Ub-C85-UBE2D1,2,3 [cytosol] (Homo sapiens)
Ub-C85-UBE2D3 [cytosol] (Homo sapiens)
Ub:UBE2D1,2,3 [cytosol] (Homo sapiens)
Ub-C85-UBE2D1,2,3 [cytosol] (Homo sapiens)
Ub-C85-UBE2D3 [cytosol] (Homo sapiens)
PEX2:PEX10:PEX12 binds PEX5S,L (in PEX5S:PEX13:PEX14) and Ub:UBE2D1,2,3 (Homo sapiens)
PEX2:PEX10:PEX12:PEX5S,L:Ub:UBE2D1,2,3:PEX13:PEX14 [peroxisomal membrane] (Homo sapiens)
Ub:UBE2D1,2,3 [cytosol] (Homo sapiens)
Ub-C85-UBE2D1,2,3 [cytosol] (Homo sapiens)
Ub-C85-UBE2D3 [cytosol] (Homo sapiens)
Ub:UBE2D1,2,3 [cytosol] (Homo sapiens)
Ub-C85-UBE2D1,2,3 [cytosol] (Homo sapiens)
Ub-C85-UBE2D3 [cytosol] (Homo sapiens)
PEX2:PEX10:PEX12 monoubiquitinates PEX5L at cysteine-11 (Homo sapiens)
PEX2:PEX10:PEX12:PEX5L:Ub:UBE2D1,2,3:PEX7:PEX13:PEX14 [peroxisomal membrane] (Homo sapiens)
Ub:UBE2D1,2,3 [cytosol] (Homo sapiens)
Ub-C85-UBE2D1,2,3 [cytosol] (Homo sapiens)
Ub-C85-UBE2D3 [cytosol] (Homo sapiens)
PEX2:PEX10:PEX12 monoubiquitinates PEX5S,L at cysteine-11 (Homo sapiens)
PEX2:PEX10:PEX12:PEX5S,L:Ub:UBE2D1,2,3:PEX13:PEX14 [peroxisomal membrane] (Homo sapiens)
Ub:UBE2D1,2,3 [cytosol] (Homo sapiens)
Ub-C85-UBE2D1,2,3 [cytosol] (Homo sapiens)
Ub-C85-UBE2D3 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P61077 UBE2D3
Gene Names
UBE2D3, UBC5C, UBCH5C
Chain
chain:1-147
Reference Genes
BioGPS Gene:7323 UBE2D3
COSMIC (genes):UBE2D3 UBE2D3
CTD Gene:7323 UBE2D3
dbSNP Gene:7323 UBE2D3
ENSEMBL:ENSG00000109332 UBE2D3
HGNC:12476 UBE2D3
KEGG Gene (Homo sapiens):7323 UBE2D3
Monarch:7323 UBE2D3
NCBI Gene:7323 UBE2D3
OMIM:602963 UBE2D3
UCSC:P61077 UBE2D3
Reference Transcript
RefSeq:NM_181888.3 UBE2D3
RefSeq:NM_181886.3 UBE2D3
RefSeq:NM_181892.3 UBE2D3
RefSeq:NM_181890.2 UBE2D3
RefSeq:NM_181887.2 UBE2D3
RefSeq:NM_003340.6 UBE2D3
RefSeq:NM_181891.2 UBE2D3
RefSeq:NM_181893.2 UBE2D3
RefSeq:NM_181889.2 UBE2D3
Other Identifiers
0002570711
0004200722
0005130050
11719272_s_at
11719273_x_at
11722999_x_at
11742939_a_at
11742940_s_at
11742941_x_at
11742942_s_at
16978470
200667_PM_at
200667_at
200668_PM_s_at
200668_s_at
200669_PM_s_at
200669_s_at
229355_PM_at
229355_at
2779993
2779994
2779995
2779996
2779997
2779998
2779999
2780000
2780001
2780003
2780004
2780005
2780008
2780010
2780017
2780018
2780032
2780033
2780034
2780035
2780036
2780037
2780038
2780039
2780040
2780047
2780048
2780053
3896295
3896296
3896298
39083_at
504_at
50666_at
7323
75179_at
8102024
8180329
8180330
8180331
8180332
8180333
8180334
8180335
91086_at
A_23_P58293
A_24_P363005
A_24_P54847
GE79686
GE85983
GO:0000122
GO:0000166
GO:0000209
GO:0003674
GO:0004842
GO:0005515
GO:0005524
GO:0005575
GO:0005576
GO:0005615
GO:0005622
GO:0005634
GO:0005654
GO:0005737
GO:0005768
GO:0005829
GO:0005886
GO:0006259
GO:0006281
GO:0006464
GO:0006513
GO:0006605
GO:0006810
GO:0006915
GO:0006950
GO:0006974
GO:0007005
GO:0007165
GO:0008150
GO:0008219
GO:0009056
GO:0009058
GO:0010008
GO:0015031
GO:0016020
GO:0016567
GO:0016740
GO:0019787
GO:0030514
GO:0031410
GO:0032446
GO:0034641
GO:0043161
GO:0043167
GO:0043226
GO:0051865
GO:0061630
GO:0061631
GO:0070062
GO:0070936
GO:0070979
GO:1903955
HMNXSV003015059
HMNXSV003054465
Hs.118797.0.A3_3p_at
Hs.118797.1.A1_3p_at
ILMN_1682443
ILMN_1785225
ILMN_1794698
ILMN_2241679
ILMN_2292963
ILMN_2320850
ILMN_2320853
PH_hs_0024881
PH_hs_0033217
U39318_at
g13097281_3p_a_at
g4507776_3p_a_at
Participates
as a member of
Ub-UBE2D1,2,3,UBE2E1,UBE2N [cytosol] (Homo sapiens)
Ub-C85-UBE2D1,2,3 [cytosol] (Homo sapiens)
as a component of
Ub:UBE2D3 [cytosol] (Homo sapiens)
Other forms of this molecule
UBE2D3 [cytosol]
UBE2D3 [nucleoplasm]
Inferred To
Ub-C85-UBE2D1 [cytosol]
(Dictyostelium discoideum)
UBC5 [cytosol]
(Saccharomyces cerevisiae)
Ube2d3 [cytosol]
(Mus musculus)
Ube2d3 [cytosol]
(Rattus norvegicus)
UBE2D3 [cytosol]
(Bos taurus)
UBE2D3 [cytosol]
(Canis familiaris)
UBE2D3 [cytosol]
(Gallus gallus)
UBE2D3 [cytosol]
(Sus scrofa)
Homologues of Ub-C85-UBE2D1 [cytosol]
(Dictyostelium discoideum)
Homologues of Ub-C85-UBE2D1 [cytosol]
(Saccharomyces cerevisiae)
UBC4 [cytosol]
(Saccharomyces cerevisiae)
ubc4 [cytosol]
(Schizosaccharomyces pombe)
ubcB [cytosol]
(Dictyostelium discoideum)
Modified Residues
Name
S-(glycyl)-L-cysteine (Cys-Gly) at 85
Coordinate
85
PsiMod Name
S-(glycyl)-L-cysteine (Cys-Gly)
PsiMod Definition
A protein modification that effectively crosslinks an L-cysteine residue and a glycine residue by a thioester bond to form S-glycyl-L-cysteine.
Cross References
RefSeq
NP_871619.1
,
NP_871617.1
,
NP_871616.1
,
NP_871620.1
,
NP_003331.1
,
NP_871618.1
,
NP_871615.1
,
NP_871622.1
,
NP_871621.1
OpenTargets
ENSG00000109332
IntEnz
2.3.2.23
HPA
ENSG00000109332-UBE2D3
GeneCards
P61077
Ensembl
ENST00000394803
,
ENSP00000345285
,
ENST00000338145
,
ENST00000321805
,
ENST00000453744
,
ENSG00000109332
,
ENST00000349311
,
ENSP00000349722
,
ENSP00000344069
,
ENSP00000337208
,
ENSP00000378280
,
ENST00000343106
,
ENSP00000396901
,
ENST00000357194
,
ENSP00000318494
,
ENSP00000378283
,
ENSP00000378282
,
ENST00000394804
,
ENST00000394801
PRO
P61077
Pharos - Targets
P61077
HMDB Protein
HMDBP00610
PDB
6T7F
,
4BVU
,
7LYB
,
5EGG
,
1X23
,
3UGB
,
4S3O
,
7JZV
,
4R8P
,
2FUH
,
5IFR
,
6CP0
,
3L1Z
,
3RPG
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q6ZNA4 RNF111
2
RNF111 [nucleoplasm]
(R-HSA-2186765)
RNF111 [cytosol]
(R-HSA-975981)
0.742
5
UniProt:Q9Y4K3 TRAF6
8
K48polyUb-TRAF6 [cytosol]
(R-HSA-6783233)
PolyUb-TRAF6 [cytosol]
(R-HSA-6782845)
TRAF6 [endosome membrane]
(R-HSA-450272)
TRAF6 [cytosol]
(R-HSA-166366)
K63polyUb-TRAF6 [cytosol]
(R-HSA-2685681)
K63polyUb-TRAF6 [plasma membrane]
(R-HSA-936980)
TRAF6 [plasma membrane]
(R-HSA-936955)
K63polyUb-TRAF6 [endosome membrane]
(R-HSA-450227)
0.658
3
UniProt:Q8IUQ4 SIAH1
1
SIAH1 [cytosol]
(R-HSA-374563)
0.553
2
UniProt:P98170 XIAP
3
XIAP [nucleoplasm]
(R-HSA-3322366)
K48pUb-XIAP [cytosol]
(R-HSA-5675477)
XIAP [cytosol]
(R-HSA-50849)
0.527
2
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