Reactome | Ub-C85-UBE2D3 [cytosol]

Ub-C85-UBE2D3 [cytosol]

Stable Identifier

R-HSA-8864191

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

UbcH5c, Ubiquitin-conjugating enzyme E2 D3, UB2D3_HUMAN

Locations in the PathwayBrowser

Expand all

Autophagy (Homo sapiens)

- Macroautophagy (Homo sapiens)
  - Selective autophagy (Homo sapiens)
    - Mitophagy (Homo sapiens)
      - PINK1-PRKN Mediated Mitophagy (Homo sapiens)
        
        PRKN ubiquitinates MOM substrates (Homo sapiens)
        
        Ub:Ub-UBE2D2,UBE2D3,UBE2N:UBE2V1,UBE2L3 [cytosol] (Homo sapiens)
        
        Ub-UBE2D2,UBE2D3,UBE2N:UBE2V1,UBE2L3 [cytosol] (Homo sapiens)
        
        Ub-C85-UBE2D3 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P61077 UBE2D3

Gene Names

UBE2D3, UBC5C, UBCH5C

Chain

chain:1-147

Reference Genes

BioGPS Gene:7323 UBE2D3

COSMIC (genes):UBE2D3 UBE2D3

CTD Gene:7323 UBE2D3

dbSNP Gene:7323 UBE2D3

ENSEMBL:ENSG00000109332 UBE2D3

HGNC:12476 UBE2D3

KEGG:hsa:7323 UBE2D3

Monarch:7323 UBE2D3

NCBI Gene:7323 UBE2D3

OMIM:602963 UBE2D3

UCSC:P61077 UBE2D3

Reference Transcript

Other Identifiers

11719272_s_at

11719273_x_at

11722999_x_at

11742939_a_at

11742940_s_at

11742941_x_at

11742942_s_at

16978470

200667_PM_at

200667_at

200668_PM_s_at

200668_s_at

200669_PM_s_at

200669_s_at

223966_PM_at

223966_at

229355_PM_at

229355_at

240383_PM_at

240383_at

2779993

2779994

2779995

2779996

2779997

2779998

2779999

2780000

2780001

2780003

2780004

2780005

2780007

2780008

2780009

2780010

2780011

2780014

2780015

2780016

2780017

2780018

2780019

2780029

2780030

2780032

2780033

2780034

2780035

2780036

2780037

2780038

2780039

2780040

2780047

2780048

2780053

3896295

3896296

3896298

39083_at

504_at

50666_at

60027_r_at

7323

75179_at

8102024

8180329

8180330

8180331

8180332

8180333

8180334

8180335

91086_at

A_23_P58293

A_24_P363005

A_24_P54847

A_24_P926684

GE586183

GE79686

GE85983

GE86446

GO:0000122

GO:0000209

GO:0003824

GO:0004842

GO:0005515

GO:0005524

GO:0005634

GO:0005654

GO:0005768

GO:0005829

GO:0005886

GO:0006281

GO:0006355

GO:0006511

GO:0006513

GO:0006915

GO:0010008

GO:0012501

GO:0016567

GO:0016740

GO:0030163

GO:0030514

GO:0031410

GO:0036211

GO:0043161

GO:0043226

GO:0051865

GO:0061630

GO:0061631

GO:0070062

GO:0070936

GO:0070979

GO:0085020

GO:0140096

GO:1903955

HMNXSV003015059

HMNXSV003029929

HMNXSV003054465

Hs.118797.0.A3_3p_at

Hs.118797.1.A1_3p_at

Hs.15617.0.A1_3p_at

ILMN_2241679

ILMN_2292963

ILMN_2320850

ILMN_2320853

PH_hs_0024881

PH_hs_0033217

U39318_at

g13097281_3p_a_at

g4507776_3p_a_at

g7959870_RC_3p_at

Participates

as a member of

as an output of

STUB1 ubiquitinates RIPK1 at K571, K604, K627 (Homo sapiens)

as a component of

Ub:UBE2D3 [cytosol] (Homo sapiens)

Other forms of this molecule

UBE2D3 [cytosol]

UBE2D3 [nucleoplasm]

Inferred To

Ube2d3 [cytosol] (Mus musculus)

Ube2d3 [cytosol] (Rattus norvegicus)

UBE2D3 [cytosol] (Bos taurus)

UBE2D3 [cytosol] (Canis familiaris)

UBE2D3 [cytosol] (Sus scrofa)

Ub-C85-UBE2D3 [cytosol] (Gallus gallus)

Ghost homologue of Ub-C85-UBE2D3 [cytosol] (Caenorhabditis elegans)

Ghost homologue of Ub-C85-UBE2D3 [cytosol] (Drosophila melanogaster)

Ghost homologue of Ub-C85-UBE2D3 [cytosol] (Plasmodium falciparum)

Ghost homologue of Ub-C85-UBE2D3 [cytosol] (Xenopus tropicalis)

Modified Residues

Name

S-(glycyl)-L-cysteine (Cys-Gly) at 85

Coordinate

PsiMod Name

S-(glycyl)-L-cysteine (Cys-Gly)

PsiMod Definition

A protein modification that effectively crosslinks an L-cysteine residue and a glycine residue by a thioester bond to form S-glycyl-L-cysteine.

Cross References

RefSeq

NP_871619.1, NP_871620.1, NP_871621.1, NP_871616.1, NP_871615.1, NP_871622.1, XP_024309970.1, NP_871618.1, NP_871617.1, NP_003331.1, XP_054206763.1

OpenTargets

ENSG00000109332

ENSEMBL

ENST00000394801, ENST00000321805, ENST00000338145, ENSP00000344069, ENST00000394803, ENST00000343106, ENSP00000318494, ENSP00000345285, ENST00000357194, ENST00000453744, ENSP00000396901, ENSP00000378283, ENSP00000378282, ENSP00000337208, ENST00000349311, ENST00000394804, ENSG00000109332, ENSP00000349722, ENSP00000378280

GeneCards

UBE2D3

HPA

ENSG00000109332-UBE2D3

PRO

P61077

Pharos - Targets

P61077

GlyGen

P61077

HMDB Protein

HMDBP00610

PDB

4BVU, 8UPF, 8SN2, 8SN0, 6CP0, 6T7F, 5IFR, 8UQA, 8UQC, 8SN1, 8UQB, 8UQ9, 8UQE, 8UQ8, 9IPU, 8AMS, 3RPG, 3L1Z, 2FUH, 1X23, 8U14, 8SN3, 8SN6, 8X7I, 8SN4, 8X7J, 8GRQ, 8SMZ, 8SN5, 5EGG, 8UQD, 4S3O, 7JZV, 4R8P, 8SN9, 3UGB, 8X7K, 8SMX, 8SNA, 7LYB, 8SN8, 8SMY, 8SMW, 8SN7

Interactors (31)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q96FW1 OTUB1	2	OTUB1 [cytosol] (R-HSA-933411) OTUB1 [nucleoplasm] (R-HSA-6783242)	0.874	14
UniProt:Q96BH1 RNF25	1	RNF25 [cytosol] (R-HSA-975976)	0.848	9
UniProt:Q99942 RNF5	1	RNF5 [endoplasmic reticulum membrane] (R-HSA-975990)	0.841	11
UniProt:O15344 MID1	1	MID1 [cytosol] (R-HSA-976027)	0.83	8
UniProt:Q9HCM9 TRIM39	1	TRIM39 [cytosol] (R-HSA-5688971)	0.8	6
UniProt:Q9Y4L5 RNF115	1	RNF115 [cytosol] (R-HSA-8850904)	0.781	11
UniProt:Q6ZNA4 RNF111	2	RNF111 [nucleoplasm] (R-HSA-2186765) RNF111 [cytosol] (R-HSA-975981)	0.742	5
UniProt:Q86UW9 DTX2	1	DTX2 [cytosol] (R-HSA-1604436)	0.718	9
UniProt:Q9BV68 RNF126	1	RNF126 [cytosol] (R-HSA-8851642)	0.712	4
UniProt:Q99PZ6 OSPG			0.669	6
UniProt:Q99496 RNF2	1	RNF2 [nucleoplasm] (R-HSA-389119)	0.666	6
UniProt:Q8N9I9 DTX3			0.666	4
UniProt:Q9Y4K3 TRAF6	8	TRAF6 [cytosol] (R-HSA-166366) K63polyUb-TRAF6 [cytosol] (R-HSA-2685681) K63polyUb-TRAF6 [plasma membrane] (R-HSA-936980) TRAF6 [plasma membrane] (R-HSA-936955) K63polyUb-TRAF6 [endosome membrane] (R-HSA-450227) TRAF6 [endosome membrane] (R-HSA-450272) PolyUb-TRAF6 [cytosol] (R-HSA-6782845) K48polyUb-TRAF6 [cytosol] (R-HSA-6783233)	0.658	3
UniProt:Q9Y3C5 RNF11			0.646	3
UniProt:Q8ND25 ZNRF1	1	ZNRF1 [cytosol] (R-HSA-8850903)	0.621	3
UniProt:Q68DV7 RNF43	10	RNF43 [plasma membrane] (R-HSA-5323531) ub-RNF43 [plasma membrane] (R-HSA-5323547) RNF43 G659Vfs41 [plasma membrane] (R-HSA-9666643) RNF43 F69C [plasma membrane] (R-HSA-5340578) RNF43 P154L [plasma membrane] (R-HSA-9666646) RNF43 R132 [plasma membrane] (R-HSA-9666650) RNF43 R117Afs41 [plasma membrane] (R-HSA-9666664) RNF43 A169T [plasma membrane] (R-HSA-9666639) RNF43 R330fs89 [plasma membrane] (R-HSA-5340581) RNF43 E174* [plasma membrane] (R-HSA-5340574)	0.592	2
UniProt:P62879 GNB2	4	GNB2 [cytosol] (R-HSA-6814421) Unfolded GNB2 [cytosol] (R-HSA-6814202) Partially folded GNB2 [cytosol] (R-HSA-8850536) GNB2 [plasma membrane] (R-HSA-164335)	0.556	3
UniProt:Q9BVG3 TRIM62	1	TRIM62 [cytosol] (R-HSA-5624340)	0.556	3
UniProt:Q9HCM9-2 TRIM39			0.556	5
UniProt:Q9UJV3-2 MID2			0.556	3
UniProt:Q9HAC8 UBTD1			0.556	6
IntAct:EBI-22462114 CCSB ORF ID			0.556	5
UniProt:Q8IUQ4 SIAH1	1	SIAH1 [cytosol] (R-HSA-374563)	0.553	2
UniProt:Q6ZN04 MEX3B			0.553	2
UniProt:Q9UKV5 AMFR	1	AMFR [endoplasmic reticulum membrane] (R-HSA-975999)	0.553	2
UniProt:Q9BY78 RNF26			0.553	2
UniProt:Q6PCD5 RFWD3			0.553	2
UniProt:Q8N5U6 RNF10			0.547	2
UniProt:P0CE12 SSPH2			0.544	7
UniProt:P98170 XIAP	3	XIAP [cytosol] (R-HSA-50849) K48pUb-XIAP [cytosol] (R-HSA-5675477) XIAP [nucleoplasm] (R-HSA-3322366)	0.527	2
UniProt:Q9NZS9 BFAR			0.488	2