Reactome | p-S317,467,556,638,T575-ULK1 [cytosol]

p-S317,467,556,638,T575-ULK1 [cytosol]

Stable Identifier

R-HSA-5673747

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Serine/threonine-protein kinase ULK1, ULK1_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:O75385 ULK1

Gene Names

ULK1, KIAA0722

Chain

chain:1-1050

Reference Genes

BioGPS Gene:8408 ULK1

COSMIC (genes):ULK1 ULK1

CTD Gene:8408 ULK1

dbSNP Gene:8408 ULK1

ENSEMBL:ENSG00000177169.10 ULK1

HGNC:12558 ULK1

KEGG Gene (Homo sapiens):8408 ULK1

Monarch:8408 ULK1

NCBI Gene:8408 ULK1

OMIM:603168 ULK1

UCSC:O75385 ULK1

Reference Transcript

RefSeq:NM_003565.2 ULK1

Other Identifiers

11744271_a_at

16759350

209333_PM_at

209333_at

3438528

3438529

3438530

3438531

3438532

3438546

3438547

3438548

3438549

3438550

3438553

3438554

3438555

3438556

3438557

3438558

3438560

3438561

3438562

3438563

3438564

3438565

3438566

3438567

3438570

3438572

3438574

3438576

3438578

3438579

3438580

34827_at

7959957

8408

A_23_P72550

A_24_P73370

GE54394

GO:0000045

GO:0000166

GO:0000407

GO:0000422

GO:0003824

GO:0004672

GO:0004674

GO:0005515

GO:0005524

GO:0005737

GO:0005739

GO:0005741

GO:0005768

GO:0005773

GO:0005776

GO:0005783

GO:0005789

GO:0005829

GO:0006468

GO:0006914

GO:0007005

GO:0007165

GO:0007409

GO:0008104

GO:0008285

GO:0010508

GO:0016236

GO:0016241

GO:0016301

GO:0016310

GO:0016740

GO:0018105

GO:0018107

GO:0023052

GO:0030154

GO:0030424

GO:0031102

GO:0031175

GO:0031267

GO:0031333

GO:0031410

GO:0031669

GO:0034045

GO:0034727

GO:0036211

GO:0042594

GO:0042802

GO:0043226

GO:0044805

GO:0044877

GO:0046777

GO:0048671

GO:0048675

GO:0048856

GO:0051020

GO:0055037

GO:0061709

GO:0065003

GO:0097629

GO:0097632

GO:0106310

GO:0140096

GO:1903059

GO:1990316

GO:2000786

HMNXSV003029832

ILMN_1705144

ILMN_1735052

ILMN_1744560

ILMN_1761288

PH_hs_0003343

TC12001049.hg

g3882164_3p_at

Participates

as a component of

p-S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [cytosol] (Homo sapiens)

Other forms of this molecule

ULK1 [recycling endosome]

p-S758-ULK1 [cytosol]

ULK1 [cytosol]

ULK1 [mitochondrial outer membrane]

p-T180,S317,S467,S556,S638,T575-ULK1 [endoplasmic reticulum membrane]

p-T180,S317,S467,S556,S638,T575-ULK1 [cytosol]

Inferred To

phospho-ULK1 [cytosol] (Bos taurus)

phospho-p-S317,467,556,638,T575-ULK1 [cytosol] (Caenorhabditis elegans)

phospho-p-S317,467,556,638,T575-ULK1 [cytosol] (Canis familiaris)

phospho-p-S317,467,556,638,T575-ULK1 [cytosol] (Danio rerio)

phospho-p-S317,467,556,638,T575-ULK1 [cytosol] (Dictyostelium discoideum)

phospho-p-S317,467,556,638,T575-ULK1 [cytosol] (Drosophila melanogaster)

phospho-p-S317,467,556,638,T575-ULK1 [cytosol] (Gallus gallus)

phospho-p-S317,467,556,638,T575-ULK1 [cytosol] (Mus musculus)

phospho-p-S317,467,556,638,T575-ULK1 [cytosol] (Rattus norvegicus)

phospho-p-S317,467,556,638,T575-ULK1 [cytosol] (Saccharomyces cerevisiae)

phospho-p-S317,467,556,638,T575-ULK1 [cytosol] (Schizosaccharomyces pombe)

phospho-p-S317,467,556,638,T575-ULK1 [cytosol] (Sus scrofa)

phospho-p-S317,467,556,638,T575-ULK1 [cytosol] (Xenopus tropicalis)

Homologues of p-S317,467,556,638,T575-ULK1 [cytosol] (Caenorhabditis elegans)

Homologues of p-S317,467,556,638,T575-ULK1 [cytosol] (Dictyostelium discoideum)

Modified Residues

Name

O-phospho-L-serine at 317

Coordinate

317

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-serine at 467

Coordinate

467

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-serine at 556

Coordinate

556

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-threonine at 575

Coordinate

575

PsiMod Name

O-phospho-L-threonine [MOD:00047]

PsiMod Definition

A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.

Name

O-phospho-L-serine at 638

Coordinate

638

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Cross References

RefSeq

NP_003556.1

ZINC - World Drugs

ULK1_HUMAN

Guide to Pharmacology - Targets

2271

OpenTargets

ENSG00000177169

ZINC - FDA approved

ULK1_HUMAN

ZINC - Substances

ULK1_HUMAN

ZINC target

O75385

ZINC - Biogenic

ULK1_HUMAN

PRO

O75385

PDB

4WNP, 4WNO, 6HYO, 6MNH, 5CI7, 6QAS

ZINC - Investigational

ULK1_HUMAN

IntEnz

2.7.11.1

GeneCards

O75385

HPA

ENSG00000177169-ULK1

Ensembl

ENSP00000324560, ENSG00000177169, ENST00000321867

Pharos - Targets

O75385

ZINC - Predictions - Purchasable

ULK1_HUMAN

HMDB Protein

HMDBP01330

Interactors (25)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O75143 ATG13	3	ATG13 [cytosol] (R-HSA-5333624) p-ATG13 [cytosol] (R-HSA-5675831) p-ATG13 [endoplasmic reticulum membrane] (R-HSA-8948049)	0.926	13
UniProt:Q8TDY2 RB1CC1	3	RB1CC1 [cytosol] (R-HSA-5333627) p-RB1CC1 [cytosol] (R-HSA-5675845) RB1CC1 [endoplasmic reticulum membrane] (R-HSA-8948046)	0.864	11
UniProt:P42345 MTOR	2	MTOR [nucleoplasm] (R-HSA-5083674) MTOR [cytosol] (R-HSA-165662)	0.702	7
IntAct:EBI-4399559 UBIQ			0.697	5
UniProt:P54619 PRKAG1	2	PRKAG1 [nucleoplasm] (R-HSA-2151202) PRKAG1 [cytosol] (R-HSA-380946)	0.669	3
UniProt:Q13131 PRKAA1	3	p-T183-PRKAA1 [cytosol] (R-HSA-380964) PRKAA1 [cytosol] (R-HSA-380935) p-T183-PRKAA1 [nucleoplasm] (R-HSA-2151206)	0.669	3
UniProt:Q96LT7-1 C9ORF72			0.667	5
UniProt:Q9BXW4 MAP1LC3C	3	MAP1LC3C [autophagosome membrane] (R-HSA-5683638) MAP1LC3C(1-147) [cytosol] (R-HSA-5682653) MAP1LC3C [cytosol] (R-HSA-5679223)	0.656	3
UniProt:Q9GZQ8 MAP1LC3B	3	MAP1LC3B [autophagosome membrane] (R-HSA-5683641) MAP1LC3B(2-121) [cytosol] (R-HSA-5682674) MAP1LC3B [cytosol] (R-HSA-5205651)	0.656	3
UniProt:Q9BSB4 ATG101	2	ATG101 [cytosol] (R-HSA-5333634) ATG101 [endoplasmic reticulum membrane] (R-HSA-8948051)	0.643	4
UniProt:Q9Y478 PRKAB1	2	PRKAB1 [nucleoplasm] (R-HSA-2151199) PRKAB1 [cytosol] (R-HSA-380968)	0.641	3
UniProt:Q9C0C7 AMBRA1	2	AMBRA1 [cytosol] (R-HSA-1632831) p-AMBRA1 [cytosol] (R-HSA-1632854)	0.641	3
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.612	8
UniProt:O95166 GABARAP	3	GABARAP [autophagosome membrane] (R-HSA-5683634) GABARAP(1-117) [cytosol] (R-HSA-5682696) GABARAP [cytosol] (R-HSA-975521)	0.609	2
UniProt:P60520 GABARAPL2	3	GABARAPL2 [autophagosome membrane] (R-HSA-5683633) GABARAPL2(1-117) [cytosol] (R-HSA-5682641) GABARAPL2 [cytosol] (R-HSA-5671758)	0.591	3
UniProt:Q96LT7 CI072			0.571	2
UniProt:O75385 ULK1	7	ULK1 [recycling endosome] (R-HSA-8854761) p-S758-ULK1 [cytosol] (R-HSA-5672131) p-S317,467,556,638,T575-ULK1 [cytosol] (R-HSA-5673747) ULK1 [cytosol] (R-HSA-1632847) ULK1 [mitochondrial outer membrane] (R-HSA-8948145) p-T180,S317,S467,S556,S638,T575-ULK1 [endoplasmic reticulum membrane] (R-HSA-8948047) p-T180,S317,S467,S556,S638,T575-ULK1 [cytosol] (R-HSA-5675858)	0.564	3
UniProt:P54646 PRKAA2	4	PRKAA2 [cytosol] (R-HSA-200405) p-T172-PRKAA2 [cytosol] (R-HSA-200417) p-T172-PRKAA2 [nucleoplasm] (R-HSA-164171) PRKAA2 [nucleoplasm] (R-HSA-163682)	0.564	2
UniProt:Q96LT7-2 C9ORF72			0.563	4
UniProt:Q9H0R8 GABARAPL1	3	GABARAPL1 [autophagosome membrane] (R-HSA-5683637) GABARAPL1(1-117) [cytosol] (R-HSA-5682659) GABARAPL1 [cytosol] (R-HSA-5671757)	0.544	2
UniProt:Q9P2M4 TBC1D14	1	TBC1D14 [recycling endosome] (R-HSA-8854764)	0.543	4
UniProt:Q9C0C7-3 AMBRA1			0.524	4
UniProt:Q9Y4K3 TRAF6	8	K48polyUb-TRAF6 [cytosol] (R-HSA-6783233) PolyUb-TRAF6 [cytosol] (R-HSA-6782845) TRAF6 [cytosol] (R-HSA-166366) K63polyUb-TRAF6 [cytosol] (R-HSA-2685681) K63polyUb-TRAF6 [plasma membrane] (R-HSA-936980) TRAF6 [plasma membrane] (R-HSA-936955) K63polyUb-TRAF6 [endosome membrane] (R-HSA-450227) TRAF6 [endosome membrane] (R-HSA-450272)	0.499	2
UniProt:Q8N122 RPTOR	3	p-S722,S792-RPTOR [cytosol] (R-HSA-3132767) RPTOR [cytosol] (R-HSA-3006727) RPTOR [nucleoplasm] (R-HSA-5083664)	0.499	3
UniProt:P04629 NTRK1	4	p-5Y-NTRK1 [Golgi membrane] (R-HSA-3008810) NTRK1 [Golgi membrane] (R-HSA-3008805) NTRK1 [plasma membrane] (R-HSA-3008784) p-5Y-NTRK1 [plasma membrane] (R-HSA-3009413)	0.499	2

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