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K63polyUb-hp-IRAK1 [cytosol]
Stable Identifier
R-HSA-451565
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Icon
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-1 family signaling (Homo sapiens)
Interleukin-1 signaling (Homo sapiens)
K63polyUb-IRAK1 dissociates (Homo sapiens)
K63polyUb-hp-IRAK1 [cytosol] (Homo sapiens)
K63polyUb-hp-IRAK1:p-Pellino-1,2,(3):UBE2N:UBE2V1 [cytosol] (Homo sapiens)
K63polyUb-hp-IRAK1:p-Pellino-1,2,(3) [cytosol] (Homo sapiens)
K63polyUb-hp-IRAK1 [cytosol] (Homo sapiens)
NEMO binds polyubiquitinated IRAK1 (Homo sapiens)
K63polyUb-hp-IRAK1 [cytosol] (Homo sapiens)
Poly-K6-Ub-hp-IRAK1:CHUK:IKBKB:IKBKG [cytosol] (Homo sapiens)
K63polyUb-hp-IRAK1 [cytosol] (Homo sapiens)
Pellino ubiquitinates IRAK1 (Homo sapiens)
K63polyUb-hp-IRAK1:p-Pellino-1,2,(3):UBE2N:UBE2V1 [cytosol] (Homo sapiens)
K63polyUb-hp-IRAK1:p-Pellino-1,2,(3) [cytosol] (Homo sapiens)
K63polyUb-hp-IRAK1 [cytosol] (Homo sapiens)
Innate Immune System (Homo sapiens)
Toll-like Receptor Cascades (Homo sapiens)
Toll Like Receptor 10 (TLR10) Cascade (Homo sapiens)
MyD88 cascade initiated on plasma membrane (Homo sapiens)
IRAK1 recruits IKK complex (Homo sapiens)
NEMO subunit of IKK complex binds to activated IRAK1 (Homo sapiens)
K63-linked polyUb p-IRAK1:TRAF6 [cytosol] (Homo sapiens)
K63polyUb-hp-IRAK1 [cytosol] (Homo sapiens)
TRAF6:K63-linked polyUb p-IRAK1:IKK complex [cytosol] (Homo sapiens)
K63-linked polyUb p-IRAK1:TRAF6 [cytosol] (Homo sapiens)
K63polyUb-hp-IRAK1 [cytosol] (Homo sapiens)
Pellino ubiquitinates hp-IRAK1 (Homo sapiens)
K63-linked polyUb p-IRAK1:TRAF6 [cytosol] (Homo sapiens)
K63polyUb-hp-IRAK1 [cytosol] (Homo sapiens)
Toll Like Receptor 2 (TLR2) Cascade (Homo sapiens)
Toll Like Receptor TLR1:TLR2 Cascade (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
IRAK1 recruits IKK complex (Homo sapiens)
NEMO subunit of IKK complex binds to activated IRAK1 (Homo sapiens)
K63-linked polyUb p-IRAK1:TRAF6 [cytosol] (Homo sapiens)
K63polyUb-hp-IRAK1 [cytosol] (Homo sapiens)
TRAF6:K63-linked polyUb p-IRAK1:IKK complex [cytosol] (Homo sapiens)
K63-linked polyUb p-IRAK1:TRAF6 [cytosol] (Homo sapiens)
K63polyUb-hp-IRAK1 [cytosol] (Homo sapiens)
Pellino ubiquitinates hp-IRAK1 (Homo sapiens)
K63-linked polyUb p-IRAK1:TRAF6 [cytosol] (Homo sapiens)
K63polyUb-hp-IRAK1 [cytosol] (Homo sapiens)
Toll Like Receptor TLR6:TLR2 Cascade (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
IRAK1 recruits IKK complex (Homo sapiens)
NEMO subunit of IKK complex binds to activated IRAK1 (Homo sapiens)
K63-linked polyUb p-IRAK1:TRAF6 [cytosol] (Homo sapiens)
K63polyUb-hp-IRAK1 [cytosol] (Homo sapiens)
TRAF6:K63-linked polyUb p-IRAK1:IKK complex [cytosol] (Homo sapiens)
K63-linked polyUb p-IRAK1:TRAF6 [cytosol] (Homo sapiens)
K63polyUb-hp-IRAK1 [cytosol] (Homo sapiens)
Pellino ubiquitinates hp-IRAK1 (Homo sapiens)
K63-linked polyUb p-IRAK1:TRAF6 [cytosol] (Homo sapiens)
K63polyUb-hp-IRAK1 [cytosol] (Homo sapiens)
Toll Like Receptor 4 (TLR4) Cascade (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
IRAK1 recruits IKK complex (Homo sapiens)
NEMO subunit of IKK complex binds to activated IRAK1 (Homo sapiens)
K63-linked polyUb p-IRAK1:TRAF6 [cytosol] (Homo sapiens)
K63polyUb-hp-IRAK1 [cytosol] (Homo sapiens)
TRAF6:K63-linked polyUb p-IRAK1:IKK complex [cytosol] (Homo sapiens)
K63-linked polyUb p-IRAK1:TRAF6 [cytosol] (Homo sapiens)
K63polyUb-hp-IRAK1 [cytosol] (Homo sapiens)
Pellino ubiquitinates hp-IRAK1 (Homo sapiens)
K63-linked polyUb p-IRAK1:TRAF6 [cytosol] (Homo sapiens)
K63polyUb-hp-IRAK1 [cytosol] (Homo sapiens)
Toll Like Receptor 5 (TLR5) Cascade (Homo sapiens)
MyD88 cascade initiated on plasma membrane (Homo sapiens)
IRAK1 recruits IKK complex (Homo sapiens)
NEMO subunit of IKK complex binds to activated IRAK1 (Homo sapiens)
K63-linked polyUb p-IRAK1:TRAF6 [cytosol] (Homo sapiens)
K63polyUb-hp-IRAK1 [cytosol] (Homo sapiens)
TRAF6:K63-linked polyUb p-IRAK1:IKK complex [cytosol] (Homo sapiens)
K63-linked polyUb p-IRAK1:TRAF6 [cytosol] (Homo sapiens)
K63polyUb-hp-IRAK1 [cytosol] (Homo sapiens)
Pellino ubiquitinates hp-IRAK1 (Homo sapiens)
K63-linked polyUb p-IRAK1:TRAF6 [cytosol] (Homo sapiens)
K63polyUb-hp-IRAK1 [cytosol] (Homo sapiens)
Literature References
PubMed ID
Title
Journal
Year
18347055
Lys63-linked polyubiquitination of IRAK-1 is required for interleukin-1 receptor- and toll-like receptor-mediated NF-kappaB activation
Conze, DB
,
Landstrom, A
,
Ashwell, JD
,
Thomas, JA
,
Wu, CJ
Mol Cell Biol
2008
External Reference Information
External Reference
UniProt:P51617 IRAK1
Gene Names
IRAK1, IRAK
Chain
chain:1-712
Reference Genes
COSMIC (genes):IRAK1 IRAK1
dbSNP Gene:3654 IRAK1
ENSEMBL:ENSG00000184216 IRAK1
Participates
as an output of
K63polyUb-IRAK1 dissociates (Homo sapiens)
as a component of
K63polyUb-hp-IRAK1:p-Pellino-1,2,(3) [cytosol] (Homo sapiens)
Poly-K6-Ub-hp-IRAK1:CHUK:IKBKB:IKBKG [cytosol] (Homo sapiens)
K63-linked polyUb p-IRAK1:TRAF6 [cytosol] (Homo sapiens)
as an input of
NEMO binds polyubiquitinated IRAK1 (Homo sapiens)
Other forms of this molecule
IRAK1 [cytosol]
p-2S,S376,T,T209,T387-IRAK1 [cytosol]
p-2S,S376,T,T209,T387-IRAK1 [plasma membrane]
p-T209,T387-IRAK1 [plasma membrane]
p-T209-IRAK1 [plasma membrane]
IRAK1 [plasma membrane]
p-2S,S376,T,T209,T387-IRAK1 [endosome membrane]
IRAK1 [endosome membrane]
p-T209,T387-IRAK1 [endosome membrane]
p-T209-IRAK1 [endosome membrane]
p-S376,T387-IRAK1 [cytosol]
K63polyUb-hp-IRAK1 [endosome membrane]
p-S,T-IRAK1 [cytosol]
Inferred To
Homologues of K63polyUb-hp-IRAK1 [cytosol]
(Saccharomyces cerevisiae)
phospho-IRAK1 [cytosol]
(Canis familiaris)
Ghost homologue of K63polyUb-hp-IRAK1 [cytosol]
(Danio rerio)
phospho-K63polyUb-hp-IRAK1 [cytosol]
(Bos taurus)
phospho-K63polyUb-hp-IRAK1 [cytosol]
(Caenorhabditis elegans)
phospho-K63polyUb-hp-IRAK1 [cytosol]
(Dictyostelium discoideum)
phospho-K63polyUb-hp-IRAK1 [cytosol]
(Drosophila melanogaster)
phospho-K63polyUb-hp-IRAK1 [cytosol]
(Mus musculus)
phospho-K63polyUb-hp-IRAK1 [cytosol]
(Rattus norvegicus)
phospho-K63polyUb-hp-IRAK1 [cytosol]
(Saccharomyces cerevisiae)
phospho-K63polyUb-hp-IRAK1 [cytosol]
(Schizosaccharomyces pombe)
phospho-K63polyUb-hp-IRAK1 [cytosol]
(Sus scrofa)
Modified Residues
Name
O-phospho-L-threonine at 209
Coordinate
209
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Name
O-phospho-L-serine at 376
Coordinate
376
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-threonine at 387
Coordinate
387
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Name
O-phospho-L-threonine at unknown position
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Name
O-phospho-L-serine at unknown position
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at unknown position
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
ubiquitinylated lysine (K63-polyubiquitin [cytosol]) at 134
Coordinate
134
Modification
K63polyUb [cytosol]
PsiMod Name
ubiquitinylated lysine [MOD:01148]
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.
Name
ubiquitinylated lysine (K63-polyubiquitin [cytosol]) at 160
Coordinate
160
Modification
K63polyUb [cytosol]
PsiMod Name
ubiquitinylated lysine [MOD:01148]
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.
Interactors (22)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9Y4K3 TRAF6
8
TRAF6 [cytosol]
(R-HSA-166366)
K63polyUb-TRAF6 [cytosol]
(R-HSA-2685681)
K63polyUb-TRAF6 [plasma membrane]
(R-HSA-936980)
TRAF6 [plasma membrane]
(R-HSA-936955)
K63polyUb-TRAF6 [endosome membrane]
(R-HSA-450227)
TRAF6 [endosome membrane]
(R-HSA-450272)
PolyUb-TRAF6 [cytosol]
(R-HSA-6782845)
K48polyUb-TRAF6 [cytosol]
(R-HSA-6783233)
0.77
4
UniProt:Q9HAT8 PELI2
2
PELI2 [cytosol]
(R-HSA-450694)
p-PELI2 [cytosol]
(R-HSA-450825)
0.743
4
UniProt:Q96FA3 PELI1
2
PELI1 [cytosol]
(R-HSA-450696)
p-PELI1 [cytosol]
(R-HSA-450815)
0.734
4
UniProt:Q99836 MYD88
8
MyD88 R196C [cytosol]
(R-HSA-5602329)
MyD88 E52del [cytosol]
(R-HSA-5602451)
MyD88 L93P [cytosol]
(R-HSA-5602612)
MyD88 S34Y [cytosol]
(R-HSA-5602521)
MyD88 E65del [cytosol]
(R-HSA-5602598)
MYD88 [endosome membrane]
(R-HSA-975123)
MYD88 [plasma membrane]
(R-HSA-937017)
MYD88 [cytosol]
(R-HSA-166059)
0.723
4
UniProt:Q13526 PIN1
2
PIN1 [nucleoplasm]
(R-HSA-936016)
PIN1 [cytosol]
(R-HSA-9626823)
0.645
10
UniProt:P58753 TIRAP
2
TIRAP [cytosol]
(R-HSA-166141)
p-4Y-TIRAP [plasma membrane]
(R-HSA-2201321)
0.623
3
UniProt:Q8N2H9-2 PELI3
0.589
2
UniProt:O43187 IRAK2
6
IRAK2 [endosome membrane]
(R-HSA-975116)
p-IRAK2 [endosome membrane]
(R-HSA-975187)
IRAK2 [plasma membrane]
(R-HSA-937014)
IRAK2 [cytosol]
(R-HSA-772534)
p-IRAK2 [plasma membrane]
(R-HSA-936949)
p-IRAK2 [cytosol]
(R-HSA-446636)
0.564
3
UniProt:Q9Y616 IRAK3
1
IRAK3 [cytosol]
(R-HSA-166103)
0.564
3
UniProt:Q9NWZ3 IRAK4
9
IRAK4 [cytosol]
(R-HSA-166081)
p-T342,T345,S346-IRAK4 [plasma membrane]
(R-HSA-936957)
IRAK4 [plasma membrane]
(R-HSA-937051)
p-T342,T345,S346-IRAK4 [endosome membrane]
(R-HSA-975149)
IRAK4 [endosome membrane]
(R-HSA-975167)
p-T342,T345,S346-IRAK4 [cytosol]
(R-HSA-446649)
IRAK4 E402* [cytosol]
(R-HSA-5602517)
IRAK4 R12C [cytosol]
(R-HSA-5602511)
IRAK4 Q293* [cytosol]
(R-HSA-5602426)
0.547
2
UniProt:Q5D1E7
1
ZC3H12A [nucleoplasm]
(R-MMU-9774235)
0.544
3
UniProt:Q96EY1 DNJA3
0.527
2
UniProt:Q13451 FKBP5
2
FKBP5 [nucleoplasm]
(R-HSA-8939165)
FKBP5 [cytosol]
(R-HSA-5618096)
0.527
2
UniProt:O60884 DNAJA2
1
DNAJA2 [cytosol]
(R-HSA-3371555)
0.527
2
UniProt:O15027 SEC16A
1
SEC16A [cytosol]
(R-HSA-5685728)
0.527
2
UniProt:P50402 EMD
4
EMD [nuclear envelope]
(R-HSA-201573)
EMD [cytosol]
(R-HSA-9613988)
EMD [endoplasmic reticulum membrane]
(R-HSA-9613998)
EMD [endosome membrane]
(R-HSA-9715092)
0.527
2
UniProt:P31689 DNAJA1
2
SOH-C149,C150-DNAJA1 [cytosol]
(R-HSA-9857072)
DNAJA1 [cytosol]
(R-HSA-3371544)
0.527
2
UniProt:Q9UNE7 STUB1
1
STUB1 [cytosol]
(R-HSA-975970)
0.527
2
UniProt:Q86WV6 STING1
5
STING [endoplasmic reticulum membrane]
(R-HSA-1834940)
K63polyUb-STING [endoplasmic reticulum membrane]
(R-HSA-3134805)
K63polyUb-STING [cytoplasmic vesicle membrane]
(R-HSA-3248021)
TMEM173 [secretory granule membrane]
(R-HSA-6804798)
TMEM173 [plasma membrane]
(R-HSA-6804815)
0.499
2
UniProt:Q92985 IRF7
5
IRF7 [cytosol]
(R-HSA-450281)
p-S477,S479-IRF7 [cytosol]
(R-HSA-450318)
p-S477,S479-IRF7 [nucleoplasm]
(R-HSA-450270)
IRF7 [endosome membrane]
(R-HSA-450274)
K63polyUb-IRF7 [endosome membrane]
(R-HSA-975154)
0.499
2
UniProt:Q15306 IRF4
2
IRF4 [nucleoplasm]
(R-HSA-9907101)
IRF4 [cytosol]
(R-HSA-1015679)
0.499
2
UniProt:Q8VCW4
2
Unc93b1 [endoplasmic reticulum membrane]
(R-MMU-1678930)
Unc93b1 [Golgi membrane]
(R-MMU-1679064)
0.499
2
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