XIAP [cytosol]

Stable Identifier
R-HSA-50849
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Baculoviral IAP repeat-containing protein 4, Inhibitor of apoptosis protein 3, X-linked inhibitor of apoptosis protein, X-linked IAP, IAP-like protein, HILP, BIRC4
Locations in the PathwayBrowser
Expand all
External Reference Information
External Reference
UniProt:P98170 XIAP
Gene Names
XIAP, API3, BIRC4, IAP3
Chain
chain:1-497
Reference Genes
BioGPS Gene:331 XIAP
COSMIC (genes):XIAP XIAP
CTD Gene:331 XIAP
dbSNP Gene:331 XIAP
ENSEMBL:ENSG00000101966.14 XIAP
HGNC:592 XIAP
KEGG Gene (Homo sapiens):331 XIAP
Monarch:331 XIAP
NCBI Gene:331 XIAP
OMIM:300079 XIAP
UCSC:P98170 XIAP
Reference Transcript
Other Identifiers
11725698_x_at
11725699_at
11725700_s_at
11755086_x_at
11757039_a_at
17106723
206536_PM_s_at
206536_s_at
225858_3p_s_at
225858_PM_s_at
225858_s_at
225859_PM_at
225859_at
228363_PM_at
228363_at
235222_3p_x_at
235222_PM_x_at
235222_x_at
243026_PM_x_at
243026_x_at
3263489
331
3989688
3989689
3989690
3989696
3989697
3989698
3989699
3989700
3989701
3989703
3989704
3989705
3989706
3989707
3989708
51813_at
69767_at
78549_at
8169742
92143_r_at
A_14_P118310
A_23_P22460
A_33_P3246990
GO:0002376
GO:0003824
GO:0004842
GO:0004869
GO:0005515
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0005856
GO:0005876
GO:0006915
GO:0006954
GO:0006974
GO:0010466
GO:0010804
GO:0012501
GO:0016055
GO:0016567
GO:0016740
GO:0023052
GO:0030414
GO:0030510
GO:0031398
GO:0036211
GO:0042127
GO:0042802
GO:0042981
GO:0043027
GO:0043066
GO:0043154
GO:0043226
GO:0045088
GO:0046330
GO:0046872
GO:0050727
GO:0051402
GO:0051604
GO:0051726
GO:0052548
GO:0055065
GO:0055070
GO:0060785
GO:0061630
GO:0070424
GO:0090263
GO:0097340
GO:0098542
GO:0098772
GO:0120283
GO:0140096
GO:1902530
GO:1990001
HMNXSV003007420
Hs.201262.0.S1_3p_x_at
Hs.201262.1.S1_3p_a_at
Hs.321435.1.A1_3p_a_at
Hs.321435.1.A1_3p_at
Hs.5367.0.A1_3p_at
Hs2Affx.1.433.S1_3p_x_at
ILMN_1815361
PH_hs_0023989
PH_hs_0041066
TC0X000604.hg
TC0X001858.hg
g1016687_3p_a_at
Participates
as a member of
as a candidate of
as a component of
as an input of
This entity regulates
Negatively
Other forms of this molecule
K48pUb-XIAP [cytosol]
XIAP [nucleoplasm]
Inferred To
XIAP [cytosol] (Bos taurus)
XIAP [cytosol] (Danio rerio)
XIAP [cytosol] (Drosophila melanogaster)
XIAP [cytosol] (Mus musculus)
XIAP [cytosol] (Rattus norvegicus)
XIAP [cytosol] (Schizosaccharomyces pombe)
XIAP [cytosol] (Sus scrofa)
BIRC4 [cytosol] (Canis familiaris)
IAP3 [cytosol] (Gallus gallus)
xiap [cytosol] (Xenopus tropicalis)
Homologues of XIAP [cytosol] (Drosophila melanogaster)
Cross References
RefSeq
Guide to Pharmacology - Targets
OpenTargets
ZINC - Substances
ZINC target
ZINC - Biogenic
PRO
PDB
ZINC - Investigational
IntEnz
HPA
GeneCards
Ensembl
Pharos - Targets
Orphanet
ZINC - Predictions - Purchasable
Interactors (59)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:P55211 CASP9  5 0.97 25
 UniProt:O43464 HTRA2      0.959 23
 UniProt:O43353 RIPK2  2 0.924 21
 UniProt:Q9NR28 DIABLO  2 0.905 9
 UniProt:P40937 RFC5  1 0.83 9
 UniProt:P42574 CASP3  5 0.825 5
 UniProt:P55210 CASP7  5 0.786 4
 UniProt:P98170 XIAP  3 0.785 5
 UniProt:P51668 UBE2D1  3 0.782 6
 UniProt:Q17RB8 LONRF1  1 0.781 7
 UniProt:P61024 CKS1B  1 0.781 7
 UniProt:A5D8V6 VPS37C  1 0.781 7
 UniProt:P83105 HTRA4      0.764 11
 UniProt:P83110-1 HTRA3      0.749 7
 UniProt:Q96FJ2 DYNLL2  4 0.731 4
 UniProt:Q96HA8 NTAQ1      0.712 4
 UniProt:P83110 HTRA3      0.705 8
 UniProt:O43447 PPIH  2 0.696 5
 UniProt:Q9NR28-1 DIABLO      0.676 4
 UniProt:Q15750 TAB1  6 0.674 4
 UniProt:Q13404 UBE2V1  1 0.667 3
 UniProt:Q9HC98 NEK6  2 0.666 4
 UniProt:Q9Y2D8 ADIP      0.666 4
 UniProt:P19447 ERCC3  1 0.666 4
 UniProt:P83110-2 HTRA3      0.661 6
 ChEBI:47924 N,N'-(HEXANE-1,6-DIYL)BIS(1-{(2S)-2-CYCLOHEXYL-2-[(N-METHYL-L-ALANYL)AMINO]ACETYL}-L-PROLYL-BETA-PHENYL-L-PHENYLALANINAMIDE)      0.618 4
 ChEBI:47922 METHYL 1-{(2S)-2-CYCLOHEXYL-2-[(N-METHYL-L-ALANYL)AMINO]ACETYL}-L-PROLYL-BETA-PHENYL-L-PHENYLALANINATE      0.618 6
 UniProt:P46531 NOTCH1  20 0.602 4
 UniProt:P0CG48 UBC  20 0.602 3
 UniProt:P63000 RAC1  6 0.591 3
 UniProt:Q96CN9 GCC1  1 0.556 3
 UniProt:P07686 HEXB  10 0.556 3
 UniProt:Q4G0R1 Q4G0R1      0.556 3
 UniProt:A0A087WZT3 A0A087WZT3      0.556 3
 UniProt:P32502  1 0.556 3
 UniProt:Q06455-2 RUNX1T1      0.556 3
 UniProt:Q01976  1 0.556 3
 UniProt:Q3E793 BOL1      0.556 3
 UniProt:Q9Y3E2 BOLA1      0.556 3
 UniProt:Q8N3J5 PPM1K  1 0.556 3
 UniProt:P38340 NTM1      0.556 3
 UniProt:Q92851-4 CASP10      0.556 3
 UniProt:Q5W5X9-3 TTC23      0.556 3
 UniProt:P47897 QARS1  2 0.556 3
 UniProt:Q96EZ8 MCRS1  1 0.556 3
 UniProt:Q92851 CASP10  4 0.556 3
 UniProt:P57078 RIPK4      0.544 2
 UniProt:P62837 UBE2D2  4 0.527 2
 UniProt:P61088 UBE2N  5 0.527 2
 UniProt:Q9HC29 NOD2  1 0.527 2
 UniProt:P61077 UBE2D3  3 0.527 2
 UniProt:Q8IUQ4 SIAH1  1 0.524 3
 UniProt:Q9Y4K3 TRAF6  8 0.519 2
 UniProt:P63167 DYNLL1  6 0.508 2
 UniProt:Q9Y5V3 MAGED1  1 0.508 2
 UniProt:O14618 CCS  2 0.499 2
 UniProt:Q9JIQ3-PRO_0000021073 DIABLO      0.499 3
 UniProt:Q08379 GOLGA2  3 0.488 2
 UniProt:P50570 DNM2  5 0.488 2
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