Reactome | K48pUb-XIAP [cytosol]

K48pUb-XIAP [cytosol]

Stable Identifier

R-HSA-5675477

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

K48pUB-Baculoviral IAP repeat-containing protein 4, Inhibitor of apoptosis protein 3, X-linked inhibitor of apoptosis protein, X-linked IAP, IAP-like protein, HILP

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P98170 XIAP

Gene Names

XIAP, API3, BIRC4, IAP3

Chain

chain:1-497

Reference Genes

COSMIC (genes):XIAP XIAP

ENSEMBL:ENSG00000101966 XIAP

HGNC:592 XIAP

UCSC:P98170 XIAP

Other Identifiers

11725698_x_at

11725699_at

11725700_s_at

11755086_x_at

11757039_a_at

17106723

206536_PM_s_at

206536_s_at

225858_3p_s_at

225858_PM_s_at

225858_s_at

225859_PM_at

225859_at

228363_PM_at

228363_at

235222_3p_x_at

235222_PM_x_at

235222_x_at

243026_PM_x_at

243026_x_at

3263489

331

3989687

3989688

3989689

3989690

3989694

3989695

3989696

3989697

3989698

3989699

3989700

3989701

3989703

3989704

3989705

3989706

3989707

3989708

51813_at

69767_at

72320_at

78549_at

8169742

92143_r_at

A_14_P118310

A_23_P22460

A_33_P3246990

GE612545

GO:0003824

GO:0004842

GO:0004869

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0006511

GO:0006915

GO:0006974

GO:0007249

GO:0008270

GO:0010804

GO:0016055

GO:0016740

GO:0019805

GO:0030414

GO:0030510

GO:0031398

GO:0032480

GO:0032481

GO:0032496

GO:0038066

GO:0042742

GO:0042802

GO:0042981

GO:0043027

GO:0043066

GO:0043123

GO:0043124

GO:0045088

GO:0046330

GO:0046872

GO:0050727

GO:0051402

GO:0051726

GO:0055070

GO:0060785

GO:0061630

GO:0070424

GO:0070427

GO:0070431

GO:0070534

GO:0090263

GO:0097039

GO:0097194

GO:0098542

GO:0098772

GO:0120283

GO:0140096

GO:1902530

HMNXSV003007420

Hs.201262.0.S1_3p_x_at

Hs.201262.1.S1_3p_a_at

Hs.321435.1.A1_3p_a_at

Hs.321435.1.A1_3p_at

Hs.5367.0.A1_3p_at

Hs2Affx.1.433.S1_3p_x_at

ILMN_1815361

PH_hs_0023989

PH_hs_0041066

TC0X000604.hg

TC0X001858.hg

g1016687_3p_a_at

Participates

as a candidate of

K48pUb- BIRC2,3,4 [cytosol] (Homo sapiens)

Other forms of this molecule

XIAP [cytosol]

XIAP [nucleoplasm]

Inferred To

BIRC8 [cytosol] (Gallus gallus)

XIAP [cytosol] (Bos taurus)

XIAP [cytosol] (Sus scrofa)

BIRC4 [cytosol] (Canis familiaris)

Diap2 [cytosol] (Drosophila melanogaster)

Diap1 [cytosol] (Drosophila melanogaster)

Homologues of K48pUb-XIAP [cytosol] (Drosophila melanogaster)

xiap [cytosol] (Danio rerio)

Xiap [cytosol] (Mus musculus)

Xiap [cytosol] (Rattus norvegicus)

Modified Residues

Name

ubiquitinylated lysine (K48polyUb [cytosol]) at unknown position

Modification

K48polyUb [cytosol]

PsiMod Name

ubiquitinylated lysine [MOD:01148]

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.

Cross References

Guide to Pharmacology - Targets

2790

OpenTargets

ENSG00000101966

ENSEMBL

ENST00000422098, ENSP00000405529, ENSG00000101966, ENST00000355640, ENSP00000360242, ENST00000371199, ENSP00000347858

ZINC - Substances

XIAP_HUMAN

ZINC - Biogenic

XIAP_HUMAN

ZINC target

P98170

PRO

P98170

GlyGen

P98170

ZINC - Investigational

XIAP_HUMAN

IntEnz

2.3.2.27

HPA

ENSG00000101966-XIAP

Pharos - Targets

P98170

Orphanet

XIAP

ZINC - Predictions - Purchasable

XIAP_HUMAN

Interactors (70)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P55211 CASP9	5	CASP9(1-416) [cytosol] (R-HSA-57033) CASP9(?-315) [cytosol] (R-HSA-141638) CASP9(331-416) [cytosol] (R-HSA-141639) p-T412-CASP9(1-416) [cytosol] (R-HSA-9627087) p-S196-CASP9(1-416) [cytosol] (R-HSA-198636)	0.97	25
UniProt:O43464 HTRA2	1	HTRA2 [mitochondrial intermembrane space] (R-HSA-56655)	0.959	23
UniProt:O43353 RIPK2	2	Ub-209-RIPK2 [cytosol] (R-HSA-706483) RIPK2 [cytosol] (R-HSA-168402)	0.951	22
UniProt:Q9NR28 DIABLO	2	DIABLO [cytosol] (R-HSA-114298) DIABLO [mitochondrial intermembrane space] (R-HSA-64637)	0.939	12
UniProt:P42574 CASP3	5	CASP3(1-277) [cytosol] (R-HSA-57021) CASP3(29-175) [nucleoplasm] (R-HSA-211194) CASP3(176-277) [nucleoplasm] (R-HSA-211203) CASP3(29-175) [cytosol] (R-HSA-141644) CASP3(176-277) [cytosol] (R-HSA-141646)	0.872	7
UniProt:Q96FJ2 DYNLL2	4	DYNLL2 [cytosol] (R-HSA-2029024) DYNLL2 [plasma membrane] (R-HSA-140527) DYNLL2 [cilium] (R-HSA-5624865) DYNLL2 [ciliary tip] (R-HSA-5625337)	0.846	6
UniProt:P55210 CASP7	5	CASP7(24-198) [nucleoplasm] (R-HSA-351927) CASP7(207-303) [nucleoplasm] (R-HSA-351924) CASP7(2-303) [cytosol] (R-HSA-57029) CASP7(24-198) [cytosol] (R-HSA-141641) CASP7(207-303) [cytosol] (R-HSA-141642)	0.836	6
UniProt:P40937 RFC5	1	RFC5 [nucleoplasm] (R-HSA-68427)	0.83	9
UniProt:P98170 XIAP	3	XIAP [cytosol] (R-HSA-50849) K48pUb-XIAP [cytosol] (R-HSA-5675477) XIAP [nucleoplasm] (R-HSA-3322366)	0.785	5
UniProt:P51668 UBE2D1	4	UBE2D1 [cytosol] (R-HSA-174236) UBE2D1 [nucleoplasm] (R-HSA-174197) Ub-C85-UBE2D1 [cytosol] (R-HSA-8864160) Ub-C85-UBE2D1 [nucleoplasm] (R-HSA-8937534)	0.782	6
UniProt:A5D8V6 VPS37C	1	VPS37C [endosome membrane] (R-HSA-184438)	0.781	7
UniProt:P61024 CKS1B	1	CKS1B [nucleoplasm] (R-HSA-187533)	0.781	7
UniProt:Q17RB8 LONRF1	1	LONRF1 [cytosol] (R-HSA-8850905)	0.781	7
UniProt:P83105 HTRA4			0.764	11
UniProt:P83110-1 HTRA3			0.749	7
UniProt:Q15750 TAB1	6	TAB1 [cytosol] (R-HSA-167923) TAB1 [endosome membrane] (R-HSA-450238) TAB1(1-444) [cytosol] (R-HSA-9729751) TAB1(1-132) [cytosol] (R-HSA-9729698) TAB1(133-504) [cytosol] (R-HSA-9729724) TAB1(445-504) [cytosol] (R-HSA-9729691)	0.748	5
UniProt:P63167 DYNLL1	6	DYNLL1 [cytosol] (R-HSA-387105) DYNLL1 [plasma membrane] (R-HSA-54017) DYNLL1 [ficolin-1-rich granule membrane] (R-HSA-6801518) DYNLL1 [tertiary granule membrane] (R-HSA-6801482) DYNLL1 [cilium] (R-HSA-5624863) DYNLL1 [ciliary tip] (R-HSA-5625335)	0.725	4
UniProt:Q96HA8 NTAQ1			0.712	4
UniProt:P83110 HTRA3			0.705	8
UniProt:O43447 PPIH	2	PPIH [nucleoplasm] (R-HSA-6806776) PPIH [cytosol] (R-HSA-9728791)	0.696	5
UniProt:Q9NR28-1 DIABLO			0.676	4
UniProt:Q13404 UBE2V1	1	UBE2V1 [cytosol] (R-HSA-205753)	0.667	3
UniProt:P19447 ERCC3	1	ERCC3 [nucleoplasm] (R-HSA-67439)	0.666	4
UniProt:Q9Y2D8 ADIP			0.666	4
UniProt:Q9HC98 NEK6	2	p-S206-NEK6 [cytosol] (R-HSA-2984253) NEK6 [cytosol] (R-HSA-2530596)	0.666	4
UniProt:P83110-2 HTRA3			0.661	6
UniProt:Q9Y240 CLC11			0.643	3
ChEBI:47922 METHYL 1-{(2S)-2-CYCLOHEXYL-2-[(N-METHYL-L-ALANYL)AMINO]ACETYL}-L-PROLYL-BETA-PHENYL-L-PHENYLALANINATE			0.618	6
ChEBI:47924 N,N'-(HEXANE-1,6-DIYL)BIS(1-{(2S)-2-CYCLOHEXYL-2-[(N-METHYL-L-ALANYL)AMINO]ACETYL}-L-PROLYL-BETA-PHENYL-L-PHENYLALANINAMIDE)			0.618	4
UniProt:P0CG48 UBC	20	UBC(381-456) [endocytic vesicle membrane] (R-HSA-939218) UBC(533-608) [endocytic vesicle membrane] (R-HSA-939220) UBC(609-684) [endocytic vesicle membrane] (R-HSA-939223) UBC(457-532) [endocytic vesicle membrane] (R-HSA-939195) UBC(153-228) [endocytic vesicle membrane] (R-HSA-939194) UBC(305-380) [endocytic vesicle membrane] (R-HSA-939228) UBC(229-304) [endocytic vesicle membrane] (R-HSA-939177) UBC(77-152) [endocytic vesicle membrane] (R-HSA-939210) UBC(1-76) [endocytic vesicle membrane] (R-HSA-939245) Ub-565-UBC(533-608) [mitochondrial outer membrane] (R-HSA-6783166) Ub-337-UBC(305-380) [mitochondrial outer membrane] (R-HSA-6783121) Ub-185-UBC(153-228) [mitochondrial outer membrane] (R-HSA-6783154) Ub-261-UBC(229-304) [mitochondrial outer membrane] (R-HSA-6783028) Ub-413-UBC(381-456) [mitochondrial outer membrane] (R-HSA-6783061) Ub-109-UBC(77-152) [mitochondrial outer membrane] (R-HSA-6783158) Ub-641-UBC(609-684) [mitochondrial outer membrane] (R-HSA-6783182) Ub-33-UBC(1-76) [mitochondrial outer membrane] (R-HSA-6783073) Ub-489-UBC(457-532) [mitochondrial outer membrane] (R-HSA-6783078) Ub-386-UBC(381-456) [mitochondrial outer membrane] (R-HSA-6783067) Ub-6-UBC(1-76) [mitochondrial outer membrane] (R-HSA-6783122)	0.602	3
UniProt:P46531 NOTCH1	20	NOTCH1 L1678P S2 cleavage fragment [extracellular region] (R-HSA-2730745) NOTCH1 I1680N S2 cleavage fragment [extracellular region] (R-HSA-2730744) NOTCH1 I1718T S2 cleavage fragment [extracellular region] (R-HSA-2730757) NOTCH1 A1701P S2 cleavage fragment [plasma membrane] (R-HSA-2730742) NOTCH1 V1676D S2 cleavage fragment [extracellular region] (R-HSA-2730755) NOTCH1 I1680N Transmembrane Fragment [plasma membrane] (R-HSA-2684869) NOTCH1 I1718T Transmembrane Fragment [plasma membrane] (R-HSA-2684881) NOTCH1 I1616T Extracellular Fragment [extracellular region] (R-HSA-2684866) NOTCH1 L1596H Extracellular Fragment [extracellular region] (R-HSA-2684853) NOTCH1 L1678P Transmembrane Fragment [plasma membrane] (R-HSA-1485591) NOTCH1 A1701P Transmembrane Fragment [plasma membrane] (R-HSA-1485585) NOTCH1 I1616N Extracellular Fragment [extracellular region] (R-HSA-2684862) NOTCH1 L1593P Extracellular Fragment [extracellular region] (R-HSA-1485584) NOTCH1 R1598P Extracellular Fragment [extracellular region] (R-HSA-1485592) NOTCH1 V1576E Extracellular Fragment [extracellular region] (R-HSA-2684852) NOTCH1 V1676D Transmembrane Fragment [plasma membrane] (R-HSA-2684874) NOTCH1 F1592S Extracellular Fragment [extracellular region] (R-HSA-2684847) NOTCH1 L1574Q Extracellular Fragment [extracellular region] (R-HSA-2691203) p-NICD1 Q2440* [nucleoplasm] (R-HSA-2902207) p-NICD1 Q2395* [nucleoplasm] (R-HSA-2902205)	0.602	4
UniProt:P63000 RAC1	6	RAC1 [plasma membrane] (R-HSA-351141) RAC1 [cytosol] (R-HSA-442615) GGC-PalmC-RAC1 [plasma membrane] (R-HSA-2316446) RAC1 [ficolin-1-rich granule membrane] (R-HSA-6804802) RAC1 [secretory granule membrane] (R-HSA-6804770) RAC1 [endoplasmic reticulum membrane] (R-HSA-5672076)	0.591	3
UniProt:Q96CN9 GCC1	1	GCC1 [cytosol] (R-HSA-6813877)	0.556	3
UniProt:P07686 HEXB	11	HEXB S62L [lysosomal lumen] (R-HSA-3700901) HEXB R284* [lysosomal lumen] (R-HSA-3700930) HEXB M26Cfs5 [lysosomal lumen] (R-HSA-3700843) HEXB I322Kfs5 [lysosomal lumen] (R-HSA-3700889) HEXB(315-556) [extracellular region] (R-HSA-6806188) HEXB(122-311) [extracellular region] (R-HSA-6806190) HEXB(315-556) [azurophil granule lumen] (R-HSA-6799134) HEXB(122-311) [azurophil granule lumen] (R-HSA-6799125) HEXB(50-107) [lysosomal lumen] (R-HSA-9842398) HEXB(122-311) [lysosomal lumen] (R-HSA-1605777) HEXB(316-556) [lysosomal lumen] (R-HSA-1605605)	0.556	3
UniProt:Q4G0R1 Q4G0R1			0.556	3
UniProt:A0A087WZT3 A0A087WZT3			0.556	3
UniProt:Q92851 CASP10	4	CASP10(1-521) [cytosol] (R-HSA-933453) CASP10(416-521) [cytosol] (R-HSA-933455) CASP10(1-219) [cytosol] (R-HSA-933454) CASP10(220-415) [cytosol] (R-HSA-933458)	0.556	3
UniProt:P32502	1	GCD7 [cytosol] (R-SCE-72519)	0.556	3
UniProt:Q06455-2 RUNX1T1			0.556	3
UniProt:Q01976	1	YSA1 [cytosol] (R-SCE-2393933)	0.556	3
UniProt:Q96EZ8 MCRS1	1	MCRS1 [nucleoplasm] (R-HSA-3321849)	0.556	3
UniProt:P47897 QARS1	2	QARS [cytosol] (R-HSA-379615) QARS [mitochondrial matrix] (R-HSA-379592)	0.556	3
UniProt:Q5W5X9-3 TTC23			0.556	3
UniProt:Q92851-4 CASP10			0.556	3
UniProt:P38340 NTM1			0.556	3
UniProt:Q8N3J5 PPM1K	2	H139Hfs13* PPM1K [mitochondrial matrix] (R-HSA-9912515) PPM1K [mitochondrial matrix] (R-HSA-5693145)	0.556	3
UniProt:Q9Y3E2 BOLA1			0.556	3
UniProt:Q3E793 BOL1			0.556	3
UniProt:P57078 RIPK4			0.544	2
UniProt:O75173 ADAMTS4	4	ADAMTS4 [extracellular region] (R-HSA-2533998) ADAMTS4 [endoplasmic reticulum lumen] (R-HSA-5173253) glc-fuc-ADAMTS4 [endoplasmic reticulum lumen] (R-HSA-5172994) O-fuc-ADAMTS4 [endoplasmic reticulum lumen] (R-HSA-5173144)	0.527	3
UniProt:P61088 UBE2N	5	UBE2N [cytosol] (R-HSA-206072) Ub-C87-UBE2N [cytosol] (R-HSA-8864210) UBE2N [nucleoplasm] (R-HSA-5682541) K63polyUb-C87-UBE2N [nucleoplasm] (R-HSA-6790511) Ub-C87-UBE2N [nucleoplasm] (R-HSA-8943013)	0.527	2
UniProt:Q96P09 BIRC8			0.527	3
UniProt:Q96IK5 GMCL1			0.527	2
UniProt:Q5T6F0 DCA12			0.527	3
UniProt:P61077 UBE2D3	3	Ub-C85-UBE2D3 [cytosol] (R-HSA-8864191) UBE2D3 [cytosol] (R-HSA-934630) UBE2D3 [nucleoplasm] (R-HSA-205341)	0.527	2
UniProt:Q86WC4 OSTM1	1	OSTM1 [lysosomal membrane] (R-HSA-2730944)	0.527	2
UniProt:Q9HC29 NOD2	1	NOD2 [cytosol] (R-HSA-168411)	0.527	2
UniProt:Q96CA5 BIRC7	1	BIRC7 [cytosol] (R-HSA-50855)	0.527	3
UniProt:Q13490 BIRC2	5	BIRC2 [cytosol] (R-HSA-50847) K48pUb-BIRC2 [cytosol] (R-HSA-5675479) BIRC2(373-618) [cytosol] (R-HSA-202931) BIRC2(1-372) [cytosol] (R-HSA-202913) K63polyUb-BIRC2 [cytosol] (R-HSA-5668512)	0.527	3
UniProt:Q99623 PHB2	1	PHB2 [mitochondrial inner membrane] (R-HSA-8953721)	0.527	3
UniProt:O75325 LRRN2			0.527	2
UniProt:P24158 PRTN3	4	PRTN3 [plasma membrane] (R-HSA-5610100) PRTN3 [extracellular region] (R-HSA-6801682) PRTN3 [azurophil granule lumen] (R-HSA-6799223) PRTN3 [cytosol] (R-HSA-448623)	0.527	4
UniProt:P62837 UBE2D2	4	Ub-C85-UBE2D2 [cytosol] (R-HSA-8864214) UBE2D2 [cytosol] (R-HSA-934628) UBE2D2 [nucleoplasm] (R-HSA-8852067) Ub-C85-UBE2D2 [nucleoplasm] (R-HSA-8864153)	0.527	2
UniProt:Q8IUQ4 SIAH1	1	SIAH1 [cytosol] (R-HSA-374563)	0.524	3
UniProt:Q9Y4K3 TRAF6	8	TRAF6 [cytosol] (R-HSA-166366) K63polyUb-TRAF6 [cytosol] (R-HSA-2685681) K63polyUb-TRAF6 [plasma membrane] (R-HSA-936980) TRAF6 [plasma membrane] (R-HSA-936955) K63polyUb-TRAF6 [endosome membrane] (R-HSA-450227) TRAF6 [endosome membrane] (R-HSA-450272) PolyUb-TRAF6 [cytosol] (R-HSA-6782845) K48polyUb-TRAF6 [cytosol] (R-HSA-6783233)	0.519	2
UniProt:Q9Y5V3 MAGED1	1	MAGED1 [cytosol] (R-HSA-196002)	0.508	2
UniProt:O14618 CCS	2	CCS [mitochondrial intermembrane space] (R-HSA-3777060) CCS [cytosol] (R-HSA-3299714)	0.499	2
UniProt:Q9JIQ3-PRO_0000021073 DIABLO			0.499	3
UniProt:Q08379 GOLGA2	3	p-S37-GOLGA2 [Golgi membrane] (R-HSA-2172179) GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-2167933) GOLGA2 [Golgi membrane] (R-HSA-6808764)	0.488	2
UniProt:P50570 DNM2	5	DNM2 [plasma membrane] (R-HSA-2984201) DNM2 [lysosomal membrane] (R-HSA-2980840) DNM2 [endocytic vesicle membrane] (R-HSA-2029000) DNM2 [cytosol] (R-HSA-2213180) DNM2 [Golgi membrane] (R-HSA-2980842)	0.488	2

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