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IRAK1
Stable Identifier
R-HSA-975127
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
endosome membrane
Synonyms
Interleukin-1 receptor-associated kinase 1, IRAK1_HUMAN
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Toll-Like Receptors Cascades (Homo sapiens)
Toll Like Receptor 7/8 (TLR7/8) Cascade (Homo sapiens)
MyD88 dependent cascade initiated on endosome (Homo sapiens)
First phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR 7/8 or 9 (Homo sapiens)
IRAK1:p-S,2T-IRAK4 :oligo-MyD88:activated TLR 7/8 or 9 [endosome membrane] (Homo sapiens)
IRAK1 [endosome membrane] (Homo sapiens)
IRAK1/or IRAK2 binds to the activated IRAK4 :MyD88:activated TLR 7/8 or 9. (Homo sapiens)
IRAK1/or IRAK2 :p-S,2T-IRAK4:oligo-MyD88:activated TLR 7/8 or 9 [endosome membrane] (Homo sapiens)
IRAK1/ IRAK2 [endosome membrane] (Homo sapiens)
IRAK1 [endosome membrane] (Homo sapiens)
Toll Like Receptor 9 (TLR9) Cascade (Homo sapiens)
MyD88 dependent cascade initiated on endosome (Homo sapiens)
First phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR 7/8 or 9 (Homo sapiens)
IRAK1:p-S,2T-IRAK4 :oligo-MyD88:activated TLR 7/8 or 9 [endosome membrane] (Homo sapiens)
IRAK1 [endosome membrane] (Homo sapiens)
IRAK1/or IRAK2 binds to the activated IRAK4 :MyD88:activated TLR 7/8 or 9. (Homo sapiens)
IRAK1/or IRAK2 :p-S,2T-IRAK4:oligo-MyD88:activated TLR 7/8 or 9 [endosome membrane] (Homo sapiens)
IRAK1/ IRAK2 [endosome membrane] (Homo sapiens)
IRAK1 [endosome membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P51617 IRAK1
Gene Names
IRAK1, IRAK
Chain
chain:1-712
Reference Genes
BioGPS Gene:3654 IRAK1
COSMIC (genes):IRAK1 IRAK1
CTD Gene:3654 IRAK1
dbSNP Gene:3654 IRAK1
ENSEMBL:ENSG00000184216 IRAK1
HGNC:6112 IRAK1
KEGG Gene (Homo sapiens):hsa:3654 IRAK1
Monarch:3654 IRAK1
NCBI Gene:3654 IRAK1
OMIM:300283 IRAK1
UCSC:P51617 IRAK1
Reference Transcript
RefSeq:NM_001025243.1 IRAK1
RefSeq:NM_001569.3 IRAK1
RefSeq:NM_001025242.1 IRAK1
Other Identifiers
0002230021
1100_at
11734006_a_at
1555784_s_at
17115428
201587_s_at
3654
4461
54476
8175977
A_23_P73780
A_33_P3286616
AAC08756
AAC41949
AAH14963
AAH54000
AAK62888
AAY88246
AF030876
AF346607
BC014963
BC054000
CAB004461
CCDS14740
CCDS35443
CCDS35444
CH471172
DQ054788
EAW72762
EAW72763
EAW72764
EAW72765
ENSG00000184216
ENSP00000358991
ENSP00000358997
ENSP00000377291
ENST00000369974
ENST00000369980
ENST00000393687
EntrezGene:3654
g4755143_3p_s_at
GE62370
GO:0000166
GO:0000187
GO:0001959
GO:0002224
GO:0002376
GO:0002755
GO:0004672
GO:0004674
GO:0004704
GO:0005515
GO:0005524
GO:0005634
GO:0005737
GO:0005811
GO:0005829
GO:0005886
GO:0006468
GO:0007165
GO:0007178
GO:0007250
GO:0007254
GO:0007568
GO:0010008
GO:0016020
GO:0016301
GO:0016310
GO:0016740
GO:0019221
GO:0031072
GO:0031663
GO:0032088
GO:0032481
GO:0032496
GO:0034134
GO:0034142
GO:0034162
GO:0034605
GO:0042803
GO:0043066
GO:0043123
GO:0043406
GO:0045087
GO:0045323
GO:0045893
GO:0046777
GO:0046982
GO:0048661
GO:0051092
GO:0051259
GO:0060337
GO:0070423
GO:0070498
GO:0070555
GO:0071222
GO:0071456
HGNC:6112
HPA054476
Hs.522819
Hs2.182018.3.S1_3p_s_at
ILMN_1738397
ILMN_2379130
ILMN_3310740
IPR000488
IPR000719
IPR008271
IPR011009
IPR011029
IPR017441
IRAK1
IRAK1-202
IRAK1-203
IRAK1-204
L76191
L76191_at
MIM:300283
NM_001025242
NM_001025243
NM_001569
NP_001020413
NP_001020414
NP_001560
PF00069
PF00531
PH_hs_0010754
SM00220
TC0X001524.hg
U52112
uc004fjr.2
uc004fjs.2
uc004fjt.2
UPI000012D873
UPI00001AFC0C
UPI0000453679
XM_011531158
XP_011529460
Participant Of
hasMember
IRAK1/ IRAK2 [endosome membrane]
hasComponent
IRAK1:p-S,2T-IRAK4 :oligo-MyD88:activated TLR 7/8 or 9 [endosome membrane]
Other forms of this molecule
K63polyUb-hp-IRAK1 [endosome membrane]
p-S376,T387-IRAK1 [cytosol]
p-2S,S376,T,T209,T387-IRAK1 [cytosol]
p-2S,S376,T,T209,T387-IRAK1 [plasma membrane]
p-T209,T387-IRAK1 [plasma membrane]
p-T209-IRAK1 [plasma membrane]
IRAK1 [plasma membrane]
IRAK1 [cytosol]
K63polyUb-hp-IRAK1 [cytosol]
p-2S,S376,T,T209,T387-IRAK1 [endosome membrane]
p-T209,T387-IRAK1 [endosome membrane]
p-T209-IRAK1 [endosome membrane]
p-S,T-IRAK1 [cytosol]
Inferred To
Homologues of IRAK1 [endosome membrane] (Danio rerio)
Homologues of IRAK1 [endosome membrane] (Xenopus tropicalis)
Ghost homologue of IRAK1 [endosome membrane] (Gallus gallus)
Ghost homologue of IRAK1 [endosome membrane] (Taeniopygia guttata)
IRAK1 [endosome membrane] (Bos taurus)
IRAK1 [endosome membrane] (Canis familiaris)
IRAK1 [endosome membrane] (Danio rerio)
IRAK1 [endosome membrane] (Drosophila melanogaster)
IRAK1 [endosome membrane] (Mus musculus)
IRAK1 [endosome membrane] (Rattus norvegicus)
IRAK1 [endosome membrane] (Sus scrofa)
IRAK1 [endosome membrane] (Xenopus tropicalis)
Cross References
RefSeq
NP_001020414.1
,
NP_001560.2
,
NP_001020413.1
ZINC - World Drugs
IRAK1_HUMAN
Brenda
2.7.11.1
ZINC - FDA approved
IRAK1_HUMAN
GeneCards
P51617
ZINC - Substances
IRAK1_HUMAN
ZINC target
P51617
PRO
P51617
Orphanet
22427
ZINC - Predictions - Purchasable
IRAK1_HUMAN
PDB
6BFN
Interactors (15)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9HAT8 PELI2
2
p-PELI2 [cytosol]
(R-HSA-450825)
PELI2 [cytosol]
(R-HSA-450694)
0.743
4
UniProt:Q96FA3 PELI1
2
p-PELI1 [cytosol]
(R-HSA-450815)
PELI1 [cytosol]
(R-HSA-450696)
0.734
4
UniProt:Q9Y4K3 TRAF6
8
K63polyUb-TRAF6 [cytosol]
(R-HSA-2685681)
K48polyUb-TRAF6 [cytosol]
(R-HSA-6783233)
TRAF6 [cytosol]
(R-HSA-166366)
K63polyUb-TRAF6 [plasma membrane]
(R-HSA-936980)
K63polyUb-TRAF6 [endosome membrane]
(R-HSA-450227)
TRAF6 [plasma membrane]
(R-HSA-936955)
TRAF6 [endosome membrane]
(R-HSA-450272)
PolyUb-TRAF6 [cytosol]
(R-HSA-6782845)
0.702
3
UniProt:Q13526 PIN1
1
PIN1 [nucleoplasm]
(R-HSA-936016)
0.645
10
UniProt:Q99836 MYD88
9
MYD88 [cytosol]
(R-HSA-166059)
MYD88 [plasma membrane]
(R-HSA-937017)
MYD88 [cytosol]
(R-HSA-193946)
MYD88 [endosome membrane]
(R-HSA-975123)
MyD88 E65del [cytosol]
(R-HSA-5602598)
MyD88 S34Y [cytosol]
(R-HSA-5602521)
MyD88 L93P [cytosol]
(R-HSA-5602612)
MyD88 E52del [cytosol]
(R-HSA-5602451)
MyD88 R196C [cytosol]
(R-HSA-5602329)
0.641
3
UniProt:Q8N2H9-2 PELI3
0.589
2
UniProt:Q9Y616 IRAK3
1
IRAK3 [cytosol]
(R-HSA-166103)
0.564
3
UniProt:O43187 IRAK2
6
p-IRAK2 [endosome membrane]
(R-HSA-975187)
IRAK2 [endosome membrane]
(R-HSA-975116)
IRAK2 [plasma membrane]
(R-HSA-937014)
IRAK2 [cytosol]
(R-HSA-772534)
p-IRAK2 [plasma membrane]
(R-HSA-936949)
p-IRAK2 [cytosol]
(R-HSA-446636)
0.564
3
UniProt:Q9NWZ3 IRAK4
9
IRAK4 Q293X [cytosol]
(R-HSA-5602426)
IRAK4 R12C [cytosol]
(R-HSA-5602511)
IRAK4 E402X [cytosol]
(R-HSA-5602517)
p-T342,T345,S346-IRAK4 [cytosol]
(R-HSA-446649)
IRAK4 [endosome membrane]
(R-HSA-975167)
p-T342,T345,S346-IRAK4 [endosome membrane]
(R-HSA-975149)
IRAK4 [cytosol]
(R-HSA-166081)
IRAK4 [plasma membrane]
(R-HSA-937051)
p-T342,T345,S346-IRAK4 [plasma membrane]
(R-HSA-936957)
0.547
2
UniProt:Q5D1E7 ZC12A
0.544
3
UniProt:P58753 TIRAP
2
p-4Y-TIRAP [plasma membrane]
(R-HSA-2201321)
TIRAP [cytosol]
(R-HSA-166141)
0.499
2
UniProt:Q86WV6 TMEM173
5
TMEM173 [secretory granule membrane]
(R-HSA-6804798)
TMEM173 [plasma membrane]
(R-HSA-6804815)
K63polyUb-STING [endoplasmic reticulum membrane]
(R-HSA-3134805)
TMEM173 [endoplasmic reticulum membrane]
(R-HSA-1834940)
K63polyUb-STING [cytoplasmic vesicle membrane]
(R-HSA-3248021)
0.499
2
UniProt:Q8VCW4 UN93B
0.499
2
UniProt:Q15306 IRF4
1
IRF4 [cytosol]
(R-HSA-1015679)
0.499
2
UniProt:Q92985 IRF7
5
IRF7 [cytosol]
(R-HSA-450281)
K63polyUb-IRF7 [endosome membrane]
(R-HSA-975154)
IRF7 [endosome membrane]
(R-HSA-450274)
p-S477,S479-IRF7 [nucleoplasm]
(R-HSA-450270)
p-S477,S479-IRF7 [cytosol]
(R-HSA-450318)
0.499
2
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