IRAK1

Stable Identifier
R-HSA-975127
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
endosome membrane
Synonyms
Interleukin-1 receptor-associated kinase 1, IRAK1_HUMAN
Locations in the PathwayBrowser
Expand all
External Reference Information
External Reference
UniProt:P51617 IRAK1
Gene Names
IRAK1, IRAK
Chain
chain:1-712
Reference Genes
BioGPS Gene:3654 IRAK1
COSMIC (genes):IRAK1 IRAK1
CTD Gene:3654 IRAK1
dbSNP Gene:3654 IRAK1
ENSEMBL:ENSG00000184216 IRAK1
HGNC:6112 IRAK1
KEGG Gene (Homo sapiens):hsa:3654 IRAK1
Monarch:3654 IRAK1
NCBI Gene:3654 IRAK1
OMIM:300283 IRAK1
UCSC:P51617 IRAK1
Reference Transcript
Other Identifiers
0002230021
1100_at
11734006_a_at
1555784_s_at
17115428
201587_s_at
3654
4461
54476
8175977
A_23_P73780
A_33_P3286616
AAC08756
AAC41949
AAH14963
AAH54000
AAK62888
AAY88246
AF030876
AF346607
BC014963
BC054000
CAB004461
CCDS14740
CCDS35443
CCDS35444
CH471172
DQ054788
EAW72762
EAW72763
EAW72764
EAW72765
ENSG00000184216
ENSP00000358991
ENSP00000358997
ENSP00000377291
ENST00000369974
ENST00000369980
ENST00000393687
EntrezGene:3654
g4755143_3p_s_at
GE62370
GO:0000166
GO:0000187
GO:0001959
GO:0002224
GO:0002376
GO:0002755
GO:0004672
GO:0004674
GO:0004704
GO:0005515
GO:0005524
GO:0005634
GO:0005737
GO:0005811
GO:0005829
GO:0005886
GO:0006468
GO:0007165
GO:0007178
GO:0007250
GO:0007254
GO:0007568
GO:0010008
GO:0016020
GO:0016301
GO:0016310
GO:0016740
GO:0019221
GO:0031072
GO:0031663
GO:0032088
GO:0032481
GO:0032496
GO:0034134
GO:0034142
GO:0034162
GO:0034605
GO:0042803
GO:0043066
GO:0043123
GO:0043406
GO:0045087
GO:0045323
GO:0045893
GO:0046777
GO:0046982
GO:0048661
GO:0051092
GO:0051259
GO:0060337
GO:0070423
GO:0070498
GO:0070555
GO:0071222
GO:0071456
HGNC:6112
HPA054476
Hs.522819
Hs2.182018.3.S1_3p_s_at
ILMN_1738397
ILMN_2379130
ILMN_3310740
IPR000488
IPR000719
IPR008271
IPR011009
IPR011029
IPR017441
IRAK1
IRAK1-202
IRAK1-203
IRAK1-204
L76191
L76191_at
MIM:300283
NM_001025242
NM_001025243
NM_001569
NP_001020413
NP_001020414
NP_001560
PF00069
PF00531
PH_hs_0010754
SM00220
TC0X001524.hg
U52112
uc004fjr.2
uc004fjs.2
uc004fjt.2
UPI000012D873
UPI00001AFC0C
UPI0000453679
XM_011531158
XP_011529460
Participant Of
hasMember
hasComponent
Other forms of this molecule
K63polyUb-hp-IRAK1 [endosome membrane]
p-S376,T387-IRAK1 [cytosol]
p-2S,S376,T,T209,T387-IRAK1 [cytosol]
p-2S,S376,T,T209,T387-IRAK1 [plasma membrane]
p-T209,T387-IRAK1 [plasma membrane]
p-T209-IRAK1 [plasma membrane]
IRAK1 [plasma membrane]
IRAK1 [cytosol]
K63polyUb-hp-IRAK1 [cytosol]
p-2S,S376,T,T209,T387-IRAK1 [endosome membrane]
p-T209,T387-IRAK1 [endosome membrane]
p-T209-IRAK1 [endosome membrane]
p-S,T-IRAK1 [cytosol]
Inferred To
Homologues of IRAK1 [endosome membrane] (Danio rerio)
Homologues of IRAK1 [endosome membrane] (Xenopus tropicalis)
Ghost homologue of IRAK1 [endosome membrane] (Gallus gallus)
Ghost homologue of IRAK1 [endosome membrane] (Taeniopygia guttata)
IRAK1 [endosome membrane] (Bos taurus)
IRAK1 [endosome membrane] (Canis familiaris)
IRAK1 [endosome membrane] (Danio rerio)
IRAK1 [endosome membrane] (Drosophila melanogaster)
IRAK1 [endosome membrane] (Mus musculus)
IRAK1 [endosome membrane] (Rattus norvegicus)
IRAK1 [endosome membrane] (Sus scrofa)
IRAK1 [endosome membrane] (Xenopus tropicalis)
Cross References
RefSeq
ZINC - World Drugs
Brenda
ZINC - FDA approved
GeneCards
ZINC - Substances
ZINC target
PRO
Orphanet
ZINC - Predictions - Purchasable
PDB
Interactors (15)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:Q9HAT8 PELI2  2 0.743 4
 UniProt:Q96FA3 PELI1  2 0.734 4
 UniProt:Q9Y4K3 TRAF6  8 0.702 3
 UniProt:Q13526 PIN1  1 0.645 10
 UniProt:Q99836 MYD88  9 0.641 3
 UniProt:Q8N2H9-2 PELI3      0.589 2
 UniProt:Q9Y616 IRAK3  1 0.564 3
 UniProt:O43187 IRAK2  6 0.564 3
 UniProt:Q9NWZ3 IRAK4  9 0.547 2
 UniProt:Q5D1E7 ZC12A      0.544 3
 UniProt:P58753 TIRAP  2 0.499 2
 UniProt:Q86WV6 TMEM173  5 0.499 2
 UniProt:Q8VCW4 UN93B      0.499 2
 UniProt:Q15306 IRF4  1 0.499 2
 UniProt:Q92985 IRF7  5 0.499 2