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p-S,T-IRAK1 [cytosol]
Stable Identifier
R-HSA-3149574
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Interleukin-1 receptor-associated kinase 1, IRAK1_HUMAN, IRAK1
Icon
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Death Receptor Signaling (Homo sapiens)
p75 NTR receptor-mediated signalling (Homo sapiens)
p75NTR signals via NF-kB (Homo sapiens)
NF-kB is activated and signals survival (Homo sapiens)
IKKbeta is activated (Homo sapiens)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62:IKK-beta [plasma membrane] (Homo sapiens)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62 [plasma membrane] (Homo sapiens)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6 [plasma membrane] (Homo sapiens)
p-S,T-IRAK1 [cytosol] (Homo sapiens)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62:Phospho-IKK-beta [plasma membrane] (Homo sapiens)
p-S,T-IRAK1 [cytosol] (Homo sapiens)
IKKbeta phosphorylates IkB causing NF-kB to dissociate (Homo sapiens)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62:Phospho-IKK-beta [plasma membrane] (Homo sapiens)
p-S,T-IRAK1 [cytosol] (Homo sapiens)
p75NTR recruits signalling complexes (Homo sapiens)
IKK-beta is recruited (Homo sapiens)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62 [plasma membrane] (Homo sapiens)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6 [plasma membrane] (Homo sapiens)
p-S,T-IRAK1 [cytosol] (Homo sapiens)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62:IKK-beta [plasma membrane] (Homo sapiens)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62 [plasma membrane] (Homo sapiens)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6 [plasma membrane] (Homo sapiens)
p-S,T-IRAK1 [cytosol] (Homo sapiens)
IRAK interacts with TRAF6 (Homo sapiens)
NGF ligand:p75NTR:Phospho-IRAK1:MYD88:TRAF6 [plasma membrane] (Homo sapiens)
NGF ligand:p75NTR:p-IRAK1:MYD88 [plasma membrane] (Homo sapiens)
p-S,T-IRAK1 [cytosol] (Homo sapiens)
NGF ligand:p75NTR:p-IRAK1:MYD88 [plasma membrane] (Homo sapiens)
p-S,T-IRAK1 [cytosol] (Homo sapiens)
IRAK is activated (Homo sapiens)
NGF ligand:p75NTR:p-IRAK1:MYD88 [plasma membrane] (Homo sapiens)
p-S,T-IRAK1 [cytosol] (Homo sapiens)
MYD88 dissociates (Homo sapiens)
NGF ligand:p75NTR:Phospho-IRAK1:MYD88:TRAF6 [plasma membrane] (Homo sapiens)
NGF ligand:p75NTR:p-IRAK1:MYD88 [plasma membrane] (Homo sapiens)
p-S,T-IRAK1 [cytosol] (Homo sapiens)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6 [plasma membrane] (Homo sapiens)
p-S,T-IRAK1 [cytosol] (Homo sapiens)
TRAF6 is auto-ubiquitinated (Homo sapiens)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62 [plasma membrane] (Homo sapiens)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6 [plasma membrane] (Homo sapiens)
p-S,T-IRAK1 [cytosol] (Homo sapiens)
p62 is recruited and forms a complex with TRAF6 (Homo sapiens)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6 [plasma membrane] (Homo sapiens)
p-S,T-IRAK1 [cytosol] (Homo sapiens)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62 [plasma membrane] (Homo sapiens)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6 [plasma membrane] (Homo sapiens)
p-S,T-IRAK1 [cytosol] (Homo sapiens)
p62 recruits an atypical PKC (Homo sapiens)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62 [plasma membrane] (Homo sapiens)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6 [plasma membrane] (Homo sapiens)
p-S,T-IRAK1 [cytosol] (Homo sapiens)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62:aPKCi [plasma membrane] (Homo sapiens)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62 [plasma membrane] (Homo sapiens)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6 [plasma membrane] (Homo sapiens)
p-S,T-IRAK1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P51617 IRAK1
Gene Names
IRAK1, IRAK
Chain
chain:1-712
Reference Genes
COSMIC (genes):IRAK1 IRAK1
dbSNP Gene:3654 IRAK1
ENSEMBL:ENSG00000184216 IRAK1
Participates
as a component of
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62:Phospho-IKK-beta [plasma membrane] (Homo sapiens)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6 [plasma membrane] (Homo sapiens)
NGF ligand:p75NTR:p-IRAK1:MYD88 [plasma membrane] (Homo sapiens)
Other forms of this molecule
IRAK1 [cytosol]
p-2S,S376,T,T209,T387-IRAK1 [cytosol]
p-2S,S376,T,T209,T387-IRAK1 [plasma membrane]
p-T209,T387-IRAK1 [plasma membrane]
p-T209-IRAK1 [plasma membrane]
IRAK1 [plasma membrane]
p-2S,S376,T,T209,T387-IRAK1 [endosome membrane]
IRAK1 [endosome membrane]
p-T209,T387-IRAK1 [endosome membrane]
p-T209-IRAK1 [endosome membrane]
K63polyUb-hp-IRAK1 [cytosol]
p-S376,T387-IRAK1 [cytosol]
K63polyUb-hp-IRAK1 [endosome membrane]
Inferred To
phospho-IRAK1 [cytosol]
(Canis familiaris)
Ghost homologue of p-S,T-IRAK1 [cytosol]
(Danio rerio)
Ghost homologue of p-S,T-IRAK1 [cytosol]
(Gallus gallus)
Ghost homologue of p-S,T-IRAK1 [cytosol]
(Xenopus tropicalis)
phospho-p-S,T-IRAK1 [cytosol]
(Bos taurus)
phospho-p-S,T-IRAK1 [cytosol]
(Mus musculus)
phospho-p-S,T-IRAK1 [cytosol]
(Rattus norvegicus)
phospho-p-S,T-IRAK1 [cytosol]
(Sus scrofa)
Modified Residues
Name
O-phospho-L-serine at unknown position
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-threonine at unknown position
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Interactors (22)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9Y4K3 TRAF6
8
TRAF6 [cytosol]
(R-HSA-166366)
K63polyUb-TRAF6 [cytosol]
(R-HSA-2685681)
K63polyUb-TRAF6 [plasma membrane]
(R-HSA-936980)
TRAF6 [plasma membrane]
(R-HSA-936955)
K63polyUb-TRAF6 [endosome membrane]
(R-HSA-450227)
TRAF6 [endosome membrane]
(R-HSA-450272)
PolyUb-TRAF6 [cytosol]
(R-HSA-6782845)
K48polyUb-TRAF6 [cytosol]
(R-HSA-6783233)
0.77
4
UniProt:Q9HAT8 PELI2
2
PELI2 [cytosol]
(R-HSA-450694)
p-PELI2 [cytosol]
(R-HSA-450825)
0.743
4
UniProt:Q96FA3 PELI1
2
PELI1 [cytosol]
(R-HSA-450696)
p-PELI1 [cytosol]
(R-HSA-450815)
0.734
4
UniProt:Q99836 MYD88
8
MyD88 R196C [cytosol]
(R-HSA-5602329)
MyD88 E52del [cytosol]
(R-HSA-5602451)
MyD88 L93P [cytosol]
(R-HSA-5602612)
MyD88 S34Y [cytosol]
(R-HSA-5602521)
MyD88 E65del [cytosol]
(R-HSA-5602598)
MYD88 [endosome membrane]
(R-HSA-975123)
MYD88 [plasma membrane]
(R-HSA-937017)
MYD88 [cytosol]
(R-HSA-166059)
0.723
4
UniProt:Q13526 PIN1
2
PIN1 [nucleoplasm]
(R-HSA-936016)
PIN1 [cytosol]
(R-HSA-9626823)
0.645
10
UniProt:P58753 TIRAP
2
TIRAP [cytosol]
(R-HSA-166141)
p-4Y-TIRAP [plasma membrane]
(R-HSA-2201321)
0.623
3
UniProt:Q8N2H9-2 PELI3
0.589
2
UniProt:O43187 IRAK2
6
IRAK2 [endosome membrane]
(R-HSA-975116)
p-IRAK2 [endosome membrane]
(R-HSA-975187)
IRAK2 [plasma membrane]
(R-HSA-937014)
IRAK2 [cytosol]
(R-HSA-772534)
p-IRAK2 [plasma membrane]
(R-HSA-936949)
p-IRAK2 [cytosol]
(R-HSA-446636)
0.564
3
UniProt:Q9Y616 IRAK3
1
IRAK3 [cytosol]
(R-HSA-166103)
0.564
3
UniProt:Q9NWZ3 IRAK4
9
IRAK4 [cytosol]
(R-HSA-166081)
p-T342,T345,S346-IRAK4 [plasma membrane]
(R-HSA-936957)
IRAK4 [plasma membrane]
(R-HSA-937051)
p-T342,T345,S346-IRAK4 [endosome membrane]
(R-HSA-975149)
IRAK4 [endosome membrane]
(R-HSA-975167)
p-T342,T345,S346-IRAK4 [cytosol]
(R-HSA-446649)
IRAK4 E402* [cytosol]
(R-HSA-5602517)
IRAK4 R12C [cytosol]
(R-HSA-5602511)
IRAK4 Q293* [cytosol]
(R-HSA-5602426)
0.547
2
UniProt:Q5D1E7
1
ZC3H12A [nucleoplasm]
(R-MMU-9774235)
0.544
3
UniProt:Q96EY1 DNJA3
0.527
2
UniProt:Q13451 FKBP5
2
FKBP5 [nucleoplasm]
(R-HSA-8939165)
FKBP5 [cytosol]
(R-HSA-5618096)
0.527
2
UniProt:O60884 DNAJA2
1
DNAJA2 [cytosol]
(R-HSA-3371555)
0.527
2
UniProt:O15027 SEC16A
1
SEC16A [cytosol]
(R-HSA-5685728)
0.527
2
UniProt:P50402 EMD
4
EMD [nuclear envelope]
(R-HSA-201573)
EMD [cytosol]
(R-HSA-9613988)
EMD [endoplasmic reticulum membrane]
(R-HSA-9613998)
EMD [endosome membrane]
(R-HSA-9715092)
0.527
2
UniProt:P31689 DNAJA1
2
SOH-C149,C150-DNAJA1 [cytosol]
(R-HSA-9857072)
DNAJA1 [cytosol]
(R-HSA-3371544)
0.527
2
UniProt:Q9UNE7 STUB1
1
STUB1 [cytosol]
(R-HSA-975970)
0.527
2
UniProt:Q86WV6 STING1
5
STING [endoplasmic reticulum membrane]
(R-HSA-1834940)
K63polyUb-STING [endoplasmic reticulum membrane]
(R-HSA-3134805)
K63polyUb-STING [cytoplasmic vesicle membrane]
(R-HSA-3248021)
TMEM173 [secretory granule membrane]
(R-HSA-6804798)
TMEM173 [plasma membrane]
(R-HSA-6804815)
0.499
2
UniProt:Q92985 IRF7
5
IRF7 [cytosol]
(R-HSA-450281)
p-S477,S479-IRF7 [cytosol]
(R-HSA-450318)
p-S477,S479-IRF7 [nucleoplasm]
(R-HSA-450270)
IRF7 [endosome membrane]
(R-HSA-450274)
K63polyUb-IRF7 [endosome membrane]
(R-HSA-975154)
0.499
2
UniProt:Q15306 IRF4
2
IRF4 [nucleoplasm]
(R-HSA-9907101)
IRF4 [cytosol]
(R-HSA-1015679)
0.499
2
UniProt:Q8VCW4
2
Unc93b1 [endoplasmic reticulum membrane]
(R-MMU-1678930)
Unc93b1 [Golgi membrane]
(R-MMU-1679064)
0.499
2
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