Reactome | MALT1 [cytosol]

MALT1 [cytosol]

Stable Identifier

R-HSA-202461

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Mucosa-associated lymphoid tissue lymphoma translocation protein 1

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Locations in the PathwayBrowser

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Immune System (Homo sapiens)

- Adaptive Immune System (Homo sapiens)
  - Signaling by the B Cell Receptor (BCR) (Homo sapiens)
    - Downstream signaling events of B Cell Receptor (BCR) (Homo sapiens)
      - Activation of NF-kappaB in B cells (Homo sapiens)
        
        CARMA1 recruits MALT1 and BCL10 forming CBM Complex (Homo sapiens)
        
        MALT1 [cytosol] (Homo sapiens)
        
        p-CARMA1:MALT1:p-BCL10 [plasma membrane] (Homo sapiens)
        
        MALT1 [cytosol] (Homo sapiens)
        
        CARMA1:BCL10:MALT1 complex recruits TAK1 and IKK (Homo sapiens)
        
        p-CARMA1:MALT1:p-BCL10 [plasma membrane] (Homo sapiens)
        
        MALT1 [cytosol] (Homo sapiens)
        
        p-CARMA1:MALT1:p-BCL10:TAK1:IKK [plasma membrane] (Homo sapiens)
        
        p-CARMA1:MALT1:p-BCL10 [plasma membrane] (Homo sapiens)
        
        MALT1 [cytosol] (Homo sapiens)
        
        TAK1 associated with the CBM complex phosphorylates IKKbeta (Homo sapiens)
        
        p-CARMA1:MALT1:p-BCL10:TAK1 [plasma membrane] (Homo sapiens)
        
        p-CARMA1:MALT1:p-BCL10 [plasma membrane] (Homo sapiens)
        
        MALT1 [cytosol] (Homo sapiens)
        
        p-CARMA1:MALT1:p-BCL10:TAK1:IKK [plasma membrane] (Homo sapiens)
        
        p-CARMA1:MALT1:p-BCL10 [plasma membrane] (Homo sapiens)
        
        MALT1 [cytosol] (Homo sapiens)
  - TCR signaling (Homo sapiens)
    - Downstream TCR signaling (Homo sapiens)
      - Activation of IKK complex (Homo sapiens)
        
        TAK1/TAB2 complex bound to TRAF6/CBM complex [plasma membrane] (Homo sapiens)
        
        Ub-TRAF6 trimer bound to CBM complex [plasma membrane] (Homo sapiens)
        
        MALT1 trimer bound to Bcl10 and CARMA1 trimer [plasma membrane] (Homo sapiens)
        
        MALT1 trimer [cytosol] (Homo sapiens)
        
        MALT1 [cytosol] (Homo sapiens)
      - Activation of TAK1-TAB2 complex (Homo sapiens)
        
        TAK1/TAB2 complex bound to TRAF6/CBM complex [plasma membrane] (Homo sapiens)
        
        Ub-TRAF6 trimer bound to CBM complex [plasma membrane] (Homo sapiens)
        
        MALT1 trimer bound to Bcl10 and CARMA1 trimer [plasma membrane] (Homo sapiens)
        
        MALT1 trimer [cytosol] (Homo sapiens)
        
        MALT1 [cytosol] (Homo sapiens)
        
        Ub-TRAF6 trimer bound to CBM complex [plasma membrane] (Homo sapiens)
        
        MALT1 trimer bound to Bcl10 and CARMA1 trimer [plasma membrane] (Homo sapiens)
        
        MALT1 trimer [cytosol] (Homo sapiens)
        
        MALT1 [cytosol] (Homo sapiens)
      - Auto-ubiquitination of TRAF6 (Homo sapiens)
        
        TRAF6 trimer bound to CBM complex [plasma membrane] (Homo sapiens)
        
        MALT1 trimer bound to Bcl10 and CARMA1 trimer [plasma membrane] (Homo sapiens)
        
        MALT1 trimer [cytosol] (Homo sapiens)
        
        MALT1 [cytosol] (Homo sapiens)
        
        Ub-TRAF6 trimer bound to CBM complex [plasma membrane] (Homo sapiens)
        
        MALT1 trimer bound to Bcl10 and CARMA1 trimer [plasma membrane] (Homo sapiens)
        
        MALT1 trimer [cytosol] (Homo sapiens)
        
        MALT1 [cytosol] (Homo sapiens)
      - Interaction and oligomerization of MALT1 to Bcl10 (Homo sapiens)
        
        MALT1 trimer [cytosol] (Homo sapiens)
        
        MALT1 [cytosol] (Homo sapiens)
        
        MALT1 trimer bound to Bcl10 and CARMA1 trimer [plasma membrane] (Homo sapiens)
        
        MALT1 trimer [cytosol] (Homo sapiens)
        
        MALT1 [cytosol] (Homo sapiens)
      - Translocation of TRAF6 to CBM complex (Homo sapiens)
        
        MALT1 trimer bound to Bcl10 and CARMA1 trimer [plasma membrane] (Homo sapiens)
        
        MALT1 trimer [cytosol] (Homo sapiens)
        
        MALT1 [cytosol] (Homo sapiens)
        
        TRAF6 trimer bound to CBM complex [plasma membrane] (Homo sapiens)
        
        MALT1 trimer bound to Bcl10 and CARMA1 trimer [plasma membrane] (Homo sapiens)
        
        MALT1 trimer [cytosol] (Homo sapiens)
        
        MALT1 [cytosol] (Homo sapiens)
      - Ubiquitination of NEMO by TRAF6 (Homo sapiens)
        
        Ub-TRAF6 trimer bound to CBM complex [plasma membrane] (Homo sapiens)
        
        MALT1 trimer bound to Bcl10 and CARMA1 trimer [plasma membrane] (Homo sapiens)
        
        MALT1 trimer [cytosol] (Homo sapiens)
        
        MALT1 [cytosol] (Homo sapiens)
- Innate Immune System (Homo sapiens)
  - C-type lectin receptors (CLRs) (Homo sapiens)
    - CLEC7A (Dectin-1) signaling (Homo sapiens)
      - CLEC7A/inflammasome pathway (Homo sapiens)
        
        ASC binds Caspase-8 complex (Homo sapiens)
        
        MALT1 oligomers:active caspase-8:ASC [cytosol] (Homo sapiens)
        
        MALT1:active caspase-8 [cytosol] (Homo sapiens)
        
        MALT1 [cytosol] (Homo sapiens)
        
        MALT1:active caspase-8 [cytosol] (Homo sapiens)
        
        MALT1 [cytosol] (Homo sapiens)
        
        Caspase-8 binds MALT (Homo sapiens)
        
        MALT1 [cytosol] (Homo sapiens)
        
        MALT1:active caspase-8 [cytosol] (Homo sapiens)
        
        MALT1 [cytosol] (Homo sapiens)
        
        Caspase-8 cleaves IL1B precursor (Homo sapiens)
        
        MALT1 oligomers:active caspase-8:ASC [cytosol] (Homo sapiens)
        
        MALT1:active caspase-8 [cytosol] (Homo sapiens)
        
        MALT1 [cytosol] (Homo sapiens)
      - K63polyUb-TAK1 autophosphorylates (Homo sapiens)
        
        p-T231-CARD9:BCL10:MALT1:K63polyUb-TRAF6 oligomers:TAB1:TAB2/TAB3:K63polyUb-34,158-TAK1 [plasma membrane] (Homo sapiens)
        
        p-T231-CARD9:BCL10:MALT1:K63polyUb-TRAF6 oligomers [plasma membrane] (Homo sapiens)
        
        p-T231-CARD9:BCL10:MALT1 oligomers [plasma membrane] (Homo sapiens)
        
        MALT1 oligomer [cytosol] (Homo sapiens)
        
        MALT1 [cytosol] (Homo sapiens)
        
        p-T231-CARD9:BCL10:MALT1:K63polyUb-TRAF6 oligomers:TAB1:TAB2/TAB3:K63polyUb-34,158-p3Y,1S-TAK1 [plasma membrane] (Homo sapiens)
        
        p-T231-CARD9:BCL10:MALT1:K63polyUb-TRAF6 oligomers [plasma membrane] (Homo sapiens)
        
        p-T231-CARD9:BCL10:MALT1 oligomers [plasma membrane] (Homo sapiens)
        
        MALT1 oligomer [cytosol] (Homo sapiens)
        
        MALT1 [cytosol] (Homo sapiens)
      - K63polyUb-TRAF6 ubiquitinates TAK1 (Homo sapiens)
        
        p-T231-CARD9:BCL10:MALT1:K63polyUb-TRAF6 oligomers:TAB1:TAB2/TAB3:K63polyUb-34,158-TAK1 [plasma membrane] (Homo sapiens)
        
        p-T231-CARD9:BCL10:MALT1:K63polyUb-TRAF6 oligomers [plasma membrane] (Homo sapiens)
        
        p-T231-CARD9:BCL10:MALT1 oligomers [plasma membrane] (Homo sapiens)
        
        MALT1 oligomer [cytosol] (Homo sapiens)
        
        MALT1 [cytosol] (Homo sapiens)
        
        p-T231-CARD9:BCL10:MALT1:K63polyUb-TRAF6 oligomers:TRIKA2 [plasma membrane] (Homo sapiens)
        
        p-T231-CARD9:BCL10:MALT1:K63polyUb-TRAF6 oligomers [plasma membrane] (Homo sapiens)
        
        p-T231-CARD9:BCL10:MALT1 oligomers [plasma membrane] (Homo sapiens)
        
        MALT1 oligomer [cytosol] (Homo sapiens)
        
        MALT1 [cytosol] (Homo sapiens)
      - K63polyUb-p-3T,1S-TAK1 phosphorylates IKK-beta (Homo sapiens)
        
        p-T231-CARD9:BCL10:MALT1:K63polyUb-TRAF6 oligomers:TAB1:TAB2/TAB3:K63polyUb-34,158-p3Y,1S-TAK1 [plasma membrane] (Homo sapiens)
        
        p-T231-CARD9:BCL10:MALT1:K63polyUb-TRAF6 oligomers [plasma membrane] (Homo sapiens)
        
        p-T231-CARD9:BCL10:MALT1 oligomers [plasma membrane] (Homo sapiens)
        
        MALT1 oligomer [cytosol] (Homo sapiens)
        
        MALT1 [cytosol] (Homo sapiens)
      - MALT1 binds BCL10 (Homo sapiens)
        
        MALT1 [cytosol] (Homo sapiens)
        
        p-T231-CARD9:BCL10 oligomers:MALT1 [plasma membrane] (Homo sapiens)
        
        MALT1 [cytosol] (Homo sapiens)
      - MALT1 oligomerizes (Homo sapiens)
        
        MALT1 [cytosol] (Homo sapiens)
        
        p-T231-CARD9:BCL10 oligomers:MALT1 [plasma membrane] (Homo sapiens)
        
        MALT1 [cytosol] (Homo sapiens)
        
        p-T231-CARD9:BCL10:MALT1 oligomers [plasma membrane] (Homo sapiens)
        
        MALT1 oligomer [cytosol] (Homo sapiens)
        
        MALT1 [cytosol] (Homo sapiens)
      - TRAF6 binds MALT1 oligomers (Homo sapiens)
        
        p-T231-CARD9:BCL10:MALT1 oligomers [plasma membrane] (Homo sapiens)
        
        MALT1 oligomer [cytosol] (Homo sapiens)
        
        MALT1 [cytosol] (Homo sapiens)
        
        p-T231-CARD9:BCL10:MALT1 oligomers:TRAF6 [plasma membrane] (Homo sapiens)
        
        p-T231-CARD9:BCL10:MALT1 oligomers [plasma membrane] (Homo sapiens)
        
        MALT1 oligomer [cytosol] (Homo sapiens)
        
        MALT1 [cytosol] (Homo sapiens)
      - TRAF6 oligomer autoubiquitinates (Homo sapiens)
        
        p-T231-CARD9:BCL10:MALT1:K63polyUb-TRAF6 oligomers [plasma membrane] (Homo sapiens)
        
        p-T231-CARD9:BCL10:MALT1 oligomers [plasma membrane] (Homo sapiens)
        
        MALT1 oligomer [cytosol] (Homo sapiens)
        
        MALT1 [cytosol] (Homo sapiens)
        
        p-T231-CARD9:BCL10:MALT1:TRAF6 oligomers [plasma membrane] (Homo sapiens)
        
        p-T231-CARD9:BCL10:MALT1 oligomers [plasma membrane] (Homo sapiens)
        
        MALT1 oligomer [cytosol] (Homo sapiens)
        
        MALT1 [cytosol] (Homo sapiens)
      - TRAF6 oligomerizes (Homo sapiens)
        
        p-T231-CARD9:BCL10:MALT1 oligomers:TRAF6 [plasma membrane] (Homo sapiens)
        
        p-T231-CARD9:BCL10:MALT1 oligomers [plasma membrane] (Homo sapiens)
        
        MALT1 oligomer [cytosol] (Homo sapiens)
        
        MALT1 [cytosol] (Homo sapiens)
        
        p-T231-CARD9:BCL10:MALT1:TRAF6 oligomers [plasma membrane] (Homo sapiens)
        
        p-T231-CARD9:BCL10:MALT1 oligomers [plasma membrane] (Homo sapiens)
        
        MALT1 oligomer [cytosol] (Homo sapiens)
        
        MALT1 [cytosol] (Homo sapiens)
      - TRIKA2 binds K63polyUb-TRAF6 oligomer (Homo sapiens)
        
        p-T231-CARD9:BCL10:MALT1:K63polyUb-TRAF6 oligomers [plasma membrane] (Homo sapiens)
        
        p-T231-CARD9:BCL10:MALT1 oligomers [plasma membrane] (Homo sapiens)
        
        MALT1 oligomer [cytosol] (Homo sapiens)
        
        MALT1 [cytosol] (Homo sapiens)
        
        p-T231-CARD9:BCL10:MALT1:K63polyUb-TRAF6 oligomers:TRIKA2 [plasma membrane] (Homo sapiens)
        
        p-T231-CARD9:BCL10:MALT1:K63polyUb-TRAF6 oligomers [plasma membrane] (Homo sapiens)
        
        p-T231-CARD9:BCL10:MALT1 oligomers [plasma membrane] (Homo sapiens)
        
        MALT1 oligomer [cytosol] (Homo sapiens)
        
        MALT1 [cytosol] (Homo sapiens)
      - Ubiquitination of NEMO by TRAF6 (Homo sapiens)
        
        Ub-TRAF6 trimer bound to CBM complex [plasma membrane] (Homo sapiens)
        
        MALT1 trimer bound to Bcl10 and CARMA1 trimer [plasma membrane] (Homo sapiens)
        
        MALT1 trimer [cytosol] (Homo sapiens)
        
        MALT1 [cytosol] (Homo sapiens)
  - Fc epsilon receptor (FCERI) signaling (Homo sapiens)
    - FCERI mediated NF-kB activation (Homo sapiens)
      - Activation of TAK1 complex bound to pUb-TRAF6 (Homo sapiens)
        
        DAG:p-5Y-PKC-theta:CBM oligomer:oligo-K63-poly Ub-TRAF6:TAK1:TAB1:TAB2/3 [plasma membrane] (Homo sapiens)
        
        DAG:p-5Y-PKC-theta:CBM oligomer:oligo-K63-poly Ub-TRAF6 [plasma membrane] (Homo sapiens)
        
        CBM oligomer:oligo-K63-poly Ub-TRAF6 oligomer [plasma membrane] (Homo sapiens)
        
        MALT1 oligomer [cytosol] (Homo sapiens)
        
        MALT1 [cytosol] (Homo sapiens)
        
        DAG:p-5Y-PKC-theta:CBM oligomer:oligo-K63-poly Ub-TRAF6:activated TAK1 complex [plasma membrane] (Homo sapiens)
        
        DAG:p-5Y-PKC-theta:CBM oligomer:oligo-K63-poly Ub-TRAF6 [plasma membrane] (Homo sapiens)
        
        CBM oligomer:oligo-K63-poly Ub-TRAF6 oligomer [plasma membrane] (Homo sapiens)
        
        MALT1 oligomer [cytosol] (Homo sapiens)
        
        MALT1 [cytosol] (Homo sapiens)
      - Auto-ubiquitination of TRAF6 (Homo sapiens)
        
        DAG:p-5Y-PKC-theta:CBM oligomer:TRAF6 oligomer [plasma membrane] (Homo sapiens)
        
        CBM oligomer:TRAF6 oligomer [plasma membrane] (Homo sapiens)
        
        MALT1 oligomer [cytosol] (Homo sapiens)
        
        MALT1 [cytosol] (Homo sapiens)
        
        DAG:p-5Y-PKC-theta:CBM oligomer:oligo-K63-poly Ub-TRAF6 [plasma membrane] (Homo sapiens)
        
        CBM oligomer:oligo-K63-poly Ub-TRAF6 oligomer [plasma membrane] (Homo sapiens)
        
        MALT1 oligomer [cytosol] (Homo sapiens)
        
        MALT1 [cytosol] (Homo sapiens)
      - Interaction of BCL10:MALT1 with CARMA1 to form CBM complex (Homo sapiens)
        
        BCL10:MALT1 [cytosol] (Homo sapiens)
        
        MALT1 [cytosol] (Homo sapiens)
        
        DAG:p-5Y-PKC-theta:CBM complex [plasma membrane] (Homo sapiens)
        
        p-CARMA1 oligomer:BCL10:MALT1 (CBM complex) [plasma membrane] (Homo sapiens)
        
        BCL10:MALT1 [cytosol] (Homo sapiens)
        
        MALT1 [cytosol] (Homo sapiens)
      - Oligomerization of BCL10 and MALT1 (Homo sapiens)
        
        DAG:p-5Y-PKC-theta:CBM complex [plasma membrane] (Homo sapiens)
        
        p-CARMA1 oligomer:BCL10:MALT1 (CBM complex) [plasma membrane] (Homo sapiens)
        
        BCL10:MALT1 [cytosol] (Homo sapiens)
        
        MALT1 [cytosol] (Homo sapiens)
        
        DAG:p-5Y-PKC-theta:CBM oligomer [plasma membrane] (Homo sapiens)
        
        CBM oligomer [plasma membrane] (Homo sapiens)
        
        MALT1 oligomer [cytosol] (Homo sapiens)
        
        MALT1 [cytosol] (Homo sapiens)
        
        MALT1 [cytosol] (Homo sapiens)
      - Oligomerization of TRAF6 (Homo sapiens)
        
        DAG:p-5Y-PKC-theta:CBM oligomer:TRAF6 [plasma membrane] (Homo sapiens)
        
        CBM oligomer:TRAF6 [plasma membrane] (Homo sapiens)
        
        BCL10 oligomer:MALT1 oligomer:TRAF6 [cytosol] (Homo sapiens)
        
        MALT1oligomer:TRAF6 [cytosol] (Homo sapiens)
        
        MALT1 oligomer [cytosol] (Homo sapiens)
        
        MALT1 [cytosol] (Homo sapiens)
        
        DAG:p-5Y-PKC-theta:CBM oligomer:TRAF6 oligomer [plasma membrane] (Homo sapiens)
        
        CBM oligomer:TRAF6 oligomer [plasma membrane] (Homo sapiens)
        
        MALT1 oligomer [cytosol] (Homo sapiens)
        
        MALT1 [cytosol] (Homo sapiens)
      - Phosphorylation of IKK-beta by TAK1 (Homo sapiens)
        
        DAG:p-5Y-PKC-theta:CBM oligomer:oligo-K63-poly Ub-TRAF6:activated TAK1 complex [plasma membrane] (Homo sapiens)
        
        DAG:p-5Y-PKC-theta:CBM oligomer:oligo-K63-poly Ub-TRAF6 [plasma membrane] (Homo sapiens)
        
        CBM oligomer:oligo-K63-poly Ub-TRAF6 oligomer [plasma membrane] (Homo sapiens)
        
        MALT1 oligomer [cytosol] (Homo sapiens)
        
        MALT1 [cytosol] (Homo sapiens)
      - Recruitment of TAK1 kinase complex to oligo-K63-pUb-TRAF6 (Homo sapiens)
        
        DAG:p-5Y-PKC-theta:CBM oligomer:oligo-K63-poly Ub-TRAF6 [plasma membrane] (Homo sapiens)
        
        CBM oligomer:oligo-K63-poly Ub-TRAF6 oligomer [plasma membrane] (Homo sapiens)
        
        MALT1 oligomer [cytosol] (Homo sapiens)
        
        MALT1 [cytosol] (Homo sapiens)
        
        DAG:p-5Y-PKC-theta:CBM oligomer:oligo-K63-poly Ub-TRAF6:TAK1:TAB1:TAB2/3 [plasma membrane] (Homo sapiens)
        
        DAG:p-5Y-PKC-theta:CBM oligomer:oligo-K63-poly Ub-TRAF6 [plasma membrane] (Homo sapiens)
        
        CBM oligomer:oligo-K63-poly Ub-TRAF6 oligomer [plasma membrane] (Homo sapiens)
        
        MALT1 oligomer [cytosol] (Homo sapiens)
        
        MALT1 [cytosol] (Homo sapiens)
      - Recruitment of TRAF6 to CBM complex by binding to MALT1 (Homo sapiens)
        
        DAG:p-5Y-PKC-theta:CBM oligomer [plasma membrane] (Homo sapiens)
        
        CBM oligomer [plasma membrane] (Homo sapiens)
        
        MALT1 oligomer [cytosol] (Homo sapiens)
        
        MALT1 [cytosol] (Homo sapiens)
        
        DAG:p-5Y-PKC-theta:CBM oligomer:TRAF6 [plasma membrane] (Homo sapiens)
        
        CBM oligomer:TRAF6 [plasma membrane] (Homo sapiens)
        
        BCL10 oligomer:MALT1 oligomer:TRAF6 [cytosol] (Homo sapiens)
        
        MALT1oligomer:TRAF6 [cytosol] (Homo sapiens)
        
        MALT1 oligomer [cytosol] (Homo sapiens)
        
        MALT1 [cytosol] (Homo sapiens)
      - Ubiquitination of NEMO by TRAF6 (Homo sapiens)
        
        Ub-TRAF6 trimer bound to CBM complex [plasma membrane] (Homo sapiens)
        
        MALT1 trimer bound to Bcl10 and CARMA1 trimer [plasma membrane] (Homo sapiens)
        
        MALT1 trimer [cytosol] (Homo sapiens)
        
        MALT1 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9UDY8 MALT1

Gene Names

MALT1, MLT

Chain

initiator methionine:, chain:2-824

Reference Genes

BioGPS Gene:10892 MALT1

COSMIC (genes):MALT1 MALT1

CTD Gene:10892 MALT1

dbSNP Gene:10892 MALT1

ENSEMBL:ENSG00000172175 MALT1

ENSEMBL_homo_sapiens_GENE:ENSG00000172175.16 MALT1

HGNC:6819 MALT1

KEGG Gene (Homo sapiens):10892 MALT1

Monarch:10892 MALT1

NCBI Gene:10892 MALT1

OMIM:604860 MALT1

UCSC:Q9UDY8 MALT1

Reference Transcript

Other Identifiers

10892

11726438_a_at

11726439_a_at

11726440_s_at

11741626_a_at

16852622

208309_PM_s_at

208309_s_at

210017_PM_at

210017_at

210018_PM_x_at

210018_x_at

232189_PM_at

232189_at

32350_at

3790260

3790261

3790264

3790268

3790270

3790273

3790274

3790277

3790281

3790282

3790285

3790286

3790287

3790288

3790290

3790293

3790294

3790297

3790298

3790299

3790301

3790302

3790303

3790304

3790305

3790306

3790307

3790308

3790309

3790310

38575_at

45916_at

8021418

84721_at

A_14_P120229

A_14_P125060

A_23_P96008

A_24_P116909

A_32_P76576

GE81680

GE85481

GE88695

GO:0001650

GO:0001923

GO:0002020

GO:0002096

GO:0002376

GO:0002726

GO:0003824

GO:0004175

GO:0004197

GO:0004842

GO:0005515

GO:0005634

GO:0005730

GO:0005737

GO:0005829

GO:0006351

GO:0006355

GO:0006508

GO:0006913

GO:0006952

GO:0007155

GO:0007250

GO:0008233

GO:0009620

GO:0012501

GO:0016740

GO:0016787

GO:0019209

GO:0023052

GO:0030154

GO:0030163

GO:0031398

GO:0031663

GO:0032449

GO:0032731

GO:0032743

GO:0032991

GO:0036094

GO:0036211

GO:0042098

GO:0042113

GO:0042802

GO:0042981

GO:0043066

GO:0043123

GO:0043226

GO:0043280

GO:0043621

GO:0045087

GO:0048471

GO:0048856

GO:0050852

GO:0050856

GO:0050870

GO:0051092

GO:0051168

GO:0051603

GO:0071222

GO:0098542

GO:0098772

GO:0140096

GO:2000321

HMNXSV003036310

HMNXSV003044553

Hs.180566.2.S2_3p_at

Hs.33417.0.S1_3p_at

ILMN_1730986

ILMN_2387791

PH_hs_0027941

TC18000205.hg

g5803077_3p_a_at

p8033

Participates

as an input of

as a component of

as a repeated unit of

MALT1 oligomer [cytosol] (Homo sapiens)

Inferred To

Homologues of MALT1 [cytosol] (Dictyostelium discoideum)

malt-1 [cytosol] (Caenorhabditis elegans)

pcp [cytosol] (Dictyostelium discoideum)

PCASP1 [cytosol] (Gallus gallus)

Malt1 [cytosol] (Mus musculus)

Malt1 [cytosol] (Rattus norvegicus)

MALT1 [cytosol] (Bos taurus)

MALT1 [cytosol] (Canis familiaris)

MALT1 [cytosol] (Dictyostelium discoideum)

MALT1 [cytosol] (Sus scrofa)

Cross References

RefSeq

NP_006776.1, NP_776216.1

Guide to Pharmacology - Targets

2983

OpenTargets

ENSG00000172175

HPA

ENSG00000172175-MALT1

GeneCards

Q9UDY8

Ensembl

ENSG00000172175, ENSP00000304161, ENST00000345724, ENSP00000497997, ENST00000649217

PRO

Q9UDY8

Pharos - Targets

Q9UDY8

Orphanet

17392

PDB

3UO8, 6F7I, 7AK0, 3V4O, 8CZO, 6GK2, 3BFO, 6YN8, 3K0W, 3V55, 7AK1, 4I1P, 8J5I, 7A41, 6YN9, 2G7R, 4I1R, 3UOA, 6H4A, 7PAV, 7PAW

Interactors (9)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O95999 BCL10	3	K48polyUb-BCL10 [cytosol] (R-HSA-8939329) BCL10 [cytosol] (R-HSA-202447) p-BCL10 [cytosol] (R-HSA-202488)	0.942	24
UniProt:Q9Y4K3 TRAF6	8	K48polyUb-TRAF6 [cytosol] (R-HSA-6783233) PolyUb-TRAF6 [cytosol] (R-HSA-6782845) TRAF6 [endosome membrane] (R-HSA-450272) K63polyUb-TRAF6 [endosome membrane] (R-HSA-450227) TRAF6 [cytosol] (R-HSA-166366) K63polyUb-TRAF6 [cytosol] (R-HSA-2685681) K63polyUb-TRAF6 [plasma membrane] (R-HSA-936980) TRAF6 [plasma membrane] (R-HSA-936955)	0.688	5
UniProt:Q9Y6K9 IKBKG	12	IKBKG D406V [cytosol] (R-HSA-5262943) IKBKG L153R [cytosol] (R-HSA-5262879) IKBKG E391* [cytosol] (R-HSA-5262924) IKBKG C417R [cytosol] (R-HSA-5262858) IKBKG R173G [cytosol] (R-HSA-5262966) IKBKG R175P [cytosol] (R-HSA-5262916) IKBKG 420Wext447 [cytosol] (R-HSA-5262978) monoSUMO1-K277,K309-IKBKG [nucleoplasm] (R-HSA-4755449) IKBKG [nucleoplasm] (R-HSA-4755413) K63polyUb-IKBKG [cytosol] (R-HSA-202530) Ub-285-IKBKG [cytosol] (R-HSA-741397) IKBKG [cytosol] (R-HSA-168108)	0.656	4
UniProt:Q9BXL7 CARD11	5	p-S559,S644,S652-CARD11 [plasma membrane] (R-HSA-1168564) CARD11 [plasma membrane] (R-HSA-2685592) p-S559,S652-CARD11 [cytosol] (R-HSA-2685625) CARD11 [cytosol] (R-HSA-202161) p-S552-CARD11 [cytosol] (R-HSA-202438)	0.589	2
UniProt:Q9UDY8 MALT1	1	MALT1 [cytosol] (R-HSA-202461)	0.558	2
UniProt:P0CG48 UBC	20	UBC(381-456) [endocytic vesicle membrane] (R-HSA-939218) UBC(533-608) [endocytic vesicle membrane] (R-HSA-939220) UBC(609-684) [endocytic vesicle membrane] (R-HSA-939223) UBC(457-532) [endocytic vesicle membrane] (R-HSA-939195) UBC(153-228) [endocytic vesicle membrane] (R-HSA-939194) UBC(305-380) [endocytic vesicle membrane] (R-HSA-939228) UBC(229-304) [endocytic vesicle membrane] (R-HSA-939177) UBC(77-152) [endocytic vesicle membrane] (R-HSA-939210) UBC(1-76) [endocytic vesicle membrane] (R-HSA-939245) Ub-565-UBC(533-608) [mitochondrial outer membrane] (R-HSA-6783166) Ub-337-UBC(305-380) [mitochondrial outer membrane] (R-HSA-6783121) Ub-185-UBC(153-228) [mitochondrial outer membrane] (R-HSA-6783154) Ub-261-UBC(229-304) [mitochondrial outer membrane] (R-HSA-6783028) Ub-413-UBC(381-456) [mitochondrial outer membrane] (R-HSA-6783061) Ub-109-UBC(77-152) [mitochondrial outer membrane] (R-HSA-6783158) Ub-641-UBC(609-684) [mitochondrial outer membrane] (R-HSA-6783182) Ub-33-UBC(1-76) [mitochondrial outer membrane] (R-HSA-6783073) Ub-489-UBC(457-532) [mitochondrial outer membrane] (R-HSA-6783078) Ub-291-UBC(229-304) [mitochondrial outer membrane] (R-HSA-6783193) Ub-595-UBC(533-608) [mitochondrial outer membrane] (R-HSA-6783130)	0.524	4
UniProt:Q13501 SQSTM1	7	SQSTM1(2-251)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9711967) SQSTM1(2-251)-ALK(1058-1620) fusion [cytosol] (R-HSA-9711954) K7 ub-SQSTM1 [cytosol] (R-HSA-9759088) p-S349 SQSTM1 [cytosol] (R-HSA-9766524) ub K420 p-S349 SQSTM1 [cytosol] (R-HSA-9766536) SQSTM1 [nucleoplasm] (R-HSA-210961) SQSTM1 [cytosol] (R-HSA-193937)	0.524	2
UniProt:Q14790 CASP8	8	CASP8(1-374) [cytosol] (R-HSA-3465404) CASP8(217-374) [mitochondrial outer membrane] (R-HSA-351869) CASP8(385-479) [mitochondrial outer membrane] (R-HSA-351828) CASP8(385-479) [cytosol] (R-HSA-76158) CASP8(375-384) [cytosol] (R-HSA-933460) CASP8(217-374) [cytosol] (R-HSA-75975) CASP8(1-216) [cytosol] (R-HSA-933456) CASP8(1-479) [cytosol] (R-HSA-57031)	0.499	10
UniProt:P48729 CSNK1A1	2	CSNK1A1 [cytosol] (R-HSA-195263) CSNK1A1 [cilium] (R-HSA-5632507)	0.499	7

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