Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
p-T209,T387-IRAK1 [endosome membrane]
Stable Identifier
R-HSA-975117
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
endosome membrane
Synonyms
p-T209,387-IRAK1, IRAK1 phosphorylated at T209, T387
Icon
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Toll-like Receptor Cascades (Homo sapiens)
Toll Like Receptor 7/8 (TLR7/8) Cascade (Homo sapiens)
MyD88 dependent cascade initiated on endosome (Homo sapiens)
Multiple IRAK1 autophosphorylation steps within the complex pIRAK4:MyD88:activated TLR7/8 or 9 (Homo sapiens)
p-T209,T387-IRAK1 [endosome membrane] (Homo sapiens)
pp-IRAK1:p-IRAK4:oligo-MyD88:activated TLR 7/8 or 9 complex [endosome membrane] (Homo sapiens)
p-T209,T387-IRAK1 [endosome membrane] (Homo sapiens)
Second phosphorylation of IRAK1 by IRAK4 bound to MyD88: activated TLR 7/8 or 9 (Homo sapiens)
pp-IRAK1:p-IRAK4:oligo-MyD88:activated TLR 7/8 or 9 complex [endosome membrane] (Homo sapiens)
p-T209,T387-IRAK1 [endosome membrane] (Homo sapiens)
Toll Like Receptor 9 (TLR9) Cascade (Homo sapiens)
MyD88 dependent cascade initiated on endosome (Homo sapiens)
Multiple IRAK1 autophosphorylation steps within the complex pIRAK4:MyD88:activated TLR7/8 or 9 (Homo sapiens)
p-T209,T387-IRAK1 [endosome membrane] (Homo sapiens)
pp-IRAK1:p-IRAK4:oligo-MyD88:activated TLR 7/8 or 9 complex [endosome membrane] (Homo sapiens)
p-T209,T387-IRAK1 [endosome membrane] (Homo sapiens)
Second phosphorylation of IRAK1 by IRAK4 bound to MyD88: activated TLR 7/8 or 9 (Homo sapiens)
pp-IRAK1:p-IRAK4:oligo-MyD88:activated TLR 7/8 or 9 complex [endosome membrane] (Homo sapiens)
p-T209,T387-IRAK1 [endosome membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P51617 IRAK1
Gene Names
IRAK1, IRAK
Chain
chain:1-712
Reference Genes
BioGPS Gene:3654 IRAK1
COSMIC (genes):IRAK1 IRAK1
CTD Gene:3654 IRAK1
dbSNP Gene:3654 IRAK1
ENSEMBL:ENSG00000184216 IRAK1
HGNC:6112 IRAK1
KEGG:hsa:3654 IRAK1
Monarch:3654 IRAK1
NCBI Gene:3654 IRAK1
OMIM:300283 IRAK1
UCSC:P51617 IRAK1
Reference Transcript
RefSeq:NM_001569.3 IRAK1
RefSeq:NM_001025243.1 IRAK1
RefSeq:NM_001025242.1 IRAK1
Participates
as a component of
pp-IRAK1:p-IRAK4:oligo-MyD88:activated TLR 7/8 or 9 complex [endosome membrane] (Homo sapiens)
Other forms of this molecule
IRAK1 [cytosol]
p-2S,S376,T,T209,T387-IRAK1 [cytosol]
p-2S,S376,T,T209,T387-IRAK1 [plasma membrane]
p-T209,T387-IRAK1 [plasma membrane]
p-T209-IRAK1 [plasma membrane]
IRAK1 [plasma membrane]
p-2S,S376,T,T209,T387-IRAK1 [endosome membrane]
IRAK1 [endosome membrane]
p-T209-IRAK1 [endosome membrane]
K63polyUb-hp-IRAK1 [cytosol]
p-S,T-IRAK1 [cytosol]
K63polyUb-hp-IRAK1 [endosome membrane]
p-S376,T387-IRAK1 [cytosol]
Modified Residues
Name
O-phospho-L-threonine at 209
Coordinate
209
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Name
O-phospho-L-threonine at 387
Coordinate
387
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Cross References
RefSeq
NP_001020413.1
,
NP_001020414.1
,
NP_001560.2
Guide to Pharmacology - Targets
2042
OpenTargets
ENSG00000184216
ENSEMBL
ENST00000393687
,
ENSP00000358997
,
ENST00000369974
,
ENSP00000377291
,
ENSP00000358991
,
ENSG00000184216
,
ENST00000369980
ZINC - FDA approved
IRAK1_HUMAN
ZINC - Substances
IRAK1_HUMAN
ZINC - Biogenic
IRAK1_HUMAN
ZINC target
P51617
PRO
P51617
GlyGen
P51617
PDB
6BFN
ZINC - Investigational
IRAK1_HUMAN
GeneCards
IRAK1
HPA
ENSG00000184216-IRAK1
Pharos - Targets
P51617
Orphanet
IRAK1
ZINC - Predictions - Purchasable
IRAK1_HUMAN
HMDB Protein
HMDBP08733
Interactors (22)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9Y4K3 TRAF6
8
TRAF6 [cytosol]
(R-HSA-166366)
K63polyUb-TRAF6 [cytosol]
(R-HSA-2685681)
K63polyUb-TRAF6 [plasma membrane]
(R-HSA-936980)
TRAF6 [plasma membrane]
(R-HSA-936955)
K63polyUb-TRAF6 [endosome membrane]
(R-HSA-450227)
TRAF6 [endosome membrane]
(R-HSA-450272)
PolyUb-TRAF6 [cytosol]
(R-HSA-6782845)
K48polyUb-TRAF6 [cytosol]
(R-HSA-6783233)
0.77
4
UniProt:Q9HAT8 PELI2
2
PELI2 [cytosol]
(R-HSA-450694)
p-PELI2 [cytosol]
(R-HSA-450825)
0.743
4
UniProt:Q96FA3 PELI1
2
PELI1 [cytosol]
(R-HSA-450696)
p-PELI1 [cytosol]
(R-HSA-450815)
0.734
4
UniProt:Q99836 MYD88
8
MYD88 [cytosol]
(R-HSA-166059)
MYD88 [plasma membrane]
(R-HSA-937017)
MYD88 [endosome membrane]
(R-HSA-975123)
MyD88 E65del [cytosol]
(R-HSA-5602598)
MyD88 S34Y [cytosol]
(R-HSA-5602521)
MyD88 L93P [cytosol]
(R-HSA-5602612)
MyD88 E52del [cytosol]
(R-HSA-5602451)
MyD88 R196C [cytosol]
(R-HSA-5602329)
0.723
4
UniProt:Q13526 PIN1
2
PIN1 [nucleoplasm]
(R-HSA-936016)
PIN1 [cytosol]
(R-HSA-9626823)
0.645
10
UniProt:P58753 TIRAP
2
p-4Y-TIRAP [plasma membrane]
(R-HSA-2201321)
TIRAP [cytosol]
(R-HSA-166141)
0.623
3
UniProt:Q8N2H9-2 PELI3
0.589
2
UniProt:O43187 IRAK2
6
IRAK2 [endosome membrane]
(R-HSA-975116)
p-IRAK2 [endosome membrane]
(R-HSA-975187)
IRAK2 [plasma membrane]
(R-HSA-937014)
IRAK2 [cytosol]
(R-HSA-772534)
p-IRAK2 [plasma membrane]
(R-HSA-936949)
p-IRAK2 [cytosol]
(R-HSA-446636)
0.564
3
UniProt:Q9Y616 IRAK3
1
IRAK3 [cytosol]
(R-HSA-166103)
0.564
3
UniProt:Q9NWZ3 IRAK4
9
IRAK4 [cytosol]
(R-HSA-166081)
p-T342,T345,S346-IRAK4 [plasma membrane]
(R-HSA-936957)
IRAK4 [plasma membrane]
(R-HSA-937051)
p-T342,T345,S346-IRAK4 [endosome membrane]
(R-HSA-975149)
IRAK4 [endosome membrane]
(R-HSA-975167)
p-T342,T345,S346-IRAK4 [cytosol]
(R-HSA-446649)
IRAK4 E402* [cytosol]
(R-HSA-5602517)
IRAK4 R12C [cytosol]
(R-HSA-5602511)
IRAK4 Q293* [cytosol]
(R-HSA-5602426)
0.547
2
UniProt:Q5D1E7
1
ZC3H12A [nucleoplasm]
(R-MMU-9774235)
0.544
3
UniProt:P50402 EMD
4
EMD [nuclear envelope]
(R-HSA-201573)
EMD [cytosol]
(R-HSA-9613988)
EMD [endoplasmic reticulum membrane]
(R-HSA-9613998)
EMD [endosome membrane]
(R-HSA-9715092)
0.527
2
UniProt:Q13451 FKBP5
2
FKBP5 [nucleoplasm]
(R-HSA-8939165)
FKBP5 [cytosol]
(R-HSA-5618096)
0.527
2
UniProt:Q9UNE7 STUB1
1
STUB1 [cytosol]
(R-HSA-975970)
0.527
2
UniProt:P31689 DNAJA1
2
SOH-C149,C150-DNAJA1 [cytosol]
(R-HSA-9857072)
DNAJA1 [cytosol]
(R-HSA-3371544)
0.527
2
UniProt:Q96EY1 DNJA3
0.527
2
UniProt:O60884 DNAJA2
1
DNAJA2 [cytosol]
(R-HSA-3371555)
0.527
2
UniProt:O15027 SEC16A
1
SEC16A [cytosol]
(R-HSA-5685728)
0.527
2
UniProt:Q92985 IRF7
5
IRF7 [cytosol]
(R-HSA-450281)
p-S477,S479-IRF7 [cytosol]
(R-HSA-450318)
p-S477,S479-IRF7 [nucleoplasm]
(R-HSA-450270)
IRF7 [endosome membrane]
(R-HSA-450274)
K63polyUb-IRF7 [endosome membrane]
(R-HSA-975154)
0.499
2
UniProt:Q15306 IRF4
2
IRF4 [nucleoplasm]
(R-HSA-9907101)
IRF4 [cytosol]
(R-HSA-1015679)
0.499
2
UniProt:Q8VCW4
2
Unc93b1 [endoplasmic reticulum membrane]
(R-MMU-1678930)
Unc93b1 [Golgi membrane]
(R-MMU-1679064)
0.499
2
UniProt:Q86WV6 STING1
5
STING [endoplasmic reticulum membrane]
(R-HSA-1834940)
K63polyUb-STING [endoplasmic reticulum membrane]
(R-HSA-3134805)
K63polyUb-STING [cytoplasmic vesicle membrane]
(R-HSA-3248021)
TMEM173 [secretory granule membrane]
(R-HSA-6804798)
TMEM173 [plasma membrane]
(R-HSA-6804815)
0.499
2
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text