p-2S,S376,T,T209,T387-IRAK1

Stable Identifier
R-HSA-937011
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
Synonyms
p-6T-IRAK1, p-3S,3T-IRAK1, Interleukin-1 receptor-associated kinase 1(phosphorylated), IRAK1_HUMAN, IRAK1
Locations in the PathwayBrowser
Summation

This is the hyperphosphorylated, active form of IRAK1. The unknown coordinate phosphorylation events are to symbolize the multiple phosphorylations that likely take place in the ProST domain (aa10-211).

External Reference Information
External Reference
Gene Names
IRAK1, IRAK
Chain
chain:1-712
Other Identifiers
0002230021
04150+2.7.11.1
04151+2.7.11.1
04926+2.7.11.1
05165+2.7.11.1
1100_at
11734006_a_at
1555784_s_at
17115428
201587_s_at
3654
4027013
4027014
4027015
4027016
4027017
4027018
4027021
4027022
4027023
4027024
4027027
4027028
4027029
4027031
4027033
4027034
4027037
4027038
4027040
4027041
4027043
4027045
4027046
4027048
4027050
4027051
4027052
4027053
4461
54476
6BFN
8175977
A_23_P73780
A_33_P3286616
AAC08756
AAC41949
AAH14963
AAH54000
AAK62888
AAY88246
AF030876
AF346607
BC014963
BC054000
CAB004461
CCDS14740
CCDS35443
CCDS35444
CH471172
D3YTB5
DQ054788
EAW72762
EAW72763
EAW72764
EAW72765
ENSG00000184216
ENSP00000358991
ENSP00000358997
ENSP00000377291
ENST00000369974
ENST00000369980
ENST00000393687
EntrezGene:3654
F8WAB6
g4755143_3p_s_at
GE62370
GO:0000166
GO:0000187
GO:0001959
GO:0002224
GO:0002376
GO:0002755
GO:0003674
GO:0004672
GO:0004674
GO:0004704
GO:0004871
GO:0005515
GO:0005524
GO:0005575
GO:0005622
GO:0005623
GO:0005634
GO:0005737
GO:0005768
GO:0005811
GO:0005829
GO:0005886
GO:0006464
GO:0006468
GO:0006950
GO:0007165
GO:0007178
GO:0007250
GO:0007254
GO:0007568
GO:0008150
GO:0008219
GO:0008283
GO:0009058
GO:0010008
GO:0016020
GO:0016032
GO:0016301
GO:0016310
GO:0016740
GO:0019221
GO:0022607
GO:0031072
GO:0031410
GO:0031663
GO:0032088
GO:0032481
GO:0032496
GO:0032991
GO:0034134
GO:0034142
GO:0034162
GO:0034605
GO:0034641
GO:0042803
GO:0043066
GO:0043123
GO:0043167
GO:0043226
GO:0043406
GO:0044403
GO:0045087
GO:0045323
GO:0045893
GO:0046777
GO:0046982
GO:0048661
GO:0051092
GO:0051259
GO:0060337
GO:0065003
GO:0070423
GO:0070498
GO:0070555
GO:0071222
GO:0071456
H7C1F0
H7C3G8
HGNC:6112
HPA054476
Hs2.182018.3.S1_3p_s_at
ILMN_1738397
ILMN_2379130
ILMN_3310740
IPR000488
IPR000719
IPR008271
IPR011009
IPR011029
IPR017441
IPR035533
IPR035536
IRAK1
IRAK1-202
IRAK1-203
IRAK1-204
L76191
L76191_at
MIM:300283
NM_001025242
NM_001025243
NM_001569
NP_001020413
NP_001020414
NP_001560
PF00069
PF00531
PH_hs_0010754
SM00220
TC0X001524.hg
U52112
uc004fjr.2
uc004fjs.2
uc004fjt.2
UPI000012D873
UPI00001AFC0C
UPI0000453679
XM_011531158
XP_011529460
Participant Of
Other forms of this molecule
Inferred To
Modified Residues
Name
O-phospho-L-threonine at 387
Coordinate
387
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Name
O-phospho-L-serine at 376
Coordinate
376
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-threonine at 209
Coordinate
209
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Name
O-phospho-L-serine at unknown position
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at unknown position
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-threonine at unknown position
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Cross References
ZINC - World Drugs
ZINC - FDA approved
GeneCards
ZINC - Substances
ZINC target
PRO
BRENDA (Homo sapiens)
ZINC - Predictions - Purchasable
Orphanet
HMDB Protein
PDB
Interactors (15)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:Q9HAT8 PELI2  2 0.743 4
 UniProt:Q96FA3 PELI1  2 0.734 4
 UniProt:Q9Y4K3 TRAF6  8 0.702 3
 UniProt:Q13526 PIN1  1 0.645 10
 UniProt:Q99836 MYD88  9 0.641 3
 UniProt:Q8N2H9-2 PELI3      0.589 2
 UniProt:O43187 IRAK2  6 0.564 3
 UniProt:Q9Y616 IRAK3  1 0.564 3
 UniProt:Q9NWZ3 IRAK4  9 0.547 2
 UniProt:Q5D1E7 ZC12A      0.544 3
 UniProt:Q92985 IRF7  5 0.499 2
 UniProt:Q8VCW4 UN93B      0.499 2
 UniProt:Q15306 IRF4  1 0.499 2
 UniProt:P58753 TIRAP  2 0.499 2
 UniProt:Q86WV6 TMEM173  5 0.499 2