Reactome | EDA2R [plasma membrane]

EDA2R [plasma membrane]

Stable Identifier

R-HSA-5669018

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Tumor necrosis factor receptor superfamily member 27, TNR27_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q9HAV5 EDA2R

Gene Names

EDA2R, TNFRSF27, XEDAR, UNQ2448/PRO5727/PRO34080

Chain

chain:1-297

Reference Genes

BioGPS Gene:60401 EDA2R

COSMIC (genes):EDA2R EDA2R

CTD Gene:60401 EDA2R

dbSNP Gene:60401 EDA2R

ENSEMBL:ENSG00000131080 EDA2R

ENSEMBL_homo_sapiens_GENE:ENSG00000131080.15 EDA2R

HGNC:17756 EDA2R

KEGG Gene (Homo sapiens):60401 EDA2R

Monarch:60401 EDA2R

NCBI Gene:60401 EDA2R

OMIM:300276 EDA2R

UCSC:Q9HAV5 EDA2R

Reference Transcript

Other Identifiers

11731889_s_at

11748901_a_at

17111725

221399_PM_at

221399_at

4011095

4011097

4011098

4011099

4011100

4011101

4011102

4011103

4011104

4011106

4011108

60401

66259_at

79199_r_at

8173299

89258_at

A_23_P171132

A_33_P3413468

GE82616

GO:0005031

GO:0005515

GO:0005886

GO:0006351

GO:0006355

GO:0008544

GO:0010668

GO:0012501

GO:0016020

GO:0023052

GO:0030154

GO:0033209

GO:0038023

GO:0043123

GO:0046330

GO:0048856

GO:0051092

GO:0060089

GO:0072332

HMNXSV003038329

HMNXSV003048895

ILMN_1767233

PH_hs_0015594

TC0X001101.hg

g11140822_3p_at

Participates

as a component of

EDA-3:EDA2R [plasma membrane] (Homo sapiens)

as an input of

EDA-3 binds EDA2R (Homo sapiens)

Inferred To

EDA2R [plasma membrane] (Gallus gallus)

Eda2r [plasma membrane] (Mus musculus)

Eda2r [plasma membrane] (Rattus norvegicus)

tnfrsf19 [plasma membrane] (Danio rerio)

tnfrsf19 [plasma membrane] (Xenopus tropicalis)

si:dkey-204l11.1 [plasma membrane] (Danio rerio)

Homologues of EDA2R [plasma membrane] (Danio rerio)

Cross References

RefSeq

NP_001311130.1, NP_001311134.1, NP_001311133.1, NP_001311135.1, XP_011529303.1, XP_011529302.1, NP_001186616.1, NP_068555.1, NP_001229239.1

Guide to Pharmacology - Targets

1896

OpenTargets

ENSG00000131080

GeneCards

Q9HAV5

HPA

ENSG00000131080-EDA2R

Ensembl

ENST00000253392, ENSP00000253392, ENSP00000379365, ENST00000374719, ENSP00000363851, ENST00000396050, ENSG00000131080, ENST00000451436, ENSP00000415242

PRO

Q9HAV5

Pharos - Targets

Q9HAV5

Orphanet

21837

Interactors (14)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q13114 TRAF3	4	TRAF3 R118W [cytosol] (R-HSA-5602321) K48polyUb-TRAF3 [cytosol] (R-HSA-936556) TRAF3 [cytosol] (R-HSA-914241) K63polyUb-TRAF3 [cytosol] (R-HSA-936402)	0.669	3
UniProt:Q9Y4K3 TRAF6	8	K48polyUb-TRAF6 [cytosol] (R-HSA-6783233) PolyUb-TRAF6 [cytosol] (R-HSA-6782845) TRAF6 [endosome membrane] (R-HSA-450272) K63polyUb-TRAF6 [endosome membrane] (R-HSA-450227) TRAF6 [cytosol] (R-HSA-166366) K63polyUb-TRAF6 [cytosol] (R-HSA-2685681) K63polyUb-TRAF6 [plasma membrane] (R-HSA-936980) TRAF6 [plasma membrane] (R-HSA-936955)	0.669	3
UniProt:P60201-2 PLP1			0.556	3
UniProt:Q8TD06 AGR3			0.556	3
UniProt:E9PQX1 TM262			0.556	3
UniProt:O43765 SGTA	1	SGTA [cytosol] (R-HSA-5423595)	0.556	3
UniProt:Q96F15 GIMA5			0.556	3
UniProt:Q8N5M9 JAGN1			0.556	3
UniProt:Q16617 NKG7			0.556	3
UniProt:P0DN84 DWORF			0.556	3
UniProt:P27449 ATP6V0C	7	ATP6V0C [endosome membrane] (R-HSA-912591) ATP6V0C [phagocytic vesicle membrane] (R-HSA-1222603) ATP6V0C [tertiary granule membrane] (R-HSA-6800991) ATP6V0C [plasma membrane] (R-HSA-6806254) ATP6V0C [azurophil granule membrane] (R-HSA-6799363) ATP6V0C [ficolin-1-rich granule membrane] (R-HSA-6800908) ATP6V0C [lysosomal membrane] (R-HSA-9640194)	0.556	3
UniProt:P05362 ICAM1	1	ICAM1 [plasma membrane] (R-HSA-197683)	0.527	2
UniProt:Q3SXM5 HSDL1			0.527	2
UniProt:Q13077 TRAF1	3	TRAF1 [cytosol] (R-HSA-5634163) TRAF1(1-163) [cytosol] (R-HSA-5634199) TRAF1(164-416) [cytosol] (R-HSA-5634204)	0.527	2

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