Reactome | IRAK2 [cytosol]

IRAK2 [cytosol]

Stable Identifier

R-HSA-772534

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Interleukin-1 receptor-associated kinase-like 2, IRAK2_HUMAN

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External Reference Information

External Reference

UniProt:O43187 IRAK2

Gene Names

IRAK2

Chain

chain:1-625

Reference Genes

BioGPS Gene:3656 IRAK2

COSMIC (genes):IRAK2 IRAK2

CTD Gene:3656 IRAK2

dbSNP Gene:3656 IRAK2

ENSEMBL:ENSG00000134070 IRAK2

ENSEMBL_homo_sapiens_GENE:ENSG00000134070.5 IRAK2

HGNC:6113 IRAK2

KEGG Gene (Homo sapiens):3656 IRAK2

Monarch:3656 IRAK2

NCBI Gene:3656 IRAK2

OMIM:603304 IRAK2

UCSC:O43187 IRAK2

Reference Transcript

RefSeq:NM_001570.3 IRAK2

Other Identifiers

11733240_at

11733241_at

1553740_PM_a_at

1553740_a_at

16937579

231779_PM_at

231779_at

2610360

2610361

2610365

2610367

2610368

2610369

2610370

2610371

2610373

2610375

2610376

2610377

2610380

2610383

2610385

2610386

2610387

2610388

2610390

2610391

3656

76762_at

8077786

A_23_P80635

A_33_P3352970

GE62955

GO:0000166

GO:0001959

GO:0002376

GO:0002755

GO:0003824

GO:0004672

GO:0005515

GO:0005524

GO:0005634

GO:0005737

GO:0005768

GO:0005829

GO:0005886

GO:0006351

GO:0006355

GO:0006468

GO:0006954

GO:0007165

GO:0007249

GO:0008063

GO:0010008

GO:0016740

GO:0023052

GO:0031410

GO:0031663

GO:0032088

GO:0034142

GO:0035556

GO:0035591

GO:0036211

GO:0042803

GO:0043226

GO:0046982

GO:0051092

GO:0060090

GO:0070498

GO:0070555

GO:0071222

GO:0071345

GO:0098542

GO:0140096

HMNXSV003031884

HMNXSV003036195

Hs.249175.0.S2_3p_at

ILMN_1745964

PH_hs_0019808

TC03000056.hg

Participates

as an input of

IRAK2 is phosphorylated downstream of IRAK4 following IL1 receptor activation (Homo sapiens)

as a member of

IRAK1, IRAK2 [cytosol] (Homo sapiens)

Other forms of this molecule

IRAK2 [endosome membrane]

p-IRAK2 [endosome membrane]

IRAK2 [plasma membrane]

p-IRAK2 [plasma membrane]

p-IRAK2 [cytosol]

Inferred To

IRAK2 [cytosol] (Bos taurus)

IRAK2 [cytosol] (Canis familiaris)

IRAK2 [cytosol] (Gallus gallus)

IRAK2 [cytosol] (Mus musculus)

IRAK2 [cytosol] (Rattus norvegicus)

IRAK2 [cytosol] (Sus scrofa)

Cross References

RefSeq

NP_001561.3

Guide to Pharmacology - Targets

2043

OpenTargets

ENSG00000134070

HPA

ENSG00000134070-IRAK2

GeneCards

O43187

Ensembl

ENST00000256458, ENSG00000134070, ENSP00000256458

PRO

O43187

Pharos - Targets

O43187

PDB

3MOP

HMDB Protein

HMDBP09473

Interactors (14)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9Y4K3 TRAF6	8	K48polyUb-TRAF6 [cytosol] (R-HSA-6783233) PolyUb-TRAF6 [cytosol] (R-HSA-6782845) TRAF6 [endosome membrane] (R-HSA-450272) K63polyUb-TRAF6 [endosome membrane] (R-HSA-450227) TRAF6 [cytosol] (R-HSA-166366) K63polyUb-TRAF6 [cytosol] (R-HSA-2685681) K63polyUb-TRAF6 [plasma membrane] (R-HSA-936980) TRAF6 [plasma membrane] (R-HSA-936955)	0.809	5
UniProt:Q9NWZ3 IRAK4	9	IRAK4 Q293* [cytosol] (R-HSA-5602426) IRAK4 R12C [cytosol] (R-HSA-5602511) IRAK4 E402* [cytosol] (R-HSA-5602517) p-T342,T345,S346-IRAK4 [cytosol] (R-HSA-446649) IRAK4 [endosome membrane] (R-HSA-975167) p-T342,T345,S346-IRAK4 [endosome membrane] (R-HSA-975149) IRAK4 [plasma membrane] (R-HSA-937051) p-T342,T345,S346-IRAK4 [plasma membrane] (R-HSA-936957) IRAK4 [cytosol] (R-HSA-166081)	0.711	6
UniProt:Q86VW0 SESD1			0.643	3
UniProt:Q99836-1 MYD88			0.576	3
UniProt:P58753 TIRAP	2	TIRAP [cytosol] (R-HSA-166141) p-4Y-TIRAP [plasma membrane] (R-HSA-2201321)	0.564	2
UniProt:P51617 IRAK1	14	K63polyUb-hp-IRAK1 [endosome membrane] (R-HSA-975112) p-S376,T387-IRAK1 [cytosol] (R-HSA-446687) p-S,T-IRAK1 [cytosol] (R-HSA-3149574) K63polyUb-hp-IRAK1 [cytosol] (R-HSA-451565) p-T209-IRAK1 [endosome membrane] (R-HSA-975189) p-T209,T387-IRAK1 [endosome membrane] (R-HSA-975117) IRAK1 [endosome membrane] (R-HSA-975127) p-2S,S376,T,T209,T387-IRAK1 [endosome membrane] (R-HSA-975157) IRAK1 [plasma membrane] (R-HSA-937045) p-T209-IRAK1 [plasma membrane] (R-HSA-937031) p-T209,T387-IRAK1 [plasma membrane] (R-HSA-166279) p-2S,S376,T,T209,T387-IRAK1 [plasma membrane] (R-HSA-937011) p-2S,S376,T,T209,T387-IRAK1 [cytosol] (R-HSA-446682) IRAK1 [cytosol] (R-HSA-446639)	0.564	3
UniProt:Q9Y616 IRAK3	1	IRAK3 [cytosol] (R-HSA-166103)	0.564	3
UniProt:P68467 PG044			0.524	2
UniProt:P10398 ARAF	4	p-S299,S302,T452,T455,S582 ARAF [cytosol] (R-HSA-5672646) p-S299,S302,T452,T455,S582 ARAF [plasma membrane] (R-HSA-5672648) p-S582 ARAF [cytosol] (R-HSA-5672681) p-S214,S582 ARAF [cytosol] (R-HSA-5672639)	0.499	2
UniProt:Q6PDS3	1	SARM-1 [cytosol] (R-MMU-2559572)	0.499	2
UniProt:Q9H0E2 TOLLIP	4	TOLLIP [cytosol] (R-HSA-446885) TOLLIP [azurophil granule lumen] (R-HSA-6799709) TOLLIP [extracellular region] (R-HSA-6800448) TOLLIP [specific granule lumen] (R-HSA-6799719)	0.499	2
UniProt:P46977 STT3A	1	STT3A [endoplasmic reticulum membrane] (R-HSA-265023)	0.499	2
UniProt:Q5D1E8 ZC3H12A	1	ZC3H12A [nucleoplasm] (R-HSA-9774235)	0.499	2
UniProt:Q13148 TADBP			0.499	2

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