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Ngfr [plasma membrane]
Stable Identifier
R-RNO-193664
Type
Protein [EntityWithAccessionedSequence]
Species
Rattus norvegicus
Compartment
plasma membrane
Synonyms
NGFR, P07174
Locations in the PathwayBrowser
Expand all
Signal Transduction (Rattus norvegicus)
Death Receptor Signaling (Rattus norvegicus)
p75 NTR receptor-mediated signalling (Rattus norvegicus)
Cell death signalling via NRAGE, NRIF and NADE (Rattus norvegicus)
NADE modulates death signalling (Rattus norvegicus)
14-3-3epsilon attentuates NADE-related apoptosis (Rattus norvegicus)
NGF ligand:p75NTR:NADE:14-3-3epsilon [plasma membrane] (Rattus norvegicus)
NGF:p75NTR:NADE [plasma membrane] (Rattus norvegicus)
mature NGF homodimer:p75NTR [plasma membrane] (Rattus norvegicus)
Ngfr [plasma membrane] (Rattus norvegicus)
NGF:p75NTR:NADE [plasma membrane] (Rattus norvegicus)
mature NGF homodimer:p75NTR [plasma membrane] (Rattus norvegicus)
Ngfr [plasma membrane] (Rattus norvegicus)
p75NTR binds to NADE (Rattus norvegicus)
NGF:p75NTR:NADE [plasma membrane] (Rattus norvegicus)
mature NGF homodimer:p75NTR [plasma membrane] (Rattus norvegicus)
Ngfr [plasma membrane] (Rattus norvegicus)
mature NGF homodimer:p75NTR [plasma membrane] (Rattus norvegicus)
Ngfr [plasma membrane] (Rattus norvegicus)
p75NTR:NADE promotes caspase2/3 activation (Rattus norvegicus)
NGF:p75NTR:NADE [plasma membrane] (Rattus norvegicus)
mature NGF homodimer:p75NTR [plasma membrane] (Rattus norvegicus)
Ngfr [plasma membrane] (Rattus norvegicus)
NRIF signals cell death from the nucleus (Rattus norvegicus)
TRAF6 binds to p75NTR:NRIF (Rattus norvegicus)
NGF ligand:p75NTR:NRIF [plasma membrane] (Rattus norvegicus)
mature NGF homodimer:p75NTR [plasma membrane] (Rattus norvegicus)
Ngfr [plasma membrane] (Rattus norvegicus)
NGF ligand:p75NTR:NRIF:TRAF6 [plasma membrane] (Rattus norvegicus)
NGF ligand:p75NTR:NRIF [plasma membrane] (Rattus norvegicus)
mature NGF homodimer:p75NTR [plasma membrane] (Rattus norvegicus)
Ngfr [plasma membrane] (Rattus norvegicus)
gamma-secretase cleaves p75NTR, releasing NRIF and TRAF6 (Rattus norvegicus)
NGF ligand:p75NTR:NRIF:TRAF6 [plasma membrane] (Rattus norvegicus)
NGF ligand:p75NTR:NRIF [plasma membrane] (Rattus norvegicus)
mature NGF homodimer:p75NTR [plasma membrane] (Rattus norvegicus)
Ngfr [plasma membrane] (Rattus norvegicus)
mature NGF homodimer:p75NTR [plasma membrane] (Rattus norvegicus)
Ngfr [plasma membrane] (Rattus norvegicus)
NFG and proNGF binds to p75NTR (Rattus norvegicus)
NGF homodimer binds to p75NTR (Rattus norvegicus)
Ngfr [plasma membrane] (Rattus norvegicus)
mature NGF homodimer:p75NTR [plasma membrane] (Rattus norvegicus)
Ngfr [plasma membrane] (Rattus norvegicus)
Regulated proteolysis of p75NTR (Rattus norvegicus)
alpha-secretase cleaves the p75NTR extracellular domain (Rattus norvegicus)
Ngfr [plasma membrane] (Rattus norvegicus)
p75NTR regulates axonogenesis (Rattus norvegicus)
Axonal growth inhibition (RHOA activation) (Rattus norvegicus)
The p75NTR:NgR:MDGI binds RHOA-GDI (Rattus norvegicus)
NGFR:RTN4R:LINGO1:RTN4,MAG,OMG [plasma membrane] (Rattus norvegicus)
NGFR:RTN4R:LINGO1 [plasma membrane] (Rattus norvegicus)
NGFR:RTN4R [plasma membrane] (Rattus norvegicus)
Ngfr [plasma membrane] (Rattus norvegicus)
RHOA:GDP:ARHGDIA:NGFR:RTN4R:LINGO1:RTN4,MAG,OMG [plasma membrane] (Rattus norvegicus)
NGFR:RTN4R:LINGO1:RTN4,MAG,OMG [plasma membrane] (Rattus norvegicus)
NGFR:RTN4R:LINGO1 [plasma membrane] (Rattus norvegicus)
NGFR:RTN4R [plasma membrane] (Rattus norvegicus)
Ngfr [plasma membrane] (Rattus norvegicus)
The p75NTR:NgR:MDGI complex reduces RHOA-GDI activity, displacing RHOA (Rattus norvegicus)
ARHGDIA:NGFR:RTN4R:LINGO1:RTN4,MAG,OMG [plasma membrane] (Rattus norvegicus)
NGFR:RTN4R:LINGO1:RTN4,MAG,OMG [plasma membrane] (Rattus norvegicus)
NGFR:RTN4R:LINGO1 [plasma membrane] (Rattus norvegicus)
NGFR:RTN4R [plasma membrane] (Rattus norvegicus)
Ngfr [plasma membrane] (Rattus norvegicus)
RHOA:GDP:ARHGDIA:NGFR:RTN4R:LINGO1:RTN4,MAG,OMG [plasma membrane] (Rattus norvegicus)
NGFR:RTN4R:LINGO1:RTN4,MAG,OMG [plasma membrane] (Rattus norvegicus)
NGFR:RTN4R:LINGO1 [plasma membrane] (Rattus norvegicus)
NGFR:RTN4R [plasma membrane] (Rattus norvegicus)
Ngfr [plasma membrane] (Rattus norvegicus)
Axonal growth stimulation (Rattus norvegicus)
NGF binding to p75NTR inactivates RHOA (Rattus norvegicus)
RHOA:GDP:ARHGDIA:NGFR [plasma membrane] (Rattus norvegicus)
Ngfr [plasma membrane] (Rattus norvegicus)
RHOA:GDP:ARHGDIA:NGFR:NGF [plasma membrane] (Rattus norvegicus)
RHOA:GDP:ARHGDIA:NGFR [plasma membrane] (Rattus norvegicus)
Ngfr [plasma membrane] (Rattus norvegicus)
p75NTR and RHOA-GDI interact (Rattus norvegicus)
Ngfr [plasma membrane] (Rattus norvegicus)
RHOA:GDP:ARHGDIA:NGFR [plasma membrane] (Rattus norvegicus)
Ngfr [plasma membrane] (Rattus norvegicus)
p75NTR signals via NF-kB (Rattus norvegicus)
NF-kB is activated and signals survival (Rattus norvegicus)
IKKbeta is activated (Rattus norvegicus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62:IKK-beta [plasma membrane] (Rattus norvegicus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62 [plasma membrane] (Rattus norvegicus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6 [plasma membrane] (Rattus norvegicus)
mature NGF homodimer:p75NTR [plasma membrane] (Rattus norvegicus)
Ngfr [plasma membrane] (Rattus norvegicus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62:Phospho-IKK-beta [plasma membrane] (Rattus norvegicus)
mature NGF homodimer:p75NTR [plasma membrane] (Rattus norvegicus)
Ngfr [plasma membrane] (Rattus norvegicus)
p75NTR recruits signalling complexes (Rattus norvegicus)
IKK-beta is recruited (Rattus norvegicus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62 [plasma membrane] (Rattus norvegicus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6 [plasma membrane] (Rattus norvegicus)
mature NGF homodimer:p75NTR [plasma membrane] (Rattus norvegicus)
Ngfr [plasma membrane] (Rattus norvegicus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62:IKK-beta [plasma membrane] (Rattus norvegicus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62 [plasma membrane] (Rattus norvegicus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6 [plasma membrane] (Rattus norvegicus)
mature NGF homodimer:p75NTR [plasma membrane] (Rattus norvegicus)
Ngfr [plasma membrane] (Rattus norvegicus)
IRAK interacts with TRAF6 (Rattus norvegicus)
NGF ligand:p75NTR:Phospho-IRAK1:MYD88:TRAF6 [plasma membrane] (Rattus norvegicus)
NGF ligand:p75NTR:p-IRAK1:MYD88 [plasma membrane] (Rattus norvegicus)
mature NGF homodimer:p75NTR [plasma membrane] (Rattus norvegicus)
Ngfr [plasma membrane] (Rattus norvegicus)
NGF ligand:p75NTR:p-IRAK1:MYD88 [plasma membrane] (Rattus norvegicus)
mature NGF homodimer:p75NTR [plasma membrane] (Rattus norvegicus)
Ngfr [plasma membrane] (Rattus norvegicus)
MYD88 dissociates (Rattus norvegicus)
NGF ligand:p75NTR:Phospho-IRAK1:MYD88:TRAF6 [plasma membrane] (Rattus norvegicus)
NGF ligand:p75NTR:p-IRAK1:MYD88 [plasma membrane] (Rattus norvegicus)
mature NGF homodimer:p75NTR [plasma membrane] (Rattus norvegicus)
Ngfr [plasma membrane] (Rattus norvegicus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6 [plasma membrane] (Rattus norvegicus)
mature NGF homodimer:p75NTR [plasma membrane] (Rattus norvegicus)
Ngfr [plasma membrane] (Rattus norvegicus)
TRAF6 is auto-ubiquitinated (Rattus norvegicus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62 [plasma membrane] (Rattus norvegicus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6 [plasma membrane] (Rattus norvegicus)
mature NGF homodimer:p75NTR [plasma membrane] (Rattus norvegicus)
Ngfr [plasma membrane] (Rattus norvegicus)
NGF ligand:p75NTR:Phospho-IRAK1:polyubiquitinated TRAF6:p62 [plasma membrane] (Rattus norvegicus)
mature NGF homodimer:p75NTR [plasma membrane] (Rattus norvegicus)
Ngfr [plasma membrane] (Rattus norvegicus)
p62 is recruited and forms a complex with TRAF6 (Rattus norvegicus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6 [plasma membrane] (Rattus norvegicus)
mature NGF homodimer:p75NTR [plasma membrane] (Rattus norvegicus)
Ngfr [plasma membrane] (Rattus norvegicus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62 [plasma membrane] (Rattus norvegicus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6 [plasma membrane] (Rattus norvegicus)
mature NGF homodimer:p75NTR [plasma membrane] (Rattus norvegicus)
Ngfr [plasma membrane] (Rattus norvegicus)
p62 recruits an atypical PKC (Rattus norvegicus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62 [plasma membrane] (Rattus norvegicus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6 [plasma membrane] (Rattus norvegicus)
mature NGF homodimer:p75NTR [plasma membrane] (Rattus norvegicus)
Ngfr [plasma membrane] (Rattus norvegicus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62:aPKCi [plasma membrane] (Rattus norvegicus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62 [plasma membrane] (Rattus norvegicus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6 [plasma membrane] (Rattus norvegicus)
mature NGF homodimer:p75NTR [plasma membrane] (Rattus norvegicus)
Ngfr [plasma membrane] (Rattus norvegicus)
p75NTR interacts with RIP2 (Rattus norvegicus)
NGF:p75NTR:RIP2 [plasma membrane] (Rattus norvegicus)
mature NGF homodimer:p75NTR [plasma membrane] (Rattus norvegicus)
Ngfr [plasma membrane] (Rattus norvegicus)
mature NGF homodimer:p75NTR [plasma membrane] (Rattus norvegicus)
Ngfr [plasma membrane] (Rattus norvegicus)
External Reference Information
External Reference
UniProt:P07174 Ngfr
Gene Names
Ngfr, Tnfrsf16
Chain
signal peptide:1-29, chain:30-425
Reference Genes
BioGPS Gene:24596 Ngfr
KEGG Gene (Rattus norvegicus):24596 Ngfr
Monarch:24596 Ngfr
NCBI Gene:24596 Ngfr
UCSC:P07174 Ngfr
Reference Transcript
RefSeq:NM_012610.2 Ngfr
Participates
as an input of
p75NTR and RHOA-GDI interact (Rattus norvegicus)
alpha-secretase cleaves the p75NTR extracellular domain (Rattus norvegicus)
NGF homodimer binds to p75NTR (Rattus norvegicus)
as a component of
RHOA:GDP:ARHGDIA:NGFR [plasma membrane] (Rattus norvegicus)
NGFR:RTN4R [plasma membrane] (Rattus norvegicus)
mature NGF homodimer:p75NTR [plasma membrane] (Rattus norvegicus)
Other forms of this molecule
Ngfr [nucleoplasm]
Ngfr [plasma membrane]
Ngfr [cytosol]
Ngfr [endosome]
Ngfr [plasma membrane]
Ngfr [extracellular region]
Tumor necrosis factor receptor superfamily member 16 [plasma membrane]
Inferred From
NGFR [plasma membrane]
(Homo sapiens)
Cross References
RefSeq
NP_036742.2
PRO
P07174
RGD
3177
PDB
1NGR
,
4F42
,
4F44
,
3IJ2
,
1SG1
,
2MIC
,
3BUK
,
2MJO
Interactors (7)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P01138 NGF
7
NGF(19-241) [extracellular region]
(R-HSA-187033)
NGF [Golgi lumen]
(R-HSA-166515)
NGF [cytosol]
(R-HSA-190059)
NGF(1-241) [endoplasmic reticulum lumen]
(R-HSA-187026)
NGF(19-241) [Golgi lumen]
(R-HSA-187036)
NGF(19-241) [endoplasmic reticulum lumen]
(R-HSA-187047)
NGF [extracellular region]
(R-HSA-167034)
0.722
3
UniProt:P20783 NTF3
1
NTF3 [extracellular region]
(R-HSA-167062)
0.655
4
UniProt:P07174 Ngfr
8
Ngfr [nucleoplasm]
(R-RNO-197473)
Ngfr [plasma membrane]
(R-RNO-194509)
Ngfr [cytosol]
(R-RNO-194458)
Ngfr [endosome]
(R-RNO-209541)
Ngfr [plasma membrane]
(R-RNO-194476)
Ngfr [extracellular region]
(R-RNO-194470)
Tumor necrosis factor receptor superfamily member 16 [plasma membrane]
(R-RNO-193863)
Ngfr [plasma membrane]
(R-RNO-193664)
0.609
2
UniProt:Q3MKQ2 BEX1
0.591
4
UniProt:Q9Y4K3 TRAF6
8
K48polyUb-TRAF6 [cytosol]
(R-HSA-6783233)
PolyUb-TRAF6 [cytosol]
(R-HSA-6782845)
TRAF6 [endosome membrane]
(R-HSA-450272)
K63polyUb-TRAF6 [endosome membrane]
(R-HSA-450227)
TRAF6 [cytosol]
(R-HSA-166366)
K63polyUb-TRAF6 [cytosol]
(R-HSA-2685681)
K63polyUb-TRAF6 [plasma membrane]
(R-HSA-936980)
TRAF6 [plasma membrane]
(R-HSA-936955)
0.589
2
UniProt:Q12933 TRAF2
5
TRAF2 [nucleoplasm]
(R-HSA-8862199)
K63polyUb-TRAF2 [nucleoplasm]
(R-HSA-8862194)
K63polyUb-TRAF2 [cytosol]
(R-HSA-8862193)
PolyUb-TRAF2 [cytosol]
(R-HSA-6782848)
TRAF2 [cytosol]
(R-HSA-66370)
0.524
3
UniProt:Q9BUZ4 TRAF4
0.524
3
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