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ULK1 [cytosol]
Stable Identifier
R-HSA-1632847
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Serine/threonine-protein kinase ULK1, ULK1_HUMAN
Locations in the PathwayBrowser
Expand all
Autophagy (Homo sapiens)
Macroautophagy (Homo sapiens)
AMPK (complex) phosphorylates ULK1 (complex) (Homo sapiens)
p-AMPK heterotrimer:AMP:ULK1:ATG13:RB1CC1:ATG101 [cytosol] (Homo sapiens)
ULK1:ATG13:RB1CC1:ATG101 [cytosol] (Homo sapiens)
ULK1 [cytosol] (Homo sapiens)
Active MTORC1 binds the ULK1 complex (Homo sapiens)
MTORC1:RHEB:GTP:ULK1:ATG13:RB1CC1:ATG101 [lysosomal membrane] (Homo sapiens)
ULK1:ATG13:RB1CC1:ATG101 [cytosol] (Homo sapiens)
ULK1 [cytosol] (Homo sapiens)
ULK1:ATG13:RB1CC1:ATG101 [cytosol] (Homo sapiens)
ULK1 [cytosol] (Homo sapiens)
Active MTORC1 phosphorylates ULK1 (Homo sapiens)
MTORC1:RHEB:GTP:ULK1:ATG13:RB1CC1:ATG101 [lysosomal membrane] (Homo sapiens)
ULK1:ATG13:RB1CC1:ATG101 [cytosol] (Homo sapiens)
ULK1 [cytosol] (Homo sapiens)
Selective autophagy (Homo sapiens)
Mitophagy (Homo sapiens)
Receptor Mediated Mitophagy (Homo sapiens)
ULK1 Translocates to the mitochondria (Homo sapiens)
ULK1 [cytosol] (Homo sapiens)
ULK1 is dephosphorylated (Homo sapiens)
ULK1:ATG13:RB1CC1:ATG101 [cytosol] (Homo sapiens)
ULK1 [cytosol] (Homo sapiens)
p-AMPK:AMP binds the ULK complex (Homo sapiens)
ULK1:ATG13:RB1CC1:ATG101 [cytosol] (Homo sapiens)
ULK1 [cytosol] (Homo sapiens)
p-AMPK heterotrimer:AMP:ULK1:ATG13:RB1CC1:ATG101 [cytosol] (Homo sapiens)
ULK1:ATG13:RB1CC1:ATG101 [cytosol] (Homo sapiens)
ULK1 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Death Receptor Signaling (Homo sapiens)
TNF signaling (Homo sapiens)
Regulation of TNFR1 signaling (Homo sapiens)
ULK1 phosphorylates RIPK1 at S357 (Homo sapiens)
ULK1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:O75385 ULK1
Gene Names
ULK1, KIAA0722
Chain
chain:1-1050
Reference Genes
BioGPS Gene:8408 ULK1
COSMIC (genes):ULK1 ULK1
CTD Gene:8408 ULK1
dbSNP Gene:8408 ULK1
ENSEMBL:ENSG00000177169 ULK1
ENSEMBL:ENSG00000177169.10 ULK1
HGNC:12558 ULK1
KEGG Gene (Homo sapiens):8408 ULK1
Monarch:8408 ULK1
NCBI Gene:8408 ULK1
OMIM:603168 ULK1
UCSC:O75385 ULK1
Reference Transcript
RefSeq:NM_003565.2 ULK1
Other Identifiers
11744271_a_at
16759350
209333_PM_at
209333_at
3438528
3438529
3438530
3438531
3438532
3438546
3438547
3438548
3438549
3438550
3438553
3438554
3438555
3438556
3438557
3438558
3438560
3438561
3438562
3438563
3438564
3438565
3438566
3438567
3438570
3438572
3438574
3438576
3438578
3438579
3438580
34827_at
7959957
8408
A_23_P72550
A_24_P73370
GE54394
GO:0000045
GO:0000166
GO:0000407
GO:0000421
GO:0003824
GO:0004672
GO:0004674
GO:0005515
GO:0005524
GO:0005737
GO:0005739
GO:0005741
GO:0005768
GO:0005773
GO:0005776
GO:0005783
GO:0005789
GO:0005829
GO:0006468
GO:0006914
GO:0007165
GO:0007409
GO:0008104
GO:0008285
GO:0010508
GO:0010803
GO:0016020
GO:0016236
GO:0016241
GO:0016301
GO:0016310
GO:0016740
GO:0018105
GO:0018107
GO:0023052
GO:0030154
GO:0030424
GO:0031102
GO:0031175
GO:0031267
GO:0031333
GO:0031410
GO:0031669
GO:0034045
GO:0034727
GO:0036211
GO:0042594
GO:0042802
GO:0043226
GO:0044805
GO:0044877
GO:0046777
GO:0048671
GO:0048675
GO:0048856
GO:0051020
GO:0055037
GO:0061709
GO:0065003
GO:0106310
GO:0140096
GO:1903059
GO:1903349
GO:1990316
GO:2000786
HMNXSV003029832
ILMN_1705144
ILMN_1735052
ILMN_1744560
ILMN_1761288
PH_hs_0003343
TC12001049.hg
g3882164_3p_at
Participates
as a component of
ULK1:ATG13:RB1CC1:ATG101 [cytosol] (Homo sapiens)
as an input of
ULK1 Translocates to the mitochondria (Homo sapiens)
Other forms of this molecule
ULK1 [recycling endosome]
p-S758-ULK1 [cytosol]
p-S317,467,556,638,T575-ULK1 [cytosol]
ULK1 [mitochondrial outer membrane]
p-T180,S317,S467,S556,S638,T575-ULK1 [endoplasmic reticulum membrane]
p-T180,S317,S467,S556,S638,T575-ULK1 [cytosol]
Inferred To
ULK1 [cytosol]
(Bos taurus)
ULK1 [cytosol]
(Caenorhabditis elegans)
ULK1 [cytosol]
(Canis familiaris)
ULK1 [cytosol]
(Danio rerio)
ULK1 [cytosol]
(Dictyostelium discoideum)
ULK1 [cytosol]
(Drosophila melanogaster)
ULK1 [cytosol]
(Gallus gallus)
ULK1 [cytosol]
(Mus musculus)
ULK1 [cytosol]
(Rattus norvegicus)
ULK1 [cytosol]
(Saccharomyces cerevisiae)
ULK1 [cytosol]
(Schizosaccharomyces pombe)
ULK1 [cytosol]
(Sus scrofa)
ULK1 [cytosol]
(Xenopus tropicalis)
Homologues of ULK1 [cytosol]
(Caenorhabditis elegans)
Homologues of ULK1 [cytosol]
(Dictyostelium discoideum)
Cross References
RefSeq
NP_003556.1
ZINC - World Drugs
ULK1_HUMAN
Guide to Pharmacology - Targets
2271
OpenTargets
ENSG00000177169
ZINC - FDA approved
ULK1_HUMAN
ZINC - Substances
ULK1_HUMAN
ZINC - Biogenic
ULK1_HUMAN
ZINC target
O75385
PRO
O75385
PDB
5CI7
,
6QAS
,
6HYO
,
4WNP
,
4WNO
,
6MNH
ZINC - Investigational
ULK1_HUMAN
HPA
ENSG00000177169-ULK1
GeneCards
O75385
Ensembl
ENST00000321867
,
ENSP00000324560
,
ENSG00000177169
Pharos - Targets
O75385
ZINC - Predictions - Purchasable
ULK1_HUMAN
HMDB Protein
HMDBP01330
Interactors (25)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O75143 ATG13
3
ATG13 [cytosol]
(R-HSA-5333624)
p-ATG13 [cytosol]
(R-HSA-5675831)
p-ATG13 [endoplasmic reticulum membrane]
(R-HSA-8948049)
0.926
13
UniProt:Q8TDY2 RB1CC1
3
RB1CC1 [cytosol]
(R-HSA-5333627)
p-RB1CC1 [cytosol]
(R-HSA-5675845)
RB1CC1 [endoplasmic reticulum membrane]
(R-HSA-8948046)
0.864
11
UniProt:P42345 MTOR
2
MTOR [nucleoplasm]
(R-HSA-5083674)
MTOR [cytosol]
(R-HSA-165662)
0.702
7
IntAct:EBI-4399559 UBIQ
0.697
5
UniProt:P54619 PRKAG1
2
PRKAG1 [nucleoplasm]
(R-HSA-2151202)
PRKAG1 [cytosol]
(R-HSA-380946)
0.669
3
UniProt:Q13131 PRKAA1
3
p-T183-PRKAA1 [nucleoplasm]
(R-HSA-2151206)
p-T183-PRKAA1 [cytosol]
(R-HSA-380964)
PRKAA1 [cytosol]
(R-HSA-380935)
0.669
3
UniProt:Q96LT7-1 C9ORF72
0.667
5
UniProt:Q9BXW4 MAP1LC3C
3
MAP1LC3C [autophagosome membrane]
(R-HSA-5683638)
MAP1LC3C(1-147) [cytosol]
(R-HSA-5682653)
MAP1LC3C [cytosol]
(R-HSA-5679223)
0.656
3
UniProt:Q9GZQ8 MAP1LC3B
3
MAP1LC3B [autophagosome membrane]
(R-HSA-5683641)
MAP1LC3B(2-121) [cytosol]
(R-HSA-5682674)
MAP1LC3B [cytosol]
(R-HSA-5205651)
0.656
3
UniProt:Q9BSB4 ATG101
2
ATG101 [cytosol]
(R-HSA-5333634)
ATG101 [endoplasmic reticulum membrane]
(R-HSA-8948051)
0.643
4
UniProt:Q9Y478 PRKAB1
2
PRKAB1 [nucleoplasm]
(R-HSA-2151199)
PRKAB1 [cytosol]
(R-HSA-380968)
0.641
3
UniProt:Q9C0C7 AMBRA1
2
p-AMBRA1 [cytosol]
(R-HSA-1632854)
AMBRA1 [cytosol]
(R-HSA-1632831)
0.641
3
UniProt:P42858 HTT
1
HTT [nucleoplasm]
(R-HSA-9023590)
0.612
8
UniProt:O95166 GABARAP
3
GABARAP [autophagosome membrane]
(R-HSA-5683634)
GABARAP(1-117) [cytosol]
(R-HSA-5682696)
GABARAP [cytosol]
(R-HSA-975521)
0.609
2
UniProt:P60520 GABARAPL2
3
GABARAPL2 [autophagosome membrane]
(R-HSA-5683633)
GABARAPL2(1-117) [cytosol]
(R-HSA-5682641)
GABARAPL2 [cytosol]
(R-HSA-5671758)
0.591
3
UniProt:Q96LT7 CI072
0.571
2
UniProt:O75385 ULK1
7
ULK1 [recycling endosome]
(R-HSA-8854761)
p-S758-ULK1 [cytosol]
(R-HSA-5672131)
p-S317,467,556,638,T575-ULK1 [cytosol]
(R-HSA-5673747)
ULK1 [cytosol]
(R-HSA-1632847)
ULK1 [mitochondrial outer membrane]
(R-HSA-8948145)
p-T180,S317,S467,S556,S638,T575-ULK1 [endoplasmic reticulum membrane]
(R-HSA-8948047)
p-T180,S317,S467,S556,S638,T575-ULK1 [cytosol]
(R-HSA-5675858)
0.564
3
UniProt:P54646 PRKAA2
4
PRKAA2 [cytosol]
(R-HSA-200405)
p-T172-PRKAA2 [cytosol]
(R-HSA-200417)
p-T172-PRKAA2 [nucleoplasm]
(R-HSA-164171)
PRKAA2 [nucleoplasm]
(R-HSA-163682)
0.564
2
UniProt:Q96LT7-2 C9ORF72
0.563
4
UniProt:Q9H0R8 GABARAPL1
3
GABARAPL1 [autophagosome membrane]
(R-HSA-5683637)
GABARAPL1(1-117) [cytosol]
(R-HSA-5682659)
GABARAPL1 [cytosol]
(R-HSA-5671757)
0.544
2
UniProt:Q9P2M4 TBC1D14
1
TBC1D14 [recycling endosome]
(R-HSA-8854764)
0.543
4
UniProt:Q9C0C7-3 AMBRA1
0.524
4
UniProt:Q9Y4K3 TRAF6
8
K48polyUb-TRAF6 [cytosol]
(R-HSA-6783233)
PolyUb-TRAF6 [cytosol]
(R-HSA-6782845)
TRAF6 [endosome membrane]
(R-HSA-450272)
K63polyUb-TRAF6 [endosome membrane]
(R-HSA-450227)
TRAF6 [cytosol]
(R-HSA-166366)
K63polyUb-TRAF6 [cytosol]
(R-HSA-2685681)
K63polyUb-TRAF6 [plasma membrane]
(R-HSA-936980)
TRAF6 [plasma membrane]
(R-HSA-936955)
0.499
2
UniProt:Q8N122 RPTOR
3
RPTOR [nucleoplasm]
(R-HSA-5083664)
RPTOR [cytosol]
(R-HSA-3006727)
p-S722,S792-RPTOR [cytosol]
(R-HSA-3132767)
0.499
3
UniProt:P04629 NTRK1
4
p-5Y-NTRK1 [Golgi membrane]
(R-HSA-3008810)
NTRK1 [Golgi membrane]
(R-HSA-3008805)
NTRK1 [plasma membrane]
(R-HSA-3008784)
p-5Y-NTRK1 [plasma membrane]
(R-HSA-3009413)
0.499
2
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