Reactome | IL1R1 [plasma membrane]

IL1R1 [plasma membrane]

Stable Identifier

R-HSA-197595

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Interleukin-1 receptor type 1, IL1R_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P14778 IL1R1

Gene Names

IL1R1, IL1R, IL1RA, IL1RT1

Chain

signal peptide:1-17, chain:18-569, chain:18-

Reference Genes

BioGPS Gene:3554 IL1R1

COSMIC - genes:IL1R1 IL1R1

CTD Gene:3554 IL1R1

dbSNP Gene:3554 IL1R1

ENSEMBL:ENSG00000115594 IL1R1

HGNC:5993 IL1R1

KEGG:hsa:3554 IL1R1

Monarch:3554 IL1R1

NCBI Gene:3554 IL1R1

OMIM:147810 IL1R1

UCSC:P14778 IL1R1

Reference Transcript

Other Identifiers

11718025_at

11756953_a_at

1368_at

16883647

202948_PM_at

202948_at

215561_PM_s_at

215561_s_at

2496963

2496964

2496965

2496966

2496974

2496976

2496977

2496978

2496988

2496989

2496991

2496993

2496994

2496995

2496997

2497000

2497001

2497002

2497003

2497004

2497005

2497006

2497007

2497008

2497009

2497010

2497012

2497013

2497014

2497015

2497016

2497017

3554

8043995

A_14_P134709

A_23_P68006

A_24_P200023

A_33_P3396389

GE57896

GO:0002020

GO:0002376

GO:0003012

GO:0004888

GO:0004896

GO:0004908

GO:0004909

GO:0005161

GO:0005515

GO:0005576

GO:0005886

GO:0006954

GO:0006955

GO:0007165

GO:0007166

GO:0009897

GO:0009986

GO:0010641

GO:0014805

GO:0016020

GO:0016787

GO:0019221

GO:0019966

GO:0032729

GO:0043123

GO:0050727

GO:0051897

GO:0061809

GO:0070498

GO:0070555

GO:2000391

GO:2000556

GO:2000661

HMNXSV003010381

HMNXSV003026332

Hs.277176.0.S1_3p_s_at

ILMN_1810584

M27492_at

PH_hs_0004694

TC02000620.hg

g4504658_3p_at

Participates

as a member of

as an input of

as a component of

Inferred To

il1r1 [plasma membrane] (Xenopus tropicalis)

il1rl2 [plasma membrane] (Danio rerio)

IL1R1 [plasma membrane] (Bos taurus)

IL1R1 [plasma membrane] (Canis familiaris)

IL1R1 [plasma membrane] (Gallus gallus)

IL1R1 [plasma membrane] (Sus scrofa)

Il1r1 [plasma membrane] (Mus musculus)

Il1r1 [plasma membrane] (Rattus norvegicus)

Cross References

RefSeq

NP_001307910.1, XP_054197790.1, XP_054197791.1, NP_001307912.1, NP_001275635.1, NP_001307907.1, XP_011509418.1, XP_005263991.1, XP_047300133.1, NP_001307911.1, NP_001307913.1, NP_001307914.1, XP_047300134.1, XP_047300132.1, XP_047300135.1, NP_001307909.1, XP_011509417.1, XP_054197787.1, XP_005263987.1, XP_054197786.1, XP_011509420.1, XP_054197789.1, NP_000868.1, XP_054197788.1

Guide to Pharmacology - Targets

1734

OpenTargets

ENSG00000115594

ENSEMBL

ENST00000410023, ENSG00000115594, ENSP00000386380

HPA

ENSG00000115594-IL1R1

GeneCards

IL1R1

PRO

P14778

Pharos - Targets

P14778

GlyGen

P14778

PDB

4DEP, 1G0Y, 1ITB, 1IRA, 4GAF

HMDB Protein

HMDBP12410

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9NPH3 IL1RAP			0.656	3
UniProt:P18510 IL1RN	1	IL1RN [plasma membrane] (R-HSA-445743)	0.609	2
UniProt:P55082 MFAP3	1	MFAP3 [extracellular region] (R-HSA-2161382)	0.527	2
UniProt:Q3ZCM7 TUBB8	3	Polyglycyl-TUBB8 [cytosol] (R-HSA-8867423) Polyglutamyl-TUBB8 [cytosol] (R-HSA-8867387) TUBB8 [cytosol] (R-HSA-6805243)	0.527	2
UniProt:P36894 BMPR1A	2	BMPR1A [plasma membrane] (R-HSA-201480) p-4S-BMPR1A [plasma membrane] (R-HSA-201448)	0.527	2
UniProt:Q9Y4K3 TRAF6	8	TRAF6 [cytosol] (R-HSA-166366) K63polyUb-TRAF6 [cytosol] (R-HSA-2685681) K63polyUb-TRAF6 [plasma membrane] (R-HSA-936980) TRAF6 [plasma membrane] (R-HSA-936955) K63polyUb-TRAF6 [endosome membrane] (R-HSA-450227) TRAF6 [endosome membrane] (R-HSA-450272) PolyUb-TRAF6 [cytosol] (R-HSA-6782845) K48polyUb-TRAF6 [cytosol] (R-HSA-6783233)	0.499	2

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