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IL1R1 [plasma membrane]
Stable Identifier
R-HSA-197595
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Interleukin-1 receptor type 1, IL1R_HUMAN
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Viral Infection Pathways (Homo sapiens)
SARS-CoV Infections (Homo sapiens)
Potential therapeutics for SARS (Homo sapiens)
IL1R1 binds IL1R1 inhibitors (Homo sapiens)
IL1R1 [plasma membrane] (Homo sapiens)
IL1R1:IL1R1 inhibitors [plasma membrane] (Homo sapiens)
IL1R1 [plasma membrane] (Homo sapiens)
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-1 family signaling (Homo sapiens)
Interleukin-1 signaling (Homo sapiens)
Hyperphosphorylated IRAK1 associates with TRAF6 (Homo sapiens)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:p-2S,S376,T,T209,T378-IRAK1 [plasma membrane] (Homo sapiens)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Homo sapiens)
IL1R1:IL1:IL1RAP [plasma membrane] (Homo sapiens)
IL1B,Myr82K-Myr83K-IL1A:IL1R1 [plasma membrane] (Homo sapiens)
IL1R1 [plasma membrane] (Homo sapiens)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:p-2S,S376,T,T209,T378-IRAK1:TRAF6 [plasma membrane] (Homo sapiens)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:p-2S,S376,T,T209,T378-IRAK1 [plasma membrane] (Homo sapiens)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Homo sapiens)
IL1R1:IL1:IL1RAP [plasma membrane] (Homo sapiens)
IL1B,Myr82K-Myr83K-IL1A:IL1R1 [plasma membrane] (Homo sapiens)
IL1R1 [plasma membrane] (Homo sapiens)
IL1 receptor antagonist protein binds Interleukin 1 receptors (Homo sapiens)
IL1R1:IL1R2 [plasma membrane] (Homo sapiens)
IL1R1 [plasma membrane] (Homo sapiens)
IL1R1:IL1R2:IL1RN [plasma membrane] (Homo sapiens)
IL1R1:IL1R2 [plasma membrane] (Homo sapiens)
IL1R1 [plasma membrane] (Homo sapiens)
IL1B,Myr82K-Myr83K-IL1A:IL1R1 (Homo sapiens)
IL1B,Myr82K-Myr83K-IL1A:IL1R1 [plasma membrane] (Homo sapiens)
IL1R1 [plasma membrane] (Homo sapiens)
IL1R1 [plasma membrane] (Homo sapiens)
IL1R1:IL1R1 inhibitors [plasma membrane] (Homo sapiens)
IL1R1 [plasma membrane] (Homo sapiens)
IL1R1 binds IL1R1 inhibitors (Homo sapiens)
IL1R1 [plasma membrane] (Homo sapiens)
IL1R1:IL1R1 inhibitors [plasma membrane] (Homo sapiens)
IL1R1 [plasma membrane] (Homo sapiens)
IL1R1:IL1:IL1RAP binds MYD88 homodimer (Homo sapiens)
IL1R1:IL1:IL1RAP [plasma membrane] (Homo sapiens)
IL1B,Myr82K-Myr83K-IL1A:IL1R1 [plasma membrane] (Homo sapiens)
IL1R1 [plasma membrane] (Homo sapiens)
IL1R1:IL1:IL1RAP:MYD88 dimer [plasma membrane] (Homo sapiens)
IL1R1:IL1:IL1RAP [plasma membrane] (Homo sapiens)
IL1B,Myr82K-Myr83K-IL1A:IL1R1 [plasma membrane] (Homo sapiens)
IL1R1 [plasma membrane] (Homo sapiens)
IL1R1:IL1:IL1RAP:MYD88 homodimer binds IRAK4 (Homo sapiens)
IL1R1:IL1:IL1RAP:IRAK4:MYD88 dimer [plasma membrane] (Homo sapiens)
IL1R1:IL1:IL1RAP:MYD88 dimer [plasma membrane] (Homo sapiens)
IL1R1:IL1:IL1RAP [plasma membrane] (Homo sapiens)
IL1B,Myr82K-Myr83K-IL1A:IL1R1 [plasma membrane] (Homo sapiens)
IL1R1 [plasma membrane] (Homo sapiens)
IL1R1:IL1:IL1RAP:MYD88 dimer [plasma membrane] (Homo sapiens)
IL1R1:IL1:IL1RAP [plasma membrane] (Homo sapiens)
IL1B,Myr82K-Myr83K-IL1A:IL1R1 [plasma membrane] (Homo sapiens)
IL1R1 [plasma membrane] (Homo sapiens)
IRAK1 binds to MYD88 within the IL1R complex (Homo sapiens)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Homo sapiens)
IL1R1:IL1:IL1RAP [plasma membrane] (Homo sapiens)
IL1B,Myr82K-Myr83K-IL1A:IL1R1 [plasma membrane] (Homo sapiens)
IL1R1 [plasma membrane] (Homo sapiens)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:IRAK1 [plasma membrane] (Homo sapiens)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Homo sapiens)
IL1R1:IL1:IL1RAP [plasma membrane] (Homo sapiens)
IL1B,Myr82K-Myr83K-IL1A:IL1R1 [plasma membrane] (Homo sapiens)
IL1R1 [plasma membrane] (Homo sapiens)
IRAK2 is phosphorylated downstream of IRAK4 following IL1 receptor activation (Homo sapiens)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Homo sapiens)
IL1R1:IL1:IL1RAP [plasma membrane] (Homo sapiens)
IL1B,Myr82K-Myr83K-IL1A:IL1R1 [plasma membrane] (Homo sapiens)
IL1R1 [plasma membrane] (Homo sapiens)
IRAK4 is activated by autophosphorylation (Homo sapiens)
IL1R1:IL1:IL1RAP:IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Homo sapiens)
IL1R1:IL1:IL1RAP:IRAK4:MYD88 dimer [plasma membrane] (Homo sapiens)
IL1R1:IL1:IL1RAP:MYD88 dimer [plasma membrane] (Homo sapiens)
IL1R1:IL1:IL1RAP [plasma membrane] (Homo sapiens)
IL1B,Myr82K-Myr83K-IL1A:IL1R1 [plasma membrane] (Homo sapiens)
IL1R1 [plasma membrane] (Homo sapiens)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Homo sapiens)
IL1R1:IL1:IL1RAP [plasma membrane] (Homo sapiens)
IL1B,Myr82K-Myr83K-IL1A:IL1R1 [plasma membrane] (Homo sapiens)
IL1R1 [plasma membrane] (Homo sapiens)
IRAK4 phosphorylates IRAK1 (Homo sapiens)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:IRAK1 [plasma membrane] (Homo sapiens)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Homo sapiens)
IL1R1:IL1:IL1RAP [plasma membrane] (Homo sapiens)
IL1B,Myr82K-Myr83K-IL1A:IL1R1 [plasma membrane] (Homo sapiens)
IL1R1 [plasma membrane] (Homo sapiens)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:p-S376,T378-IRAK1 [plasma membrane] (Homo sapiens)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Homo sapiens)
IL1R1:IL1:IL1RAP [plasma membrane] (Homo sapiens)
IL1B,Myr82K-Myr83K-IL1A:IL1R1 [plasma membrane] (Homo sapiens)
IL1R1 [plasma membrane] (Homo sapiens)
IRAK4-activated IRAK1 autophosphorylates (Homo sapiens)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:p-2S,S376,T,T209,T378-IRAK1 [plasma membrane] (Homo sapiens)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Homo sapiens)
IL1R1:IL1:IL1RAP [plasma membrane] (Homo sapiens)
IL1B,Myr82K-Myr83K-IL1A:IL1R1 [plasma membrane] (Homo sapiens)
IL1R1 [plasma membrane] (Homo sapiens)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:p-S376,T378-IRAK1 [plasma membrane] (Homo sapiens)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Homo sapiens)
IL1R1:IL1:IL1RAP [plasma membrane] (Homo sapiens)
IL1B,Myr82K-Myr83K-IL1A:IL1R1 [plasma membrane] (Homo sapiens)
IL1R1 [plasma membrane] (Homo sapiens)
Interleukin-1 receptor type 1: Interleukin 1 binds Interleukin-1 receptor accessory protein, membrane associated isoform (Homo sapiens)
IL1B,Myr82K-Myr83K-IL1A:IL1R1 [plasma membrane] (Homo sapiens)
IL1R1 [plasma membrane] (Homo sapiens)
IL1R1:IL1:IL1RAP [plasma membrane] (Homo sapiens)
IL1B,Myr82K-Myr83K-IL1A:IL1R1 [plasma membrane] (Homo sapiens)
IL1R1 [plasma membrane] (Homo sapiens)
TRAF6 binding leads to IRAK1:TRAF6 release (Homo sapiens)
IL1R1:IL1:IL1RAP:MYD88 dimer [plasma membrane] (Homo sapiens)
IL1R1:IL1:IL1RAP [plasma membrane] (Homo sapiens)
IL1B,Myr82K-Myr83K-IL1A:IL1R1 [plasma membrane] (Homo sapiens)
IL1R1 [plasma membrane] (Homo sapiens)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:p-2S,S376,T,T209,T378-IRAK1:TRAF6 [plasma membrane] (Homo sapiens)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:p-2S,S376,T,T209,T378-IRAK1 [plasma membrane] (Homo sapiens)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Homo sapiens)
IL1R1:IL1:IL1RAP [plasma membrane] (Homo sapiens)
IL1B,Myr82K-Myr83K-IL1A:IL1R1 [plasma membrane] (Homo sapiens)
IL1R1 [plasma membrane] (Homo sapiens)
The Interleukin 1 receptor complex binds Tollip (Homo sapiens)
IL1R1:IL1:IL1RAP:IRAK4:MYD88 dimer [plasma membrane] (Homo sapiens)
IL1R1:IL1:IL1RAP:MYD88 dimer [plasma membrane] (Homo sapiens)
IL1R1:IL1:IL1RAP [plasma membrane] (Homo sapiens)
IL1B,Myr82K-Myr83K-IL1A:IL1R1 [plasma membrane] (Homo sapiens)
IL1R1 [plasma membrane] (Homo sapiens)
IL1R1:IL1:IL1RAP:IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Homo sapiens)
IL1R1:IL1:IL1RAP:IRAK4:MYD88 dimer [plasma membrane] (Homo sapiens)
IL1R1:IL1:IL1RAP:MYD88 dimer [plasma membrane] (Homo sapiens)
IL1R1:IL1:IL1RAP [plasma membrane] (Homo sapiens)
IL1B,Myr82K-Myr83K-IL1A:IL1R1 [plasma membrane] (Homo sapiens)
IL1R1 [plasma membrane] (Homo sapiens)
Interleukin-10 signaling (Homo sapiens)
IL10 negatively regulates plasma membrane-associated inflammatory mediators (Homo sapiens)
IL10-downregulated plasma membrane proteins [plasma membrane] (Homo sapiens)
IL1R1 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P14778 IL1R1
Gene Names
IL1R1, IL1R, IL1RA, IL1RT1
Chain
signal peptide:1-17, chain:18-569, chain:18-
Reference Genes
BioGPS Gene:3554 IL1R1
COSMIC (genes):IL1R1 IL1R1
CTD Gene:3554 IL1R1
dbSNP Gene:3554 IL1R1
ENSEMBL:ENSG00000115594 IL1R1
ENSEMBL_homo_sapiens_GENE:ENSG00000115594.12 IL1R1
HGNC:5993 IL1R1
KEGG Gene (Homo sapiens):3554 IL1R1
Monarch:3554 IL1R1
NCBI Gene:3554 IL1R1
OMIM:147810 IL1R1
UCSC:P14778 IL1R1
Reference Transcript
RefSeq:XM_017003989.1 IL1R1
RefSeq:NM_001320985.1 IL1R1
RefSeq:NM_001320981.1 IL1R1
RefSeq:NM_001320980.1 IL1R1
RefSeq:XM_011511116.1 IL1R1
RefSeq:NM_000877.3 IL1R1
RefSeq:NM_001320983.1 IL1R1
RefSeq:NM_001320984.1 IL1R1
RefSeq:XM_011511118.2 IL1R1
RefSeq:XM_005263934.4 IL1R1
RefSeq:NM_001320978.1 IL1R1
RefSeq:XM_011511115.2 IL1R1
RefSeq:XM_005263930.4 IL1R1
RefSeq:NM_001320982.1 IL1R1
RefSeq:XM_011511117.1 IL1R1
RefSeq:NM_001288706.1 IL1R1
Other Identifiers
11718025_at
11756953_a_at
1368_at
16883647
202948_PM_at
202948_at
215561_PM_s_at
215561_s_at
2496989
2496993
2496997
2497000
2497001
2497002
2497004
2497006
2497007
2497009
2497010
2497012
2497015
2497016
2497017
3554
8043995
A_14_P134709
A_23_P68006
A_24_P200023
A_33_P3396389
GE57896
GO:0002020
GO:0002376
GO:0003824
GO:0003953
GO:0004888
GO:0004908
GO:0004909
GO:0005161
GO:0005515
GO:0005576
GO:0005886
GO:0006954
GO:0006955
GO:0007165
GO:0007166
GO:0009897
GO:0009986
GO:0016020
GO:0016787
GO:0019221
GO:0019966
GO:0023052
GO:0032729
GO:0048870
GO:0050135
GO:0050727
GO:0060089
GO:0061809
GO:0070498
GO:0070555
GO:2000391
GO:2000556
GO:2000661
HMNXSV003026332
Hs.277176.0.S1_3p_s_at
ILMN_1810584
M27492_at
PH_hs_0004694
TC02000620.hg
g4504658_3p_at
Participates
as a member of
IL10-downregulated plasma membrane proteins [plasma membrane] (Homo sapiens)
IL1R1:IL1R2 [plasma membrane] (Homo sapiens)
as an input of
IL1R1 binds IL1R1 inhibitors (Homo sapiens)
IL1B,Myr82K-Myr83K-IL1A:IL1R1 (Homo sapiens)
as a component of
IL1R1:IL1R1 inhibitors [plasma membrane] (Homo sapiens)
IL1B,Myr82K-Myr83K-IL1A:IL1R1 [plasma membrane] (Homo sapiens)
Inferred To
il1r1 [plasma membrane]
(Xenopus tropicalis)
IL1R1 [plasma membrane]
(Bos taurus)
IL1R1 [plasma membrane]
(Canis familiaris)
IL1R1 [plasma membrane]
(Gallus gallus)
IL1R1 [plasma membrane]
(Sus scrofa)
Il1r1 [plasma membrane]
(Mus musculus)
Il1r1 [plasma membrane]
(Rattus norvegicus)
Cross References
RefSeq
NP_001307911.1
,
XP_011509417.1
,
XP_016859478.1
,
XP_011509418.1
,
NP_001307909.1
,
XP_011509420.1
,
NP_001275635.1
,
XP_011509419.1
,
NP_001307913.1
,
NP_001307914.1
,
NP_001307910.1
,
NP_000868.1
,
NP_001307907.1
,
NP_001307912.1
,
XP_005263987.1
,
XP_005263991.1
Guide to Pharmacology - Targets
1734
OpenTargets
ENSG00000115594
GeneCards
P14778
HPA
ENSG00000115594-IL1R1
Ensembl
ENST00000410023
,
ENSP00000386380
,
ENSG00000115594
PRO
P14778
Pharos - Targets
P14778
HMDB Protein
HMDBP12410
PDB
1IRA
,
4DEP
,
4GAF
,
1G0Y
,
1ITB
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9NPH3 IL1RAP
0.667
3
UniProt:Q9Y4K3 TRAF6
8
K48polyUb-TRAF6 [cytosol]
(R-HSA-6783233)
PolyUb-TRAF6 [cytosol]
(R-HSA-6782845)
TRAF6 [endosome membrane]
(R-HSA-450272)
K63polyUb-TRAF6 [endosome membrane]
(R-HSA-450227)
TRAF6 [cytosol]
(R-HSA-166366)
K63polyUb-TRAF6 [cytosol]
(R-HSA-2685681)
K63polyUb-TRAF6 [plasma membrane]
(R-HSA-936980)
TRAF6 [plasma membrane]
(R-HSA-936955)
0.499
2
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