Rui Xiao

 ORCID
https://orcid.org/0000-0001-5541-6685
Reviewed Pathways (4/4)
Date Identifier Pathway Reference
2024-07-16 R-HSA-9855142 Cellular responses to mechanical stimuli BibTex
2024-07-16 R-HSA-9860931 Response of endothelial cells to shear stress BibTex
2024-07-16 R-HSA-9856530 High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells BibTex
2024-07-16 R-HSA-9860927 Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells BibTex
Reviewed Reactions (63/63)
Date Identifier Reaction Reference
2024-07-16 R-HSA-9858800 TRPV4 tetramer:CALM1:Ca2+ transports calcium ions (Ca2+) from the extracellular region to the cytosol BibTex
2024-07-16 R-HSA-9865670 TRPV4 tetramer binds CALM1:Ca2+ (calmodulin:Ca2+) BibTex
2024-07-16 R-MMU-9858790 Trpv4 tetramer transports calcium ions (Ca2+) from the extracellular region to the cytosol BibTex
2024-07-16 R-BTA-9858823 TRPV4 tetramer transports calcium ions (Ca2+) from the extracellular region to the cytosol BibTex
2024-07-16 R-HSA-9855089 PIEZO1 trimer passively transports cations across the plasma membrane according to their electrochemical gradients BibTex
2024-07-16 R-MMU-9855091 Piezo1 trimer passively transports cations across the plasma membrane according to their concentration gradients BibTex
2024-07-16 R-HSA-9861293 ADM:CALCRL:RAMP2:G-alpha(s):GTP:G-beta:G-gamma dissociates BibTex
2024-07-16 R-HSA-9861324 ADM:CALCRL:RAMP2:G-alpha(s):GDP:G-beta:G-gamma exchanges GDP for GTP BibTex
2024-07-16 R-HSA-9861300 ADM:CALCRL:RAMP2 binds G(s):GDP:Gbeta:Ggamma heterotrimer BibTex
2024-07-16 R-HSA-9861332 ADM (Adrenomedullin) binds CALCRL:RAMP2 BibTex
2024-07-16 R-HSA-9861331 Secretion of ADM (Adrenomedullin) BibTex
2024-07-16 R-HSA-8985983 p-Y701-STAT1 dimer translocates from the cytosol to the nucleus BibTex
2024-07-16 R-HSA-9865511 Phosphorylation of STAT1 on tyrosine-701 is enhanced by p-S172-IKBKE BibTex
2024-07-16 R-HSA-9865492 Phosphorylation of IKBKE on serine-172 in response to low shear stress BibTex
2024-07-16 R-HSA-9855161 Pannexin-1 (PANX1) channel transports ATP from the cytosol to the extracellular region BibTex
2024-07-16 R-HSA-9860787 P2RY2 binds ATP BibTex
2024-07-16 R-MMU-9857696 Pannexin-1 (Panx1) channel transports ATP from the cytosol to the extracellular region BibTex
2024-07-16 R-HSA-9860759 p-T816-PKN2 phosphorylates AKT1 on serine-308 BibTex
2024-07-16 R-HSA-9860800 mTORC2 phosphorylates AKT1 on serine-473 BibTex
2024-07-16 R-HSA-9860833 AKT1 binds phosphoinositol-3,4,5-trisphosphate (PIP3) BibTex
2024-07-16 R-HSA-9860816 Phospho-PI3K in p-Y713-PECAM1:CDH5:PIK3CA,B,D:p-Y464-PIK3R2:p-Y801,Y1054,Y1175-KDR:p-Y1063,Y1230-FLT4:CTNNB1 phosphorylates phosphoinositol-4,5-bisphosphate to yield phosphoinositol-3,4,5-trisphosphate BibTex
2024-07-16 R-HSA-9860571 Phosphorylation of PI3K in p-Y713-PECAM1:CDH5:PIK3CA,B,D:PIK3R2:p-Y801,Y1054,Y1175-KDR:p-Y1063,Y1230-FLT4:CTNNB1 BibTex
2024-07-16 R-HSA-9860477 PI3K binds p-Y801,Y1054,Y1175-KDR in p-Y713-PECAM1:CDH5:p-Y801,Y1054,Y1175-KDR:p-Y1063,Y1230-FLT4:CTNNB1 BibTex
2024-07-16 R-HSA-9860500 Phosphorylation of KDR (VEGFR2) and FLT4 (VEGFR3) and PECAM1 in PECAM1:CDH5:KDR:FLT4:CTNNB1 BibTex
2024-07-16 R-BTA-9860818 SRC phosphorylates PECAM1 BibTex
2024-07-16 R-MMU-9860515 Phosphorylation of Kdr and Flt4 in Pecam1:Cdh5:Kdr:Flt4:Ctnnb1 in response to shear stress BibTex
2024-07-16 R-MMU-9860569 Pik3ca,b,d:Pik3r2 (Pi3k) binds p-Y799,Y1052,Y1172-Kdr in Pecam1:Cdh5:p-Y799,Y1052,Y1172-Kdr:p-Y1063,Y1230-Flt4:Ctnnb1 BibTex
2024-07-16 R-MMU-9860560 Phosphorylation of Pi3k in Pecam1:Cdh5:PiK3ca,b,d:Pik3r2:p-799,Y1052,Y1172-Kdr:p-Y1063,Y1230-Flt4:Ctnnb1 BibTex
2024-07-16 R-MMU-9863577 Phospho-Pi3k in p-Pecam1:Cdh5:Pik3ca,b,d:p-Y458-Pik3r2:p-Y799,Y1052,Y1172-Kdr:p-Y1063,Y1230-Flt4:Ctnnb1 phosphorylates phosphatidylinositol-4,5-bisphosphate to yield phosphatidylinositol-3,4,5-trisphosphate BibTex
2024-07-16 R-MMU-9863573 Akt1 binds phosphoinositol-3,4,5-trisphosphate BibTex
2024-07-16 R-HSA-9860785 PDPK1 (PDK1) phosphorylates PKN2 on threonine-816 BibTex
2024-07-16 R-HSA-9860796 Phosphorylation of PDPK1 on serine-241 BibTex
2024-07-16 R-HSA-9861318 PKA phosphorylates NOS3 (eNOS) on serine-633 BibTex
2024-07-16 R-HSA-9861511 Ca2+ activates Calpain2 (m-Calpain) BibTex
2024-07-16 R-HSA-9855106 Calpain2 (m-Calpain) cleaves TLN1 (Talin-1) BibTex
2024-07-16 R-MMU-9855152 Calpain2 cleaves Tln1 (Talin-1) BibTex
2024-07-16 R-HSA-9860808 p-T816-PKN2 phosphorylates NOS3 (eNOS) on serine-1179 BibTex
2024-07-16 R-HSA-9860792 Phospho-AKT1 phosphorylates NOS3 (eNOS) on serine-1177 BibTex
2024-07-16 R-HSA-9858803 MMP14 translocates from the Golgi membrane to the plasma membrane BibTex
2024-07-16 R-MMU-9858820 Mmp14 translocates from the Golgi membrane to the plasma membrane BibTex
2024-07-16 R-HSA-9861485 Calpain2 (m-Calpain, CAPN2:CAPNS:Ca2+) cleaves VCL (Vinculin) BibTex
2024-07-16 R-HSA-9865238 PP2A dephosphorylates serine-715 of PDE4D5 in p-S715-PDE4D5:integrin alpha5:integrin beta1:fibronectin BibTex
2024-07-16 R-HSA-9865520 PPP2CA and PPP2R1A,B bind PPP2R2A in p-S26-ANXA2:p-S715-PDE4D5:ITGA5:ITGB1:fibronectin BibTex
2024-07-16 R-HSA-9865501 PPP2R2A binds p-S715-PDE4D5 in p-S26-ANXA2:p-S715-PDE4D5:ITGA5:ITGB1:fibronectin BibTex
2024-07-16 R-HSA-9865182 p-S715-PDE4D5 binds p-S26-ANXA2:integrin alpha5:integrin beta1:fibronectin (p-S26-ANXA2:ITGA5:ITGB1:fibronectin) BibTex
2024-07-16 R-HSA-9865228 p-S26-ANXA2:integrin alpha5:integrin beta1 (p-S26-ANXA2:ITGA5:ITGB1) binds fibronectin (FN1) matrix BibTex
2024-07-16 R-HSA-9865215 p-S26-ANXA2 binds integrin alpha5:beta1 at the plasma membrane BibTex
2024-07-16 R-HSA-9865167 PTPN1 (PTP1B) dephosphorylates tyrosine-24 of ANXA2 (Annexin-2) BibTex
2024-07-16 R-BTA-9865179 Integrin alpha5:integrin beta1 (ITGA5:ITGB1) binds fibronectin (FN1) matrix BibTex
2024-07-16 R-BTA-9865199 p-S585-PDE4D binds integrin alpha5 (ITGA5) in ITGA5:ITGB1:fibronectin BibTex
2024-07-16 R-BTA-9865863 PPP2R2A binds p-S585-PDE4D:ITGA5:ITGB1:fibronectin BibTex
2024-07-16 R-BTA-9865867 PPP2CA and PPP2R1A bind PPP2R2A:p-S585-PDE4D:ITGA5:ITGB1:fibronectin BibTex
2024-07-16 R-BTA-9865216 PP2A dephosphorylates p-S585-PDE4D in p-S585-PDE4D:integrin alpha5:beta1:fibronectin BibTex
2024-07-16 R-HSA-9865748 PDE4D5 in p-S26-ANXA2:PP2A:PDE4D5:ITGA5:ITGB1:fibronectin hydrolyzes cAMP to yield AMP BibTex
2024-07-16 R-BTA-9865751 PDE4D in PDE4D:ITGA5:ITGB1:fibronectin hydrolyzes cAMP to yield AMP BibTex
2024-07-16 R-HSA-9865524 p-Y701-STAT1 binds the NLRP3 gene BibTex
2024-07-16 R-HSA-9861469 p-Y397-PTK2 (FAK) phosphorylates CHUK (IKKA) BibTex
2024-07-16 R-HSA-9861484 Phosphorylation of PTK2 (FAK) on tyrosine-397 in response to turbulent blood flow BibTex
2024-07-16 R-HSA-9865176 p-Y407-YAP1 translocates from the cytosol to the nucleoplasm BibTex
2024-07-16 R-HSA-9865196 p-Y393-ABL1 phosphorylates tyrosine-407 of YAP1 BibTex
2024-07-16 R-HSA-9865184 Phosphorylation of ABL1 on tyrosine-393 in response to oscillatory shear stress BibTex
2024-07-16 R-HSA-9865226 PP2A dephosphorylates serine-127 of YAP1 BibTex
2024-07-16 R-HSA-9861486 PTK2 (FAK) and Gq/11 enhance the degradation of NFKBIA (IkBalpha), phosphorylation of RELA (p65) on serine-536, and translocation of p-S536-RELA:NFKB1 (p65:p50) to the nucleus BibTex
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