P2RY2 binds ATP

Stable Identifier
R-HSA-9860787
Type
Reaction [binding]
Species
Homo sapiens
Compartment
extracellular region, plasma membrane
ReviewStatus
5/5
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P2RY2 binds ATP
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The purinergic receptor P2RY2 (P2Y2, P2U) binds ATP (Erb et al. 1995, Nicholas et al. 1996) and activates signaling by the G protein alpha subunit Gq or G11 (Gq/11) (inferred from rabbit homologs in Murthy and Makhlouf 1998). Both P2RY2 and its associated G protein alpha subunit, Gq/G11, are required for elevated cytosolic Ca2+ and activation of nitric oxide synthase 3 (NOS3, eNOS) in response to shear stress (Wang et al. 2015, 2016). P2RY2 and Gq/11 may act through phospholipase C beta (PLCbeta) to activate NOS3.
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Orthologous Events
P2RY2 binds ATP (Bos taurus)
P2RY2 binds ATP (Canis familiaris)
P2RY2 binds ATP (Danio rerio)
P2RY2 binds ATP (Gallus gallus)
P2RY2 binds ATP (Mus musculus)
P2RY2 binds ATP (Rattus norvegicus)
P2RY2 binds ATP (Sus scrofa)
P2RY2 binds ATP (Xenopus tropicalis)
Authored
May, B  (2024-02-07)
Reviewed
Xiao, R  (2024-07-16)
Created
May, B  (2024-02-10)
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