ADM:CALCRL:RAMP2 binds G(s):GDP:Gbeta:Ggamma heterotrimer

Stable Identifier
R-HSA-9861300
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
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ADM:CALCRL:RAMP2 binds G(s):GDP:Gbeta:Ggamma heterotrimer
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The CALCRL:RAMP2 receptor bound to ADM binds the Gs alpha subunit of the heterotrimeric G protein complex G alpha s:G beta:G gamma (Weston et al. 2016, Woolley et al. 2017, Inoue et al. 2019, Liang et al. 2020, RoehrKasse et al. 2020). Activation of the CALCLR:RAMP2 receptor (AM1 receptor) results in synthesis of cAMP and activation of CREB and ERK (Garelja et al. 2020).
Literature References
PubMed ID Title Journal Year
32296767 Structure and Dynamics of Adrenomedullin Receptors AM1 and AM2 Reveal Key Mechanisms in the Control of Receptor Phenotype by Receptor Activity-Modifying Proteins

Hay, DL, Khoshouei, M, Deganutti, G, Wootten, D, Christopoulos, A, Reynolds, CA, Furness, SGB, Liang, YL, Koole, C, Belousoff, MJ, Miller, LJ, Zhang, X, Fletcher, MM, Danev, R, Sexton, PM

ACS Pharmacol Transl Sci 2020
27566546 Receptor Activity-modifying Protein-directed G Protein Signaling Specificity for the Calcitonin Gene-related Peptide Family of Receptors

Woodlock, DA, Reynolds, CA, Hodgson, R, Weston, C, Poyner, DR, Dowell, SJ, Shah, A, Watkins, HA, Winfield, I, Ladds, G, Mobarec, JC, Harris, M

J Biol Chem 2016
32487746 Biochemical characterization of G protein coupling to calcitonin gene-related peptide and adrenomedullin receptors using a native PAGE assay

Warner, ML, Booe, JM, Roehrkasse, AM, Pioszak, AA

J Biol Chem 2020
31160049 Illuminating G-Protein-Coupling Selectivity of GPCRs

Russell, RB, Kishi, T, Inoue, A, Gutkind, JS, Ishida, S, Shinjo, Y, Singh, G, Kawakami, K, Ono, Y, Uwamizu, A, Arang, N, Raimondi, F, Kadji, FMN, Aoki, J

Cell 2019
28705698 Receptor activity-modifying protein dependent and independent activation mechanisms in the coupling of calcitonin gene-related peptide and adrenomedullin receptors to Gs

Hay, DL, Reynolds, CA, Poyner, DR, Conner, AC, Simms, J, Woolley, MJ, Garelja, ML, Walker, CS, Mobarec, JC

Biochem Pharmacol 2017
Participants
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Output
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Authored
May, B  (2024-02-12)
Reviewed
Xiao, R  (2024-07-16)
Created
May, B  (2024-02-16)
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