p-Y407-YAP1 translocates from the cytosol to the nucleoplasm

Stable Identifier
R-HSA-9865176
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
cytosol, nucleoplasm
ReviewStatus
5/5
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p-Y407-YAP1 translocates from the cytosol to the nucleoplasm
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In response to turbulent flow across endothelial cells, YAP1 is phosphorylated on tyrosine-407 (Li et al. 2019) and transits to the nucleus (Wang et al. 2016, Li et al. 2019, Nakajima et al. 2017). The phosphorylation and nuclear localization require interaction between integrin alpha5 (ITGA5) on endothelial cells and extracellular fibronectin, a stiff extracellular matrix (Dupont et al. 2011, Li et al. 2019). Within the nucleus, YAP1 interacts with TEAD proteins at promoters to activate transcription.
Literature References
PubMed ID Title Journal Year
28350986 Flow-Dependent Endothelial YAP Regulation Contributes to Vessel Maintenance

Nakajima, H, Yamamoto, K, Agarwala, S, Terai, K, Fukui, H, Fukuhara, S, Ando, K, Miyazaki, T, Yokota, Y, Schmelzer, E, Belting, HG, Affolter, M, Lecaudey, V, Mochizuki, N

Dev Cell 2017
30629551 c-Abl regulates YAPY357 phosphorylation to activate endothelial atherogenic responses to disturbed flow

Li, B, He, J, Lv, H, Liu, Y, Lv, X, Zhang, C, Zhu, Y, Ai, D

J Clin Invest 2019
21654799 Role of YAP/TAZ in mechanotransduction

Dupont, S, Morsut, L, Aragona, M, Enzo, E, Giulitti, S, Cordenonsi, M, Zanconato, F, Le Digabel, J, Forcato, M, Bicciato, S, Elvassore, N, Piccolo, S

Nature 2011
27671657 Flow-dependent YAP/TAZ activities regulate endothelial phenotypes and atherosclerosis

Wang, KC, Yeh, YT, Nguyen, P, Limqueco, E, Lopez, J, Thorossian, S, Guan, KL, Li, YJ, Chien, S

Proc Natl Acad Sci U S A 2016
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Orthologous Events
p-Y407-YAP1 translocates from the cytosol to the nucleoplasm (Bos taurus)
p-Y407-YAP1 translocates from the cytosol to the nucleoplasm (Caenorhabditis elegans)
p-Y407-YAP1 translocates from the cytosol to the nucleoplasm (Canis familiaris)
p-Y407-YAP1 translocates from the cytosol to the nucleoplasm (Danio rerio)
p-Y407-YAP1 translocates from the cytosol to the nucleoplasm (Drosophila melanogaster)
p-Y407-YAP1 translocates from the cytosol to the nucleoplasm (Gallus gallus)
p-Y407-YAP1 translocates from the cytosol to the nucleoplasm (Mus musculus)
p-Y407-YAP1 translocates from the cytosol to the nucleoplasm (Rattus norvegicus)
p-Y407-YAP1 translocates from the cytosol to the nucleoplasm (Sus scrofa)
p-Y407-YAP1 translocates from the cytosol to the nucleoplasm (Xenopus tropicalis)
Authored
May, B  (2024-03-07)
Reviewed
Xiao, R  (2024-07-16)
Created
May, B  (2024-03-09)
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