MMP14 translocates from the Golgi membrane to the plasma membrane

Stable Identifier
R-HSA-9858803
Type
Reaction [uncertain]
Species
Homo sapiens
Compartment
Golgi membrane, plasma membrane
ReviewStatus
5/5
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MMP14 translocates from the Golgi membrane to the plasma membrane
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Matrix metalloprotease 14 (MMP14, MT1-MMP) is activated by translocation to the plasma membrane in response to laminar flow stress (wall shear stress) (inferred from mouse cells). The translocation is synergistically enhanced by calcium influx through PIEZO1 channels and sphingosine 1-phosphate (inferred from mouse cells). MMP14 plays a role in subsequent angiogenesis (inferred from mouse cells).
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
S1P [extracellular region]
Regulator
Ca2+ [cytosol]
Inferred From
Mmp14 translocates from the Golgi membrane to the plasma membrane (Mus musculus)
Authored
May, B  (2024-01-14)
Reviewed
Xiao, R  (2024-07-16)
Created
May, B  (2024-01-14)
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