AKT1 binds phosphoinositol-3,4,5-trisphosphate (PIP3)

Stable Identifier
R-HSA-9860833
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
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AKT1 binds phosphoinositol-3,4,5-trisphosphate (PIP3)
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The Pleckstrin Homology (PH) domain of AKT1 (PKB) binds phosphatidylinositol-3,4,5-trisphosphate at the plasma membrane (Thomas et al. 2002, inferred from the mouse homolog).
Literature References
PubMed ID Title Journal Year
12176338 High-resolution structure of the pleckstrin homology domain of protein kinase b/akt bound to phosphatidylinositol (3,4,5)-trisphosphate

Alessi, DR, van Aalten, DM, Thomas, CC, Deak, M

Curr Biol 2002
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Inferred From
Akt1 binds phosphoinositol-3,4,5-trisphosphate (Mus musculus)
Authored
May, B  (2024-02-07)
Reviewed
Xiao, R  (2024-07-16)
Created
May, B  (2024-02-10)
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