Phosphorylation of IKBKE on serine-172 in response to low shear stress

Stable Identifier
R-HSA-9865492
Type
Reaction [uncertain]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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Phosphorylation of IKBKE on serine-172 in response to low shear stress
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Low shear stress, which acts similarly to oscillating shear stress, occurs at inner curves and bifurcations of blood vessels where it causes phosphorylation of IKBKE (IKKepsilon) on serine-172 by an uncharacterized mechanism (Zhu et al. 2021, Lv et al. 2024). Phosphorylated IKBKE participates in inflammation and atherosclerosis, as demonstrated by a knockdown of IKBKE in mice that resulted in a substantial reduction in atherosclerotic lesions (Lv et al. 2024).
Literature References
PubMed ID Title Journal Year
33370582 Akt phosphorylation regulated by IKKε in response to low shear stress leads to endothelial inflammation via activating IRF3

Gu, Y, Yu, W, Yang, H, Zhu, L, Zhang, J, Chen, S, Chu, P, Ye, P, Wang, F, Chao, Y, Kong, X

Cell Signal 2021
38315275 Low-Shear Stress Promotes Atherosclerosis via Inducing Endothelial Cell Pyroptosis Mediated by IKKε/STAT1/NLRP3 Pathway

Gu, Y, Lv, Y, Wang, D, Yang, H, Zhu, L, Kong, C, Jiang, Z, Chen, S, Qian, Z, Zhou, W, Jin, G

Inflammation 2024
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Orthologous Events
Phosphorylation of IKBKE on serine-172 in response to low shear stress (Bos taurus)
Phosphorylation of IKBKE on serine-172 in response to low shear stress (Canis familiaris)
Phosphorylation of IKBKE on serine-172 in response to low shear stress (Danio rerio)
Phosphorylation of IKBKE on serine-172 in response to low shear stress (Drosophila melanogaster)
Phosphorylation of IKBKE on serine-172 in response to low shear stress (Gallus gallus)
Phosphorylation of IKBKE on serine-172 in response to low shear stress (Mus musculus)
Phosphorylation of IKBKE on serine-172 in response to low shear stress (Rattus norvegicus)
Phosphorylation of IKBKE on serine-172 in response to low shear stress (Sus scrofa)
Phosphorylation of IKBKE on serine-172 in response to low shear stress (Xenopus tropicalis)
Authored
May, B  (2024-03-09)
Reviewed
Xiao, R  (2024-07-16)
Created
May, B  (2024-03-13)
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