Phosphorylation of ABL1 on tyrosine-393 in response to oscillatory shear stress

Stable Identifier
R-HSA-9865184
Type
Reaction [uncertain]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Phosphorylation of ABL1 on tyrosine-393 in response to oscillatory shear stress
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Through an uncharacterized mechanism, oscillatory shear stress and the binding of integrin apha5:integrin beta1 (ITGA5:ITGB1) to fibronectin matrix cause ABL to be phosphorylated on tyrosine-393 of the reference isoform, which corresponds to tyrosine-412 of isoform 2 (Li et al. 2019).
Literature References
PubMed ID Title Journal Year
30629551 c-Abl regulates YAPY357 phosphorylation to activate endothelial atherogenic responses to disturbed flow

Lv, X, Li, B, Ai, D, He, J, Zhu, Y, Liu, Y, Lv, H, Zhang, C

J Clin Invest 2019
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
p-S26-ANXA2:ITGA5:ITGB1:Ca2+:fibronectin [plasma membrane] (Homo sapiens)
Orthologous Events
Phosphorylation of ABL1 on tyrosine-393 in response to oscillatory shear stress (Bos taurus)
Phosphorylation of ABL1 on tyrosine-393 in response to oscillatory shear stress (Caenorhabditis elegans)
Phosphorylation of ABL1 on tyrosine-393 in response to oscillatory shear stress (Canis familiaris)
Phosphorylation of ABL1 on tyrosine-393 in response to oscillatory shear stress (Drosophila melanogaster)
Phosphorylation of ABL1 on tyrosine-393 in response to oscillatory shear stress (Gallus gallus)
Phosphorylation of ABL1 on tyrosine-393 in response to oscillatory shear stress (Mus musculus)
Phosphorylation of ABL1 on tyrosine-393 in response to oscillatory shear stress (Rattus norvegicus)
Phosphorylation of ABL1 on tyrosine-393 in response to oscillatory shear stress (Sus scrofa)
Phosphorylation of ABL1 on tyrosine-393 in response to oscillatory shear stress (Xenopus tropicalis)
Authored
May, B  (2024-03-07)
Reviewed
Xiao, R  (2024-07-16)
Created
May, B  (2024-03-09)
Cite Us!