p-T816-PKN2 phosphorylates NOS3 (eNOS) on serine-1179

Stable Identifier
R-HSA-9860808
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
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p-T816-PKN2 phosphorylates NOS3 (eNOS) on serine-1179
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Phosphorylated PKN2 phosphorylates NOS3 (eNOS) on serine-1179 in endothelial cells in response to laminar shear flow (Jin et al. 2021).
Literature References
PubMed ID Title Journal Year
34499618 Protein kinase N2 mediates flow-induced endothelial NOS activation and vascular tone regulation

Jin, YJ, Chennupati, R, Li, R, Liang, G, Wang, S, Iring, A, Graumann, J, Wettschureck, N, Offermanns, S

J Clin Invest 2021
Participants
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Output
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as an event of
Catalyst Activity

protein serine kinase activity of p-T816-PKN2 [cytosol]

Physical Entity
p-T816-PKN2 [cytosol] (Homo sapiens)
Activity
protein serine kinase activity (GO:0106310)
Orthologous Events
p-T816-PKN2 phosphorylates NOS3 (eNOS) on serine-1179 (Bos taurus)
p-T816-PKN2 phosphorylates NOS3 (eNOS) on serine-1179 (Dictyostelium discoideum)
p-T816-PKN2 phosphorylates NOS3 (eNOS) on serine-1179 (Drosophila melanogaster)
p-T816-PKN2 phosphorylates NOS3 (eNOS) on serine-1179 (Mus musculus)
p-T816-PKN2 phosphorylates NOS3 (eNOS) on serine-1179 (Rattus norvegicus)
p-T816-PKN2 phosphorylates NOS3 (eNOS) on serine-1179 (Saccharomyces cerevisiae)
p-T816-PKN2 phosphorylates NOS3 (eNOS) on serine-1179 (Schizosaccharomyces pombe)
p-T816-PKN2 phosphorylates NOS3 (eNOS) on serine-1179 (Sus scrofa)
Authored
May, B  (2024-02-07)
Reviewed
Xiao, R  (2024-07-16)
Created
May, B  (2024-02-10)
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