Reactome | PKA phosphorylates NOS3 (eNOS) on serine-633

PKA phosphorylates NOS3 (eNOS) on serine-633

Stable Identifier

R-HSA-9861318

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

ReviewStatus

5/5

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PKA phosphorylates NOS3 (eNOS) on serine-633

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Protein kinase A (PKA) is activated by Adrenomedullin signaling in response to laminar flow shear stress and phosphorylates NOS3 (eNOS) on serine-633 (Iring et al. 2019, also inferred from bovine homologs in Boo et al. 2002). Gs (ADM signaling) and Gq/11 (ATP signaling) activate NOS3 activity additively (Iring et al. 2019), resulting in release of nitric oxide from endothelial cells that causes vasodilation.

Literature References

PubMed ID	Title	Journal	Year
31205027	Shear stress-induced endothelial adrenomedullin signaling regulates vascular tone and blood pressure Wettschureck, N, Graumann, J, Nakayama, A, Weinstein, LS, Günther, S, Künne, C, Wang, S, Offermanns, S, Dancs, PT, Sokol, AM, Jin, YJ, Chen, M, Albarrán-Juárez, J, Tonack, S, Siragusa, M, Martínez, A, Iring, A, Fleming, I	J Clin Invest	2019